IMP

Process View

Homo sapiens

3 genes annotated in human

presynaptic membrane organization

The maintenance of membrane composition in a presynaptic membrane, a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "presynaptic membrane organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "presynaptic membrane organization" (in gray)

Name	Description	Probability	Func Analog Organism
HP	haptoglobin	0.884
A2M	alpha-2-macroglobulin	0.821
ALB	albumin	0.672
APOC1	apolipoprotein C-I	0.629
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.620
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.363
MYO16	myosin XVI	0.362
LCAT	lecithin-cholesterol acyltransferase	0.298
DLG4	discs, large homolog 4 (Drosophila)	0.218
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.200
FGA	fibrinogen alpha chain	0.194
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.178
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.155
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.121
ADRB2	adrenergic, beta-2-, receptor, surface	0.113
APOC3	apolipoprotein C-III	0.094
APOA2	apolipoprotein A-II	0.068
PLTP	phospholipid transfer protein	0.065
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.063
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.056
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.054
BAI1	brain-specific angiogenesis inhibitor 1	0.052
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.049
APOC2	apolipoprotein C-II	0.038
ECSIT	ECSIT homolog (Drosophila)	0.035
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	0.034
MAPT	microtubule-associated protein tau	0.032
TTR	transthyretin	0.030
ANAPC7	anaphase promoting complex subunit 7	0.028
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.028
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.026
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.026
PLP1	proteolipid protein 1	0.026
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.025
TBC1D10A	TBC1 domain family, member 10A	0.023
CAV1	caveolin 1, caveolae protein, 22kDa	0.022
NRXN1	neurexin 1	0.022	Mouse Fly
PDZD2	PDZ domain containing 2	0.022
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.021
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.020
APOA1	apolipoprotein A-I	0.020	Human
NCOA3	nuclear receptor coactivator 3	0.020
ANAPC4	anaphase promoting complex subunit 4	0.020
GRIA3	glutamate receptor, ionotrophic, AMPA 3	0.020
MARK1	MAP/microtubule affinity-regulating kinase 1	0.020
RNF2	ring finger protein 2	0.019
NLGN1	neuroligin 1	0.019	Human Mouse Rat
FAM83C	family with sequence similarity 83, member C	0.018
TMCC2	transmembrane and coiled-coil domain family 2	0.018
ANAPC5	anaphase promoting complex subunit 5	0.018
DCTN1	dynactin 1	0.018
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.017
LOXL4	lysyl oxidase-like 4	0.017
SYT13	synaptotagmin XIII	0.016
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.016
SPOP	speckle-type POZ protein	0.016
FRK	fyn-related kinase	0.016
CLEC4G	C-type lectin domain family 4, member G	0.016
DCX	doublecortin	0.016
PPFIA2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	0.015
OLIG2	oligodendrocyte lineage transcription factor 2	0.015
GAP43	growth associated protein 43	0.015
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.015
NRXN3	neurexin 3	0.015	Fly
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.015
CHGB	chromogranin B (secretogranin 1)	0.014
SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.014
GRM3	glutamate receptor, metabotropic 3	0.014
APOE	apolipoprotein E	0.014
DLG2	discs, large homolog 2 (Drosophila)	0.014
ERC2	ELKS/RAB6-interacting/CAST family member 2	0.014
MAST3	microtubule associated serine/threonine kinase 3	0.014
NOL4	nucleolar protein 4	0.014
NRCAM	neuronal cell adhesion molecule	0.014
SOX10	SRY (sex determining region Y)-box 10	0.013
SLC6A15	solute carrier family 6 (neutral amino acid transporter), member 15	0.013
GFAP	glial fibrillary acidic protein	0.013
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.013
FGF14	fibroblast growth factor 14	0.013
GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2	0.013
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.013
BAI3	brain-specific angiogenesis inhibitor 3	0.013
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.013
CSRNP3	cysteine-serine-rich nuclear protein 3	0.013
UNC5C	unc-5 homolog C (C. elegans)	0.013
NFASC	neurofascin	0.013
DFNB31	deafness, autosomal recessive 31	0.013
OPRK1	opioid receptor, kappa 1	0.013
ASTN1	astrotactin 1	0.012
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.012
SEPT4	septin 4	0.012
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.012
LSAMP	limbic system-associated membrane protein	0.012
LDLR	low density lipoprotein receptor	0.012
NCAN	neurocan	0.012
APOB	apolipoprotein B (including Ag(x) antigen)	0.012
PKNOX2	PBX/knotted 1 homeobox 2	0.011
SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)	0.011
ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.011
CDH8	cadherin 8, type 2	0.011
PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	0.011
RALYL	RALY RNA binding protein-like	0.011
LPPR4	lipid phosphate phosphatase-related protein type 4	0.011
BMI1	BMI1 polycomb ring finger oncogene	0.011
APP	amyloid beta (A4) precursor protein	0.011
HPR	haptoglobin-related protein	0.011
SCN2A	sodium channel, voltage-gated, type II, alpha subunit	0.011
CNTNAP2	contactin associated protein-like 2	0.011	Fly
SYN2	synapsin II	0.011
EZR	ezrin	0.011
PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	0.011
FGF12	fibroblast growth factor 12	0.011
TMEM35	transmembrane protein 35	0.011
CNTN1	contactin 1	0.011	Human
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.010
HMP19	HMP19 protein	0.010
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.010
LRRTM4	leucine rich repeat transmembrane neuronal 4	0.010	Mouse
CDH10	cadherin 10, type 2 (T2-cadherin)	0.010
PTPRS	protein tyrosine phosphatase, receptor type, S	0.010
SPEF2	sperm flagellar 2	0.010
OPCML	opioid binding protein/cell adhesion molecule-like	0.010
TAGLN3	transgelin 3	0.010