IMP

Process View

Rattus norvegicus

34 genes annotated in rat

ionotropic glutamate receptor signaling pathway

A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ionotropic glutamate receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ionotropic glutamate receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Grin1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.974
Dlg4	discs, large homolog 4 (Drosophila)	0.958
Prkcg	protein kinase C, gamma	0.954
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.953
Gria1	glutamate receptor, ionotropic, AMPA 1	0.947
Grin2a	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.831
Gria2	glutamate receptor, ionotropic, AMPA 2	0.729
Dlgap3	discs, large (Drosophila) homolog-associated protein 3	0.617
Pick1	protein interacting with PRKCA 1	0.444
Camkv	CaM kinase-like vesicle-associated	0.419
Kcnd2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.413
Grip1	glutamate receptor interacting protein 1	0.388
Kcnc2	potassium voltage gated channel, Shaw-related subfamily, member 2	0.298
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.259
Grm7	glutamate receptor, metabotropic 7	0.173
Gabbr1	gamma-aminobutyric acid (GABA) B receptor 1	0.163
Magi2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.151
Scn8a	sodium channel, voltage gated, type VIII, alpha subunit	0.141
Chrm3	cholinergic receptor, muscarinic 3	0.128
Lrrc7	leucine rich repeat containing 7	0.122
Hpcal4	hippocalcin-like 4	0.121
Gria3	glutamate receptor, ionotrophic, AMPA 3	0.116
Unc5a	unc-5 homolog A (C. elegans)	0.109
Tnr	tenascin R	0.106
Matk	megakaryocyte-associated tyrosine kinase	0.100
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.096
Sema6b	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	0.090
Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.089
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.085
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.080
Sptan1	spectrin, alpha, non-erythrocytic 1	0.079
Camk4	calcium/calmodulin-dependent protein kinase IV	0.078
Lin7b	lin-7 homolog b (C. elegans)	0.076
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.073
Epn1	Epsin 1	0.069
Nlgn3	neuroligin 3	0.063	Mouse Rat
Syn1	synapsin I	0.062
Mobp	myelin-associated oligodendrocyte basic protein	0.058
Pnck	pregnancy upregulated non-ubiquitously expressed CaM kinase	0.057
Map2	microtubule-associated protein 2	0.056
Gria4	glutamate receptor, ionotrophic, AMPA 4	0.055
Prkcb	protein kinase C, beta	0.055
Camk2b	calcium/calmodulin-dependent protein kinase II beta	0.053
Hk1	hexokinase 1	0.050
Cnksr2	connector enhancer of kinase suppressor of Ras 2	0.050
Ryr2	ryanodine receptor 2, cardiac	0.050
Shank1	SH3 and multiple ankyrin repeat domains 1	0.046	Mouse
Gng7	guanine nucleotide binding protein (G protein), gamma 7	0.046
Bcan	brevican	0.044
Agap2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.043
Grin3a	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	0.040
Nrxn3	neurexin 3	0.040
Tanc1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	0.039
Grik5	glutamate receptor, ionotropic, kainate 5	0.038
Mog	myelin oligodendrocyte glycoprotein	0.038
Unc13a	unc-13 homolog A (C. elegans)	0.035
Itgb1	integrin, beta 1	0.034
Esr2	estrogen receptor 2 (ER beta)	0.034
Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	0.033
Hnmt	histamine N-methyltransferase	0.032
Nfasc	neurofascin	0.032
RGD1562618	similar to RIKEN cDNA 6030419C18 gene	0.032
Kalrn	kalirin, RhoGEF kinase	0.031
Kcnt1	potassium channel, subfamily T, member 1	0.030
Atp2b3	ATPase, Ca++ transporting, plasma membrane 3	0.029
Foxj1	forkhead box J1	0.028
Grid1	glutamate receptor, ionotropic, delta 1	0.028
Nrxn2	neurexin 2	0.028
Grm3	glutamate receptor, metabotropic 3	0.027
Aqp4	aquaporin 4	0.026
Mgat3	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	0.026
Mpp3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.026
Gabrd	gamma-aminobutyric acid (GABA) A receptor, delta	0.025
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.025
Epha7	Eph receptor A7	0.025
Chrna2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	0.024
Naaladl1	N-acetylated alpha-linked acidic dipeptidase-like 1	0.024
Adap1	ArfGAP with dual PH domains 1	0.024
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.024
Rnf112	ring finger protein 112	0.024
Cplx2	complexin 2	0.024
Dpp6	dipeptidylpeptidase 6	0.023
Rnf207	ring finger protein 207	0.022
Znf536	zinc finger protein 536	0.022
Itpka	inositol 1,4,5-trisphosphate 3-kinase A	0.022
Slc1a1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	0.021
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.021
Nlgn2	neuroligin 2	0.020	Mouse Rat
Thpo	thrombopoietin	0.020
Ank2	ankyrin 2, neuronal	0.020
Kcnab1	potassium voltage-gated channel, shaker-related subfamily, beta member 1	0.019
Gpr12	G protein-coupled receptor 12	0.019
Dgkb	diacylglycerol kinase, beta	0.019
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.019
Gpr61	G protein-coupled receptor 61	0.019
Syt12	synaptotagmin XII	0.019
Slc12a5	solute carrier family 12 (potassium-chloride transporter), member 5	0.019
Foxg1	forkhead box G1	0.018
Col20a1	collagen, type XX, alpha 1	0.018
Syn2	synapsin II	0.018
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.018
Chrnb2	cholinergic receptor, nicotinic, beta 2 (neuronal)	0.018
Gpat2	glycerol-3-phosphate acyltransferase 2, mitochondrial	0.018
Hrh3	histamine receptor H3	0.018
Itpr1	inositol 1,4,5-triphosphate receptor, type 1	0.017
Adra2a	adrenergic, alpha-2A-, receptor	0.017
Ddn	dendrin	0.017
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.017
Frem3	FRAS1 related extracellular matrix 3	0.017
Klhl17	kelch-like 17 (Drosophila)	0.017
Nlgn1	neuroligin 1	0.016
Znf532	zinc finger protein 532	0.016
Otud7a	OTU domain containing 7A	0.016
Sparc	secreted protein, acidic, cysteine-rich (osteonectin)	0.016
Gnao1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.016
Cntfr	ciliary neurotrophic factor receptor	0.016
Rgs14	regulator of G-protein signaling 14	0.016
Sptbn2	spectrin, beta, non-erythrocytic 2	0.015
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.015
Stx1b	syntaxin 1B	0.015
Nhlh1	nescient helix loop helix 1	0.015
Sdcbp	syndecan binding protein	0.015
Mapk4	mitogen-activated protein kinase 4	0.015
Syt7	synaptotagmin VII	0.015
Mag	myelin-associated glycoprotein	0.015
Itm2b	integral membrane protein 2B	0.014
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.014
Lrfn2	leucine rich repeat and fibronectin type III domain containing 2	0.014
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.014
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.013
Gad2	glutamate decarboxylase 2	0.013
Dlg3	discs, large homolog 3 (Drosophila)	0.013	Rat
Ptk2b	PTK2B protein tyrosine kinase 2 beta	0.013
Slc9a2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	0.013
Psap	prosaposin	0.013
Cd9	CD9 molecule	0.012
Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1	0.012
Prrt1	proline-rich transmembrane protein 1	0.012
Clcn2	chloride channel 2	0.012
Grm5	glutamate receptor, metabotropic 5	0.012
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.012
Mmp7	matrix metallopeptidase 7	0.012
Lhx5	LIM homeobox 5	0.012
Slc28a3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	0.012
Rnf165	ring finger protein 165	0.012
Faah	fatty acid amide hydrolase	0.012
Myt1l	myelin transcription factor 1-like	0.012
Hrasls5	HRAS-like suppressor family, member 5	0.012
Slc6a15	solute carrier family 6 (neutral amino acid transporter), member 15	0.012
Vamp1	vesicle-associated membrane protein 1	0.012
Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	0.011
Ptprm	protein tyrosine phosphatase, receptor type, M	0.011
Grip2	glutamate receptor interacting protein 2	0.011
Slit1	slit homolog 1 (Drosophila)	0.011
Tcea2	transcription elongation factor A (SII), 2	0.011
Shd	src homology 2 domain-containing transforming protein D	0.011
Lhx1	LIM homeobox 1	0.011
Trhr2	thyrotropin releasing hormone receptor 2	0.011
Psd	pleckstrin and Sec7 domain containing	0.011
Mprip	myosin phosphatase Rho interacting protein	0.011
Cspg5	chondroitin sulfate proteoglycan 5	0.011
Neurod2	neurogenic differentiation 2	0.011
Rhbdl1	rhomboid, veinlet-like 1 (Drosophila)	0.011
Drd1a	dopamine receptor D1A	0.011
Nckap1	NCK-associated protein 1	0.011
Camk2d	calcium/calmodulin-dependent protein kinase II delta	0.010
Pde4a	phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)	0.010
Ucn2	urocortin 2	0.010
Sstr3	somatostatin receptor 3	0.010	Rat
Pdha2	pyruvate dehydrogenase (lipoamide) alpha 2	0.010
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.010
Nrsn2	neurensin 2	0.010
Rimbp2	RIMS binding protein 2	0.010