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Process View

Homo sapiens

28 genes annotated in human

xenobiotic metabolic process

The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "xenobiotic metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "xenobiotic metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
RARA	retinoic acid receptor, alpha	0.998
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.996
GSTM1	glutathione S-transferase mu 1	0.992
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	0.971
GSTM2	glutathione S-transferase mu 2 (muscle)	0.960
S100A8	S100 calcium binding protein A8	0.957	Human
S100A6	S100 calcium binding protein A6	0.932	Human
RXRA	retinoid X receptor, alpha	0.923	Human
SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	0.902
SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	0.869
SULT1A4	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4	0.863	Human Zebrafish Rat Fly
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.841
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.833
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.781
S100A9	S100 calcium binding protein A9	0.752	Human
MED25	mediator complex subunit 25	0.742
ANXA2	annexin A2	0.704
S100A4	S100 calcium binding protein A4	0.684	Human
GSTM4	glutathione S-transferase mu 4	0.617
NCOA1	nuclear receptor coactivator 1	0.599
NCOR2	nuclear receptor corepressor 2	0.562
S100A11	S100 calcium binding protein A11	0.504	Human
S100B	S100 calcium binding protein B	0.502	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.382
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.346	Fly
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.268
S100A1	S100 calcium binding protein A1	0.221	Human
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.205	Human
ALS2CR12	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12	0.165
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.161	Fly
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	0.119
AREG	amphiregulin	0.113
NCOR1	nuclear receptor corepressor 1	0.103
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.095
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.093	Fly
LGALS1	lectin, galactoside-binding, soluble, 1	0.087
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.087
S100A2	S100 calcium binding protein A2	0.085	Human
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.085	Human Zebrafish Fly
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.083
ADH6	alcohol dehydrogenase 6 (class V)	0.082
HR	hairless homolog (mouse)	0.073
FKBP4	FK506 binding protein 4, 59kDa	0.070
AGER	advanced glycosylation end product-specific receptor	0.063
TMSB10	thymosin beta 10	0.061
HRG	histidine-rich glycoprotein	0.058
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.056
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.056
CAPG	capping protein (actin filament), gelsolin-like	0.055
C6	complement component 6	0.054
HNF4A	hepatocyte nuclear factor 4, alpha	0.053
S100P	S100 calcium binding protein P	0.053	Human
GSTM3	glutathione S-transferase mu 3 (brain)	0.052
KNG1	kininogen 1	0.052
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.050
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.048
FMO4	flavin containing monooxygenase 4	0.048	Human
SPOP	speckle-type POZ protein	0.048
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.048	Human
PCDHA4	protocadherin alpha 4	0.046
GSTM5	glutathione S-transferase mu 5	0.046	Human
C8B	complement component 8, beta polypeptide	0.045
TIMP1	TIMP metallopeptidase inhibitor 1	0.045
S100A10	S100 calcium binding protein A10	0.044	Human
LGALS3	lectin, galactoside-binding, soluble, 3	0.043
UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	0.043
F9	coagulation factor IX	0.043
IGSF21	immunoglobin superfamily, member 21	0.042
SKIL	SKI-like oncogene	0.041
NPC2	Niemann-Pick disease, type C2	0.041
NCOA3	nuclear receptor coactivator 3	0.040
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.039	Human
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.038
PGR	progesterone receptor	0.038
C8A	complement component 8, alpha polypeptide	0.038
MASP2	mannan-binding lectin serine peptidase 2	0.037
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.035
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.034
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.032	Human
FAM46A	family with sequence similarity 46, member A	0.031
AADAC	arylacetamide deacetylase (esterase)	0.031
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.031	Human
CD63	CD63 molecule	0.030
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.030
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.030
CLIC1	chloride intracellular channel 1	0.029
APCS	amyloid P component, serum	0.028
CSTA	cystatin A (stefin A)	0.027
CTSB	cathepsin B	0.027
CSTB	cystatin B (stefin B)	0.027
HIPK2	homeodomain interacting protein kinase 2	0.026
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.026
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.026
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.026
UGT1A10	UDP glucuronosyltransferase 1 family, polypeptide A10	0.026
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.026
S100A12	S100 calcium binding protein A12	0.025
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.025
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.025	Human Fly
BHMT	betaine--homocysteine S-methyltransferase	0.025
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.025	Human
PIK3C2G	phosphoinositide-3-kinase, class 2, gamma polypeptide	0.024
DAO	D-amino-acid oxidase	0.024
PRDX1	peroxiredoxin 1	0.024
F11	coagulation factor XI	0.023
CCL16	chemokine (C-C motif) ligand 16	0.022
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.022
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.022
ITIH2	inter-alpha (globulin) inhibitor H2	0.022
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.021	Human
C4BPB	complement component 4 binding protein, beta	0.021
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.021	Human Fly
XDH	xanthine dehydrogenase	0.021
PON1	paraoxonase 1	0.020
ESR1	estrogen receptor 1	0.020
EMP3	epithelial membrane protein 3	0.020
MTTP	microsomal triglyceride transfer protein	0.020
S100A13	S100 calcium binding protein A13	0.020
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.020
TTPA	tocopherol (alpha) transfer protein	0.020
UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28	0.019
PPARA	peroxisome proliferator-activated receptor alpha	0.019	Human
GLYAT	glycine-N-acyltransferase	0.019
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.018
UGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17	0.018	Human
OTC	ornithine carbamoyltransferase	0.018
CFHR4	complement factor H-related 4	0.018
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.018	Human
PROX1	prospero homeobox 1	0.018
CRP	C-reactive protein, pentraxin-related	0.017
TM4SF4	transmembrane 4 L six family member 4	0.017
LECT2	leukocyte cell-derived chemotaxin 2	0.017
AFM	afamin	0.017
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.017
PRKG2	protein kinase, cGMP-dependent, type II	0.017
CA5A	carbonic anhydrase VA, mitochondrial	0.016
TSPO	translocator protein (18kDa)	0.016
GC	group-specific component (vitamin D binding protein)	0.016
PON3	paraoxonase 3	0.015	Rat
A1CF	APOBEC1 complementation factor	0.015
LGALS4	lectin, galactoside-binding, soluble, 4	0.015
FMO1	flavin containing monooxygenase 1	0.015	Human
SLPI	secretory leukocyte peptidase inhibitor	0.015
ZG16	zymogen granule protein 16 homolog (rat)	0.015
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.014
TIMP2	TIMP metallopeptidase inhibitor 2	0.014
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.014
SGK2	serum/glucocorticoid regulated kinase 2	0.014
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.014	Fly
FMO3	flavin containing monooxygenase 3	0.014	Human
UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	0.014
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.014
NADSYN1	NAD synthetase 1	0.014
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.014
F13B	coagulation factor XIII, B polypeptide	0.014
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.013
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.013
AGXT2	alanine--glyoxylate aminotransferase 2	0.013
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.013
FXYD3	FXYD domain containing ion transport regulator 3	0.013
TAT	tyrosine aminotransferase	0.013
ENOX1	ecto-NOX disulfide-thiol exchanger 1	0.013
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.013
IL1RN	interleukin 1 receptor antagonist	0.013
ALDOB	aldolase B, fructose-bisphosphate	0.012
G6PC	glucose-6-phosphatase, catalytic subunit	0.012
ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	0.012
PGRMC1	progesterone receptor membrane component 1	0.012
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.012
RARG	retinoic acid receptor, gamma	0.012
REG1A	regenerating islet-derived 1 alpha	0.012
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.012
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.011
GSTA3	glutathione S-transferase alpha 3	0.011	Human Rat
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.011
FMO2	flavin containing monooxygenase 2 (non-functional)	0.011
ATOX1	ATX1 antioxidant protein 1 homolog (yeast)	0.011
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	0.011
C4BPA	complement component 4 binding protein, alpha	0.011
APOBEC1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.011
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.011
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.011
TMPRSS2	transmembrane protease, serine 2	0.011
TM4SF5	transmembrane 4 L six family member 5	0.011
ACVR1B	activin A receptor, type IB	0.011
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.011
HAL	histidine ammonia-lyase	0.011
LRRC31	leucine rich repeat containing 31	0.011
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.011
BCMO1	beta-carotene 15,15'-monooxygenase 1	0.010
HGFAC	HGF activator	0.010
PI3	peptidase inhibitor 3, skin-derived	0.010
NOP10	NOP10 ribonucleoprotein homolog (yeast)	0.010
PML	promyelocytic leukemia	0.010
UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	0.010
SLC17A3	solute carrier family 17 (sodium phosphate), member 3	0.010
AICDA	activation-induced cytidine deaminase	0.010
ACSM5	acyl-CoA synthetase medium-chain family member 5	0.010
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.010