The network for 'disruption by host of symbiont cells' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

disruption by host of symbiont cells

Any process in which an organism has a negative effect on the functioning of the symbiont's cells. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.

Homo sapiens
Name Description Probability Func Analog Organism
CXCL3 chemokine (C-X-C motif) ligand 3 1.000
IL8 interleukin 8 1.000
CXCL2 chemokine (C-X-C motif) ligand 2 0.992
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.971
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.953
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.770
IL6 interleukin 6 (interferon, beta 2) 0.720
CCL20 chemokine (C-C motif) ligand 20 0.527
IL1B interleukin 1, beta 0.379
NCF2 neutrophil cytosolic factor 2 0.225
CYBA cytochrome b-245, alpha polypeptide 0.187
INADL InaD-like (Drosophila) 0.112
NCF4 neutrophil cytosolic factor 4, 40kDa 0.099
IER3 immediate early response 3 0.092
SETD7 SET domain containing (lysine methyltransferase) 7 0.075
CXCL5 chemokine (C-X-C motif) ligand 5 0.072
TRIM9 tripartite motif containing 9 0.066
LIF leukemia inhibitory factor (cholinergic differentiation factor) 0.061
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.059
PI3 peptidase inhibitor 3, skin-derived 0.056
SOD2 superoxide dismutase 2, mitochondrial 0.054
RNASE3 ribonuclease, RNase A family, 3 0.049
MMP10 matrix metallopeptidase 10 (stromelysin 2) 0.041
BPI bactericidal/permeability-increasing protein 0.039
ELANE elastase, neutrophil expressed 0.038
DEFA4 defensin, alpha 4, corticostatin 0.038
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.038
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.037
AZU1 azurocidin 1 0.036
LCN2 lipocalin 2 0.032
MPO myeloperoxidase 0.031
CCL7 chemokine (C-C motif) ligand 7 0.030
FPR1 formyl peptide receptor 1 0.030
PRKCB protein kinase C, beta 0.029
PRKCD protein kinase C, delta 0.028
PGLYRP1 peptidoglycan recognition protein 1 0.028
CDCP1 CUB domain containing protein 1 0.027
PASK PAS domain containing serine/threonine kinase 0.027
CCL2 chemokine (C-C motif) ligand 2 0.026
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.026
PRTN3 proteinase 3 0.025
GPR97 G protein-coupled receptor 97 0.025
MMP8 matrix metallopeptidase 8 (neutrophil collagenase) 0.025
CAMP cathelicidin antimicrobial peptide 0.024
TFPI2 tissue factor pathway inhibitor 2 0.024
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.023
DPP4 dipeptidyl-peptidase 4 0.023
PROCR protein C receptor, endothelial 0.022
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 0.021
MPZL2 myelin protein zero-like 2 0.021
CXCR2 chemokine (C-X-C motif) receptor 2 0.021
ORM1 orosomucoid 1 0.021
CAV2 caveolin 2 0.021
CSF3 colony stimulating factor 3 (granulocyte) 0.020
NFE2 nuclear factor (erythroid-derived 2), 45kDa 0.019
SELE selectin E 0.019
S100A12 S100 calcium binding protein A12 0.018
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.018
PF4 platelet factor 4 0.017
LRP1 low density lipoprotein receptor-related protein 1 0.017
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.016
EREG epiregulin 0.016
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.016
ACTG1 actin, gamma 1 0.016
CFL2 cofilin 2 (muscle) 0.016
LAMB3 laminin, beta 3 0.015
IL1R2 interleukin 1 receptor, type II 0.015
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.015
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.015
ZC3H12A zinc finger CCCH-type containing 12A 0.014
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.014
PTX3 pentraxin 3, long 0.014
G0S2 G0/G1switch 2 0.013
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.013
GFI1 growth factor independent 1 transcription repressor 0.013
HBD hemoglobin, delta 0.013
INHBA inhibin, beta A 0.013
VNN1 vanin 1 0.013
CMA1 chymase 1, mast cell 0.013
MASP2 mannan-binding lectin serine peptidase 2 0.013
IL1RAP interleukin 1 receptor accessory protein 0.013
EPHA2 EPH receptor A2 0.013
IL18R1 interleukin 18 receptor 1 0.013
LTF lactotransferrin 0.013
IL13RA2 interleukin 13 receptor, alpha 2 0.012
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.012
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.012
RETN resistin 0.012
MYL4 myosin, light chain 4, alkali; atrial, embryonic 0.012
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.012
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.012
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.012
FFAR2 free fatty acid receptor 2 0.011
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.011
LAMC2 laminin, gamma 2 0.011
F3 coagulation factor III (thromboplastin, tissue factor) 0.011
LTC4S leukotriene C4 synthase 0.011
DEFA1B defensin, alpha 1B 0.011
IL1RN interleukin 1 receptor antagonist 0.011
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Ctsg cathepsin G 0.933
S100a9 S100 calcium binding protein A9 (calgranulin B) 0.858
Ngp neutrophilic granule protein 0.764
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.708
Mmp8 matrix metallopeptidase 8 0.663
Mpo myeloperoxidase 0.601
Cxcl2 chemokine (C-X-C motif) ligand 2 0.557
Ccl4 chemokine (C-C motif) ligand 4 0.557
Il1rn interleukin 1 receptor antagonist 0.532
Saa3 serum amyloid A 3 0.400
Cma1 chymase 1, mast cell 0.390
Gzmb granzyme B 0.379
Elane elastase, neutrophil expressed 0.347
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.341
Irg1 immunoresponsive gene 1 0.319
Clec4d C-type lectin domain family 4, member d 0.302
Slfn4 schlafen 4 0.291
Il18rap interleukin 18 receptor accessory protein 0.279
Camp cathelicidin antimicrobial peptide 0.278
Mcpt4 mast cell protease 4 0.265
Il1r2 interleukin 1 receptor, type II 0.222
Ccl7 chemokine (C-C motif) ligand 7 0.220
Cpa3 carboxypeptidase A3, mast cell 0.209
Gzmc granzyme C 0.205
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.202
C5ar1 complement component 5a receptor 1 0.191
Clec4e C-type lectin domain family 4, member e 0.160
Fasl Fas ligand (TNF superfamily, member 6) 0.159
Il1b interleukin 1 beta 0.156
Ccl8 chemokine (C-C motif) ligand 8 0.144
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.143
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.142
Batf basic leucine zipper transcription factor, ATF-like 0.138
Prg2 proteoglycan 2, bone marrow 0.136
Ccl3 chemokine (C-C motif) ligand 3 0.126
Fpr1 formyl peptide receptor 1 0.119
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.111
Gbp1 guanylate binding protein 1 0.108
Ccl12 chemokine (C-C motif) ligand 12 0.105
Cxcr2 chemokine (C-X-C motif) receptor 2 0.104
Mcpt2 mast cell protease 2 0.103
Chi3l3 chitinase 3-like 3 0.102
Ltc4s leukotriene C4 synthase 0.101
Il1rl1 interleukin 1 receptor-like 1 0.101
Xcl1 chemokine (C motif) ligand 1 0.096
Fcgr1 Fc receptor, IgG, high affinity I 0.096
Ifitm6 interferon induced transmembrane protein 6 0.094
Ccl22 chemokine (C-C motif) ligand 22 0.091
Fpr2 formyl peptide receptor 2 0.088
Il2rb interleukin 2 receptor, beta chain 0.087
Gzmf granzyme F 0.086
Niacr1 niacin receptor 1 0.083
Gfi1b growth factor independent 1B 0.080
Ltf lactotransferrin 0.075
Cma2 chymase 2, mast cell 0.073
Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide 0.067
Mmp10 matrix metallopeptidase 10 0.067
Slpi secretory leukocyte peptidase inhibitor 0.062
Mmp13 matrix metallopeptidase 13 0.060
Rsad2 radical S-adenosyl methionine domain containing 2 0.058
Ccl11 chemokine (C-C motif) ligand 11 0.057
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.057
Aoah acyloxyacyl hydrolase 0.056
Ubd ubiquitin D 0.055
Tg thyroglobulin 0.054
Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G 0.053
Mcpt8 mast cell protease 8 0.053
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.053
Folr2 folate receptor 2 (fetal) 0.052
Prtn3 proteinase 3 0.051
Areg amphiregulin 0.051
1100001G20Rik RIKEN cDNA 1100001G20 gene 0.050
Hp haptoglobin 0.049
Cst7 cystatin F (leukocystatin) 0.049
LOC100504404 h-2 class II histocompatibility antigen, E-K alpha chain-like 0.049
Pgk2 phosphoglycerate kinase 2 0.048
Fosl1 fos-like antigen 1 0.047
Plaur plasminogen activator, urokinase receptor 0.047
Gdf15 growth differentiation factor 15 0.047
Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) 0.044
Rhag Rhesus blood group-associated A glycoprotein 0.044
Gp1ba glycoprotein 1b, alpha polypeptide 0.043
C2 complement component 2 (within H-2S) 0.042
Il1a interleukin 1 alpha 0.042
Fcna ficolin A 0.042
Prl2b1 prolactin family 2, subfamily b, member 1 0.040
H2-M9 histocompatibility 2, M region locus 9 0.039
Ccl5 chemokine (C-C motif) ligand 5 0.036
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.036
Cidec cell death-inducing DFFA-like effector c 0.035
Tnfaip2 tumor necrosis factor, alpha-induced protein 2 0.035
Cd300lf CD300 antigen like family member F 0.034
Adipoq adiponectin, C1Q and collagen domain containing 0.033
Ms4a3 membrane-spanning 4-domains, subfamily A, member 3 0.033
Cxcl1 chemokine (C-X-C motif) ligand 1 0.033
Trim10 tripartite motif-containing 10 0.032
Prol1 proline rich, lacrimal 1 0.032
Il6 interleukin 6 0.031
Ctsw cathepsin W 0.031
Sh2d2a SH2 domain protein 2A 0.031
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism