The network for 'regulation of synapse organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of synapse organization

Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

Drosophila melanogaster
Name Description Probability Func Analog Organism
CaMKII Calcium/calmodulin-dependent protein kinase II 1.000
wit wishful thinking 0.999
neuroligin CG13772 gene product from transcript CG13772-RA 0.999
Mad Mothers against dpp 0.996
ena enabled 0.993
scb scab 0.993
caz cabeza 0.988
Acsl Acyl-CoA synthetase long-chain 0.985
TBPH CG10327 gene product from transcript CG10327-RC 0.978
Fak56D Focal Adhesion Kinase 0.976
Hem HEM-protein 0.974
nwk nervous wreck 0.971
mys myospheroid 0.971
Dad Daughters against dpp 0.967
unc-104 CG8566 gene product from transcript CG8566-RB 0.959
Cip4 CG15015 gene product from transcript CG15015-RA 0.954
Arp14D Actin-related protein 14D 0.951
brp bruchpilot 0.944
trio CG18214 gene product from transcript CG18214-RA 0.941
robo roundabout 0.940
cpx complexin 0.932
RhoGAP92B CG4755 gene product from transcript CG4755-RA 0.928
rut rutabaga 0.919
stnB stoned B 0.906
hiw highwire 0.905
p120ctn Adherens junction protein p120 0.888
Arp66B Actin-related protein 66B 0.885
Ank2 Ankyrin 2 0.884
Syx1A Syntaxin 1A 0.867
jeb jelly belly 0.865
Nrx-1 Neurexin 1 0.862
synaptogyrin CG10808 gene product from transcript CG10808-RA 0.845
CG32635 CG32635 gene product from transcript CG32635-RA 0.827
chb chromosome bows 0.820
cpb capping protein beta 0.806
Mob2 CG11711 gene product from transcript CG11711-RC 0.793
mnb minibrain 0.790
Akt1 CG4006 gene product from transcript CG4006-RA 0.776
BicD Bicaudal D 0.770
wnd wallenda 0.769
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.756
Cul-2 Cullin-2 0.745
Dap160 Dynamin associated protein 160 0.731
hpo hippo 0.722
Caki Calcium/calmodulin-dependent protein kinase 0.721
Fmr1 CG6203 gene product from transcript CG6203-RC 0.717
shot short stop 0.717
Hip14 Huntingtin-interacting protein 14 0.716
WASp CG1520 gene product from transcript CG1520-RA 0.712
stai stathmin 0.699
Alk CG8250 gene product from transcript CG8250-RA 0.698
S6k RPS6-p70-protein kinase 0.683
ci cubitus interruptus 0.680
NetB Netrin-B 0.676
bsk basket 0.675
LanA Laminin A 0.666
beta4GalNAcTA CG8536 gene product from transcript CG8536-RA 0.662
GluRIIA Glutamate receptor IIA 0.661
cv-c crossveinless c 0.647
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.645
Fas2 Fasciclin 2 0.633
endoA endophilin A 0.628
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.586
Appl beta amyloid protein precursor-like 0.577
dnc dunce 0.571
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.566
milt milton 0.562
Atg1 Autophagy-specific gene 1 0.556
tgo tango 0.552
dap dacapo 0.544
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.532
Syt4 Synaptotagmin 4 0.518
Sac1 CG9128 gene product from transcript CG9128-RB 0.495
Sema-1b CG6446 gene product from transcript CG6446-RA 0.492
alpha-Spec alpha Spectrin 0.490
Mob4 CG3403 gene product from transcript CG3403-RA 0.484
Aplip1 APP-like protein interacting protein 1 0.480
dock dreadlocks 0.475
Sema-1a CG18405 gene product from transcript CG18405-RD 0.473
fz2 frizzled 2 0.470
dlp dally-like 0.462
CCKLR-17D1 CCK-like receptor at 17D1 0.460
Pak3 CG14895 gene product from transcript CG14895-RA 0.454
CG17184 CG17184 gene product from transcript CG17184-RB 0.452
Snap Soluble NSF attachment protein 0.449
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.448
Sra-1 specifically Rac1-associated protein 1 0.437
hts hu li tai shao 0.432
Pten CG5671 gene product from transcript CG5671-RB 0.430
shn schnurri 0.422
oa2 octopamine receptor 2 0.418
kel kelch 0.417
Rab3 Rab-protein 3 0.396
Frq1 Frequenin 1 0.386
stan starry night 0.382
SNF4Agamma SNF4/AMP-activated protein kinase gamma subunit 0.371
pAbp polyA-binding protein 0.371
Gad1 Glutamic acid decarboxylase 1 0.361
ik2 IkappaB kinase-like 2 0.350
rtGEF rho-type guanine exchange factor 0.348
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-9 Protein UNC-9 0.065
dpy-22 Protein DPY-22 0.062
ina-1 Protein INA-1 0.050
unc-108 Protein UNC-108 0.046
spc-1 Protein SPC-1 0.046
unc-32 Protein UNC-32 0.044
flt-1 Protein FLT-1 0.041
ZC449.5 Protein ZC449.5 0.035
cdc-42 Protein CDC-42 0.032
egl-18 Protein EGL-18 0.030
pha-4 Protein PHA-4 0.029
ain-1 Protein AIN-1 0.028
ceh-13 Protein CEH-13 0.027
exc-5 Protein EXC-5 0.026
plp-1 Protein PLP-1 0.024
egl-44 Protein EGL-44 0.023
unc-73 Protein UNC-73 0.022
crm-1 Protein CRM-1 0.022
cst-2 Protein CST-2 0.021
ncam-1 Protein NCAM-1 0.021
ceh-20 Protein CEH-20 0.021
prx-13 Protein PRX-13 0.020
cap-1 Protein CAP-1 0.019
obr-3 Protein OBR-3 0.019
tps-1 Protein TPS-1 0.017
elt-6 Protein ELT-6 0.016
mig-2 Protein MIG-2 0.016
tag-123 Protein TAG-123 0.016
abts-1 Protein ABTS-1 0.016
eat-16 Protein EAT-16 0.016
CELE_C39E9.11 Protein C39E9.11 0.015
unc-18 Protein UNC-18 0.015
sma-6 Protein SMA-6 0.014
unc-69 Protein UNC-69 0.014
CELE_C08F11.13 Protein C08F11.13 0.014
pqn-51 Protein PQN-51 0.014
T19A5.1 Protein T19A5.1 0.013
goa-1 Protein GOA-1 0.013
madf-5 Protein MADF-5 0.013
chd-7 Protein CHD-7 0.013
F27C1.2 Protein F27C1.2 0.012
dnj-12 Protein DNJ-12 0.012
clic-1 Protein CLIC-1 0.012
cst-1 Protein CST-1 0.012
tag-241 Protein TAG-241 0.011
C11E4.6 Protein C11E4.6 0.011
rig-6 Protein RIG-6 0.011
rgs-6 Protein RGS-6 0.010
clh-5 Protein CLH-5 0.010
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Danio rerio
Name Description Probability Func Analog Organism
boc brother of CDO 0.860
olfm2 olfactomedin 2 0.772
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.751
srsf2 serine/arginine-rich splicing factor 2 0.671
lhx2b LIM homeobox 2b 0.660
lama4 laminin, alpha 4 0.651
nlgn2b neuroligin 2b 0.647
nf1a neurofibromin 1a 0.647
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.631
tac1 tachykinin 1 0.619
robo2 roundabout homolog 2 0.612
ldb2a LIM-domain binding factor 2a 0.609
smo smoothened homolog (Drosophila) 0.591
smad9 MAD homolog 9 (Drosophila) 0.589
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.540
si:dkeyp-104h9.6 si:dkeyp-104h9.6 0.535
lama2 laminin, alpha 2 0.534
nlgn4b neuroligin 4b 0.515
dkk1b dickkopf 1b 0.509
slit3 slit (Drosophila) homolog 3 0.486
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.486
roraa RAR-related orphan receptor A, paralog a 0.485
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.476
szl sizzled 0.470
slc17a6b solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b 0.465
mef2cb myocyte enhancer factor 2cb 0.460
smad1 MAD homolog 1 (Drosophila) 0.458
kpna4 karyopherin alpha 4 (importin alpha 3) 0.452
thsd7a thrombospondin, type I, domain containing 7A 0.444
mmp2 matrix metalloproteinase 2 0.440
pcdh8 protocadherin 8 0.426
extl3 exostoses (multiple)-like 3 0.416
camk2g1 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 0.414
dlg2 discs, large (Drosophila) homolog 2 0.411
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.410
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.402
spns2 spinster homolog 2 (Drosophila) 0.396
dlg1 discs, large (Drosophila) homolog 1 0.392
flot1 flotillin 1 0.375
pknox1.2 pbx/knotted 1 homeobox 1.2 0.375
ikzf5 IKAROS family zinc finger 5 0.366
plxna3 plexin A3 0.356
nlgn2a neuroligin 2a 0.353
arf2 ADP-ribosylation factor 2 0.349
dync1h1 dynein, cytoplasmic 1, heavy chain 1 0.343
alcamb activated leukocyte cell adhesion molecule b 0.343
ptpra protein tyrosine phosphatase, receptor type, A 0.340
celsr1a cadherin EGF LAG seven-pass G-type receptor 1a 0.331
prkcz protein kinase C, zeta 0.310
si:ch211-232m7.1 si:ch211-232m7.1 0.308
rnd3a Rho family GTPase 3a 0.307
mfn2 mitofusin 2 0.304
nrg2a neuregulin 2a 0.302
antxr1 anthrax toxin receptor 1 0.298
frem3 Fras1 related extracellular matrix 3 0.289
unc5b unc-5 homolog B (C. elegans) 0.289
myf6 myogenic factor 6 0.288
mef2d myocyte enhancer factor 2d 0.286
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.282
zmynd11 zinc finger, MYND domain containing 11 0.279
nlgn3b neuroligin 3b 0.278
slit1b slit homolog 1b (Drosophila) 0.278
fstl1b follistatin-like 1b 0.276
nlgn1 neuroligin 1 0.276
cirbp cold inducible RNA binding protein 0.276
foxp2 forkhead box P2 0.276
cdc42 cell division cycle 42 0.274
slit2 slit (Drosophila) homolog 2 0.273
foxn4 forkhead box N4 0.272
psen1 presenilin 1 0.271
gad1b glutamate decarboxylase 1b 0.268
six3b sine oculis homeobox homolog 3b 0.267
mxi1 max interacting protein 0.263
ephb4b eph receptor B4b 0.263
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.261
ntrk2a neurotrophic tyrosine kinase, receptor, type 2a 0.252
npc1 Niemann-Pick disease, type C1 0.252
spsb4a splA/ryanodine receptor domain and SOCS box containing 4a 0.249
gro2 groucho 2 0.248
mapk1 mitogen-activated protein kinase 1 0.246
mnx1 motor neuron and pancreas homeobox 1 0.244
igf1rb insulin-like growth factor 1b receptor 0.242
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.237
dlc deltaC 0.236
limk1 LIM domain kinase 1 0.234
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.233
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.233
arpc5a actin related protein 2/3 complex, subunit 5A 0.232
irx4a iroquois homeobox protein 4a 0.231
plxnb2a plexin b2a 0.228
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.224
pkp2 plakophilin 2 0.223
pdlim2 PDZ and LIM domain 2 (mystique) 0.218
stau2 staufen, RNA binding protein, homolog 2 (Drosophila) 0.218
sncb synuclein, beta 0.218
ext1a exostoses (multiple) 1a 0.216
zdhhc8b zinc finger, DHHC-type containing 8b 0.214
antxr2a anthrax toxin receptor 2a 0.213
cdh2 cadherin 2, neuronal 0.211
zbtb4 zinc finger and BTB domain containing 4 0.210
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Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.673
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.271
DLG4 discs, large homolog 4 (Drosophila) 0.211
MAPK8 mitogen-activated protein kinase 8 0.166
GRB2 growth factor receptor-bound protein 2 0.093
SPRR2A small proline-rich protein 2A 0.057
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.048
SMAD1 SMAD family member 1 0.044
FASLG Fas ligand (TNF superfamily, member 6) 0.043
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.035
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.035
FYN FYN oncogene related to SRC, FGR, YES 0.032
KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4 0.031
FUS fused in sarcoma 0.031
WIPF1 WAS/WASL interacting protein family, member 1 0.029
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.029
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.025
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.024
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.024
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.022
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.021
NCK1 NCK adaptor protein 1 0.021
GRB7 growth factor receptor-bound protein 7 0.021
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.021
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.018
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.018
TSC1 tuberous sclerosis 1 0.016
DAAM1 dishevelled associated activator of morphogenesis 1 0.015
BMP2 bone morphogenetic protein 2 0.015
GDA guanine deaminase 0.014
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.014
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.014
CUL1 cullin 1 0.014
PTPRC protein tyrosine phosphatase, receptor type, C 0.013
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.013
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.013
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.012
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.011
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.011
ATN1 atrophin 1 0.011
PRMT1 protein arginine methyltransferase 1 0.011
SYK spleen tyrosine kinase 0.010
ITSN1 intersectin 1 (SH3 domain protein) 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.363
Gria2 glutamate receptor, ionotropic, AMPA 2 0.312
Dlg4 discs, large homolog 4 (Drosophila) 0.208
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.160
Syn1 synapsin I 0.132
Map2 microtubule-associated protein 2 0.130
Sirpa signal-regulatory protein alpha 0.114
Adrbk1 adrenergic, beta, receptor kinase 1 0.109
Myt1l myelin transcription factor 1-like 0.088
Nrxn3 neurexin 3 0.072
Ppp2r2c protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform 0.063
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.058
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.056
Syt3 synaptotagmin III 0.055
Nfasc neurofascin 0.048
Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.047
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.047
Shank1 SH3 and multiple ankyrin repeat domains 1 0.046
Camkv CaM kinase-like vesicle-associated 0.046
Il2rg interleukin 2 receptor, gamma 0.044
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.043
Mprip myosin phosphatase Rho interacting protein 0.039
Grik5 glutamate receptor, ionotropic, kainate 5 0.039
Sema6b sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.039
Dgkz diacylglycerol kinase zeta 0.035
Svop SV2 related protein 0.034
Csnk1g3 casein kinase 1, gamma 3 0.033
Adap1 ArfGAP with dual PH domains 1 0.033
Stk10 serine/threonine kinase 10 0.032
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.032
Glg1 golgi apparatus protein 1 0.032
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.032
Ryr2 ryanodine receptor 2, cardiac 0.030
Ptprs protein tyrosine phosphatase, receptor type, S 0.029
Stx1b syntaxin 1B 0.029
Kcnf1 potassium voltage-gated channel, subfamily F, member 1 0.029
Amph amphiphysin 0.029
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.028
Baiap2 BAI1-associated protein 2 0.028
Syp synaptophysin 0.027
Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.027
Syn2 synapsin II 0.026
Fkbp1a FK506 binding protein 1a 0.026
Nlgn3 neuroligin 3 0.025
Zc3h7b zinc finger CCCH-type containing 7B 0.025
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.025
Nrxn1 neurexin 1 0.025
Gzmf granzyme F 0.025
Lphn1 latrophilin 1 0.025
Gabre gamma-aminobutyric acid (GABA) A receptor, epsilon 0.024
Ckm creatine kinase, muscle 0.024
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.024
Chrm3 cholinergic receptor, muscarinic 3 0.024
Gria1 glutamate receptor, ionotropic, AMPA 1 0.023
Scn8a sodium channel, voltage gated, type VIII, alpha subunit 0.023
Prkca protein kinase C, alpha 0.023
Gad2 glutamate decarboxylase 2 0.023
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.022
Acvr1 activin A receptor, type I 0.022
Shank2 SH3 and multiple ankyrin repeat domains 2 0.022
Coro7 coronin 7 0.022
Fgfr1 Fibroblast growth factor receptor 1 0.022
Hpcal4 hippocalcin-like 4 0.022
Rgs9 regulator of G-protein signaling 9 0.022
Cd14 CD14 molecule 0.021
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.021
Rims1 regulating synaptic membrane exocytosis 1 0.021
Tcof1 Treacher Collins-Franceschetti syndrome 1 homolog (human) 0.021
Mgat3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.021
Lin7b lin-7 homolog b (C. elegans) 0.020
RT1-DMa RT1 class II, locus DMa 0.020
Vav1 vav 1 guanine nucleotide exchange factor 0.020
Bsn bassoon 0.020
Ppyr1 pancreatic polypeptide receptor 1 0.020
Nlgn2 neuroligin 2 0.020
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.020
Apba1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.019
Gja4 gap junction protein, alpha 4 0.019
Prkcd protein kinase C, delta 0.019
Rab1b RAB1B, member RAS oncogene family 0.019
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.019
Nrxn2 neurexin 2 0.018
Eef1a2 eukaryotic translation elongation factor 1 alpha 2 0.018
Ctxn1 cortexin 1 0.018
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.018
Dlg3 discs, large homolog 3 (Drosophila) 0.018
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.018
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.017
Flnb filamin, beta 0.017
Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.017
Ctsj cathepsin J 0.017
Pcnxl3 pecanex-like 3 (Drosophila) 0.017
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.016
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.016
Inpp5d inositol polyphosphate-5-phosphatase D 0.016
RGD1309414 similar to KIAA0913 protein 0.016
Arl5a ADP-ribosylation factor-like 5A 0.016
Pip5k1c phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.016
Camk4 calcium/calmodulin-dependent protein kinase IV 0.016
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.016
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism