IMP

Process View

Homo sapiens

3 genes annotated in human

Multi-species View

negative regulation of interleukin 5 production

GO:0032714

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of interleukin 5 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of interleukin 5 production" (in gray)

Name	Description	Probability	Func Analog Organism
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.999
GLIS2	GLIS family zinc finger 2	0.906
JUP	junction plakoglobin	0.590
TCF4	transcription factor 4	0.572
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.548
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.537
HIC1	hypermethylated in cancer 1	0.500
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.466
PSEN1	presenilin 1	0.430
IFNA10	interferon, alpha 10	0.419	Human
APP	amyloid beta (A4) precursor protein	0.373
BTRC	beta-transducin repeat containing	0.349
CTNNBIP1	catenin, beta interacting protein 1	0.347
IFNA14	interferon, alpha 14	0.319
IFNA4	interferon, alpha 4	0.308
TNIK	TRAF2 and NCK interacting kinase	0.302
HDAC9	histone deacetylase 9	0.238
HDAC7	histone deacetylase 7	0.234
IFNA21	interferon, alpha 21	0.233	Human
SNAP23	synaptosomal-associated protein, 23kDa	0.210
IFNA16	interferon, alpha 16	0.129	Human
EMD	emerin	0.112
AR	androgen receptor	0.106
IFNA17	interferon, alpha 17	0.095
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.073
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.071	Human
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.069
CYLC1	cylicin, basic protein of sperm head cytoskeleton 1	0.062
IFNA13	interferon, alpha 13	0.050
C6orf10	chromosome 6 open reading frame 10	0.050
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.049
STAT5A	signal transducer and activator of transcription 5A	0.041
CDH5	cadherin 5, type 2 (vascular endothelium)	0.040
STX11	syntaxin 11	0.040
PTK7	PTK7 protein tyrosine kinase 7	0.039
ZFYVE9	zinc finger, FYVE domain containing 9	0.033
IKZF4	IKAROS family zinc finger 4 (Eos)	0.032
TAS2R16	taste receptor, type 2, member 16	0.028
FERMT2	fermitin family member 2	0.028
IFNA5	interferon, alpha 5	0.028	Human
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.027
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.027
CREBBP	CREB binding protein	0.025
NCSTN	nicastrin	0.025
HTN1	histatin 1	0.025
AXIN1	axin 1	0.024
STATH	statherin	0.024
RUNX3	runt-related transcription factor 3	0.024
DPYSL2	dihydropyrimidinase-like 2	0.024
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.024
TRIM48	tripartite motif containing 48	0.023
IFNA7	interferon, alpha 7	0.023	Human
IL21	interleukin 21	0.023
CDX4	caudal type homeobox 4	0.023
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.022
SEMG2	semenogelin II	0.022
TAAR2	trace amine associated receptor 2	0.022
KAT5	K(lysine) acetyltransferase 5	0.021
FBLN1	fibulin 1	0.021
HTN3	histatin 3	0.021
IFNA8	interferon, alpha 8	0.020	Human
CSN3	casein kappa	0.020
ZC3H7B	zinc finger CCCH-type containing 7B	0.020
TAS2R7	taste receptor, type 2, member 7	0.020
CLDN17	claudin 17	0.019
TRPC7	transient receptor potential cation channel, subfamily C, member 7	0.019
SETD8	SET domain containing (lysine methyltransferase) 8	0.019
AFM	afamin	0.019
PSMD5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.018
IFNA2	interferon, alpha 2	0.018
AMELY	amelogenin, Y-linked	0.018
HFE	hemochromatosis	0.018
FGL1	fibrinogen-like 1	0.018
OR7A10	olfactory receptor, family 7, subfamily A, member 10	0.018
RUNX1	runt-related transcription factor 1	0.018
CSN1S1	casein alpha s1	0.018
OR2B2	olfactory receptor, family 2, subfamily B, member 2	0.017
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.017
CRISP1	cysteine-rich secretory protein 1	0.017
GCNT4	glucosaminyl (N-acetyl) transferase 4, core 2	0.016
SPO11	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)	0.016
SLCO1B1	solute carrier organic anion transporter family, member 1B1	0.016
CRYAB	crystallin, alpha B	0.016
GNGT1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	0.016
COLEC10	collectin sub-family member 10 (C-type lectin)	0.016
ICOS	inducible T-cell co-stimulator	0.016
OR52A1	olfactory receptor, family 52, subfamily A, member 1	0.016
FABP2	fatty acid binding protein 2, intestinal	0.015
CRYGB	crystallin, gamma B	0.015
ZNF81	zinc finger protein 81	0.015
CYLC2	cylicin, basic protein of sperm head cytoskeleton 2	0.015
PRKD2	protein kinase D2	0.015
PLAC1	placenta-specific 1	0.015
SLCO1B3	solute carrier organic anion transporter family, member 1B3	0.015
ANP32C	acidic (leucine-rich) nuclear phosphoprotein 32 family, member C	0.015
TAS2R8	taste receptor, type 2, member 8	0.014
HESX1	HESX homeobox 1	0.014
CD6	CD6 molecule	0.014
GYPA	glycophorin A (MNS blood group)	0.014
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.014
JRK	jerky homolog (mouse)	0.014
NLK	nemo-like kinase	0.014
ASCL3	achaete-scute complex homolog 3 (Drosophila)	0.014
ODAM	odontogenic, ameloblast asssociated	0.014
C9orf131	chromosome 9 open reading frame 131	0.014
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.014
HIST1H3J	histone cluster 1, H3j	0.014
IFNA6	interferon, alpha 6	0.014	Human
IL5	interleukin 5 (colony-stimulating factor, eosinophil)	0.014
HIST1H1B	histone cluster 1, H1b	0.014
ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	0.013
MTMR8	myotubularin related protein 8	0.013
SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	0.013
C10orf67	chromosome 10 open reading frame 67	0.013
HIST1H1A	histone cluster 1, H1a	0.013
LIPF	lipase, gastric	0.013
NTS	neurotensin	0.013
TMEM212	transmembrane protein 212	0.013
ADAM2	ADAM metallopeptidase domain 2	0.013
TSGA13	testis specific, 13	0.013
GNRHR	gonadotropin-releasing hormone receptor	0.013
C11orf40	chromosome 11 open reading frame 40	0.012
DSPP	dentin sialophosphoprotein	0.012
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.012
GPR22	G protein-coupled receptor 22	0.012
B3GALT1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.012
CTAGE1	cutaneous T-cell lymphoma-associated antigen 1	0.012
CD4	CD4 molecule	0.012
KRTAP1-1	keratin associated protein 1-1	0.012
LECT2	leukocyte cell-derived chemotaxin 2	0.012
MITF	microphthalmia-associated transcription factor	0.012
CSN2	casein beta	0.012
CTNNA3	catenin (cadherin-associated protein), alpha 3	0.012
HNF4G	hepatocyte nuclear factor 4, gamma	0.012
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.012
TNFSF18	tumor necrosis factor (ligand) superfamily, member 18	0.012
ZNF157	zinc finger protein 157	0.012
MORC1	MORC family CW-type zinc finger 1	0.012
NMBR	neuromedin B receptor	0.012
TMPRSS11B	transmembrane protease, serine 11B	0.012
LALBA	lactalbumin, alpha-	0.012
SPATA16	spermatogenesis associated 16	0.012
LGALS13	lectin, galactoside-binding, soluble, 13	0.012
PMP2	peripheral myelin protein 2	0.012
ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif, 6	0.012
ZNF221	zinc finger protein 221	0.011
HDAC1	histone deacetylase 1	0.011
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.011
CCDC36	coiled-coil domain containing 36	0.011
WWTR1	WW domain containing transcription regulator 1	0.011
KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	0.011
CLDN16	claudin 16	0.011
GPRC6A	G protein-coupled receptor, family C, group 6, member A	0.011
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.011
SI	sucrase-isomaltase (alpha-glucosidase)	0.011
SCN11A	sodium channel, voltage-gated, type XI, alpha subunit	0.011
GYPB	glycophorin B (MNS blood group)	0.011
PDE6C	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	0.011
PDE6H	phosphodiesterase 6H, cGMP-specific, cone, gamma	0.011
IMPG1	interphotoreceptor matrix proteoglycan 1	0.011
IAPP	islet amyloid polypeptide	0.011
RRH	retinal pigment epithelium-derived rhodopsin homolog	0.011
C12orf50	chromosome 12 open reading frame 50	0.011
PLSCR2	phospholipid scramblase 2	0.011
CFHR5	complement factor H-related 5	0.011
KERA	keratocan	0.011
FOXP3	forkhead box P3	0.011	Mouse
GLRA3	glycine receptor, alpha 3	0.011
LOC55908	hepatocellular carcinoma-associated gene TD26	0.011
FLG	filaggrin	0.011
C9	complement component 9	0.011
TLL1	tolloid-like 1	0.011
SNTG1	syntrophin, gamma 1	0.011
ZFHX4	zinc finger homeobox 4	0.011
LAX1	lymphocyte transmembrane adaptor 1	0.011
IFNG	interferon, gamma	0.010
PDC	phosducin	0.010
OPHN1	oligophrenin 1	0.010
ZBBX	zinc finger, B-box domain containing	0.010
IFNA1	interferon, alpha 1	0.010	Human
SLC13A1	solute carrier family 13 (sodium/sulfate symporters), member 1	0.010
IFLTD1	intermediate filament tail domain containing 1	0.010
ADAM29	ADAM metallopeptidase domain 29	0.010
PRG4	proteoglycan 4	0.010
CXorf1	chromosome X open reading frame 1	0.010
CCR9	chemokine (C-C motif) receptor 9	0.010
SLC25A21	solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21	0.010
EDDM3B	epididymal protein 3B	0.010
GPR1	G protein-coupled receptor 1	0.010
RNF133	ring finger protein 133	0.010
HYAL4	hyaluronoglucosaminidase 4	0.010
TEX12	testis expressed 12	0.010
TSHB	thyroid stimulating hormone, beta	0.010
TBL1X	transducin (beta)-like 1X-linked	0.010
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.010
KRTAP2-4	keratin associated protein 2-4	0.010
KIF24	kinesin family member 24	0.010