IMP

Process View

Homo sapiens

3 genes annotated in human

Multi-species View

urea metabolic process

GO:0019627

The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "urea metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "urea metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.998
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.984
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.953	Human
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.706	Human
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.580
CLTC	clathrin, heavy chain (Hc)	0.561
ADH6	alcohol dehydrogenase 6 (class V)	0.456
ALDOB	aldolase B, fructose-bisphosphate	0.409
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.350
HIP1	huntingtin interacting protein 1	0.333
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.278
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.232	Human
TADA3	transcriptional adaptor 3	0.201
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.192
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.167
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.163
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.159
AADAC	arylacetamide deacetylase (esterase)	0.154
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.131
NCOA1	nuclear receptor coactivator 1	0.122
ANXA10	annexin A10	0.119
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.117
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.100
ELP4	elongation protein 4 homolog (S. cerevisiae)	0.099
FABP1	fatty acid binding protein 1, liver	0.092
CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	0.090	Human
TTPA	tocopherol (alpha) transfer protein	0.088
ASCC2	activating signal cointegrator 1 complex subunit 2	0.077
CLTCL1	clathrin, heavy chain-like 1	0.073
ACRV1	acrosomal vesicle protein 1	0.070
GLYAT	glycine-N-acyltransferase	0.068
HRG	histidine-rich glycoprotein	0.067
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.064
PDCD7	programmed cell death 7	0.059
AGXT2	alanine--glyoxylate aminotransferase 2	0.058
FMO4	flavin containing monooxygenase 4	0.058
ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5	0.057
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.056
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.054
GSTA3	glutathione S-transferase alpha 3	0.052
PLG	plasminogen	0.052
C8B	complement component 8, beta polypeptide	0.050
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.049
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.049
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.049
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.048
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.048
LAMC3	laminin, gamma 3	0.048
F11	coagulation factor XI	0.047
HPX	hemopexin	0.047
MAT1A	methionine adenosyltransferase I, alpha	0.046
GYS2	glycogen synthase 2 (liver)	0.046
ELP3	elongation protein 3 homolog (S. cerevisiae)	0.046
OTC	ornithine carbamoyltransferase	0.044
ELP2	elongation protein 2 homolog (S. cerevisiae)	0.043
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.043	Human
HGD	homogentisate 1,2-dioxygenase	0.043
POU2F1	POU class 2 homeobox 1	0.042
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.042
GATM	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	0.041
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.040
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.040
DNM1	dynamin 1	0.040
XDH	xanthine dehydrogenase	0.039
RAB3D	RAB3D, member RAS oncogene family	0.038
ORM1	orosomucoid 1	0.038
DNASE1L3	deoxyribonuclease I-like 3	0.037
SGSM2	small G protein signaling modulator 2	0.037
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.036	Human
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.036
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.036
PON1	paraoxonase 1	0.035
F13B	coagulation factor XIII, B polypeptide	0.035
ARG1	arginase, liver	0.034	Rat
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.034
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.033
ANGPTL3	angiopoietin-like 3	0.032
HOXB7	homeobox B7	0.031
MEP1B	meprin A, beta	0.031
MAST1	microtubule associated serine/threonine kinase 1	0.031
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.031
MTTP	microsomal triglyceride transfer protein	0.030
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.030
SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	0.029
A1CF	APOBEC1 complementation factor	0.029
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.028
HAVCR1	hepatitis A virus cellular receptor 1	0.028
FASLG	Fas ligand (TNF superfamily, member 6)	0.028
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.027
CPB2	carboxypeptidase B2 (plasma)	0.027
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.027
MAN2A2	mannosidase, alpha, class 2A, member 2	0.026
HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.026
APOBEC1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.026
FOXO1	forkhead box O1	0.026
ATP10B	ATPase, class V, type 10B	0.026
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.025
C9orf68	chromosome 9 open reading frame 68	0.025
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.024
TM4SF4	transmembrane 4 L six family member 4	0.024
CNGA1	cyclic nucleotide gated channel alpha 1	0.023
PAH	phenylalanine hydroxylase	0.023
F9	coagulation factor IX	0.023
FGL1	fibrinogen-like 1	0.023
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.023
ZMAT2	zinc finger, matrin-type 2	0.023
C8A	complement component 8, alpha polypeptide	0.022
ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	0.022
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.022
SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.022
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.022
ADH4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.021
MVK	mevalonate kinase	0.021
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.021	Mouse
HNF4G	hepatocyte nuclear factor 4, gamma	0.021
UGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17	0.021
C9	complement component 9	0.021
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.021
ZNF717	zinc finger protein 717	0.021
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.020
G6PC	glucose-6-phosphatase, catalytic subunit	0.020
MTA2	metastasis associated 1 family, member 2	0.020
PFN2	profilin 2	0.020
A2M	alpha-2-macroglobulin	0.020
TM4SF20	transmembrane 4 L six family member 20	0.020
PIPOX	pipecolic acid oxidase	0.020
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.020
ANXA13	annexin A13	0.019
LIPC	lipase, hepatic	0.019
CCDC30	coiled-coil domain containing 30	0.019
HAL	histidine ammonia-lyase	0.019
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.019
SAA4	serum amyloid A4, constitutive	0.019
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.019
HABP2	hyaluronan binding protein 2	0.019
FABP2	fatty acid binding protein 2, intestinal	0.019
SPINT3	serine peptidase inhibitor, Kunitz type, 3	0.019
AFM	afamin	0.019
C4BPB	complement component 4 binding protein, beta	0.018
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.018
APOC4	apolipoprotein C-IV	0.018
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.018
HHLA2	HERV-H LTR-associating 2	0.018
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.018
CCDC113	coiled-coil domain containing 113	0.017
REG3A	regenerating islet-derived 3 alpha	0.017
MUC3A	mucin 3A, cell surface associated	0.017
HEY2	hairy/enhancer-of-split related with YRPW motif 2	0.017
STIM2	stromal interaction molecule 2	0.017
DPYS	dihydropyrimidinase	0.017
PTPRS	protein tyrosine phosphatase, receptor type, S	0.017
NTS	neurotensin	0.017
PAX9	paired box 9	0.017
SLCO1B3	solute carrier organic anion transporter family, member 1B3	0.017
TUT1	terminal uridylyl transferase 1, U6 snRNA-specific	0.017
POF1B	premature ovarian failure, 1B	0.016
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.016
C4BPA	complement component 4 binding protein, alpha	0.016
UGT2A3	UDP glucuronosyltransferase 2 family, polypeptide A3	0.016
AKTIP	AKT interacting protein	0.016
TTC18	tetratricopeptide repeat domain 18	0.016
SREBF2	sterol regulatory element binding transcription factor 2	0.016
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.016
TBCD	tubulin folding cofactor D	0.016
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.016
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.016
FOXO3	forkhead box O3	0.015
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.015
LPA	lipoprotein, Lp(a)	0.015
FMNL2	formin-like 2	0.015
F5	coagulation factor V (proaccelerin, labile factor)	0.015
TEC	tec protein tyrosine kinase	0.015
ZKSCAN3	zinc finger with KRAB and SCAN domains 3	0.015
TCN1	transcobalamin I (vitamin B12 binding protein, R binder family)	0.015
LRRC31	leucine rich repeat containing 31	0.015
TMC7	transmembrane channel-like 7	0.015
TTR	transthyretin	0.015
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.015
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.015
PRSS1	protease, serine, 1 (trypsin 1)	0.015
SPRR2B	small proline-rich protein 2B	0.015
ARHGAP17	Rho GTPase activating protein 17	0.014
GNMT	glycine N-methyltransferase	0.014
RGN	regucalcin (senescence marker protein-30)	0.014
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.014
DAO	D-amino-acid oxidase	0.014
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.014
FMNL3	formin-like 3	0.014
MAS1	MAS1 oncogene	0.014
ORM2	orosomucoid 2	0.014
ZFYVE19	zinc finger, FYVE domain containing 19	0.014
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.014
CIDEB	cell death-inducing DFFA-like effector b	0.014
MEST	mesoderm specific transcript homolog (mouse)	0.014
SORT1	sortilin 1	0.014
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.014
APOC2	apolipoprotein C-II	0.014
FBXW8	F-box and WD repeat domain containing 8	0.014
ALDH4A1	aldehyde dehydrogenase 4 family, member A1	0.014
CES3	carboxylesterase 3	0.014
SLC38A4	solute carrier family 38, member 4	0.013
PLA2G1B	phospholipase A2, group IB (pancreas)	0.013
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.013
APOF	apolipoprotein F	0.013
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	0.013
CCDC68	coiled-coil domain containing 68	0.013
CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	0.013	Human
FAM59A	family with sequence similarity 59, member A	0.013
MOSC1	MOCO sulphurase C-terminal domain containing 1	0.013
UTY	ubiquitously transcribed tetratricopeptide repeat gene, Y-linked	0.013
APOC3	apolipoprotein C-III	0.013
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.013
PLA2G10	phospholipase A2, group X	0.013
EPHX2	epoxide hydrolase 2, cytoplasmic	0.012
ETNK2	ethanolamine kinase 2	0.012
ZNF512B	zinc finger protein 512B	0.012
GLB1L	galactosidase, beta 1-like	0.012
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.012
UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	0.012
CBS	cystathionine-beta-synthase	0.012
LRTOMT	leucine rich transmembrane and 0-methyltransferase domain containing	0.012
BBOX1	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	0.012
GCKR	glucokinase (hexokinase 4) regulator	0.012
MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	0.012
SQSTM1	sequestosome 1	0.012
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.012
TMEM27	transmembrane protein 27	0.012
LRRC1	leucine rich repeat containing 1	0.012
NDRG2	NDRG family member 2	0.012
IRF3	interferon regulatory factor 3	0.012
HPD	4-hydroxyphenylpyruvate dioxygenase	0.012
MFSD9	major facilitator superfamily domain containing 9	0.012
CRISP3	cysteine-rich secretory protein 3	0.012
CLCA4	chloride channel accessory 4	0.012
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.012
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.012
COBL	cordon-bleu homolog (mouse)	0.012
RLN2	relaxin 2	0.012
ZNF438	zinc finger protein 438	0.012
ASGR2	asialoglycoprotein receptor 2	0.012
LRRC6	leucine rich repeat containing 6	0.012
PON3	paraoxonase 3	0.011
DNAJC22	DnaJ (Hsp40) homolog, subfamily C, member 22	0.011
COLEC10	collectin sub-family member 10 (C-type lectin)	0.011
C6orf105	chromosome 6 open reading frame 105	0.011
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.011
PIAS4	protein inhibitor of activated STAT, 4	0.011
MPP1	membrane protein, palmitoylated 1, 55kDa	0.011
ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	0.011
USF1	upstream transcription factor 1	0.011
TF	transferrin	0.011
SI	sucrase-isomaltase (alpha-glucosidase)	0.011
ETV3	ets variant 3	0.011
MPPE1	metallophosphoesterase 1	0.011
MUC13	mucin 13, cell surface associated	0.011
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.011
MED19	mediator complex subunit 19	0.011
DPPA4	developmental pluripotency associated 4	0.011
FGGY	FGGY carbohydrate kinase domain containing	0.011
SORL1	sortilin-related receptor, L(DLR class) A repeats containing	0.011
REG1A	regenerating islet-derived 1 alpha	0.011
PEAK1	NKF3 kinase family member	0.011
PTH	parathyroid hormone	0.011
DUOX2	dual oxidase 2	0.011
AMOT	angiomotin	0.011
RNLS	renalase, FAD-dependent amine oxidase	0.011
AMPD1	adenosine monophosphate deaminase 1	0.011
SLC26A3	solute carrier family 26, member 3	0.011
CFHR4	complement factor H-related 4	0.011
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.011
SPINK1	serine peptidase inhibitor, Kazal type 1	0.011
LRRC19	leucine rich repeat containing 19	0.011
GCNT4	glucosaminyl (N-acetyl) transferase 4, core 2	0.011
C6	complement component 6	0.011
TNNT1	troponin T type 1 (skeletal, slow)	0.011
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.011
CCL16	chemokine (C-C motif) ligand 16	0.011
NXF3	nuclear RNA export factor 3	0.010
BANP	BTG3 associated nuclear protein	0.010
TAF13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa	0.010
ZG16	zymogen granule protein 16 homolog (rat)	0.010
RDH16	retinol dehydrogenase 16 (all-trans)	0.010
FOXO4	forkhead box O4	0.010
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.010
UPK1B	uroplakin 1B	0.010
HIST1H1E	histone cluster 1, H1e	0.010
MTERFD2	MTERF domain containing 2	0.010
ZNF461	zinc finger protein 461	0.010
LGALS4	lectin, galactoside-binding, soluble, 4	0.010
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.010
PHKA1	phosphorylase kinase, alpha 1 (muscle)	0.010
HSD17B6	hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)	0.010
C5	complement component 5	0.010
STARD5	StAR-related lipid transfer (START) domain containing 5	0.010
ASXL2	additional sex combs like 2 (Drosophila)	0.010
PDE3B	phosphodiesterase 3B, cGMP-inhibited	0.010
SMAD7	SMAD family member 7	0.010
CCDC106	coiled-coil domain containing 106	0.010
OPHN1	oligophrenin 1	0.010
IL17RB	interleukin 17 receptor B	0.010
APOB	apolipoprotein B (including Ag(x) antigen)	0.010
TMC5	transmembrane channel-like 5	0.010
PEPD	peptidase D	0.010
EFNA1	ephrin-A1	0.010
ZNF300	zinc finger protein 300	0.010
PEX11A	peroxisomal biogenesis factor 11 alpha	0.010
ADCK1	aarF domain containing kinase 1	0.010