The network for 'negative regulation of hormone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.

Rattus norvegicus
Name Description Probability Func Analog Organism
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.110
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.110
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.090
Phkg1 phosphorylase kinase, gamma 1 0.087
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.077
Fgf16 fibroblast growth factor 16 0.077
Lep leptin 0.077
Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 0.077
Glp1r glucagon-like peptide 1 receptor 0.075
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.069
Pla2g5 phospholipase A2, group V 0.067
Ins2 insulin 2 0.063
Olr1696 olfactory receptor 1696 0.063
Aldh6a1 aldehyde dehydrogenase 6 family, member A1 0.062
Apoa4 apolipoprotein A-IV 0.062
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.058
Gip gastric inhibitory polypeptide 0.058
Grifin galectin-related inter-fiber protein 0.058
Sox17 SRY (sex determining region Y)-box 17 0.056
Hcrtr1 hypocretin (orexin) receptor 1 0.056
Avp arginine vasopressin 0.054
Adrb1 adrenergic, beta-1-, receptor 0.053
Mapk15 mitogen-activated protein kinase 15 0.052
Egr4 early growth response 4 0.052
Adam1a a disintegrin and metallopeptidase domain 1a 0.049
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.049
Mrgprf MAS-related GPR, member F 0.048
Ucn urocortin 0.048
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.046
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.046
Tacr1 tachykinin receptor 1 0.045
Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.045
Hand1 heart and neural crest derivatives expressed 1 0.045
Trhr2 thyrotropin releasing hormone receptor 2 0.045
Plin perilipin 0.044
Trim17 tripartite motif-containing 17 0.044
Pax6 paired box 6 0.043
Hrh2 histamine receptor H 2 0.043
Necab2 N-terminal EF-hand calcium binding protein 2 0.042
Lim2 lens intrinsic membrane protein 2 0.042
Btc betacellulin 0.042
Sdc3 syndecan 3 0.042
Slc4a3 solute carrier family 4 (anion exchanger), member 3 0.042
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.042
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.041
Rho rhodopsin 0.041
Hbz hemoglobin, zeta 0.040
Crhbp corticotropin releasing hormone binding protein 0.040
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.040
Opn1mw opsin 1 (cone pigments), medium-wave-sensitive 0.040
Cyp51 cytochrome P450, family 51 0.039
Gper G protein-coupled estrogen receptor 1 0.038
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.038
Drd1a dopamine receptor D1A 0.038
RGD1309821 similar to KIAA1161 protein 0.037
Prph2 peripherin 2 0.036
Adcyap1 adenylate cyclase activating polypeptide 1 0.036
Tpcr12 putative olfactory receptor 0.036
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.036
Rxrg retinoid X receptor gamma 0.036
Hcrtr2 hypocretin (orexin) receptor 2 0.035
Necab1 N-terminal EF-hand calcium binding protein 1 0.035
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.035
Syt4 synaptotagmin IV 0.035
Adora1 adenosine A1 receptor 0.035
Vip vasoactive intestinal peptide 0.034
Tas2r126 taste receptor, type 2, member 126 0.034
Pnma1 paraneoplastic antigen MA1 0.034
Phox2a paired-like homeobox 2a 0.034
Mospd4 motile sperm domain containing 4 0.034
Kcnk3 potassium channel, subfamily K, member 3 0.034
Fasn fatty acid synthase 0.033
Mchr1 melanin-concentrating hormone receptor 1 0.033
Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.033
Adora2a adenosine A2a receptor 0.033
Hpcal4 hippocalcin-like 4 0.033
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.033
Cgm4 carcinoembryonic antigen gene family 4 0.032
Psp parotid secretory protein 0.032
Rgs9 regulator of G-protein signaling 9 0.032
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.032
Notch3 Notch homolog 3 (Drosophila) 0.032
Ghr growth hormone receptor 0.031
Teddm1 transmembrane epididymal protein 1 0.031
Hrh3 histamine receptor H3 0.031
Syt8 synaptotagmin VIII 0.031
Col10a1 collagen, type X, alpha 1 0.031
LOC64038 sertolin 0.030
Gpr6 G protein-coupled receptor 6 0.030
Gdf9 growth differentiation factor 9 0.030
Hr hairless 0.030
Afap1 actin filament associated protein 1 0.030
Rab3b RAB3B, member RAS oncogene family 0.029
Rhobtb2 Rho-related BTB domain containing 2 0.029
Mc5r melanocortin 5 receptor 0.029
Pomc proopiomelanocortin 0.029
Neu2 sialidase 2 (cytosolic sialidase) 0.028
Fbxo2 F-box protein 2 0.028
Cacng4 calcium channel, voltage-dependent, gamma subunit 4 0.028
Sqle squalene epoxidase 0.028
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
per2 period homolog 2 (Drosophila) 0.382
igf3 insulin-like growth factor 3 0.302
mchr1b melanin-concentrating hormone receptor 1b 0.278
cyp19a1a cytochrome P450, family 19, subfamily A, polypeptide 1a 0.239
mchr1a melanin-concentrating hormone receptor 1a 0.235
uts1 urotensin 1 0.202
drd2b dopamine receptor D2b 0.192
gfra1a gdnf family receptor alpha 1a 0.177
nlgn1 neuroligin 1 0.158
spry4 sprouty (Drosophila) homolog 4 0.157
hcrt hypocretin (orexin) neuropeptide precursor 0.151
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.143
col7a1l collagen type VII alpha 1-like 0.143
fabp11a fatty acid binding protein 11a 0.126
ptgs2a prostaglandin-endoperoxide synthase 2a 0.123
cldn2 claudin 2 0.122
gfra1b gdnf family receptor alpha 1b 0.116
nr1d2b nuclear receptor subfamily 1, group D, member 2b 0.114
bmp15 bone morphogenetic protein 15 0.112
cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b 0.111
LOC100332193 growth hormone secretagogue receptor type 1-like 0.110
xgb x globin 0.110
inhbaa inhibin, beta Aa 0.096
mao monoamine oxidase 0.095
foxa3 forkhead box A3 0.091
fshb follicle stimulating hormone, beta polypeptide 0.080
gsdf gonadal somatic cell derived factor 0.078
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.077
tef thyrotroph embryonic factor 0.074
pgr progesterone receptor 0.073
ncam2 neural cell adhesion molecule 2 0.069
sst2 somatostatin 2 0.069
glud1b glutamate dehydrogenase 1b 0.068
si:dkey-258f14.5 si:dkey-258f14.5 0.067
gli2b GLI-Kruppel family member GLI2b 0.066
drd2l dopamine receptor D2 like 0.066
ghsra growth hormone secretagogue receptor a 0.062
hcrtr2 hypocretin (orexin) receptor 2 0.062
dab1a disabled homolog 1a (Drosophila) 0.055
dbh dopamine beta hydroxylase 0.055
mtnr1ba melatonin receptor type 1B a 0.054
rag2 recombination activating gene 2 0.054
slc8a4b solute carrier family 8 (sodium/calcium exchanger), member 4b 0.054
ddb2 damage-specific DNA binding protein 2 0.053
paqr7b progestin and adipoQ receptor family member VII, b 0.053
ghrl ghrelin/obestatin preprohormone 0.053
uts2a urotensin 2, alpha 0.051
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.050
htr1aa 5-hydroxytryptamine (serotonin) receptor 1A a 0.049
neurog3 neurogenin 3 0.049
kiss1rb KISS1 receptor b 0.049
cry-dash cryptochrome DASH 0.047
zp3 zona pellucida glycoprotein 3 0.047
col4a6 collagen, type IV, alpha 6 0.046
si:dkey-228g21.4 si:dkey-228g21.4 0.046
fshr follicle stimulating hormone receptor 0.046
prok2 prokineticin 2 0.046
lhcgr luteinizing hormone/choriogonadotropin receptor 0.046
mc4r melanocortin 4 receptor 0.046
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.045
or111-10 odorant receptor, family D, subfamily 111, member 10 0.045
LOC100006361 galanin-like 0.045
fzd7b frizzled homolog 7b 0.044
cry5 cryptochrome 5 0.044
mef2a myocyte enhancer factor 2a 0.043
mapk6 mitogen-activated protein kinase 6 0.042
fancl Fanconi anemia, complementation group L 0.042
mc2r melanocortin 2 receptor 0.041
cpla2 cytosolic phospholipase a2 0.041
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.041
aldob aldolase b, fructose-bisphosphate 0.039
slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.039
hoxc12b homeo box C12b 0.038
htr1ab 5-hydroxytryptamine (serotonin) receptor 1A b 0.038
ryr2a ryanodine receptor 2a (cardiac) 0.037
gata6 GATA-binding protein 6 0.037
th2 tyrosine hydroxylase 2 0.037
ddc dopa decarboxylase 0.036
cry1b cryptochrome 1b 0.035
gcm2 glial cells missing homolog 2 (Drosophila) 0.035
ptgesl prostaglandin E synthase 2-like 0.034
bcl2l1 bcl2-like 1 0.034
hspb6 heat shock protein, alpha-crystallin-related, b6 0.033
tlr3 toll-like receptor 3 0.033
oprk1 opioid receptor, kappa 1 0.033
dedd1 death effector domain-containing 1 0.033
inha inhibin, alpha 0.033
pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.032
gdf11 growth differentiation factor 11 0.032
vipr2 vasoactive intestinal peptide receptor 2 0.032
ins preproinsulin 0.032
npas2 neuronal PAS domain protein 2 0.031
lyz lysozyme 0.031
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.031
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.030
duox dual oxidase 0.029
krt18 keratin 18 0.029
ap1m2 adaptor-related protein complex 1, mu 2 subunit 0.028
chat choline acetyltransferase 0.028
LOC799612 prolactin 2 0.027
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Irk3 Inwardly rectifying potassium channel 3 0.017
foxo forkhead box, sub-group O 0.014
Eip63F-1 Ecdysone-induced protein 63F 1 0.011
Pde8 Phosphodiesterase 8 0.010
Pink1 PTEN-induced putative kinase 1 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
HDAC2 histone deacetylase 2 0.608
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.548
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.545
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.357
ADORA2A adenosine A2a receptor 0.298
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.266
LIN7B lin-7 homolog B (C. elegans) 0.264
MPDZ multiple PDZ domain protein 0.259
MED15 mediator complex subunit 15 0.254
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.243
CRHR1 corticotropin releasing hormone receptor 1 0.232
CRH corticotropin releasing hormone 0.140
IL1R1 interleukin 1 receptor, type I 0.129
GRB10 growth factor receptor-bound protein 10 0.124
SIRT1 sirtuin 1 0.099
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.068
VAC14 Vac14 homolog (S. cerevisiae) 0.062
BMPR1B bone morphogenetic protein receptor, type IB 0.061
ZNF746 zinc finger protein 746 0.060
IL6R interleukin 6 receptor 0.060
IRS1 insulin receptor substrate 1 0.056
DLG4 discs, large homolog 4 (Drosophila) 0.056
INSR insulin receptor 0.050
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.049
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.047
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.047
IGF1R insulin-like growth factor 1 receptor 0.041
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.036
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.035
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.033
NSF N-ethylmaleimide-sensitive factor 0.031
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.031
PTEN phosphatase and tensin homolog 0.023
CHRNA4 cholinergic receptor, nicotinic, alpha 4 0.023
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.023
GAB1 GRB2-associated binding protein 1 0.023
KCNJ11 potassium inwardly-rectifying channel, subfamily J, member 11 0.022
IL1RAP interleukin 1 receptor accessory protein 0.020
RBBP7 retinoblastoma binding protein 7 0.020
BMP8A bone morphogenetic protein 8a 0.019
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.018
IL8 interleukin 8 0.018
PINK1 PTEN induced putative kinase 1 0.018
FRS2 fibroblast growth factor receptor substrate 2 0.018
GJD2 gap junction protein, delta 2, 36kDa 0.017
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.016
FGF18 fibroblast growth factor 18 0.016
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.016
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.016
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.015
NOG noggin 0.015
KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 0.015
KCNJ16 potassium inwardly-rectifying channel, subfamily J, member 16 0.015
ACAN aggrecan 0.015
KRTAP4-12 keratin associated protein 4-12 0.014
SH2B1 SH2B adaptor protein 1 0.014
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.013
LIFR leukemia inhibitory factor receptor alpha 0.013
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.013
MAGEA11 melanoma antigen family A, 11 0.013
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.013
PDCD2 programmed cell death 2 0.013
RCOR1 REST corepressor 1 0.012
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.012
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.012
WNT2 wingless-type MMTV integration site family member 2 0.012
MTNR1A melatonin receptor 1A 0.011
GPR6 G protein-coupled receptor 6 0.011
SCTR secretin receptor 0.011
COL2A1 collagen, type II, alpha 1 0.011
FOXO3 forkhead box O3 0.011
IL1RN interleukin 1 receptor antagonist 0.011
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.011
FST follistatin 0.010
PTPRN protein tyrosine phosphatase, receptor type, N 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.985
Clock circadian locomotor output cycles kaput 0.978
Lep leptin 0.909
Insr insulin receptor 0.896
Esr1 estrogen receptor 1 (alpha) 0.810
Nos3 nitric oxide synthase 3, endothelial cell 0.781
Per2 period homolog 2 (Drosophila) 0.729
Nos2 nitric oxide synthase 2, inducible 0.678
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.594
Esr2 estrogen receptor 2 (beta) 0.561
Apc adenomatosis polyposis coli 0.388
Cry1 cryptochrome 1 (photolyase-like) 0.368
Cry2 cryptochrome 2 (photolyase-like) 0.331
Lepr leptin receptor 0.266
LOC100048884 novel member of the major urinary protein (Mup) gene family 0.260
Ghr growth hormone receptor 0.229
Fst follistatin 0.221
Fshr follicle stimulating hormone receptor 0.219
Pomc pro-opiomelanocortin-alpha 0.215
Mup19 major urinary protein 19 0.212
Mup10 major urinary protein 10 0.181
Ptgs2 prostaglandin-endoperoxide synthase 2 0.169
Tnf tumor necrosis factor 0.168
Mup1 major urinary protein 1 0.152
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.149
Ccl2 chemokine (C-C motif) ligand 2 0.143
Mup12 major urinary protein 12 0.139
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.121
Nos1 nitric oxide synthase 1, neuronal 0.112
Mup8 major urinary protein 8 0.102
Pparg peroxisome proliferator activated receptor gamma 0.100
Bglap bone gamma carboxyglutamate protein 0.099
Pim3 proviral integration site 3 0.096
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.092
Fgf8 fibroblast growth factor 8 0.089
Mup4 major urinary protein 4 0.089
Ctnnb1 catenin (cadherin associated protein), beta 1 0.087
Mup11 major urinary protein 11 0.086
Mup5 major urinary protein 5 0.083
Smad3 MAD homolog 3 (Drosophila) 0.081
Mup9 major urinary protein 9 0.081
Gata4 GATA binding protein 4 0.081
Mup14 major urinary protein 14 0.076
Mup17 major urinary protein 17 0.072
Mup13 major urinary protein 13 0.072
Bmpr1a bone morphogenetic protein receptor, type 1A 0.069
Htt huntingtin 0.066
Plin1 perilipin 1 0.066
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 0.066
Mup7 major urinary protein 7 0.065
Gnrh1 gonadotropin releasing hormone 1 0.063
Il1a interleukin 1 alpha 0.062
Tgfbr2 transforming growth factor, beta receptor II 0.062
Col1a1 collagen, type I, alpha 1 0.060
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.060
Stat3 signal transducer and activator of transcription 3 0.059
Prlr prolactin receptor 0.058
Mup15 major urinary protein 15 0.057
Per1 period homolog 1 (Drosophila) 0.056
LOC100048885 major urinary protein LOC100048885 0.056
Mup2 major urinary protein 2 0.054
Mup3 major urinary protein 3 0.053
Tlr2 toll-like receptor 2 0.052
Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 0.052
Il1r1 interleukin 1 receptor, type I 0.050
Thra thyroid hormone receptor alpha 0.050
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.049
Plcg1 phospholipase C, gamma 1 0.047
Vegfa vascular endothelial growth factor A 0.047
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.044
Kiss1 KiSS-1 metastasis-suppressor 0.044
Crh corticotropin releasing hormone 0.043
Ar androgen receptor 0.042
Prkg1 protein kinase, cGMP-dependent, type I 0.042
Svs5 seminal vesicle secretory protein 5 0.042
Pten phosphatase and tensin homolog 0.041
Nf1 neurofibromatosis 1 0.041
Cav1 caveolin 1, caveolae protein 0.039
Mstn myostatin 0.039
Socs1 suppressor of cytokine signaling 1 0.039
Sfrp2 secreted frizzled-related protein 2 0.038
Cidec cell death-inducing DFFA-like effector c 0.038
Igh immunoglobulin heavy chain complex 0.036
Cd70 CD70 antigen 0.035
Inhba inhibin beta-A 0.035
Ern2 endoplasmic reticulum (ER) to nucleus signalling 2 0.034
Adipoq adiponectin, C1Q and collagen domain containing 0.034
Tgfb1 transforming growth factor, beta 1 0.034
Irs2 insulin receptor substrate 2 0.033
Il1b interleukin 1 beta 0.033
Pnpla2 patatin-like phospholipase domain containing 2 0.033
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.032
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.032
Casr calcium-sensing receptor 0.032
Apoe apolipoprotein E 0.031
Sstr3 somatostatin receptor 3 0.031
Csf1 colony stimulating factor 1 (macrophage) 0.030
Cd80 CD80 antigen 0.029
Cps1 carbamoyl-phosphate synthetase 1 0.027
Orm2 orosomucoid 2 0.027
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism