IMP

Process View

Homo sapiens

11 genes annotated in human

plasminogen activation

The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "plasminogen activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "plasminogen activation" (in gray)

Name	Description	Probability	Func Analog Organism
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	1.000
PLAU	plasminogen activator, urokinase	1.000	Human
PLAT	plasminogen activator, tissue	1.000
PLAUR	plasminogen activator, urokinase receptor	0.990
KNG1	kininogen 1	0.720
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.678
PLG	plasminogen	0.627	Human
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.538
VTN	vitronectin	0.513
C1S	complement component 1, s subcomponent	0.497
ORM1	orosomucoid 1	0.492
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.436
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.435
C1R	complement component 1, r subcomponent	0.401
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.391
FN1	fibronectin 1	0.375
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.346
LPA	lipoprotein, Lp(a)	0.214	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.183
GAST	gastrin	0.181
PCOLCE	procollagen C-endopeptidase enhancer	0.132
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.116
TGFB1	transforming growth factor, beta 1	0.101
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.101
NNMT	nicotinamide N-methyltransferase	0.071
SPHK1	sphingosine kinase 1	0.067
INHBA	inhibin, beta A	0.061
C3	complement component 3	0.060
ENG	endoglin	0.059
SAA4	serum amyloid A4, constitutive	0.057
CYR61	cysteine-rich, angiogenic inducer, 61	0.054
CPN1	carboxypeptidase N, polypeptide 1	0.050
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.045
COL1A1	collagen, type I, alpha 1	0.044
AEBP1	AE binding protein 1	0.043
EMP1	epithelial membrane protein 1	0.037
TNC	tenascin C	0.036
GJB1	gap junction protein, beta 1, 32kDa	0.031
TTR	transthyretin	0.031
C8A	complement component 8, alpha polypeptide	0.031
F2	coagulation factor II (thrombin)	0.028
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.028
LRP1	low density lipoprotein receptor-related protein 1	0.028
TFR2	transferrin receptor 2	0.027
FGB	fibrinogen beta chain	0.025
F10	coagulation factor X	0.024
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.023
MASP2	mannan-binding lectin serine peptidase 2	0.023
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.022
EBP	emopamil binding protein (sterol isomerase)	0.022
LAMC3	laminin, gamma 3	0.021
SRPX	sushi-repeat containing protein, X-linked	0.021
OSMR	oncostatin M receptor	0.021
PIGR	polymeric immunoglobulin receptor	0.020
AMT	aminomethyltransferase	0.020
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.020
AFM	afamin	0.019
ITIH1	inter-alpha (globulin) inhibitor H1	0.019
APOE	apolipoprotein E	0.019
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.018
HSPG2	heparan sulfate proteoglycan 2	0.018
SPP2	secreted phosphoprotein 2, 24kDa	0.018
GAS6	growth arrest-specific 6	0.018
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.017
TIMP3	TIMP metallopeptidase inhibitor 3	0.017
C4BPB	complement component 4 binding protein, beta	0.017
NSDHL	NAD(P) dependent steroid dehydrogenase-like	0.017
IGFBP3	insulin-like growth factor binding protein 3	0.017
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.017
IGF1	insulin-like growth factor 1 (somatomedin C)	0.017
FAP	fibroblast activation protein, alpha	0.017
AMBP	alpha-1-microglobulin/bikunin precursor	0.016
COL6A3	collagen, type VI, alpha 3	0.016
XDH	xanthine dehydrogenase	0.016
ECM1	extracellular matrix protein 1	0.016
APOB	apolipoprotein B (including Ag(x) antigen)	0.016
RDH16	retinol dehydrogenase 16 (all-trans)	0.016
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.016
CP	ceruloplasmin (ferroxidase)	0.016
WFDC2	WAP four-disulfide core domain 2	0.015
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.015
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.015
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.014
IL8	interleukin 8	0.014
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.014
ARG1	arginase, liver	0.014
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.013
APOA1	apolipoprotein A-I	0.013
SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	0.013
A2M	alpha-2-macroglobulin	0.013
C2	complement component 2	0.013
VEGFC	vascular endothelial growth factor C	0.013
CLEC4G	C-type lectin domain family 4, member G	0.013
FGG	fibrinogen gamma chain	0.012
TFF1	trefoil factor 1	0.012
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.012
FOSL1	FOS-like antigen 1	0.012
THY1	Thy-1 cell surface antigen	0.012
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.012
RAB17	RAB17, member RAS oncogene family	0.012
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.012
HRG	histidine-rich glycoprotein	0.012
ITIH3	inter-alpha (globulin) inhibitor H3	0.012
SC4MOL	sterol-C4-methyl oxidase-like	0.012
PDPN	podoplanin	0.012
APOD	apolipoprotein D	0.011
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.011
HPX	hemopexin	0.011
LIPC	lipase, hepatic	0.011
ALDOB	aldolase B, fructose-bisphosphate	0.011
PKLR	pyruvate kinase, liver and RBC	0.011
PRODH2	proline dehydrogenase (oxidase) 2	0.011
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.011
PON3	paraoxonase 3	0.011
TMPRSS2	transmembrane protease, serine 2	0.011	Human
PVR	poliovirus receptor	0.011
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.011
ADH6	alcohol dehydrogenase 6 (class V)	0.011
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.010
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.010