The network for 'rab protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rab protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.

Rattus norvegicus
Name Description Probability Func Analog Organism
Rab1 RAB1, member RAS oncogene family 0.091
Arl1 ADP-ribosylation factor-like 1 0.091
Rap1b RAP1B, member of RAS oncogene family 0.026
Hk1 hexokinase 1 0.025
Arf1 ADP-ribosylation factor 1 0.024
Tmem59 transmembrane protein 59 0.024
Rab7a RAB7A, member RAS oncogene family 0.023
Wdfy1 WD repeat and FYVE domain containing 1 0.021
Scamp1 secretory carrier membrane protein 1 0.021
Arf3 ADP-ribosylation factor 3 0.020
Smg5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.020
Tmem30a transmembrane protein 30A 0.019
RGD1564560 similar to RCK 0.019
Sec62 SEC62 homolog (S. cerevisiae) 0.018
Zfp91 zinc finger protein 91 0.018
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.017
Copb1 coatomer protein complex, subunit beta 1 0.017
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.017
Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 0.017
Tnrc6b trinucleotide repeat containing 6B 0.017
Cttn cortactin 0.016
Nsf N-ethylmaleimide-sensitive factor 0.016
Pum1 pumilio homolog 1 (Drosophila) 0.016
Map1lc3b microtubule-associated protein 1 light chain 3 beta 0.015
Synrg synergin, gamma 0.015
Ulk1 Unc-51 like kinase 1 (C. elegans) 0.015
Dync1i2 dynein cytoplasmic 1 intermediate chain 2 0.015
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.015
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.015
Exoc5 exocyst complex component 5 0.014
Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.014
Yme1l1 YME1-like 1 (S. cerevisiae) 0.014
Ubn2 ubinuclein 2 0.014
Snx2 sorting nexin 2 0.014
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.014
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.014
Pitpna phosphatidylinositol transfer protein, alpha 0.014
Dctn1 dynactin 1 0.014
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.013
Aplp2 amyloid beta (A4) precursor-like protein 2 0.013
Pigm phosphatidylinositol glycan anchor biosynthesis, class M 0.013
Trim3 tripartite motif-containing 3 0.013
Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.013
Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.013
Arf4 ADP-ribosylation factor 4 0.013
Jarid1a jumonji, AT rich interactive domain 1A (Rbp2 like) 0.013
Atp6v1b2 ATPase, H transporting, lysosomal V1 subunit B2 0.013
Tmed2 transmembrane emp24 domain trafficking protein 2 0.013
Triobp TRIO and F-actin binding protein 0.013
Inpp4a inositol polyphosphate-4-phosphatase, type 1 0.013
Cdkn2aip CDKN2A interacting protein 0.013
Vps4b vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.013
Rab18 RAB18, member RAS oncogene family 0.012
Vps29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.012
Hdac7 histone deacetylase 7 0.012
Glg1 golgi apparatus protein 1 0.012
Snap23 synaptosomal-associated protein 23 0.012
Pik3c2a phosphoinositide-3-kinase, class 2, alpha polypeptide 0.012
Mtpn myotrophin 0.012
Gnb5 guanine nucleotide binding protein (G protein), beta 5 0.012
Gclm glutamate cysteine ligase, modifier subunit 0.012
Alg2 asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) 0.012
Sptlc1 serine palmitoyltransferase, long chain base subunit 1 0.012
Map2k7 mitogen activated protein kinase kinase 7 0.012
RGD1565411 similar to 2610317D23Rik protein 0.012
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.012
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.012
Ap2a2 adaptor-related protein complex 2, alpha 2 subunit 0.012
LOC100359595 hypothetical protein LOC100359595 0.011
RGD621098 similar to RIKEN cDNA D230025D16Rik 0.011
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.011
LOC100360986 mCG1035404-like 0.011
Arcn1 archain 1 0.011
Zer1 zer-1 homolog (C. elegans) 0.011
Vps52 vacuolar protein sorting 52 homolog (S. cerevisiae) 0.011
Abr active BCR-related gene 0.011
Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.011
Ppp6c protein phosphatase 6, catalytic subunit 0.011
Serp1 stress-associated endoplasmic reticulum protein 1 0.011
Arpc5 actin related protein 2/3 complex, subunit 5 0.011
Lrp6 low density lipoprotein receptor-related protein 6 0.011
Mospd2 motile sperm domain containing 2 0.011
Rab3a RAB3A, member RAS oncogene family 0.011
Arhgap5 Rho GTPase activating protein 5 0.011
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.011
Bin2 bridging integrator 2 0.011
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.011
Spryd3 SPRY domain containing 3 0.011
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.011
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.011
Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor 0.010
Btd biotinidase 0.010
Rbm9 RNA binding motif protein 9 0.010
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.010
Akirin2 akirin 2 0.010
Slc22a17 solute carrier family 22, member 17 0.010
Vps4a vacuolar protein sorting 4 homolog A (S. cerevisiae) 0.010
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.010
Topors topoisomerase I binding, arginine/serine-rich 0.010
Atp6v1h ATPase, H+ transporting, lysosomal V1 subunit H 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Hph HIF prolyl hydroxylase 0.037
Rala Ras-related protein 0.029
baz bazooka 0.029
CG6509 CG6509 gene product from transcript CG6509-RB 0.028
stai stathmin 0.024
Su(H) Suppressor of Hairless 0.024
CG4552 CG4552 gene product from transcript CG4552-RA 0.021
sima similar 0.017
synj synaptojanin 0.017
sec15 CG7034 gene product from transcript CG7034-RA 0.016
Rheb CG1081 gene product from transcript CG1081-RA 0.014
Syx7 Syntaxin 7 0.013
ken ken and barbie 0.013
CG11178 CG11178 gene product from transcript CG11178-RA 0.012
CG1233 CG1233 gene product from transcript CG1233-RB 0.012
Dlic Dynein light intermediate chain 0.012
rab3-GAP CG7061 gene product from transcript CG7061-RA 0.011
SCAR CG4636 gene product from transcript CG4636-RA 0.011
mop myopic 0.011
Lis-1 Lissencephaly-1 0.011
CG11055 CG11055 gene product from transcript CG11055-RB 0.011
CalpB Calpain-B 0.011
Kap3 Kinesin associated protein 3 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
GDI2 GDP dissociation inhibitor 2 0.999
GABARAPL1 GABA(A) receptor-associated protein like 1 0.999
RAB4A RAB4A, member RAS oncogene family 0.999
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.997
BIN1 bridging integrator 1 0.996
RABGAP1 RAB GTPase activating protein 1 0.996
RAB5A RAB5A, member RAS oncogene family 0.991
C19orf50 chromosome 19 open reading frame 50 0.989
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 0.989
NBR1 neighbor of BRCA1 gene 1 0.962
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.955
RAB3IP RAB3A interacting protein (rabin3) 0.942
EEA1 early endosome antigen 1 0.937
MYCBP2 MYC binding protein 2 0.929
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.914
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.884
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.870
CHD3 chromodomain helicase DNA binding protein 3 0.840
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 0.806
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.739
KCTD13 potassium channel tetramerisation domain containing 13 0.737
PRKCZ protein kinase C, zeta 0.701
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.699
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.676
RAB11FIP2 RAB11 family interacting protein 2 (class I) 0.630
PDPK1 3-phosphoinositide dependent protein kinase-1 0.612
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.597
RGMA RGM domain family, member A 0.594
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.572
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.559
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.554
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.553
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.543
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.515
PNPLA6 patatin-like phospholipase domain containing 6 0.510
EZR ezrin 0.485
RGS2 regulator of G-protein signaling 2, 24kDa 0.477
STBD1 starch binding domain 1 0.438
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.401
RAB11A RAB11A, member RAS oncogene family 0.400
WBP2 WW domain binding protein 2 0.372
NCKAP1 NCK-associated protein 1 0.369
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.364
RABGAP1L RAB GTPase activating protein 1-like 0.337
CRTC2 CREB regulated transcription coactivator 2 0.330
SPHAR S-phase response (cyclin related) 0.322
ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae) 0.310
SPOP speckle-type POZ protein 0.307
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.305
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.301
FRMD6 FERM domain containing 6 0.282
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.281
FRYL FRY-like 0.273
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.265
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.263
TSC2 tuberous sclerosis 2 0.260
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.249
OCRL oculocerebrorenal syndrome of Lowe 0.246
ATG14 ATG14 autophagy related 14 homolog (S. cerevisiae) 0.240
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.235
TSC1 tuberous sclerosis 1 0.228
MECP2 methyl CpG binding protein 2 (Rett syndrome) 0.227
MINK1 misshapen-like kinase 1 0.226
SIRT6 sirtuin 6 0.219
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.216
PLCG1 phospholipase C, gamma 1 0.209
KIAA0930 KIAA0930 0.203
PPP6R1 protein phosphatase 6, regulatory subunit 1 0.203
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.201
NISCH nischarin 0.195
CNOT8 CCR4-NOT transcription complex, subunit 8 0.182
RAB14 RAB14, member RAS oncogene family 0.178
FAM193A family with sequence similarity 193, member A 0.177
DCAF10 DDB1 and CUL4 associated factor 10 0.177
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.176
RABAC1 Rab acceptor 1 (prenylated) 0.175
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.171
RAB1B RAB1B, member RAS oncogene family 0.163
RAB24 RAB24, member RAS oncogene family 0.160
SIN3B SIN3 homolog B, transcription regulator (yeast) 0.159
CARD11 caspase recruitment domain family, member 11 0.153
RAB2A RAB2A, member RAS oncogene family 0.146
USP47 ubiquitin specific peptidase 47 0.135
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.133
NCK1 NCK adaptor protein 1 0.132
LZTR1 leucine-zipper-like transcription regulator 1 0.132
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 0.130
RALGDS ral guanine nucleotide dissociation stimulator 0.128
TROVE2 TROVE domain family, member 2 0.127
GDI1 GDP dissociation inhibitor 1 0.126
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.125
SETX senataxin 0.120
RAB22A RAB22A, member RAS oncogene family 0.120
SQSTM1 sequestosome 1 0.114
FNBP1 formin binding protein 1 0.111
GOLGB1 golgin B1 0.111
CUL7 cullin 7 0.110
AKT1S1 AKT1 substrate 1 (proline-rich) 0.108
TRAPPC10 trafficking protein particle complex 10 0.108
PGRMC1 progesterone receptor membrane component 1 0.108
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Mus musculus
Name Description Probability Func Analog Organism
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.523
Zdhhc17 zinc finger, DHHC domain containing 17 0.385
Rab5a RAB5A, member RAS oncogene family 0.224
Anapc2 anaphase promoting complex subunit 2 0.194
Stx12 syntaxin 12 0.193
Dhx40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.133
Dnm1 dynamin 1 0.133
Chmp2b chromatin modifying protein 2B 0.132
Pcnxl3 pecanex-like 3 (Drosophila) 0.130
Eps15 epidermal growth factor receptor pathway substrate 15 0.125
Rragc Ras-related GTP binding C 0.125
D15Ertd621e DNA segment, Chr 15, ERATO Doi 621, expressed 0.122
Iqsec1 IQ motif and Sec7 domain 1 0.110
Stxbp3a syntaxin binding protein 3A 0.106
Nckap1 NCK-associated protein 1 0.101
Rbm7 RNA binding motif protein 7 0.095
Abtb1 ankyrin repeat and BTB (POZ) domain containing 1 0.089
Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.088
Tmem30a transmembrane protein 30A 0.088
Strn4 striatin, calmodulin binding protein 4 0.081
Cic capicua homolog (Drosophila) 0.079
Rab18 RAB18, member RAS oncogene family 0.075
Lamp2 lysosomal-associated membrane protein 2 0.073
Glg1 golgi apparatus protein 1 0.068
Ube3b ubiquitin protein ligase E3B 0.068
Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform 0.068
Cc2d1a coiled-coil and C2 domain containing 1A 0.066
R3hdm2 R3H domain containing 2 0.063
Camta2 calmodulin binding transcription activator 2 0.061
Ap1b1 adaptor protein complex AP-1, beta 1 subunit 0.061
Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 0.061
Copb1 coatomer protein complex, subunit beta 1 0.059
Sacm1l SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae) 0.058
Abcg2 ATP-binding cassette, sub-family G (WHITE), member 2 0.058
Nek7 NIMA (never in mitosis gene a)-related expressed kinase 7 0.057
Evi5 ecotropic viral integration site 5 0.057
Fbxw5 F-box and WD-40 domain protein 5 0.055
Lrp1 low density lipoprotein receptor-related protein 1 0.053
Camk2g calcium/calmodulin-dependent protein kinase II gamma 0.053
Fnip1 folliculin interacting protein 1 0.052
Cpne3 copine III 0.051
Golga2 golgi autoantigen, golgin subfamily a, 2 0.051
Rnf103 ring finger protein 103 0.048
C78339 expressed sequence C78339 0.048
Hdac5 histone deacetylase 5 0.045
Atg13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.043
Sh2d3c SH2 domain containing 3C 0.042
Mtap7d1 microtubule-associated protein 7 domain containing 1 0.042
Bnip3l BCL2/adenovirus E1B interacting protein 3-like 0.042
Dctn1 dynactin 1 0.041
Tmem184b transmembrane protein 184b 0.041
Fndc3a fibronectin type III domain containing 3A 0.040
Dlgap4 discs, large homolog-associated protein 4 (Drosophila) 0.040
March7 membrane-associated ring finger (C3HC4) 7 0.039
Ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.039
Ap1m2 adaptor protein complex AP-1, mu 2 subunit 0.039
Bap1 Brca1 associated protein 1 0.039
Arhgap31 Rho GTPase activating protein 31 0.039
Rxrb retinoid X receptor beta 0.038
Ubr4 ubiquitin protein ligase E3 component n-recognin 4 0.038
Numa1 nuclear mitotic apparatus protein 1 0.037
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.037
Neurl4 neuralized homolog 4 (Drosophila) 0.037
Golga4 golgi autoantigen, golgin subfamily a, 4 0.037
Rabep1 rabaptin, RAB GTPase binding effector protein 1 0.037
Igsf8 immunoglobulin superfamily, member 8 0.037
Rasa1 RAS p21 protein activator 1 0.036
Flii flightless I homolog (Drosophila) 0.036
Atxn2 ataxin 2 0.036
Cdc42bpb CDC42 binding protein kinase beta 0.035
A930001N09Rik RIKEN cDNA A930001N09 gene 0.035
Nek9 NIMA (never in mitosis gene a)-related expressed kinase 9 0.035
Megf8 multiple EGF-like-domains 8 0.035
3230401D17Rik RIKEN cDNA 3230401D17 gene 0.035
Arhgap21 Rho GTPase activating protein 21 0.035
Rab14 RAB14, member RAS oncogene family 0.035
Tmem184a transmembrane protein 184a 0.034
Atxn7l3 ataxin 7-like 3 0.034
Copb2 coatomer protein complex, subunit beta 2 (beta prime) 0.034
Ipo13 importin 13 0.034
Bahd1 bromo adjacent homology domain containing 1 0.034
Chmp5 chromatin modifying protein 5 0.034
Slc30a9 solute carrier family 30 (zinc transporter), member 9 0.034
Ankrd13d ankyrin repeat domain 13 family, member D 0.033
Dgkd diacylglycerol kinase, delta 0.033
Mkl1 MKL (megakaryoblastic leukemia)/myocardin-like 1 0.033
Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 0.033
Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) 0.032
Rusc2 RUN and SH3 domain containing 2 0.032
Dstn destrin 0.032
Cript cysteine-rich PDZ-binding protein 0.032
Dync1i2 dynein cytoplasmic 1 intermediate chain 2 0.031
Myo18a myosin XVIIIA 0.031
Ypel3 yippee-like 3 (Drosophila) 0.031
Abca7 ATP-binding cassette, sub-family A (ABC1), member 7 0.031
Osbpl11 oxysterol binding protein-like 11 0.030
Pitpnm1 phosphatidylinositol transfer protein, membrane-associated 1 0.030
Arl6 ADP-ribosylation factor-like 6 0.030
Plxnd1 plexin D1 0.030
Gclc glutamate-cysteine ligase, catalytic subunit 0.030
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GYL1 Gyl1p 0.029
BET3 Bet3p 0.021
SEC2 Sec2p 0.012
YIP3 Yip3p 0.012
YPT52 Ypt52p 0.010