IMP
Process View
The network for 'establishment of t cell polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
establishment of t cell polarity
The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CCR5 | chemokine (C-C motif) receptor 5 | 1.000 | |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.993 | |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.985 | |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.972 | |
| IL1B | interleukin 1, beta | 0.879 | |
| IDE | insulin-degrading enzyme | 0.858 | |
| IL8 | interleukin 8 | 0.814 | |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.805 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.777 | |
| DPP4 | dipeptidyl-peptidase 4 | 0.720 | |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.669 | |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.657 | |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 0.556 | |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.555 | |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.455 | |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.397 | |
| CCL22 | chemokine (C-C motif) ligand 22 | 0.363 | |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.350 | |
| IL6 | interleukin 6 (interferon, beta 2) | 0.348 | |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.308 | |
| CCL3 | chemokine (C-C motif) ligand 3 | 0.291 | |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.287 | |
| IFNG | interferon, gamma | 0.267 | |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 0.253 | |
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.231 | |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.216 | |
| TNF | tumor necrosis factor | 0.165 | |
| MYL9 | myosin, light chain 9, regulatory | 0.156 | |
| VCAM1 | vascular cell adhesion molecule 1 | 0.151 | |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.147 | |
| CCR4 | chemokine (C-C motif) receptor 4 | 0.147 | |
| RGS1 | regulator of G-protein signaling 1 | 0.134 | |
| CD83 | CD83 molecule | 0.133 | |
| IL10 | interleukin 10 | 0.111 | |
| SELE | selectin E | 0.105 | |
| DARC | Duffy blood group, chemokine receptor | 0.104 | |
| CCR1 | chemokine (C-C motif) receptor 1 | 0.099 | |
| CCL7 | chemokine (C-C motif) ligand 7 | 0.092 | |
| MMP12 | matrix metallopeptidase 12 (macrophage elastase) | 0.091 | |
| IL7R | interleukin 7 receptor | 0.086 | |
| IL2RB | interleukin 2 receptor, beta | 0.080 | |
| IL2RG | interleukin 2 receptor, gamma | 0.074 | |
| ASCC2 | activating signal cointegrator 1 complex subunit 2 | 0.073 | |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.068 | |
| ICAM1 | intercellular adhesion molecule 1 | 0.064 | |
| CXCL6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.063 | |
| FPR3 | formyl peptide receptor 3 | 0.061 | |
| IL32 | interleukin 32 | 0.059 | |
| CH25H | cholesterol 25-hydroxylase | 0.056 | |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.049 | |
| ARRB1 | arrestin, beta 1 | 0.048 | |
| EBI3 | Epstein-Barr virus induced 3 | 0.046 | |
| SLAMF8 | SLAM family member 8 | 0.045 | |
| MEN1 | multiple endocrine neoplasia I | 0.045 | |
| FLNA | filamin A, alpha | 0.044 | |
| UBD | ubiquitin D | 0.043 | |
| CCL11 | chemokine (C-C motif) ligand 11 | 0.043 | |
| CCR3 | chemokine (C-C motif) receptor 3 | 0.040 | |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.040 | |
| IL1R2 | interleukin 1 receptor, type II | 0.040 | |
| SLAMF7 | SLAM family member 7 | 0.037 | |
| BCL2A1 | BCL2-related protein A1 | 0.037 | |
| FLNB | filamin B, beta | 0.034 | |
| IL21R | interleukin 21 receptor | 0.033 | |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.032 | |
| LTA | lymphotoxin alpha (TNF superfamily, member 1) | 0.031 | |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.031 | |
| XCL2 | chemokine (C motif) ligand 2 | 0.031 | |
| MMP9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 0.031 | |
| IL10RA | interleukin 10 receptor, alpha | 0.030 | |
| STAT4 | signal transducer and activator of transcription 4 | 0.030 | |
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 0.029 | |
| CLEC10A | C-type lectin domain family 10, member A | 0.028 | |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.028 | |
| CCL23 | chemokine (C-C motif) ligand 23 | 0.028 | |
| CD80 | CD80 molecule | 0.028 | |
| CCL17 | chemokine (C-C motif) ligand 17 | 0.028 | |
| TARP | TCR gamma alternate reading frame protein | 0.027 | |
| MSC | musculin | 0.027 | |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.026 | |
| CCL21 | chemokine (C-C motif) ligand 21 | 0.026 | |
| IL18RAP | interleukin 18 receptor accessory protein | 0.025 | |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.024 | |
| APOC1 | apolipoprotein C-I | 0.023 | |
| INHBA | inhibin, beta A | 0.023 | |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.023 | |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.023 | |
| TRAF1 | TNF receptor-associated factor 1 | 0.022 | |
| GNLY | granulysin | 0.022 | |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.022 | |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4 | 0.021 | |
| DNASE1L3 | deoxyribonuclease I-like 3 | 0.020 | |
| RGS16 | regulator of G-protein signaling 16 | 0.020 | |
| SRGN | serglycin | 0.019 | |
| CD69 | CD69 molecule | 0.019 | |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.019 | |
| HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | 0.018 | |
| CCRL2 | chemokine (C-C motif) receptor-like 2 | 0.018 | |
| MMP10 | matrix metallopeptidase 10 (stromelysin 2) | 0.018 | |
| CXCR6 | chemokine (C-X-C motif) receptor 6 | 0.018 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.657 | |
| Chrm2 | cholinergic receptor, muscarinic 2, cardiac | 0.353 | |
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.250 | |
| Efnb2 | ephrin B2 | 0.228 | |
| Actn1 | actinin, alpha 1 | 0.209 | |
| Iqcb1 | IQ calmodulin-binding motif containing 1 | 0.198 | |
| Nsf | N-ethylmaleimide sensitive fusion protein | 0.185 | |
| Rpgrip1l | Rpgrip1-like | 0.121 | |
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.103 | |
| Wdr1 | WD repeat domain 1 | 0.093 | |
| Irf5 | interferon regulatory factor 5 | 0.089 | |
| Ntf3 | neurotrophin 3 | 0.088 | |
| Adm | adrenomedullin | 0.039 | |
| Dync1h1 | dynein cytoplasmic 1 heavy chain 1 | 0.032 | |
| Ltb | lymphotoxin B | 0.032 | |
| Invs | inversin | 0.029 | |
| Cnn1 | calponin 1 | 0.027 | |
| Eno1 | enolase 1, alpha non-neuron | 0.025 | |
| Tagln | transgelin | 0.024 | |
| Msn | moesin | 0.023 | |
| Elmo1 | engulfment and cell motility 1, ced-12 homolog (C. elegans) | 0.022 | |
| Ppp2r1a | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 0.022 | |
| Flnb | filamin, beta | 0.021 | |
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.021 | |
| Acta2 | actin, alpha 2, smooth muscle, aorta | 0.019 | |
| Nphp1 | nephronophthisis 1 (juvenile) homolog (human) | 0.019 | |
| Dlgap1 | discs, large (Drosophila) homolog-associated protein 1 | 0.018 | |
| Cd37 | CD37 antigen | 0.017 | |
| Cnn2 | calponin 2 | 0.017 | |
| Lmod1 | leiomodin 1 (smooth muscle) | 0.016 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.016 | |
| Nrp1 | neuropilin 1 | 0.015 | |
| Cd3d | CD3 antigen, delta polypeptide | 0.015 | |
| Il16 | interleukin 16 | 0.015 | |
| Chd5 | chromodomain helicase DNA binding protein 5 | 0.015 | |
| Spna2 | spectrin alpha 2 | 0.014 | |
| Cltc | clathrin, heavy polypeptide (Hc) | 0.014 | |
| Gja1 | gap junction protein, alpha 1 | 0.013 | |
| Chrm3 | cholinergic receptor, muscarinic 3, cardiac | 0.013 | |
| Lpp | LIM domain containing preferred translocation partner in lipoma | 0.013 | |
| Ptk2b | PTK2 protein tyrosine kinase 2 beta | 0.013 | |
| Arpc2 | actin related protein 2/3 complex, subunit 2 | 0.013 | |
| Tuba1a | tubulin, alpha 1A | 0.012 | |
| Src | Rous sarcoma oncogene | 0.012 | |
| Shank2 | SH3/ankyrin domain gene 2 | 0.011 | |
| Gnai2 | guanine nucleotide binding protein (G protein), alpha inhibiting 2 | 0.011 | |
| Ap2a2 | adaptor protein complex AP-2, alpha 2 subunit | 0.011 | |
| Laptm5 | lysosomal-associated protein transmembrane 5 | 0.011 | |
| Cfl1 | cofilin 1, non-muscle | 0.010 | |
| Cd3g | CD3 antigen, gamma polypeptide | 0.010 |