IMP
Process View
heparin metabolic process
The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "heparin metabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Tgfbr2 | transforming growth factor, beta receptor II | 0.651 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.641 | ||
| Sulf2 | sulfatase 2 | 0.393 | Fly | |
| Sulf1 | sulfatase 1 | 0.271 | Fly | |
| Tgfbr3 | transforming growth factor, beta receptor III | 0.096 | ||
| Prrx1 | paired related homeobox 1 | 0.089 | ||
| Fzd1 | frizzled homolog 1 (Drosophila) | 0.064 | ||
| Cdh11 | cadherin 11 | 0.054 | ||
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.054 | ||
| Gpc3 | glypican 3 | 0.046 | ||
| Kif3a | kinesin family member 3A | 0.035 | ||
| Bmp5 | bone morphogenetic protein 5 | 0.031 | ||
| Glg1 | golgi apparatus protein 1 | 0.030 | ||
| Smad5 | MAD homolog 5 (Drosophila) | 0.029 | ||
| Fn1 | fibronectin 1 | 0.029 | ||
| Aebp1 | AE binding protein 1 | 0.025 | ||
| Galnt2 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 | 0.025 | ||
| Arhgap29 | Rho GTPase activating protein 29 | 0.024 | ||
| Bmpr2 | bone morphogenic protein receptor, type II (serine/threonine kinase) | 0.023 | ||
| Galc | galactosylceramidase | 0.022 | ||
| Myo10 | myosin X | 0.022 | ||
| Hgf | hepatocyte growth factor | 0.021 | ||
| Itga5 | integrin alpha 5 (fibronectin receptor alpha) | 0.021 | ||
| Ednrb | endothelin receptor type B | 0.020 | ||
| Scara3 | scavenger receptor class A, member 3 | 0.020 | ||
| Mme | membrane metallo endopeptidase | 0.019 | ||
| Itgav | integrin alpha V | 0.019 | ||
| Large | like-glycosyltransferase | 0.018 | ||
| Gna12 | guanine nucleotide binding protein, alpha 12 | 0.017 | ||
| Vim | vimentin | 0.017 | ||
| Dgcr2 | DiGeorge syndrome critical region gene 2 | 0.016 | ||
| Apaf1 | apoptotic peptidase activating factor 1 | 0.016 | ||
| Maged1 | melanoma antigen, family D, 1 | 0.015 | ||
| Scn7a | sodium channel, voltage-gated, type VII, alpha | 0.014 | ||
| Tll1 | tolloid-like | 0.014 | ||
| Ptprg | protein tyrosine phosphatase, receptor type, G | 0.014 | ||
| Mmp2 | matrix metallopeptidase 2 | 0.013 | ||
| Sema3c | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.013 | ||
| Ggcx | gamma-glutamyl carboxylase | 0.013 | ||
| Cdk14 | cyclin-dependent kinase 14 | 0.013 | ||
| Wwc2 | WW, C2 and coiled-coil domain containing 2 | 0.013 | ||
| Lama4 | laminin, alpha 4 | 0.013 | ||
| Timp2 | tissue inhibitor of metalloproteinase 2 | 0.013 | ||
| Ctdsp2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | 0.013 | ||
| Rcn3 | reticulocalbin 3, EF-hand calcium binding domain | 0.013 | ||
| Cyr61 | cysteine rich protein 61 | 0.013 | ||
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.012 | ||
| Pygb | brain glycogen phosphorylase | 0.012 | ||
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.012 | ||
| Sh3rf1 | SH3 domain containing ring finger 1 | 0.012 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.012 | ||
| Met | met proto-oncogene | 0.012 | ||
| Ski | ski sarcoma viral oncogene homolog (avian) | 0.012 | ||
| Dqx1 | DEAQ RNA-dependent ATPase | 0.012 | ||
| Twsg1 | twisted gastrulation homolog 1 (Drosophila) | 0.012 | ||
| Plxnb2 | plexin B2 | 0.011 | ||
| Nedd4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.011 | ||
| Hs2st1 | heparan sulfate 2-O-sulfotransferase 1 | 0.011 | ||
| Sfrp2 | secreted frizzled-related protein 2 | 0.011 | ||
| Ids | iduronate 2-sulfatase | 0.011 | ||
| Elk3 | ELK3, member of ETS oncogene family | 0.011 | ||
| Sh3bgrl3 | SH3 domain binding glutamic acid-rich protein-like 3 | 0.011 | ||
| Dsel | dermatan sulfate epimerase-like | 0.011 | ||
| Soat1 | sterol O-acyltransferase 1 | 0.011 | ||
| Ergic1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | 0.010 | ||
| Sema3a | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.010 | ||
| Tbxas1 | thromboxane A synthase 1, platelet | 0.010 | ||
| Rps6ka3 | ribosomal protein S6 kinase polypeptide 3 | 0.010 |