The network for 'cortical cytoskeleton organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cortical cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.

Danio rerio
Name Description Probability Func Analog Organism
sept2 septin 2 0.790
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.598
arpc5a actin related protein 2/3 complex, subunit 5A 0.448
myl9l myosin, light polypeptide 9, like 0.350
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.349
rab1a RAB1A, member RAS oncogene family 0.323
dynlt3 dynein, light chain, Tctex-type 3 0.314
lasp1 LIM and SH3 protein 1 0.303
perp PERP, TP53 apoptosis effector 0.236
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.213
arpc5b actin related protein 2/3 complex, subunit 5B 0.202
rap1b RAS related protein 1b 0.201
gnai2l guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like 0.201
gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.196
pfn2 profilin 2 0.192
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.189
arf2 ADP-ribosylation factor 2 0.188
rras related RAS viral (r-ras) oncogene homolog 0.174
rab22a RAB22A, member RAS oncogene family 0.165
gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.162
calub calumenin b 0.159
esyt3 extended synaptotagmin-like protein 3 0.148
snx12 sorting nexin 12 0.146
cd82a CD82 antigen, a 0.144
si:dkey-222f8.3 si:dkey-222f8.3 0.138
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.138
tpte transmembrane phosphatase with tensin homology 0.133
psen1 presenilin 1 0.132
rhoab ras homolog gene family, member Ab 0.129
gnal guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.128
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.127
nxph1 neurexophilin 1 0.121
LOC560606 novel protein similar to human and mouse leishmanolysin-like (metallopeptidase M8 family) (LMLN) 0.121
sh3bgrl3 SH3 domain binding glutamic acid-rich protein like 3 0.119
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.119
guk1 guanylate kinase 1 0.119
dlg2 discs, large (Drosophila) homolog 2 0.116
im:7154036 im:7154036 0.115
sept8a septin 8a 0.111
arhgef1 rho guanine nucleotide exchange factor (GEF) 1 0.109
pak2a p21 (CDKN1A)-activated kinase 2a 0.104
gnat1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 0.103
cdc42 cell division cycle 42 0.100
ap2b1 adaptor-related protein complex 2, beta 1 subunit 0.100
snx6 sorting nexin 6 0.099
iqgap1 IQ motif containing GTPase activating protein 1 0.099
arrb2b arrestin, beta 2b 0.098
cnn2 calponin 2 0.098
zgc:123010 zgc:123010 0.098
flii flightless I homolog (Drosophila) 0.097
golga7 golgi autoantigen, golgin subfamily a, 7 0.093
spast spastin 0.093
jak1 Janus kinase 1 0.093
tbcb tubulin folding cofactor B 0.092
ube2na ubiquitin-conjugating enzyme E2Na 0.090
cyb5b cytochrome b5 type B 0.087
hug HuG 0.084
zgc:73328 zgc:73328 0.084
rhoac ras homolog gene family, member Ac 0.084
pfn2l profilin 2 like 0.083
gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.083
stk10 serine/threonine kinase 10 0.083
il13ra2 interleukin 13 receptor, alpha 2 0.083
cbfb core-binding factor, beta subunit 0.083
slc30a1 solute carrier family 30 (zinc transporter), member 1 0.080
lima1 LIM domain and actin binding 1 0.078
apg3l APG3 autophagy 3-like 0.078
gna11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.078
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.077
rhoaa ras homolog gene family, member Aa 0.076
appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.076
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.076
foxn1 forkhead box N1 0.075
ap1b1 adaptor-related protein complex 1, beta 1 subunit 0.075
npepl1 aminopeptidase-like 1 0.075
zgc:101072 zgc:101072 0.073
capza1a capping protein (actin filament) muscle Z-line, alpha 1a 0.072
ube2a ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.071
twf1a twinfilin, actin-binding protein, homolog 1a 0.071
tpd52l2b tumor protein D52-like 2b 0.071
ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.070
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.070
synj1 synaptojanin 1 0.069
fmr1 fragile X mental retardation 1 0.068
opn1sw2 opsin 1 (cone pigments), short-wave-sensitive 2 0.067
gnaz guanine nucleotide binding protein (G protein), alpha z polypeptide 0.067
ap1s2 adaptor-related protein complex 1, sigma 2 subunit 0.067
ube2v2 ubiquitin-conjugating enzyme E2 variant 2 0.066
dynlrb1 dynein, light chain, roadblock-type 1 0.066
actr3 ARP3 actin-related protein 3 homolog (yeast) 0.066
sri sorcin 0.065
vps26a vacuolar protein sorting 26 homolog A (yeast) 0.065
arpc4 actin related protein 2/3 complex, subunit 4 0.065
cfl2l cofilin 2, like 0.065
zgc:153867 zgc:153867 0.065
zgc:64040 zgc:64040 0.064
tas2r202 taste receptor, type 2, member 202 0.063
zgc:56525 zgc:56525 0.063
slc30a9 solute carrier family 30 (zinc transporter), member 9 0.063
stk17b serine/threonine kinase 17b (apoptosis-inducing) 0.063
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rac1 CG2248 gene product from transcript CG2248-RA 0.919
ena enabled 0.619
Pi3K68D Phosphotidylinositol 3 kinase 68D 0.552
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.431
Rho1 CG8416 gene product from transcript CG8416-RB 0.383
chic chickadee 0.367
Abl Abl tyrosine kinase 0.345
unc-104 CG8566 gene product from transcript CG8566-RB 0.326
cno canoe 0.275
Sbf SET domain binding factor 0.241
sn singed 0.239
r2d2 CG7138 gene product from transcript CG7138-RB 0.230
Akt1 CG4006 gene product from transcript CG4006-RA 0.227
Rac2 CG8556 gene product from transcript CG8556-RA 0.227
wit wishful thinking 0.189
Arc-p34 CG10954 gene product from transcript CG10954-RA 0.187
CG17082 CG17082 gene product from transcript CG17082-RD 0.163
Arf79F ADP ribosylation factor 79F 0.152
Sra-1 specifically Rac1-associated protein 1 0.152
rok Rho-kinase 0.142
mbc myoblast city 0.140
Dcr-2 Dicer-2 0.128
ras raspberry 0.127
Rab5 Rab-protein 5 0.121
drk downstream of receptor kinase 0.119
nimC4 nimrod C4 0.119
GluRIIA Glutamate receptor IIA 0.111
dlp dally-like 0.107
hiw highwire 0.104
cta concertina 0.102
mts microtubule star 0.100
Wnk CG7177 gene product from transcript CG7177-RA 0.098
gish gilgamesh 0.097
stnB stoned B 0.093
lace CG4162 gene product from transcript CG4162-RA 0.092
kst karst 0.092
beta-Spec beta Spectrin 0.088
G-oalpha47A G protein oalpha 47A 0.082
G-ialpha65A G protein alphai subunit 65A 0.079
pod1 CG4532 gene product from transcript CG4532-RF 0.079
Eb1 CG3265 gene product from transcript CG3265-RF 0.078
Tbh Tyramine beta hydroxylase 0.077
Ank2 Ankyrin 2 0.075
Ggamma1 G protein gamma 1 0.069
Mlc-c Myosin light chain cytoplasmic 0.065
ifc infertile crescent 0.064
Hr96 Hormone receptor-like in 96 0.061
Rala Ras-related protein 0.058
cpb capping protein beta 0.058
CG12187 CG12187 gene product from transcript CG12187-RA 0.058
Ras85D Ras oncogene at 85D 0.058
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.057
ttk tramtrack 0.056
cpx complexin 0.056
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.055
Cdc42 CG12530 gene product from transcript CG12530-RA 0.054
Gbeta13F G protein beta-subunit 13F 0.054
BicD Bicaudal D 0.054
HSPC300 CG30173 gene product from transcript CG30173-RA 0.053
dnc dunce 0.053
CG32635 CG32635 gene product from transcript CG32635-RA 0.052
Pvr PDGF- and VEGF-receptor related 0.052
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.052
neuroligin CG13772 gene product from transcript CG13772-RA 0.051
Fhos CG42610 gene product from transcript CG42610-RC 0.049
Snap25 Synapse protein 25 0.049
pan pangolin 0.049
Pak3 CG14895 gene product from transcript CG14895-RA 0.048
CDase Ceramidase 0.046
Mad Mothers against dpp 0.043
bif bifocal 0.042
norpA no receptor potential A 0.042
p120ctn Adherens junction protein p120 0.040
Sara Smad anchor for receptor activation 0.040
par-6 CG5884 gene product from transcript CG5884-RA 0.040
Arf51F ADP ribosylation factor 51F 0.040
Rab3 Rab-protein 3 0.039
Syx1A Syntaxin 1A 0.039
mtm myotubularin 0.039
insc inscuteable 0.039
Ras64B Ras oncogene at 64B 0.038
scb scab 0.038
drpr draper 0.037
Rab21 CG17515 gene product from transcript CG17515-RC 0.037
pnut peanut 0.036
Gef26 CG9491 gene product from transcript CG9491-RB 0.036
Tre1 trapped in endoderm-1 0.035
CG31352 CG31352 gene product from transcript CG31352-RA 0.034
sina seven in absentia 0.032
flw flapwing 0.032
VGlut Vesicular glutamate transporter 0.031
baz bazooka 0.031
p130CAS CG1212 gene product from transcript CG1212-RA 0.031
cbt cabut 0.030
trio CG18214 gene product from transcript CG18214-RA 0.030
sdt stardust 0.030
smo smoothened 0.030
RanBPM Ran-binding protein M 0.030
Fak56D Focal Adhesion Kinase 0.029
swm second mitotic wave missing 0.029
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Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.973
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.927
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.480
GAS7 growth arrest-specific 7 0.297
STRN3 striatin, calmodulin binding protein 3 0.237
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.132
GDA guanine deaminase 0.126
STRN striatin, calmodulin binding protein 0.115
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.109
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.103
CTTNBP2NL CTTNBP2 N-terminal like 0.102
SORBS3 sorbin and SH3 domain containing 3 0.096
HTT huntingtin 0.088
SLMAP sarcolemma associated protein 0.083
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.082
DLG4 discs, large homolog 4 (Drosophila) 0.060
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 0.054
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.051
ARHGAP1 Rho GTPase activating protein 1 0.045
RAB1A RAB1A, member RAS oncogene family 0.043
RHOA ras homolog gene family, member A 0.043
ELP2 elongation protein 2 homolog (S. cerevisiae) 0.042
ANKRD28 ankyrin repeat domain 28 0.042
MOBKL3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.039
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.038
MSN moesin 0.037
BZW1 basic leucine zipper and W2 domains 1 0.037
EZR ezrin 0.034
STK24 serine/threonine kinase 24 0.034
CAPNS1 calpain, small subunit 1 0.033
MOBKL1A MOB1, Mps One Binder kinase activator-like 1A (yeast) 0.031
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.029
ADAM17 ADAM metallopeptidase domain 17 0.029
DNM2 dynamin 2 0.029
SOS1 son of sevenless homolog 1 (Drosophila) 0.026
TRIM63 tripartite motif containing 63 0.026
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.025
ABI1 abl-interactor 1 0.024
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.023
ADAM19 ADAM metallopeptidase domain 19 0.022
ELP4 elongation protein 4 homolog (S. cerevisiae) 0.022
ARFIP2 ADP-ribosylation factor interacting protein 2 0.021
FIBP fibroblast growth factor (acidic) intracellular binding protein 0.021
CHERP calcium homeostasis endoplasmic reticulum protein 0.021
NCKAP1 NCK-associated protein 1 0.020
PDIA3 protein disulfide isomerase family A, member 3 0.020
ABI2 abl-interactor 2 0.020
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.019
ZYX zyxin 0.018
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.018
PFN1 profilin 1 0.018
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.017
WASF2 WAS protein family, member 2 0.017
FMNL1 formin-like 1 0.016
WASF1 WAS protein family, member 1 0.016
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.015
JUP junction plakoglobin 0.014
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.013
DIAPH1 diaphanous homolog 1 (Drosophila) 0.013
PRKCI protein kinase C, iota 0.013
NCF2 neutrophil cytosolic factor 2 0.012
CAPZB capping protein (actin filament) muscle Z-line, beta 0.012
LAPTM5 lysosomal protein transmembrane 5 0.011
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.011
SIKE1 suppressor of IKBKE 1 0.011
CD44 CD44 molecule (Indian blood group) 0.011
CORO1A coronin, actin binding protein, 1A 0.011
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.011
TAGLN2 transgelin 2 0.011
MYH9 myosin, heavy chain 9, non-muscle 0.011
STON2 stonin 2 0.010
EHD1 EH-domain containing 1 0.010
SPAG9 sperm associated antigen 9 0.010
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.010
OCRL oculocerebrorenal syndrome of Lowe 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SLA2 Sla2p 0.869
PRK1 Prk1p 0.687
END3 End3p 0.572
ARK1 Ark1p 0.392
ARC40 Arc40p 0.368
BOI1 Boi1p 0.323
PAN1 Pan1p 0.249
ARC18 Arc18p 0.152
BBC1 Bbc1p 0.110
ARP2 Arp2p 0.086
ARC35 Arc35p 0.086
ARC15 Arc15p 0.083
YPT1 Ypt1p 0.071
PKC1 Pkc1p 0.066
AKL1 Akl1p 0.064
YPT31 Ypt31p 0.055
YAP1802 hypothetical protein 0.047
ENT2 Ent2p 0.039
ENT1 Ent1p 0.036
MYO5 Myo5p 0.033
YPT32 Ypt32p 0.032
YPT10 Ypt10p 0.030
LSB1 Lsb1p 0.029
RHO1 Rho1p 0.026
YOR111W hypothetical protein 0.026
CBK1 Cbk1p 0.024
ABP1 Abp1p 0.021
BEM1 Bem1p 0.020
EDE1 Ede1p 0.019
VRP1 Vrp1p 0.018
SEC2 Sec2p 0.017
MDM32 Mdm32p 0.016
AIM21 Aim21p 0.016
CMD1 Cmd1p 0.014
TWF1 Twf1p 0.014
ARP10 Arp10p 0.014
YPT52 Ypt52p 0.013
BEM3 Bem3p 0.013
YLR264C-A hypothetical protein 0.013
UGO1 Ugo1p 0.012
SRD1 Srd1p 0.012
PRS2 Prs2p 0.012
MYO3 Myo3p 0.011
YER186C hypothetical protein 0.011
YOL038C-A hypothetical protein 0.011
MER1 Mer1p 0.011
LEU2 Leu2p 0.011
SED5 Sed5p 0.011
STE2 Ste2p 0.010
YLR162W hypothetical protein 0.010
SGE1 Sge1p 0.010
FIR1 Fir1p 0.010
YIP3 Yip3p 0.010
SEC15 Sec15p 0.010
GYL1 Gyl1p 0.010
AGE1 Age1p 0.010
STE5 Ste5p 0.010