IMP

Process View

Saccharomyces cerevisiae

33 genes annotated in yeast

Multi-species View

negative regulation of protein maturation

GO:1903318

Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation.

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Known genes in the process in yeast Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein maturation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein maturation" (in gray)

Name	Description	Probability	Func Analog Organism
CDC55	Cdc55p	0.811
PPH21	Pph21p	0.766
MAD2	Mad2p	0.763
RTS1	Rts1p	0.621
CDC20	Cdc20p	0.566
PPH22	Pph22p	0.550
SLK19	Slk19p	0.454
CSE4	Cse4p	0.371
HHF2	Hhf2p	0.327
MAD3	Mad3p	0.307
TIP41	Tip41p	0.264
CTF13	Ctf13p	0.199
CKB1	Ckb1p	0.161
GLC7	Glc7p	0.159
KIP1	Kip1p	0.147
PSP2	Psp2p	0.146
YPI1	Ypi1p	0.145
CHL4	Chl4p	0.139
CDC24	Cdc24p	0.135
ASE1	Ase1p	0.117
MCM21	Mcm21p	0.108
PHB1	Phb1p	0.108
RAD23	Rad23p	0.107
BCK1	Bck1p	0.104
SDS22	Sds22p	0.099
MPS1	Mps1p	0.096
TOR2	Tor2p	0.095
STI1	Sti1p	0.095
PCL10	Pcl10p	0.093
KSP1	Ksp1p	0.084
GAC1	Gac1p	0.074
BTN2	Btn2p	0.073
SCC2	Scc2p	0.072
SAP4	Sap4p	0.072
WWM1	Wwm1p	0.059
MLC1	Mlc1p	0.058
NOG1	Nog1p	0.057
PHB2	Phb2p	0.052
BUB3	Bub3p	0.051	Worm Fly
ECO1	Eco1p	0.051
ZDS2	Zds2p	0.049
NBL1	Nbl1p	0.047
MAD1	Mad1p	0.047
CBF1	Cbf1p	0.047
CTF8	Ctf8p	0.047
STU1	Stu1p	0.045
GIP2	Gip2p	0.044	Yeast
GLG1	Glg1p	0.044
MTW1	Mtw1p	0.043
HTA1	Hta1p	0.043
YBP2	Ybp2p	0.042
TPD3	Tpd3p	0.042
CTF3	Ctf3p	0.042
CMK1	Cmk1p	0.042
IML3	Iml3p	0.041
TRA1	Tra1p	0.041
FIN1	Fin1p	0.041
REG1	Reg1p	0.041
NOP6	Nop6p	0.041
RSC3	Rsc3p	0.039
NSL1	Nsl1p	0.039
SMC5	Smc5p	0.038
FMP48	Fmp48p	0.037
PAN1	Pan1p	0.035
RRD2	Rrd2p	0.035
PSY4	Psy4p	0.035
RAD54	Rad54p	0.035
SPC110	Spc110p	0.035
YKL075C	hypothetical protein	0.035
CHK1	Chk1p	0.033
CDC28	Cdc28p	0.033
HTB1	Htb1p	0.032
TAF10	Taf10p	0.032
CAB3	Cab3p	0.032
ESC1	Esc1p	0.030
APM2	Apm2p	0.030
SAP190	Sap190p	0.029
CCT2	Cct2p	0.029
SUS1	Sus1p	0.028
TBS1	Tbs1p	0.028
PPZ1	Ppz1p	0.026
PIG2	Pig2p	0.025	Yeast
URN1	Urn1p	0.025
CRP1	Crp1p	0.025
YMR210W	hypothetical protein	0.025
YIL151C	hypothetical protein	0.024
MPH1	Mph1p	0.024
BMH2	Bmh2p	0.024	Human
SPC105	Spc105p	0.024
PRP28	Prp28p	0.023
LEU2	Leu2p	0.023
YLR162W	hypothetical protein	0.023
SRD1	Srd1p	0.023
GFD2	Gfd2p	0.023
ATG27	Atg27p	0.023
ADH2	Adh2p	0.023
UBR1	Ubr1p	0.023
RPN7	Rpn7p	0.023
ARE2	Are2p	0.023
YLR264C-A	hypothetical protein	0.022
ZPR1	Zpr1p	0.022
YNL234W	hypothetical protein	0.022
RTG2	Rtg2p	0.022
TAF11	Taf11p	0.022
YLR419W	hypothetical protein	0.022
PRE4	Pre4p	0.022
NOB1	Nob1p	0.021
AHP1	Ahp1p	0.021
YOL038C-A	hypothetical protein	0.021
ESP1	Esp1p	0.021
YGR235C	hypothetical protein	0.021
SPO12	Spo12p	0.021
TID3	Tid3p	0.021
SFI1	Sfi1p	0.021
YML053C	hypothetical protein	0.021
PRE6	Pre6p	0.020
NBP2	Nbp2p	0.020
SAP185	Sap185p	0.020
YER039C-A	hypothetical protein	0.020
SPC24	Spc24p	0.020
CAJ1	Caj1p	0.020
RHO1	Rho1p	0.020
BMH1	Bmh1p	0.020	Human
KIN3	Kin3p	0.020
ARG8	Arg8p	0.020
BAT2	Bat2p	0.020
YKR011C	hypothetical protein	0.020
YDL012C	hypothetical protein	0.020
UBC1	Ubc1p	0.019
IRC15	Irc15p	0.019
ATG20	Atg20p	0.019
ZDS1	Zds1p	0.019
AQR1	Aqr1p	0.019
LCB4	Lcb4p	0.019
FRQ1	Frq1p	0.019
HMG2	Hmg2p	0.019
PBS2	Pbs2p	0.019
NDD1	Ndd1p	0.019
REH1	Reh1p	0.019
MER1	Mer1p	0.019
YGL010W	hypothetical protein	0.019
YBR085C-A	hypothetical protein	0.019
CIN8	Cin8p	0.019
DNA2	Dna2p	0.019
YNR062C	hypothetical protein	0.019
SCC4	Scc4p	0.018
NCE103	Nce103p	0.018
CDC15	Cdc15p	0.018
AIM18	Aim18p	0.018
TPI1	Tpi1p	0.018
YBR296C-A	hypothetical protein	0.018
CSR2	Csr2p	0.018
HSP82	Hsp82p	0.018
ICS2	Ics2p	0.018
HAP3	Hap3p	0.018
SET4	Set4p	0.018
UPS3	Ups3p	0.018
BRN1	Brn1p	0.018
SLX8	Slx8p	0.018
YLR281C	hypothetical protein	0.017
SRO77	Sro77p	0.017
TSC3	Tsc3p	0.017
PCT1	Pct1p	0.017
BUB1	Bub1p	0.017
OPY1	Opy1p	0.017
LIF1	Lif1p	0.017
PSP1	Psp1p	0.017
CUP1-1	Cup1-1p	0.017
CTS1	Cts1p	0.017
OSH3	Osh3p	0.017
YPL168W	hypothetical protein	0.017
ZPS1	Zps1p	0.017
ATP6	Atp6p	0.017
BFA1	Bfa1p	0.017
YAR068W	hypothetical protein	0.017
SLI15	Sli15p	0.017
VHS2	Vhs2p	0.017
CPD1	Cpd1p	0.016
SKM1	Skm1p	0.016	Human
ECT1	Ect1p	0.016
YMR1	Ymr1p	0.016
APM1	Apm1p	0.016
FRA2	Fra2p	0.016
MPT5	Mpt5p	0.016
GSH2	Gsh2p	0.016
SPL2	Spl2p	0.016
YNL144C	hypothetical protein	0.016
HIR1	Hir1p	0.016
RAD61	Rad61p	0.016
TAF7	Taf7p	0.016
PRS2	Prs2p	0.016
MIA40	Mia40p	0.016
PAM1	Pam1p	0.016
CYM1	Cym1p	0.015
CIN1	Cin1p	0.015
HOR2	Hor2p	0.015
ALT2	Alt2p	0.015
SUR1	Sur1p	0.015
YBR013C	hypothetical protein	0.015
SGE1	Sge1p	0.015
ARR2	Arr2p	0.015
HAA1	Haa1p	0.015
UBC9	Ubc9p	0.015
BSC1	Bsc1p	0.015
OPT2	Opt2p	0.015
NTO1	Nto1p	0.015
PBP4	Pbp4p	0.015
CHA1	Cha1p	0.015
BIO2	Bio2p	0.015
AUA1	Aua1p	0.015
PSH1	Psh1p	0.015
CMD1	Cmd1p	0.015
HO	Hop	0.015
URA3	Ura3p	0.015
TOS8	Tos8p	0.015
DIF1	Dif1p	0.015
HPF1	Hpf1p	0.015
YDL085C-A	hypothetical protein	0.015
APL4	Apl4p	0.015
ARP10	Arp10p	0.015
YKR075C	hypothetical protein	0.015
PTR2	Ptr2p	0.015
YPR097W	hypothetical protein	0.015
YBL107C	hypothetical protein	0.015
YLR042C	hypothetical protein	0.014
GSY1	Gsy1p	0.014
YOR059C	hypothetical protein	0.014
CKB2	Ckb2p	0.014
YPL068C	hypothetical protein	0.014
YOR131C	hypothetical protein	0.014
VPS5	Vps5p	0.014
SET2	Set2p	0.014
YIR016W	hypothetical protein	0.014
RPN11	Rpn11p	0.014
RPN9	Rpn9p	0.014
GIP3	Gip3p	0.014
RPT2	Rpt2p	0.014
KEL2	Kel2p	0.014
CHC1	Chc1p	0.014
YOL013W-A	hypothetical protein	0.014
DOP1	Dop1p	0.014
HXT3	Hxt3p	0.014
BCK2	Bck2p	0.014
YGR079W	hypothetical protein	0.014
MYO1	Myo1p	0.014
ENT1	Ent1p	0.014
FAR1	Far1p	0.014
YPR157W	hypothetical protein	0.014
AQY2	Aqy2p	0.014
MF(ALPHA)2	Mf(alpha)2p	0.014
SRX1	Srx1p	0.014
INN1	Inn1p	0.013
PPE1	Ppe1p	0.013
BNA4	Bna4p	0.013
SAP155	Sap155p	0.013
YDR306C	hypothetical protein	0.013
FAS2	Fas2p	0.013
PCD1	Pcd1p	0.013
SPS4	Sps4p	0.013
GYL1	Gyl1p	0.013
SPG3	Spg3p	0.013
FMT1	Fmt1p	0.013
MDM20	Mdm20p	0.013
YER163C	hypothetical protein	0.013
PUP2	Pup2p	0.013
GLG2	Glg2p	0.013
PPN1	Ppn1p	0.013
IRC8	Irc8p	0.013
YKR045C	hypothetical protein	0.013
APD1	Apd1p	0.013
AZF1	Azf1p	0.013
CTF19	Ctf19p	0.013
YLR040C	hypothetical protein	0.013
YIR035C	hypothetical protein	0.013
TOF2	Tof2p	0.013
YPL066W	hypothetical protein	0.013
CAR1	Car1p	0.013
YLR407W	hypothetical protein	0.013
RMD5	Rmd5p	0.013
AHA1	Aha1p	0.013
NOG2	Nog2p	0.012
HHO1	Hho1p	0.012
MRK1	Mrk1p	0.012
CDC23	Cdc23p	0.012
YNL155W	hypothetical protein	0.012
MMP1	Mmp1p	0.012
YJL055W	hypothetical protein	0.012
APC5	Apc5p	0.012
MDJ2	Mdj2p	0.012
WSS1	Wss1p	0.012
YAR066W	hypothetical protein	0.012
YLR108C	hypothetical protein	0.012
SWC7	Swc7p	0.012
ARO10	Aro10p	0.012
OKP1	Okp1p	0.012
MFA2	Mfa2p	0.012
YAL037C-A	hypothetical protein	0.012
ULA1	Ula1p	0.012
PRR1	Prr1p	0.012
ATO3	Ato3p	0.012
CKA1	Cka1p	0.012	Human
MDV1	Mdv1p	0.012
YKL069W	hypothetical protein	0.012
YGR035C	hypothetical protein	0.012
DIC1	Dic1p	0.012
TPM2	Tpm2p	0.012
RNP1	Rnp1p	0.012
YLL053C	hypothetical protein	0.012
GAL83	Gal83p	0.012
RRP1	Rrp1p	0.012
RRN5	Rrn5p	0.012
SGV1	Sgv1p	0.012
UFD2	Ufd2p	0.012
POP6	Pop6p	0.012
FRK1	Frk1p	0.012
YAL064W	hypothetical protein	0.012
YOL014W	hypothetical protein	0.012
YML003W	hypothetical protein	0.012
PTI1	Pti1p	0.012
MNN4	Mnn4p	0.012
TIR3	Tir3p	0.012
YGK3	Ygk3p	0.012
YGL006W-A	hypothetical protein	0.012
YDR222W	hypothetical protein	0.012
YBL029W	hypothetical protein	0.012
RPT4	Rpt4p	0.012
YMR317W	hypothetical protein	0.012
YNL067W-B	hypothetical protein	0.012
AIM14	Aim14p	0.012
STD1	Std1p	0.012
TYE7	Tye7p	0.012
HAL1	Hal1p	0.012
ENA5	Ena5p	0.012
YDR034C-A	hypothetical protein	0.011
AAD15	Aad15p	0.011
RSN1	Rsn1p	0.011
PDR15	Pdr15p	0.011
YNL033W	hypothetical protein	0.011
MEI5	Mei5p	0.011
SWI1	Swi1p	0.011
YFR006W	hypothetical protein	0.011
RPT1	Rpt1p	0.011
JLP2	Jlp2p	0.011
YOR387C	hypothetical protein	0.011
PUP3	Pup3p	0.011
CDC6	Cdc6p	0.011
UBP11	Ubp11p	0.011
VIK1	Vik1p	0.011
GDI1	Gdi1p	0.011
DOG1	Dog1p	0.011
WSC3	Wsc3p	0.011
REE1	Ree1p	0.011
IZH4	Izh4p	0.011
MF(ALPHA)1	Mf(alpha)1p	0.011
MND1	Mnd1p	0.011
CCA1	Cca1p	0.011
DUR1,2	Dur1,2p	0.011
NSE5	Nse5p	0.011
YPL216W	hypothetical protein	0.011
BIT61	Bit61p	0.011
EEB1	Eeb1p	0.011
RRN9	Rrn9p	0.011
FRE5	Fre5p	0.011
ERV2	Erv2p	0.011
SLA2	Sla2p	0.011
ENO1	Eno1p	0.011
YHR033W	hypothetical protein	0.011
GNT1	Gnt1p	0.011
YNL024C	hypothetical protein	0.011
YAR029W	hypothetical protein	0.011
YNL058C	hypothetical protein	0.011
YPR096C	hypothetical protein	0.011
HEM14	Hem14p	0.011
NKP2	Nkp2p	0.011
RDS3	Rds3p	0.011
BUR6	Bur6p	0.011
YPR117W	hypothetical protein	0.011
YMR295C	hypothetical protein	0.011
YIR042C	hypothetical protein	0.011
NMT1	Nmt1p	0.011
POM34	Pom34p	0.011
KIC1	Kic1p	0.011
NNK1	Nnk1p	0.011
RTS2	Rts2p	0.011
SUT1	Sut1p	0.011
AAD6	Aad6p	0.011
CIT2	Cit2p	0.011
GIC1	Gic1p	0.011
YBR096W	hypothetical protein	0.011
PHM6	Phm6p	0.011
RTT105	Rtt105p	0.011
YNL162W-A	hypothetical protein	0.011
GCV1	Gcv1p	0.011
CHL1	Chl1p	0.011
IOC3	Ioc3p	0.011
CTR2	Ctr2p	0.010
YJR115W	hypothetical protein	0.010
MTM1	Mtm1p	0.010
YLR412C-A	hypothetical protein	0.010
SEC20	Sec20p	0.010
YNL018C	hypothetical protein	0.010
CTK2	Ctk2p	0.010
HMRA1	Hmra1p	0.010
HMS1	Hms1p	0.010
MDN1	Mdn1p	0.010
RLP7	Rlp7p	0.010
YGL235W	hypothetical protein	0.010
KNH1	Knh1p	0.010
HUR1	Hur1p	0.010
YJR120W	hypothetical protein	0.010
DBF20	Dbf20p	0.010
VBA5	Vba5p	0.010
AIM9	Aim9p	0.010
YLR363W-A	hypothetical protein	0.010
NRG2	Nrg2p	0.010
YPL113C	hypothetical protein	0.010
YEA6	Yea6p	0.010
PHO11	Pho11p	0.010
YPR159C-A	hypothetical protein	0.010
YNL260C	hypothetical protein	0.010
MET8	Met8p	0.010
YCH1	Ych1p	0.010
STB6	Stb6p	0.010
DAT1	Dat1p	0.010
YGL015C	hypothetical protein	0.010
YLR225C	hypothetical protein	0.010
YCR102C	hypothetical protein	0.010
PRM4	Prm4p	0.010
SSF2	Ssf2p	0.010
RPN2	Rpn2p	0.010
STE2	Ste2p	0.010
THP3	Thp3p	0.010
HEM3	Hem3p	0.010
YLR422W	hypothetical protein	0.010
YML100W-A	hypothetical protein	0.010
PPX1	Ppx1p	0.010
YLR445W	hypothetical protein	0.010
PTC4	Ptc4p	0.010
SPO14	Spo14p	0.010
CAB1	Cab1p	0.010
COS12	Cos12p	0.010
TKL2	Tkl2p	0.010