IMP
Process View
Homo sapiens
16 genes annotated in human
alzheimer s disease
DOID:10652
A dementia and a tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "alzheimer s disease"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| PSEN1 | presenilin 1 | 1.000 | ||
| APP | amyloid beta (A4) precursor protein | 0.635 | ||
| APOE | apolipoprotein E | 0.593 | ||
| NOSTRIN | nitric oxide synthase trafficker | 0.520 | ||
| A2M | alpha-2-macroglobulin | 0.474 | ||
| GGA2 | golgi-associated, gamma adaptin ear containing, ARF binding protein 2 | 0.434 | ||
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.404 | ||
| FLNB | filamin B, beta | 0.313 | ||
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.219 | Human | |
| APOC1 | apolipoprotein C-I | 0.217 | ||
| ECSIT | ECSIT homolog (Drosophila) | 0.175 | ||
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.150 | ||
| NCSTN | nicastrin | 0.136 | ||
| HP | haptoglobin | 0.123 | ||
| PLAUR | plasminogen activator, urokinase receptor | 0.106 | ||
| PLTP | phospholipid transfer protein | 0.090 | ||
| PKP4 | plakophilin 4 | 0.059 | ||
| TP53BP1 | tumor protein p53 binding protein 1 | 0.056 | ||
| PSEN2 | presenilin 2 (Alzheimer disease 4) | 0.054 | ||
| SORT1 | sortilin 1 | 0.049 | Human | |
| APH1A | anterior pharynx defective 1 homolog A (C. elegans) | 0.048 | ||
| APBA1 | amyloid beta (A4) precursor protein-binding, family A, member 1 | 0.047 | ||
| GAA | glucosidase, alpha; acid | 0.043 | ||
| BACE1 | beta-site APP-cleaving enzyme 1 | 0.027 | ||
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.027 | ||
| SRI | sorcin | 0.026 | ||
| MAPK8IP1 | mitogen-activated protein kinase 8 interacting protein 1 | 0.025 | ||
| CDC37 | cell division cycle 37 homolog (S. cerevisiae) | 0.023 | ||
| SYNRG | synergin, gamma | 0.023 | ||
| SEPT8 | septin 8 | 0.023 | ||
| LCAT | lecithin-cholesterol acyltransferase | 0.021 | ||
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.021 | ||
| UBQLN1 | ubiquilin 1 | 0.021 | ||
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.020 | ||
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.017 | ||
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.017 | ||
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.017 | ||
| EPS15 | epidermal growth factor receptor pathway substrate 15 | 0.015 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.015 | Human | |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.014 | ||
| PRAM1 | PML-RARA regulated adaptor molecule 1 | 0.014 | ||
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.014 | ||
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.013 | Human | |
| MAST1 | microtubule associated serine/threonine kinase 1 | 0.013 | ||
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 0.013 | ||
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.013 | ||
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.012 | ||
| RNF32 | ring finger protein 32 | 0.012 | ||
| C16orf53 | chromosome 16 open reading frame 53 | 0.012 | ||
| CALR | calreticulin | 0.011 | ||
| IGF2R | insulin-like growth factor 2 receptor | 0.011 | ||
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.011 | ||
| ELAVL3 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) | 0.011 | ||
| GCDH | glutaryl-CoA dehydrogenase | 0.011 | ||
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.010 | ||
| NOS3 | nitric oxide synthase 3 (endothelial cell) | 0.010 | ||
| BLMH | bleomycin hydrolase | 0.004 | ||
| PLD3 | phospholipase D family, member 3 | 0.002 | ||
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.002 | ||
| ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.002 | ||
| MPO | myeloperoxidase | 0.002 | ||
| HFE | hemochromatosis | 0.001 | ||
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | 0.000 | ||
| PLAU | plasminogen activator, urokinase | 0.000 | ||
| ADAM10 | ADAM metallopeptidase domain 10 | 0.000 |