IMP
Process View
activation of mapkk activity
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
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Click on a gene's description to view its network relationships with genes known to be involved in "activation of mapkk activity"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Ntrk1 | neurotrophic tyrosine kinase, receptor, type 1 | 0.140 | ||
| Cd4 | Cd4 molecule | 0.103 | ||
| Itgam | integrin, alpha M | 0.098 | ||
| Cx3cr1 | chemokine (C-X3-C motif) receptor 1 | 0.079 | ||
| Unc5b | unc-5 homolog B (C. elegans) | 0.073 | ||
| Drd2 | dopamine receptor D2 | 0.061 | ||
| Hnrnpf | heterogeneous nuclear ribonucleoprotein F | 0.059 | ||
| Bcan | brevican | 0.055 | ||
| Ptpn12 | protein tyrosine phosphatase, non-receptor type 12 | 0.049 | ||
| Clstn3 | calsyntenin 3 | 0.049 | ||
| Socs3 | suppressor of cytokine signaling 3 | 0.048 | ||
| Pak2 | p21 protein (Cdc42/Rac)-activated kinase 2 | 0.047 | Yeast | |
| Wdr26 | WD repeat domain 26 | 0.046 | ||
| Nek9 | NIMA (never in mitosis gene a)- related kinase 9 | 0.046 | ||
| Flt1 | FMS-related tyrosine kinase 1 | 0.043 | ||
| RGD1564664 | similar to LOC387763 protein | 0.040 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.040 | ||
| Met | met proto-oncogene | 0.040 | ||
| Myo1d | myosin ID | 0.035 | ||
| Strn | striatin, calmodulin binding protein | 0.034 | ||
| Adora2a | adenosine A2a receptor | 0.032 | Rat | |
| Slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.030 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.029 | ||
| Hpca | hippocalcin | 0.028 | ||
| Atp7b | ATPase, Cu++ transporting, beta polypeptide | 0.028 | ||
| Adora1 | adenosine A1 receptor | 0.026 | ||
| Mapk3 | mitogen activated protein kinase 3 | 0.025 | ||
| Ptafr | platelet-activating factor receptor | 0.025 | ||
| Cdh17 | cadherin 17 | 0.024 | ||
| Kcnab2 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | 0.024 | ||
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.023 | ||
| Trhr2 | thyrotropin releasing hormone receptor 2 | 0.023 | ||
| Slc1a2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | 0.023 | ||
| Glra1 | glycine receptor, alpha 1 | 0.023 | ||
| Hr | hairless | 0.023 | ||
| Pkn2 | protein kinase N2 | 0.022 | ||
| Uhmk1 | U2AF homology motif (UHM) kinase 1 | 0.022 | ||
| Map6 | microtubule-associated protein 6 | 0.022 | ||
| Arnt | aryl hydrocarbon receptor nuclear translocator | 0.022 | ||
| Clic4 | chloride intracellular channel 4 | 0.022 | ||
| Adam10 | ADAM metallopeptidase domain 10 | 0.021 | ||
| Cfp | complement factor properdin | 0.021 | ||
| Tgfbr3 | transforming growth factor, beta receptor III | 0.021 | ||
| Reg1a | regenerating islet-derived 1 alpha | 0.020 | ||
| Shank2 | SH3 and multiple ankyrin repeat domains 2 | 0.020 | ||
| Slc8a3 | solute carrier family 8 (sodium/calcium exchanger), member 3 | 0.020 | ||
| Itpkb | inositol 1,4,5-trisphosphate 3-kinase B | 0.020 | ||
| Gpr173 | G-protein coupled receptor 173 | 0.020 | ||
| Vom2r53 | vomeronasal 2 receptor, 53 | 0.019 | ||
| Cbl | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.019 | ||
| Soat1 | sterol O-acyltransferase 1 | 0.019 | ||
| Nckap1 | NCK-associated protein 1 | 0.019 | ||
| Slc9a5 | solute carrier family 9 (sodium/hydrogen exchanger), member 5 | 0.019 | ||
| Kcnk1 | potassium channel, subfamily K, member 1 | 0.019 | ||
| Arhgap23 | Rho GTPase activating protein 23 | 0.018 | ||
| Ndst1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.018 | ||
| Kcnj4 | potassium inwardly-rectifying channel, subfamily J, member 4 | 0.018 | ||
| Gucy2d | guanylate cyclase 2d | 0.018 | ||
| Grp | gastrin releasing peptide | 0.017 | ||
| Calcrl | calcitonin receptor-like | 0.017 | ||
| Cdkn2b | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 0.017 | ||
| Crk | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.017 | ||
| Kcnj5 | potassium inwardly-rectifying channel, subfamily J, member 5 | 0.017 | ||
| Jak1 | Janus kinase 1 | 0.017 | ||
| Smad3 | SMAD family member 3 | 0.017 | ||
| Apba2 | amyloid beta (A4) precursor protein-binding, family A, member 2 | 0.016 | ||
| LOC100361706 | lambda-chain C1-region-like | 0.016 | ||
| Map3k3 | mitogen activated protein kinase kinase kinase 3 | 0.016 | ||
| Notch3 | Notch homolog 3 (Drosophila) | 0.016 | ||
| Tle4 | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 0.016 | ||
| Pax6 | paired box 6 | 0.016 | ||
| LOC100360986 | mCG1035404-like | 0.016 | ||
| B3gat1 | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | 0.015 | ||
| Prph2 | peripherin 2 | 0.015 | ||
| Rap1b | RAP1B, member of RAS oncogene family | 0.015 | ||
| Colec12 | collectin sub-family member 12 | 0.015 | ||
| Il1r1 | interleukin 1 receptor, type I | 0.015 | ||
| Nmbr | neuromedin B receptor | 0.015 | ||
| Prdm2 | PR domain containing 2, with ZNF domain | 0.015 | ||
| Zfp36l1 | zinc finger protein 36, C3H type-like 1 | 0.015 | ||
| Ebi3 | Epstein-Barr virus induced 3 | 0.014 | ||
| Gata4 | GATA binding protein 4 | 0.014 | ||
| Pnlip | pancreatic lipase | 0.014 | ||
| Extl3 | exostoses (multiple)-like 3 | 0.014 | ||
| Snrk | SNF related kinase | 0.014 | ||
| Zg16 | zymogen granule protein 16 | 0.014 | ||
| Trh | thyrotropin releasing hormone | 0.014 | ||
| Picalm | phosphatidylinositol binding clathrin assembly protein | 0.014 | ||
| Fgf21 | fibroblast growth factor 21 | 0.014 | ||
| Prap1 | proline-rich acidic protein 1 | 0.014 | ||
| Smad7 | SMAD family member 7 | 0.014 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.014 | ||
| Rpe65 | retinal pigment epithelium 65 | 0.013 | ||
| Slc9a1 | solute carrier family 9 (sodium/hydrogen exchanger), member 1 | 0.013 | ||
| Epas1 | endothelial PAS domain protein 1 | 0.013 | ||
| Gabrg1 | gamma-aminobutyric acid (GABA) A receptor, gamma 1 | 0.013 | ||
| Prkacb | protein kinase, cAMP dependent, catalytic, beta | 0.013 | ||
| Mchr1 | melanin-concentrating hormone receptor 1 | 0.013 | ||
| Adra2c | adrenergic, alpha-2C-, receptor | 0.013 | ||
| Ptger2 | prostaglandin E receptor 2 (subtype EP2) | 0.013 | ||
| Plau | plasminogen activator, urokinase | 0.013 | ||
| Ccr3 | chemokine (C-C motif) receptor 3 | 0.013 | ||
| RGD1309414 | similar to KIAA0913 protein | 0.013 | ||
| Calcr | calcitonin receptor | 0.013 | ||
| Hrh3 | histamine receptor H3 | 0.013 | ||
| Hnf4a | hepatocyte nuclear factor 4, alpha | 0.013 | ||
| Gpr83 | G protein-coupled receptor 83 | 0.013 | ||
| Syt13 | synaptotagmin XIII | 0.012 | ||
| Cd38 | CD38 molecule | 0.012 | ||
| Galnt1 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) | 0.012 | ||
| Marcks | myristoylated alanine rich protein kinase C substrate | 0.012 | ||
| Drd1a | dopamine receptor D1A | 0.012 | ||
| Accn2 | amiloride-sensitive cation channel 2, neuronal | 0.012 | ||
| St8sia4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 0.012 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.012 | ||
| Nrg1 | neuregulin 1 | 0.012 | ||
| Gpr6 | G protein-coupled receptor 6 | 0.012 | ||
| Tacr1 | tachykinin receptor 1 | 0.012 | ||
| Pfkfb4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.012 | ||
| RT1-Ha | RT1 class II, locus Ha | 0.012 | ||
| Ddr2 | discoidin domain receptor tyrosine kinase 2 | 0.012 | ||
| LOC680122 | similar to sin3 associated polypeptide | 0.012 | ||
| Timp3 | TIMP metallopeptidase inhibitor 3 | 0.012 | ||
| Mllt4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.012 | ||
| Ahr | aryl hydrocarbon receptor | 0.012 | ||
| Csnk1g3 | casein kinase 1, gamma 3 | 0.011 | ||
| Syt7 | synaptotagmin VII | 0.011 | ||
| Glp1r | glucagon-like peptide 1 receptor | 0.011 | ||
| Mpeg1 | macrophage expressed 1 | 0.011 | ||
| Gper | G protein-coupled estrogen receptor 1 | 0.011 | ||
| Gata6 | GATA binding protein 6 | 0.011 | ||
| Bcl2l1 | Bcl2-like 1 | 0.011 | ||
| Prkar2a | protein kinase, cAMP dependent regulatory, type II alpha | 0.011 | ||
| LOC301128 | similar to jumonji domain containing 2B | 0.011 | ||
| Creb1 | cAMP responsive element binding protein 1 | 0.011 | ||
| Nab1 | Ngfi-A binding protein 1 | 0.011 | ||
| Gfra2 | GDNF family receptor alpha 2 | 0.011 | ||
| Slco2a1 | solute carrier organic anion transporter family, member 2a1 | 0.011 | ||
| Ncan | neurocan | 0.011 | ||
| Sert1 | Sertoli cell protein 1 | 0.011 | ||
| Myo9b | myosin IXb | 0.011 | ||
| Cyth1 | cytohesin 1 | 0.011 | ||
| Mdm2 | Mdm2 p53 binding protein homolog (mouse) | 0.011 | ||
| Slc20a2 | solute carrier family 20 (phosphate transporter), member 2 | 0.011 | ||
| Cxcl6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.011 | ||
| Th | tyrosine hydroxylase | 0.011 | ||
| Kcnk10 | potassium channel, subfamily K, member 10 | 0.011 | ||
| Nr2f6 | nuclear receptor subfamily 2, group F, member 6 | 0.011 | ||
| Dlgap3 | discs, large (Drosophila) homolog-associated protein 3 | 0.011 | ||
| Adora3 | adenosine A3 receptor | 0.011 | Rat | |
| Csf3 | colony stimulating factor 3 (granulocyte) | 0.011 | ||
| Kcnq3 | potassium voltage-gated channel, KQT-like subfamily, member 3 | 0.011 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.011 | ||
| Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 0.010 | ||
| Smad1 | SMAD family member 1 | 0.010 | ||
| Cpne9 | copine family member IX | 0.010 | ||
| Erbb3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.010 | Rat | |
| Tgfb1 | transforming growth factor, beta 1 | 0.010 | ||
| Nedd4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.010 | ||
| Ifna1 | interferon-alpha 1 | 0.010 | ||
| Plxnb2 | plexin B2 | 0.010 | ||
| Sox17 | SRY (sex determining region Y)-box 17 | 0.010 | ||
| Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.010 | ||
| Gad1 | glutamate decarboxylase 1 | 0.010 | ||
| Mapk9 | mitogen-activated protein kinase 9 | 0.010 | ||
| Slc6a7 | solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 | 0.010 |