IMP

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Homo sapiens

3 genes annotated in human

adenylate cyclase activating dopamine receptor signaling pathway

The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "adenylate cyclase activating dopamine receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "adenylate cyclase activating dopamine receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.996
MPDZ	multiple PDZ domain protein	0.994
TBC1D10A	TBC1 domain family, member 10A	0.991
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.943
EZR	ezrin	0.922
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.871
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.833
PTEN	phosphatase and tensin homolog	0.814
ADRB2	adrenergic, beta-2-, receptor, surface	0.754	Human
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.558	Mouse
ADORA2A	adenosine A2a receptor	0.547
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.471
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.320
ARRB1	arrestin, beta 1	0.153
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.109
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.096
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.093
ARRDC3	arrestin domain containing 3	0.089
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.062
MSN	moesin	0.054
NF2	neurofibromin 2 (merlin)	0.053
NUCB1	nucleobindin 1	0.051
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.047
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.046	Human
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.045	Human
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.039
GOPC	golgi-associated PDZ and coiled-coil motif containing	0.037
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.035
GHRHR	growth hormone releasing hormone receptor	0.033
SSTR3	somatostatin receptor 3	0.032
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.031
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D	0.030	Human
EMX1	empty spiracles homeobox 1	0.030
OPRD1	opioid receptor, delta 1	0.030
OR2H1	olfactory receptor, family 2, subfamily H, member 1	0.028
OPRK1	opioid receptor, kappa 1	0.027
TSHR	thyroid stimulating hormone receptor	0.027
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.026
CCKBR	cholecystokinin B receptor	0.026
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.026
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.025
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.025
SLC22A14	solute carrier family 22, member 14	0.024
FOXD3	forkhead box D3	0.024
KCNF1	potassium voltage-gated channel, subfamily F, member 1	0.023
GPR6	G protein-coupled receptor 6	0.023
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.022	Human
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.022
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	0.021
CALCR	calcitonin receptor	0.021
ACRV1	acrosomal vesicle protein 1	0.021
FEZF2	FEZ family zinc finger 2	0.021
EFNA2	ephrin-A2	0.021
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.020
LBX1	ladybird homeobox 1	0.020
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.019
P2RY2	purinergic receptor P2Y, G-protein coupled, 2	0.019
SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	0.019
RIMS4	regulating synaptic membrane exocytosis 4	0.019
ADRA1D	adrenergic, alpha-1D-, receptor	0.019	Fly
TEF	thyrotrophic embryonic factor	0.019
HTR3A	5-hydroxytryptamine (serotonin) receptor 3A	0.018
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.018
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.018	Fly
FGF8	fibroblast growth factor 8 (androgen-induced)	0.018
CRHR2	corticotropin releasing hormone receptor 2	0.018
SCRT1	scratch homolog 1, zinc finger protein (Drosophila)	0.018
CRHR1	corticotropin releasing hormone receptor 1	0.018
ADORA1	adenosine A1 receptor	0.017
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.017
ADRB3	adrenergic, beta-3-, receptor	0.017	Human
YAP1	Yes-associated protein 1	0.017
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.017
NTSR1	neurotensin receptor 1 (high affinity)	0.017
TBX5	T-box 5	0.017
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	0.017
MUSK	muscle, skeletal, receptor tyrosine kinase	0.016
KCNH1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.016
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.016
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.016
CLCN1	chloride channel 1, skeletal muscle	0.016
PYY	peptide YY	0.016
GRM5	glutamate receptor, metabotropic 5	0.015
DSCAML1	Down syndrome cell adhesion molecule like 1	0.015
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.015
ESRRB	estrogen-related receptor beta	0.015
PADI4	peptidyl arginine deiminase, type IV	0.015
SLC14A2	solute carrier family 14 (urea transporter), member 2	0.015
P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	0.015
DRD1	dopamine receptor D1	0.015
CRP	C-reactive protein, pentraxin-related	0.015
SMR3A	submaxillary gland androgen regulated protein 3A	0.015
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.015
COPG2	coatomer protein complex, subunit gamma 2	0.015
CDK5R2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.015
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.015
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.014
FGF18	fibroblast growth factor 18	0.014
MAPK10	mitogen-activated protein kinase 10	0.014
C19orf26	chromosome 19 open reading frame 26	0.014
HCRTR1	hypocretin (orexin) receptor 1	0.014
ADRA2B	adrenergic, alpha-2B-, receptor	0.014
CHRNB4	cholinergic receptor, nicotinic, beta 4	0.014
AANAT	aralkylamine N-acetyltransferase	0.014
NELL1	NEL-like 1 (chicken)	0.014
THPO	thrombopoietin	0.014
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.013
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.013
WNT1	wingless-type MMTV integration site family, member 1	0.013
AQP7	aquaporin 7	0.013
SLC18A1	solute carrier family 18 (vesicular monoamine), member 1	0.013
SCTR	secretin receptor	0.013
PRDM8	PR domain containing 8	0.013
TNP2	transition protein 2 (during histone to protamine replacement)	0.013
NPPC	natriuretic peptide C	0.013
NOS1	nitric oxide synthase 1 (neuronal)	0.013
SSTR4	somatostatin receptor 4	0.013
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.013
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.013	Human
FOXN1	forkhead box N1	0.013
KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	0.013
SPTB	spectrin, beta, erythrocytic	0.013
CDH8	cadherin 8, type 2	0.013
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.013
CCR3	chemokine (C-C motif) receptor 3	0.013
TREH	trehalase (brush-border membrane glycoprotein)	0.013
TACR3	tachykinin receptor 3	0.012
GLRA1	glycine receptor, alpha 1	0.012
TRPM3	transient receptor potential cation channel, subfamily M, member 3	0.012
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.012
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.012
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.012
CNNM1	cyclin M1	0.012
ACHE	acetylcholinesterase	0.012
MYF6	myogenic factor 6 (herculin)	0.012
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.012
ZP2	zona pellucida glycoprotein 2 (sperm receptor)	0.012
NEUROG3	neurogenin 3	0.012
SSTR1	somatostatin receptor 1	0.012
FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.012
NPAS1	neuronal PAS domain protein 1	0.012
GRIK4	glutamate receptor, ionotropic, kainate 4	0.012
AFF2	AF4/FMR2 family, member 2	0.012
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.012	Human
NECAB2	N-terminal EF-hand calcium binding protein 2	0.012
GH2	growth hormone 2	0.012
EPB41L1	erythrocyte membrane protein band 4.1-like 1	0.012
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.012
SRCIN1	SRC kinase signaling inhibitor 1	0.012
BAI1	brain-specific angiogenesis inhibitor 1	0.012
ADRA1A	adrenergic, alpha-1A-, receptor	0.012	Fly
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.012
PLEKHA2	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2	0.012
VIPR2	vasoactive intestinal peptide receptor 2	0.012
TRH	thyrotropin-releasing hormone	0.012
PRODH2	proline dehydrogenase (oxidase) 2	0.012
NKX2-1	NK2 homeobox 1	0.011
ZNF771	zinc finger protein 771	0.011
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.011
CHRND	cholinergic receptor, nicotinic, delta	0.011
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.011
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.011
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	0.011
NCS1	neuronal calcium sensor 1	0.011
IL1RAPL1	interleukin 1 receptor accessory protein-like 1	0.011
PSG7	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)	0.011
TBX1	T-box 1	0.011
PAX6	paired box 6	0.011
GP5	glycoprotein V (platelet)	0.011
ADRA1B	adrenergic, alpha-1B-, receptor	0.011	Fly
TUBA8	tubulin, alpha 8	0.011
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.011
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.011
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.011
KLHL35	kelch-like 35 (Drosophila)	0.011
CHRD	chordin	0.011
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.011
KCNT1	potassium channel, subfamily T, member 1	0.011
FAM163A	family with sequence similarity 163, member A	0.011
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.011
HRH3	histamine receptor H3	0.011
GUCA2B	guanylate cyclase activator 2B (uroguanylin)	0.011
WNT7A	wingless-type MMTV integration site family, member 7A	0.011
OSBP2	oxysterol binding protein 2	0.011
AVPR1B	arginine vasopressin receptor 1B	0.011
NXPH3	neurexophilin 3	0.011
HES2	hairy and enhancer of split 2 (Drosophila)	0.011
NGF	nerve growth factor (beta polypeptide)	0.011
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.011
CAMK1G	calcium/calmodulin-dependent protein kinase IG	0.011
HNF1B	HNF1 homeobox B	0.011
LHX5	LIM homeobox 5	0.011
PAX8	paired box 8	0.011
CCK	cholecystokinin	0.011
CHRNE	cholinergic receptor, nicotinic, epsilon	0.011
NRCAM	neuronal cell adhesion molecule	0.011
EVX1	even-skipped homeobox 1	0.011
RHO	rhodopsin	0.011
TBR1	T-box, brain, 1	0.011
KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	0.011
GSX2	GS homeobox 2	0.011
LPAR4	lysophosphatidic acid receptor 4	0.011
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.011
DOC2B	double C2-like domains, beta	0.011
POU4F3	POU class 4 homeobox 3	0.011
GBX2	gastrulation brain homeobox 2	0.011
ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.011
CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	0.011
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.011
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.011
FRMPD4	FERM and PDZ domain containing 4	0.011
CPLX2	complexin 2	0.011
P2RX3	purinergic receptor P2X, ligand-gated ion channel, 3	0.011
GRIK1	glutamate receptor, ionotropic, kainate 1	0.010
OPRL1	opiate receptor-like 1	0.010
APOC3	apolipoprotein C-III	0.010
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.010
HTR6	5-hydroxytryptamine (serotonin) receptor 6	0.010
ATP10A	ATPase, class V, type 10A	0.010
ONECUT1	one cut homeobox 1	0.010
PLA2G1B	phospholipase A2, group IB (pancreas)	0.010
RYR2	ryanodine receptor 2 (cardiac)	0.010
ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	0.010
GIF	gastric intrinsic factor (vitamin B synthesis)	0.010
SSTR5	somatostatin receptor 5	0.010
TFF2	trefoil factor 2	0.010
PTH	parathyroid hormone	0.010
DCC	deleted in colorectal carcinoma	0.010
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.010
BFSP1	beaded filament structural protein 1, filensin	0.010
GPC5	glypican 5	0.010
GH1	growth hormone 1	0.010
HOXD12	homeobox D12	0.010