IMP

Process View

Homo sapiens

1 genes annotated in human

Multi-species View

negative regulation of axon guidance

GO:1902668

Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of axon guidance"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of axon guidance" (in gray)

Name	Description	Probability	Func Analog Organism
VEGFA	vascular endothelial growth factor A	1.000
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.973
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.891
FZD1	frizzled homolog 1 (Drosophila)	0.565
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.479
COL3A1	collagen, type III, alpha 1	0.450
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.358
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.312
TGFB3	transforming growth factor, beta 3	0.253
LRP6	low density lipoprotein receptor-related protein 6	0.166
FAP	fibroblast activation protein, alpha	0.106
PGF	placental growth factor	0.104
SLIT2	slit homolog 2 (Drosophila)	0.071
SFRP4	secreted frizzled-related protein 4	0.062
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.061
CDH5	cadherin 5, type 2 (vascular endothelium)	0.058
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.054
TGFB1	transforming growth factor, beta 1	0.052
DMPK	dystrophia myotonica-protein kinase	0.050
ATN1	atrophin 1	0.049
COL5A1	collagen, type V, alpha 1	0.044
RBMS3	RNA binding motif, single stranded interacting protein 3	0.040
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.036
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.030
CRIP2	cysteine-rich protein 2	0.029
COL14A1	collagen, type XIV, alpha 1	0.028
NRP2	neuropilin 2	0.028
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.027
RGS5	regulator of G-protein signaling 5	0.026
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.026
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.025
BNC2	basonuclin 2	0.025
TGFBR1	transforming growth factor, beta receptor 1	0.025
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.024
LENG8	leukocyte receptor cluster (LRC) member 8	0.024
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.023
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.023
POSTN	periostin, osteoblast specific factor	0.023
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.022
FZD8	frizzled homolog 8 (Drosophila)	0.021
SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.021	Rat
TGFB2	transforming growth factor, beta 2	0.020
LUM	lumican	0.020
GLI3	GLI family zinc finger 3	0.019
COL4A5	collagen, type IV, alpha 5	0.019
KCNRG	potassium channel regulator	0.019
PDGFC	platelet derived growth factor C	0.019
LSM11	LSM11, U7 small nuclear RNA associated	0.018
LAMA4	laminin, alpha 4	0.018
STC1	stanniocalcin 1	0.018
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.018
JAG2	jagged 2	0.018
FLRT2	fibronectin leucine rich transmembrane protein 2	0.017
BMP4	bone morphogenetic protein 4	0.016
TGFBR3	transforming growth factor, beta receptor III	0.016
RAI1	retinoic acid induced 1	0.016
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.015
PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	0.015
MAST2	microtubule associated serine/threonine kinase 2	0.015
FBXL7	F-box and leucine-rich repeat protein 7	0.015
PTN	pleiotrophin	0.014
AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	0.014
FZD2	frizzled homolog 2 (Drosophila)	0.014
ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	0.014
ELN	elastin	0.014
STC2	stanniocalcin 2	0.014
MFAP4	microfibrillar-associated protein 4	0.014
SNAI2	snail homolog 2 (Drosophila)	0.014
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.013
GLT8D2	glycosyltransferase 8 domain containing 2	0.013
BICC1	bicaudal C homolog 1 (Drosophila)	0.013
PCDH17	protocadherin 17	0.013
FBLN1	fibulin 1	0.013
FGD1	FYVE, RhoGEF and PH domain containing 1	0.013
COL1A2	collagen, type I, alpha 2	0.013
PTPRD	protein tyrosine phosphatase, receptor type, D	0.013
PTPRG	protein tyrosine phosphatase, receptor type, G	0.012
MPP1	membrane protein, palmitoylated 1, 55kDa	0.012
OLFM2	olfactomedin 2	0.012
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.012
SLC16A2	solute carrier family 16, member 2 (monocarboxylic acid transporter 8)	0.012
GPC1	glypican 1	0.012
KLHL5	kelch-like 5 (Drosophila)	0.012
LAMB1	laminin, beta 1	0.012
SEMA5B	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.012
LTBP4	latent transforming growth factor beta binding protein 4	0.011
JAG1	jagged 1	0.011
NAV3	neuron navigator 3	0.011
FBLN5	fibulin 5	0.011
EDNRA	endothelin receptor type A	0.011
SVEP1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.011
NOV	nephroblastoma overexpressed gene	0.011
LDB2	LIM domain binding 2	0.011
PARVA	parvin, alpha	0.011
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	0.011
BDKRB2	bradykinin receptor B2	0.011
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.011
EFNB2	ephrin-B2	0.010
SOCS5	suppressor of cytokine signaling 5	0.010
OSTF1	osteoclast stimulating factor 1	0.010
WDR73	WD repeat domain 73	0.010
VEGFC	vascular endothelial growth factor C	0.010
NMT2	N-myristoyltransferase 2	0.010