The network for 'endocrine hormone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endocrine hormone secretion

The regulated release of a hormone into the circulatory system.

Danio rerio
Name Description Probability Func Analog Organism
igf3 insulin-like growth factor 3 0.827
inhbab inhibin, beta Ab 0.788
acvr2b activin receptor IIb 0.753
inha inhibin, alpha 0.687
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.639
csnk1db casein kinase 1, delta b 0.566
pou1f1 POU domain, class 1, transcription factor 1 0.542
lhcgr luteinizing hormone/choriogonadotropin receptor 0.505
tef thyrotroph embryonic factor 0.477
acvr2a activin receptor IIa 0.407
inhbaa inhibin, beta Aa 0.350
star steroidogenic acute regulatory protein 0.305
cry3 cryptochrome 3 0.278
gdf9 growth differentiation factor 9 0.270
nr1d2b nuclear receptor subfamily 1, group D, member 2b 0.269
hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 0.257
paqr7b progestin and adipoQ receptor family member VII, b 0.252
paqr8 progestin and adipoQ receptor family member VIII 0.240
prl prolactin 0.191
hif1al hypoxia-inducible factor 1, alpha subunit, like 0.169
zp3 zona pellucida glycoprotein 3 0.157
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.123
si:dkey-177p2.6 si:dkey-177p2.6 0.123
mbnl2 muscleblind-like 2 (Drosophila) 0.122
gstt1b glutathione S-transferase theta 1b 0.118
fshb follicle stimulating hormone, beta polypeptide 0.117
gstt1a glutathione S-transferase theta 1a 0.113
hsf2 heat shock factor 2 0.106
si:dkey-258f14.5 si:dkey-258f14.5 0.106
gh1 growth hormone 1 0.098
znf395b zinc finger protein 395b 0.089
rspo1 R-spondin homolog (Xenopus laevis) 0.089
figla factor in the germline alpha 0.084
dedd1 death effector domain-containing 1 0.084
nt5c2l1 5'-nucleotidase, cytosolic II, like 1 0.077
cldn2 claudin 2 0.075
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.070
ptpn11b protein tyrosine phosphatase, non-receptor type 11, b 0.069
cry1b cryptochrome 1b 0.069
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.069
mycl1b v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b 0.068
aplp2 amyloid beta (A4) precursor-like protein 2 0.064
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.062
cpla2 cytosolic phospholipase a2 0.059
aldocb aldolase C, fructose-bisphosphate, b 0.058
ptgds prostaglandin D2 synthase 0.058
zgc:162126 zgc:162126 0.057
htr1aa 5-hydroxytryptamine (serotonin) receptor 1A a 0.057
hbae1 hemoglobin alpha embryonic-1 0.054
cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.052
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.052
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.051
fabp2 fatty acid binding protein 2, intestinal 0.051
atp6v0cb ATPase, H+ transporting, lysosomal, V0 subunit c, b 0.051
dmrt1 doublesex and mab-3 related transcription factor 1 0.051
ppp4cb protein phosphatase 4 (formerly X), catalytic subunit b 0.050
cldnc claudin c 0.050
zgc:153063 zgc:153063 0.050
scg3 secretogranin III 0.049
klf2a Kruppel-like factor 2a 0.049
per2 period homolog 2 (Drosophila) 0.045
fam43b family with sequence similarity 43, member B 0.044
tdrd1 tudor domain containing 1 0.043
ptgs2a prostaglandin-endoperoxide synthase 2a 0.042
stk38l serine/threonine kinase 38 like 0.042
slc16a9a solute carrier family 16 (monocarboxylic acid transporters), member 9a 0.041
metrn meteorin, glial cell differentiation regulator 0.040
cldna claudin a 0.040
si:ch211-248e11.2 si:ch211-248e11.2 0.040
gngt2a guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a 0.039
dab1a disabled homolog 1a (Drosophila) 0.039
kidins220b kinase D-interacting substrate of 220b 0.039
si:dkey-12o15.1 si:dkey-12o15.1 0.038
ildr1b immunoglobulin-like domain containing receptor 1b 0.038
zfand5a zinc finger, AN1-type domain 5a 0.038
tshz1 teashirt family zinc finger 1 0.037
pgr progesterone receptor 0.037
upf3b UPF3 regulator of nonsense transcripts homolog B (yeast) 0.036
dynlrb1 dynein, light chain, roadblock-type 1 0.036
stk35l serine/threonine kinase 35, like 0.036
bmpr1ab bone morphogenetic protein receptor, type 1ab 0.034
figf c-fos induced growth factor 0.034
im:7150937 im:7150937 0.034
ahcyl1 S-adenosylhomocysteine hydrolase-like 1 0.034
LOC797097 PLAC8-like protein 1-like 0.033
dhcr7 7-dehydrocholesterol reductase 0.033
otpb orthopedia homolog b 0.033
cyp2p6 cytochrome P450, family 2, subfamily P, polypeptide 6 0.033
zgc:136614 zgc:136614 0.032
ptgesl prostaglandin E synthase 2-like 0.032
spsb4a splA/ryanodine receptor domain and SOCS box containing 4a 0.032
synpr synaptoporin 0.032
isl2a islet2a 0.032
zgc:113210 zgc:113210 0.031
LOC100538108 tissue-type plasminogen activator-like 0.031
hsp70l heat shock cognate 70-kd protein, like 0.031
ppp3ca protein phosphatase 3, catalytic subunit, alpha isozyme 0.031
ptprb protein tyrosine phosphatase, receptor type, b 0.031
p2rx8 purinergic receptor P2X, ligand-gated ion channel, 8 0.030
ptgs1 prostaglandin-endoperoxide synthase 1 0.030
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CRH corticotropin releasing hormone 0.613
IL1R1 interleukin 1 receptor, type I 0.567
TDGF1 teratocarcinoma-derived growth factor 1 0.508
C1QA complement component 1, q subcomponent, A chain 0.442
C1QB complement component 1, q subcomponent, B chain 0.342
MPDZ multiple PDZ domain protein 0.334
CRHR1 corticotropin releasing hormone receptor 1 0.287
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.278
IL1RAP interleukin 1 receptor accessory protein 0.113
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.102
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.071
SSTR2 somatostatin receptor 2 0.049
SPDEF SAM pointed domain containing ets transcription factor 0.046
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.042
SSTR3 somatostatin receptor 3 0.039
IL1RN interleukin 1 receptor antagonist 0.039
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.037
IL8 interleukin 8 0.034
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.033
C1QC complement component 1, q subcomponent, C chain 0.032
CGB5 chorionic gonadotropin, beta polypeptide 5 0.032
NDP Norrie disease (pseudoglioma) 0.030
UNC119 unc-119 homolog (C. elegans) 0.030
CSNK1E casein kinase 1, epsilon 0.027
MYO6 myosin VI 0.027
IGSF21 immunoglobin superfamily, member 21 0.026
CCKBR cholecystokinin B receptor 0.023
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.022
FST follistatin 0.021
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.020
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.019
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 0.018
APLP1 amyloid beta (A4) precursor-like protein 1 0.017
CRAMP1L Crm, cramped-like (Drosophila) 0.017
OCLN occludin 0.016
FSHB follicle stimulating hormone, beta polypeptide 0.015
GJD2 gap junction protein, delta 2, 36kDa 0.015
EPAS1 endothelial PAS domain protein 1 0.015
ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.014
FRS2 fibroblast growth factor receptor substrate 2 0.014
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.014
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.014
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.013
SMAD3 SMAD family member 3 0.013
CXCL2 chemokine (C-X-C motif) ligand 2 0.013
CCL20 chemokine (C-C motif) ligand 20 0.012
AVPR2 arginine vasopressin receptor 2 0.012
MARCO macrophage receptor with collagenous structure 0.012
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 0.012
TACR1 tachykinin receptor 1 0.012
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.011
KCNF1 potassium voltage-gated channel, subfamily F, member 1 0.011
OPRD1 opioid receptor, delta 1 0.011
TGFB3 transforming growth factor, beta 3 0.010
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.010
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.010
HOXD12 homeobox D12 0.010
NRP1 neuropilin 1 0.010
IL6 interleukin 6 (interferon, beta 2) 0.010
FOXG1 forkhead box G1 0.010
TAL1 T-cell acute lymphocytic leukemia 1 0.010
FSCN2 fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) 0.010
LRP6 low density lipoprotein receptor-related protein 6 0.010
CXCL3 chemokine (C-X-C motif) ligand 3 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Gata5 GATA binding protein 5 0.838
Gata4 GATA binding protein 4 0.675
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.482
Per2 period homolog 2 (Drosophila) 0.390
Fshr follicle stimulating hormone receptor 0.319
Efnb2 ephrin B2 0.283
Amhr2 anti-Mullerian hormone type 2 receptor 0.264
Ephb2 Eph receptor B2 0.240
Smad6 MAD homolog 6 (Drosophila) 0.239
Fst follistatin 0.235
Fzd8 frizzled homolog 8 (Drosophila) 0.230
C1qa complement component 1, q subcomponent, alpha polypeptide 0.221
Per1 period homolog 1 (Drosophila) 0.182
Zfpm2 zinc finger protein, multitype 2 0.161
Gopc golgi associated PDZ and coiled-coil motif containing 0.143
Efnb1 ephrin B1 0.142
Esr1 estrogen receptor 1 (alpha) 0.117
Wnt5a wingless-related MMTV integration site 5A 0.106
Clock circadian locomotor output cycles kaput 0.100
Inhba inhibin beta-A 0.094
Ar androgen receptor 0.093
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.093
Eda ectodysplasin-A 0.085
Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 0.083
Rhbdf1 rhomboid family 1 (Drosophila) 0.081
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.075
Tgfb2 transforming growth factor, beta 2 0.074
Jag1 jagged 1 0.069
Hcn1 hyperpolarization-activated, cyclic nucleotide-gated K+ 1 0.068
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.067
Foxf1a forkhead box F1a 0.067
Ppara peroxisome proliferator activated receptor alpha 0.065
Gata6 GATA binding protein 6 0.059
Gab2 growth factor receptor bound protein 2-associated protein 2 0.058
G6pc glucose-6-phosphatase, catalytic 0.057
Gpr27 G protein-coupled receptor 27 0.056
Pgr progesterone receptor 0.052
C1qb complement component 1, q subcomponent, beta polypeptide 0.051
Prlr prolactin receptor 0.050
Epha4 Eph receptor A4 0.050
Cry2 cryptochrome 2 (photolyase-like) 0.050
Tyrobp TYRO protein tyrosine kinase binding protein 0.049
Tbx2 T-box 2 0.049
Gdnf glial cell line derived neurotrophic factor 0.049
Krtap6-1 keratin associated protein 6-1 0.049
Drd2 dopamine receptor D2 0.048
Notch1 Notch gene homolog 1 (Drosophila) 0.044
Ptk7 PTK7 protein tyrosine kinase 7 0.044
Sox4 SRY-box containing gene 4 0.041
Thrb thyroid hormone receptor beta 0.041
Npy1r neuropeptide Y receptor Y1 0.041
Klf3 Kruppel-like factor 3 (basic) 0.040
Rxra retinoid X receptor alpha 0.040
Efna5 ephrin A5 0.040
Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 0.040
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.039
Slc26a4 solute carrier family 26, member 4 0.039
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.038
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.037
Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), member 2 0.037
Wnt4 wingless-related MMTV integration site 4 0.036
Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 0.035
Lhb luteinizing hormone beta 0.035
Cml2 camello-like 2 0.035
Mc3r melanocortin 3 receptor 0.035
Hrg histidine-rich glycoprotein 0.035
Inhbb inhibin beta-B 0.034
Nkx3-1 NK-3 transcription factor, locus 1 (Drosophila) 0.034
Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 0.034
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.033
Fgf10 fibroblast growth factor 10 0.032
St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.031
F7 coagulation factor VII 0.030
Fgfr2 fibroblast growth factor receptor 2 0.030
Otc ornithine transcarbamylase 0.030
Foxa2 forkhead box A2 0.030
Npr3 natriuretic peptide receptor 3 0.029
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.029
Esr2 estrogen receptor 2 (beta) 0.028
Gnrh1 gonadotropin releasing hormone 1 0.028
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.028
Mc5r melanocortin 5 receptor 0.027
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.026
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.026
Krt6a keratin 6A 0.026
Lepr leptin receptor 0.025
Olfr155 olfactory receptor 155 0.025
Cyp2c54 cytochrome P450, family 2, subfamily c, polypeptide 54 0.025
Dhh desert hedgehog 0.025
Acvr1 activin A receptor, type 1 0.025
Bmpr1a bone morphogenetic protein receptor, type 1A 0.025
Myod1 myogenic differentiation 1 0.024
Acvr2b activin receptor IIB 0.024
Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 0.024
Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 0.024
Hoxb6 homeobox B6 0.023
Fzd1 frizzled homolog 1 (Drosophila) 0.023
Cox8c cytochrome c oxidase, subunit VIIIc 0.022
Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 0.022
Tacr1 tachykinin receptor 1 0.022
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Rattus norvegicus
Name Description Probability Func Analog Organism
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.046
Hcrt hypocretin 0.046
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.045
Gja6 gap junction protein, alpha 6 0.039
Chrm2 cholinergic receptor, muscarinic 2 0.034
Kcnn3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 0.034
Ucn urocortin 0.031
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.030
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.030
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.029
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.028
Ccbp2 chemokine binding protein 2 0.028
Trh thyrotropin releasing hormone 0.028
Crhr2 corticotropin releasing hormone receptor 2 0.028
Pdyn prodynorphin 0.027
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.026
Smad9 SMAD family member 9 0.026
Mchr1 melanin-concentrating hormone receptor 1 0.026
Hhip Hedgehog-interacting protein 0.026
Fam148b family with sequence similarity 148, member B 0.026
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.025
Lox lysyl oxidase 0.025
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.024
Csrnp2 cysteine-serine-rich nuclear protein 2 0.024
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.023
Avp arginine vasopressin 0.023
Gpr182 G protein-coupled receptor 182 0.020
Lamc1 laminin, gamma 1 0.020
Nkx6-1 NK6 homeobox 1 0.020
Aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.019
Unc13a unc-13 homolog A (C. elegans) 0.019
Teddm1 transmembrane epididymal protein 1 0.018
Spag4 sperm associated antigen 4 0.018
Itgam integrin, alpha M 0.018
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.017
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.017
Lep leptin 0.017
Syt10 synaptotagmin X 0.017
Igsf1 immunoglobulin superfamily, member 1 0.017
Ednrb endothelin receptor type B 0.017
Insr insulin receptor 0.017
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.016
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.016
Cbln2 cerebellin 2 precursor 0.016
Mep1a meprin 1 alpha 0.016
Syt13 synaptotagmin XIII 0.016
Foxe3 forkhead box E3 0.016
Col1a2 collagen, type I, alpha 2 0.015
Olr1701 olfactory receptor 1701 0.015
Chrna9 cholinergic receptor, nicotinic, alpha 9 0.015
Nmnat2 nicotinamide nucleotide adenylyltransferase 2 0.015
Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 0.015
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.015
Mamdc4 MAM domain containing 4 0.014
Bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.014
Cmklr1 chemokine-like receptor 1 0.014
Fgf7 fibroblast growth factor 7 0.014
Has2 hyaluronan synthase 2 0.014
Cadm4 cell adhesion molecule 4 0.014
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.013
Fgf8 fibroblast growth factor 8 0.013
Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.013
Pnoc prepronociceptin 0.013
Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 0.013
Lbxcor1 LBXCOR1 homolog (mouse) 0.013
Marcks myristoylated alanine rich protein kinase C substrate 0.013
Prss21 protease, serine, 21 0.013
Hand1 heart and neural crest derivatives expressed 1 0.013
Pmch pro-melanin-concentrating hormone 0.013
Wisp2 WNT1 inducible signaling pathway protein 2 0.012
Cga glycoprotein hormones, alpha polypeptide 0.012
Dll3 delta-like 3 (Drosophila) 0.012
Hfe hemochromatosis 0.012
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.012
Afap1 actin filament associated protein 1 0.012
Shank1 SH3 and multiple ankyrin repeat domains 1 0.012
Fev FEV (ETS oncogene family) 0.012
Slc38a5 solute carrier family 38, member 5 0.012
Notch3 Notch homolog 3 (Drosophila) 0.012
Ins1 insulin 1 0.012
Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 0.012
Mmp12 matrix metallopeptidase 12 0.012
Ush1c Usher syndrome 1C homolog (human) 0.012
Casq2 calsequestrin 2 (cardiac muscle) 0.012
Ifitm3 interferon induced transmembrane protein 3 0.012
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.011
Lims1 LIM and senescent cell antigen-like domains 1 0.011
Lama5 laminin, alpha 5 0.011
RGD1306404 similar to mKIAA1402 protein 0.011
Synpo synaptopodin 0.011
Prl2a1 Prolactin family 2, subfamily a, member 1 0.011
Olr1356 olfactory receptor 1356 0.011
Ghrl ghrelin/obestatin prepropeptide 0.011
Syt8 synaptotagmin VIII 0.011
Prrt4 proline-rich transmembrane protein 4 0.011
Gpr135 G protein-coupled receptor 135 0.011
Wap whey acidic protein 0.011
Cort cortistatin 0.011
Prokr2 prokineticin receptor 2 0.011
Ghsr growth hormone secretagogue receptor 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism