IMP

Process View

Danio rerio

3 genes annotated in zebrafish

proximal tubule development

GO:0072014

The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in zebrafish Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "proximal tubule development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "proximal tubule development" (in gray)

Name	Description	Probability	Func Analog Organism
osr2	odd-skipped related 2 (Drosophila)	0.707	Zebrafish
notch1a	notch homolog 1a	0.693
mib	mind bomb	0.615
foxj1a	forkhead box J1a	0.408
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.357
eya1	eyes absent homolog 1	0.349
shha	sonic hedgehog a	0.312
osr1	odd-skipped related 1 (Drosophila)	0.236
jag1b	jagged 1b	0.169
flr	fleer	0.164
dlc	deltaC	0.156
foxa3	forkhead box A3	0.156
pax2a	paired box gene 2a	0.148
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.131
cdh2	cadherin 2, neuronal	0.116
lrrc6	leucine rich repeat containing 6	0.097
pcdh18b	protocadherin 18b	0.072
hoxa13a	homeo box A13a	0.061
dlb	deltaB	0.059
ccdc40	coiled-coil domain containing 40	0.058
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.058
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.057
cldn15a	claudin 15a	0.055
etv2	ets variant gene 2	0.055
lhx1a	LIM homeobox 1a	0.054
hnf1bb	HNF1 homeobox Bb	0.053
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.053
foxj1b	forkhead box J1b	0.052
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.051
nrarpa	notch-regulated ankyrin repeat protein a	0.046
aqp8a.1	aquaporin 8a, tandem duplicate 1	0.045
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.043
scube2	signal peptide, CUB domain, EGF-like 2	0.043
gli2a	GLI-Kruppel family member GLI2a	0.043
tbx5a	T-box 5a	0.042
nkx6.1	NK6 transcription factor related, locus 1 (Drosophila)	0.041
wnt11	wingless-type MMTV integration site family, member 11	0.039
her12	hairy-related 12	0.037
crb2a	crumbs homolog 2a	0.036
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.035
wt1b	wilms tumor 1b	0.035
gsc	goosecoid	0.035
tbx22	T-box 22	0.032
cftr	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)	0.031
ahr2	aryl hydrocarbon receptor 2	0.031
jag2	jagged 2	0.030
neurog1	neurogenin 1	0.030
twist2	twist2	0.029
notch3	notch homolog 3	0.029
coe2	coe2	0.028
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.028
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.028
mdh1a	malate dehydrogenase 1a, NAD (soluble)	0.026
tgfb3	transforming growth factor, beta 3	0.025
supt6h	suppressor of Ty 6 homolog	0.025
lrrc50	leucine rich repeat containing 50	0.025
dzip1	DAZ interacting protein 1	0.024
foxa2	forkhead box A2	0.024
arl13b	ADP-ribosylation factor-like 13b	0.023
cdx4	caudal type homeo box transcription factor 4	0.023
prdm1a	PR domain containing 1a, with ZNF domain	0.021
rest	RE1-silencing transcription factor	0.021
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.020
ntla	no tail a	0.019
bon	bonnie and clyde	0.019
aplnrb	apelin receptor b	0.019
ift52	intraflagellar transport protein 52	0.019
acox1	acyl-Coenzyme A oxidase 1, palmitoyl	0.019
bmp2b	bone morphogenetic protein 2b	0.017
fabp11a	fatty acid binding protein 11a	0.017
axin1	axin 1	0.017
lmo4a	LIM domain only 4a	0.016
wdr69	WD repeat domain 69	0.016
pkd2	polycystic kidney disease 2	0.016
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.016
fn1	fibronectin 1	0.016
plod2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.015
plxna3	plexin A3	0.015
pcdh18a	protocadherin 18a	0.015
prkci	protein kinase C, iota	0.015
aqp3a	aquaporin 3a	0.015
tmem2	transmembrane protein 2	0.015
crb2b	crumbs homolog 2b	0.015
phf8	PHD finger protein 8	0.015
lypd6	LY6/PLAUR domain containing 6	0.014
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.014
nkx2.3	NK2 transcription factor related 3	0.014
kdrl	kinase insert domain receptor like	0.014
lfng	lunatic fringe homolog	0.014
trim33	tripartite motif-containing 33	0.014
lrp2	low density lipoprotein-related protein 2	0.014
ndrg1	N-myc downstream regulated gene 1	0.013
hes6	hairy and enhancer of split 6 (Drosophila)	0.013
fzd8a	frizzled homolog 8a	0.013
ccbe1	collagen and calcium binding EGF domains 1	0.013
mecom	MDS1 and EVI1 complex locus	0.013
olig2	oligodendrocyte lineage transcription factor 2	0.013
si:dkey-71l1.7	si:dkey-71l1.7	0.013
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.012
lhx6	LIM homeobox 6	0.012
rnd1l	Rho family GTPase 1 like	0.012
rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.012
csnk1a1	casein kinase 1, alpha 1	0.012
LOC100536988	Gig2-like protein DreQ	0.011
satb2	SATB homeobox 2	0.011
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.011
cat	catalase	0.011
lama1	laminin, alpha 1	0.011
traf3ip1	TNF receptor-associated factor 3 interacting protein 1	0.011
ift57	intraflagellar transport protein 57	0.011
aqp8a.2	aquaporin 8a, tandem duplicate 2	0.011
podxl	podocalyxin-like	0.011
aqp10a	aquaporin 10a	0.011
slc20a1a	solute carrier family 20, member 1a	0.011
prnprs3	prion protein, related sequence 3	0.010
ccbl1	cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)	0.010
igf2b	insulin-like growth factor 2b	0.010