IMP

Process View

Rattus norvegicus

1 genes annotated in rat

sympathetic nervous system development

The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "sympathetic nervous system development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "sympathetic nervous system development" (in gray)

Name	Description	Probability	Func Analog Organism
Nfib	nuclear factor I/B	0.131
Foxc2	forkhead box C2	0.117
Hrh1	histamine receptor H 1	0.076
Gtf2a1	general transcription factor IIA, 1	0.073
Gata6	GATA binding protein 6	0.071
Gna11	guanine nucleotide binding protein, alpha 11	0.054
Hist1h1d	histone cluster 1, H1d	0.053
Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	0.051
Dmd	dystrophin	0.038
Strn	striatin, calmodulin binding protein	0.037
Esr1	estrogen receptor 1	0.037
Unc5b	unc-5 homolog B (C. elegans)	0.036
Rasa2	RAS p21 protein activator 2	0.035
Prdm2	PR domain containing 2, with ZNF domain	0.035
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.031
Hand2	heart and neural crest derivatives expressed 2	0.030
Cdkn2b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.028
Fcer2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.028
Ceacam1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.027
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.027
Jund	jun D proto-oncogene	0.026
Nfya	nuclear transcription factor-Y alpha	0.025
Gpr182	G protein-coupled receptor 182	0.025
Foxi2	forkhead box I2	0.025
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.024
Arrb1	arrestin, beta 1	0.023
Met	met proto-oncogene	0.023
Hlf	hepatic leukemia factor	0.023
Ddr1	discoidin domain receptor tyrosine kinase 1	0.022
Scn5a	sodium channel, voltage-gated, type V, alpha subunit	0.022
Grm5	glutamate receptor, metabotropic 5	0.021
Cdcp1	CUB domain containing protein 1	0.021
Col9a1	collagen, type IX, alpha 1	0.021
Adrb1	adrenergic, beta-1-, receptor	0.021
Myo9a	myosin IXA	0.020
Bmp6	bone morphogenetic protein 6	0.020
Rock1	Rho-associated coiled-coil containing protein kinase 1	0.020
Nos2	nitric oxide synthase 2, inducible	0.019
Apoc4	apolipoprotein C-IV	0.018
Acacb	acetyl-Coenzyme A carboxylase beta	0.018
Robo2	roundabout homolog 2 (Drosophila)	0.018
Kcng2	potassium voltage-gated channel, subfamily G, member 2	0.018
Pip4k2b	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	0.017
LOC100361261	rCG23560-like	0.017
Ppp2r2c	protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform	0.017
Nr2c2	nuclear receptor subfamily 2, group C, member 2	0.017
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.017
Smad3	SMAD family member 3	0.017
Magi2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.016
Epha7	Eph receptor A7	0.016
Myo1a	myosin IA	0.016
Dcaf17	DDB1 and CUL4 associated factor 17	0.016
Fgd4	FYVE, RhoGEF and PH domain containing 4	0.016
Ube3a	ubiquitin protein ligase E3A	0.016
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.016	Mouse
Bcl2	B-cell CLL/lymphoma 2	0.016
Kremen1	kringle containing transmembrane protein 1	0.015
Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	0.015
Fam172a	family with sequence similarity 172, member A	0.015
Insr	insulin receptor	0.015
Epha3	Eph receptor A3	0.015
Tnrc6b	trinucleotide repeat containing 6B	0.015
Twist2	twist homolog 2 (Drosophila)	0.015
Ncoa2	nuclear receptor coactivator 2	0.015
Cmklr1	chemokine-like receptor 1	0.015
Tcf4	transcription factor 4	0.014
Abp10	annexin V-binding protein ABP-10	0.014
RT1-DOa	RT1 class II, locus DOa	0.014
Tef	thyrotrophic embryonic factor	0.014
Nab1	Ngfi-A binding protein 1	0.014
Prp2l1	proline rich protein 2-like 1	0.014
Atxn3	ataxin 3	0.014
Mthfr	methylenetetrahydrofolate reductase (NAD(P)H)	0.013
Htt	huntingtin	0.013
Ctnnd2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.013
Fat2	FAT tumor suppressor homolog 2 (Drosophila)	0.013
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.013
Efna5	ephrin A5	0.013
Ralgds	ral guanine nucleotide dissociation stimulator	0.013
Nrxn1	neurexin 1	0.013
Cckar	cholecystokinin A receptor	0.013
Galnt5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	0.013
Dync2h1	dynein cytoplasmic 2 heavy chain 1	0.013
Il7	interleukin 7	0.012
Ccnd2	cyclin D2	0.012
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.012
Tubb2b	tubulin, beta 2b	0.012
Rbbp9	retinoblastoma binding protein 9	0.012
Hfe	hemochromatosis	0.012
Lims1	LIM and senescent cell antigen-like domains 1	0.012
Tpt1	tumor protein, translationally-controlled 1	0.012
Fgf1	fibroblast growth factor 1	0.012
Myo10	myosin X	0.012
Akt3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	0.012
Arnt	aryl hydrocarbon receptor nuclear translocator	0.012
Klk1c10	T-kininogenase	0.012
Arhgap23	Rho GTPase activating protein 23	0.012
Chn2	chimerin (chimaerin) 2	0.012
Foxd1	forkhead box D1	0.012
Pxdn	peroxidasin homolog (Drosophila)	0.012
Rbm9	RNA binding motif protein 9	0.012
Ptprv	protein tyrosine phosphatase, receptor type, V	0.012
Prkg2	protein kinase, cGMP-dependent, type II	0.011
Stat5b	signal transducer and activator of transcription 5B	0.011
Notch1	Notch homolog 1, translocation-associated (Drosophila)	0.011
Cryba4	crystallin, beta A4	0.011
Mfhas1	malignant fibrous histiocytoma amplified sequence 1	0.011
Gab2	GRB2-associated binding protein 2	0.011
Tstd2	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	0.011
Lyst	lysosomal trafficking regulator	0.011
Dpysl3	dihydropyrimidinase-like 3	0.011
Macf1	microtubule-actin crosslinking factor 1	0.011
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.011	Rat
Rara	retinoic acid receptor, alpha	0.011
Plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.011
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.011
Trpc1	transient receptor potential cation channel, subfamily C, member 1	0.011
Gpr176	G protein-coupled receptor 176	0.011
LOC257642	rRNA promoter binding protein	0.011
Lhx1	LIM homeobox 1	0.011
Rgs12	regulator of G-protein signaling 12	0.011
Dck	deoxycytidine kinase	0.010
Prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.010
Qk	quaking	0.010
Hoxc4	homeo box C4	0.010
Kcna6	potassium voltage gated channel, shaker related subfamily, member 6	0.010
Isl2	ISL LIM homeobox 2	0.010
Cd8b	CD8b molecule	0.010
Pik3r3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.010
Kitlg	KIT ligand	0.010
Stk11	serine/threonine kinase 11	0.010
Pgap2	post-GPI attachment to proteins 2	0.010
Rin1	Ras and Rab interactor 1	0.010
Yy1	YY1 transcription factor	0.010
Mllt4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.010