The network for 'negative regulation of stem cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of stem cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.

Drosophila melanogaster
Name Description Probability Func Analog Organism
E(spl) Enhancer of split 0.964
HLHmdelta E(spl) region transcript mdelta 0.847
HLHm7 E(spl) region transcript m7 0.804
HLHmgamma E(spl) region transcript mgamma 0.764
H Hairless 0.523
HLHmbeta E(spl) region transcript mbeta 0.407
HLHm5 E(spl) region transcript m5 0.402
dsh dishevelled 0.400
HLHm3 E(spl) region transcript m3 0.291
fz frizzled 0.266
hh hedgehog 0.226
Tom Twin of m4 0.187
ci cubitus interruptus 0.185
wg wingless 0.109
ftz fushi tarazu 0.093
malpha E(spl) region transcript malpha 0.081
Ser Serrate 0.068
tld tolloid 0.062
ac achaete 0.062
sc scute 0.061
ato atonal 0.052
vg vestigial 0.052
slp1 sloppy paired 1 0.047
tin tinman 0.044
eyg eyegone 0.044
run runt 0.037
dpp decapentaplegic 0.035
m4 E(spl) region transcript m4 0.032
tkv thickveins 0.030
hkb huckebein 0.029
byn brachyenteron 0.028
m2 E(spl) region transcript m2 0.027
ft fat 0.027
sca scabrous 0.025
ham hamlet 0.024
dy dusky 0.024
brk brinker 0.023
sli slit 0.021
Doc2 Dorsocross2 0.020
amos absent MD neurons and olfactory sensilla 0.019
HLH54F CG5005 gene product from transcript CG5005-RA 0.019
Ubx Ultrabithorax 0.019
crp cropped 0.018
bi bifid 0.018
en engrailed 0.018
Notum CG13076 gene product from transcript CG13076-RB 0.017
sna snail 0.017
ase asense 0.016
dpn deadpan 0.016
ro rough 0.015
fz2 frizzled 2 0.015
Gsc Goosecoid 0.014
cno canoe 0.014
Tollo CG6890 gene product from transcript CG6890-RA 0.013
gcm glial cells missing 0.013
Kr Kruppel 0.012
fng fringe 0.012
tap target of Poxn 0.012
ptc patched 0.012
glo glorund 0.011
ths thisbe 0.011
wts warts 0.011
CG14869 CG14869 gene product from transcript CG14869-RB 0.011
kirre kin of irre 0.011
twi twist 0.010
mxc multi sex combs 0.010
nkd naked cuticle 0.010
os outstretched 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
foxj1a forkhead box J1a 0.895
pax8 paired box gene 8 0.835
jag1b jagged 1b 0.679
fzd7a frizzled homolog 7a 0.610
etv2 ets variant gene 2 0.506
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.438
dla deltaA 0.406
pax2a paired box gene 2a 0.406
jag2 jagged 2 0.404
osr2 odd-skipped related 2 (Drosophila) 0.391
wt1a wilms tumor 1a 0.391
gata6 GATA-binding protein 6 0.383
spry4 sprouty (Drosophila) homolog 4 0.352
tbx2a T-box gene 2a 0.302
wnt8b wingless-type MMTV integration site family, member 8b 0.282
wnt1 wingless-type MMTV integration site family, member 1 0.281
hhex hematopoietically expressed homeobox 0.276
notch3 notch homolog 3 0.273
dlb deltaB 0.270
bmp4 bone morphogenetic protein 4 0.245
hoxb1a homeo box B1a 0.238
hoxd11a homeo box D11a 0.212
notch2 notch homolog 2 0.192
dlc deltaC 0.183
waca WW domain containing adaptor with coiled-coil a 0.181
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.177
gata3 GATA-binding protein 3 0.174
lhx1a LIM homeobox 1a 0.168
foxa3 forkhead box A3 0.164
pou3f3b POU class 3 homeobox 3b 0.163
ascl1a achaete-scute complex-like 1a (Drosophila) 0.162
sox3 SRY-box containing gene 3 0.161
smg7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.161
wnt11r wingless-type MMTV integration site family, member 11, related 0.159
crabp2b cellular retinoic acid binding protein 2, b 0.158
vsx2 visual system homeobox 2 0.157
pea3 ETS-domain transcription factor pea3 0.153
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.149
dvl3 dishevelled, dsh homolog 3 (Drosophila) 0.146
vcana versican a 0.144
eya1 eyes absent homolog 1 0.134
hnf1bb HNF1 homeobox Bb 0.131
epha4a eph receptor A4a 0.129
nkx2.3 NK2 transcription factor related 3 0.127
mnx1 motor neuron and pancreas homeobox 1 0.126
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.126
wnt4a wingless-type MMTV integration site family, member 4a 0.124
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.121
sb:cb81 sb:cb81 0.118
gdnf glial cell derived neurotrophic factor 0.117
wnt5b wingless-type MMTV integration site family, member 5b 0.116
bmp2b bone morphogenetic protein 2b 0.116
fgf3 fibroblast growth factor 3 0.115
rarab retinoic acid receptor, alpha b 0.115
ism1 isthmin 1 0.113
wt1b wilms tumor 1b 0.113
neo1 neogenin 1 0.113
tpbgl trophoblast glycoprotein-like 0.113
cdh1 cadherin 1, epithelial 0.112
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.110
tll1 tolloid-like 1 0.105
tmem2 transmembrane protein 2 0.105
gbx2 gastrulation brain homeo box 2 0.102
fgf17 fibroblast growth factor 17 0.102
hoxc8a homeo box C8a 0.099
tjp1 tight junction protein 1 (zona occludens 1) 0.099
ncs1a neuronal calcium sensor 1a 0.097
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.096
gli2a GLI-Kruppel family member GLI2a 0.096
ccdc40 coiled-coil domain containing 40 0.093
spaw southpaw 0.093
fn1 fibronectin 1 0.092
barhl1.2 BarH-like 1.2 0.091
hoxb1b homeo box B1b 0.090
lsr lipolysis stimulated lipoprotein receptor 0.089
foxi1 forkhead box I1 0.087
otpb orthopedia homolog b 0.085
il17rd interleukin 17 receptor D 0.084
gbx1 gastrulation brain homeobox 1 0.083
foxn4 forkhead box N4 0.083
ythdf1 YTH domain family, member 1 0.082
hoxd3a homeo box D3a 0.082
cldn5a claudin 5a 0.082
fli1a friend leukemia integration 1a 0.081
hmx3 homeo box (H6 family) 3 0.081
flrt3 fibronectin leucine rich transmembrane 3 0.080
clic4 chloride intracellular channel 4 0.079
sp5l Sp5 transcription factor-like 0.079
insm1a insulinoma-associated 1a 0.078
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.078
sim1a single-minded homolog 1a (Drosophila) 0.077
fn1b fibronectin 1b 0.077
axin2 axin 2 (conductin, axil) 0.076
gyltl1b glycosyltransferase-like 1b 0.076
lhx1b LIM homeobox 1b 0.075
ef1 ETS-related factor1 0.074
hnf1ba HNF1 homeobox Ba 0.074
slc38a3 solute carrier family 38, member 3 0.072
klf4a Kruppel-like transcription factor 4a 0.071
neurod4 neurogenic differentiation 4 0.070
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Homo sapiens
Name Description Probability Func Analog Organism
NOTCH1 notch 1 0.972
JAG1 jagged 1 0.927
POU5F1 POU class 5 homeobox 1 0.773
NOTCH3 notch 3 0.725
AR androgen receptor 0.690
NKX2-1 NK2 homeobox 1 0.593
TBX5 T-box 5 0.589
PAX8 paired box 8 0.543
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.482
NOTCH2 notch 2 0.336
JAG2 jagged 2 0.319
CREBBP CREB binding protein 0.305
AXIN1 axin 1 0.304
DLL1 delta-like 1 (Drosophila) 0.288
CAV1 caveolin 1, caveolae protein, 22kDa 0.221
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.218
RFWD2 ring finger and WD repeat domain 2 0.204
TP73 tumor protein p73 0.180
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.159
LRRK2 leucine-rich repeat kinase 2 0.151
TWIST2 twist homolog 2 (Drosophila) 0.140
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.139
CTNNBIP1 catenin, beta interacting protein 1 0.124
FOXD3 forkhead box D3 0.124
PDX1 pancreatic and duodenal homeobox 1 0.119
FZD1 frizzled homolog 1 (Drosophila) 0.105
MAML1 mastermind-like 1 (Drosophila) 0.103
GATA4 GATA binding protein 4 0.102
CDX2 caudal type homeobox 2 0.094
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.086
FGF3 fibroblast growth factor 3 0.084
SMAD1 SMAD family member 1 0.083
HNF1A HNF1 homeobox A 0.079
ATN1 atrophin 1 0.077
WDYHV1 WDYHV motif containing 1 0.072
FZD8 frizzled homolog 8 (Drosophila) 0.068
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.065
GFI1B growth factor independent 1B transcription repressor 0.065
MNX1 motor neuron and pancreas homeobox 1 0.062
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.062
FBLN1 fibulin 1 0.060
TBX1 T-box 1 0.058
SOCS1 suppressor of cytokine signaling 1 0.056
WT1 Wilms tumor 1 0.056
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.055
BBS10 Bardet-Biedl syndrome 10 0.054
SIM2 single-minded homolog 2 (Drosophila) 0.054
SOX2 SRY (sex determining region Y)-box 2 0.054
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.054
LBX1 ladybird homeobox 1 0.052
BBS1 Bardet-Biedl syndrome 1 0.052
REV3L REV3-like, catalytic subunit of DNA polymerase zeta (yeast) 0.051
HES2 hairy and enhancer of split 2 (Drosophila) 0.047
WNT10A wingless-type MMTV integration site family, member 10A 0.046
NCOA2 nuclear receptor coactivator 2 0.045
HNF4A hepatocyte nuclear factor 4, alpha 0.045
FOXA2 forkhead box A2 0.043
PAX7 paired box 7 0.042
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.042
GEMIN6 gem (nuclear organelle) associated protein 6 0.042
TBX2 T-box 2 0.041
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.041
AMOTL1 angiomotin like 1 0.040
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.040
SOX1 SRY (sex determining region Y)-box 1 0.039
CEP164 centrosomal protein 164kDa 0.038
C9orf100 chromosome 9 open reading frame 100 0.038
DSP desmoplakin 0.036
INHBB inhibin, beta B 0.035
NEUROG3 neurogenin 3 0.035
REPS2 RALBP1 associated Eps domain containing 2 0.034
TAL1 T-cell acute lymphocytic leukemia 1 0.034
RUNX1 runt-related transcription factor 1 0.033
PYY peptide YY 0.033
BHLHE23 basic helix-loop-helix family, member e23 0.033
ERG v-ets erythroblastosis virus E26 oncogene homolog (avian) 0.032
APC adenomatous polyposis coli 0.031
HNF1B HNF1 homeobox B 0.031
NOG noggin 0.031
WDR5 WD repeat domain 5 0.029
ESPN espin 0.029
FGF8 fibroblast growth factor 8 (androgen-induced) 0.029
KRTAP4-12 keratin associated protein 4-12 0.028
FOXO1 forkhead box O1 0.028
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.028
EFNA2 ephrin-A2 0.028
PITX1 paired-like homeodomain 1 0.028
ADAM9 ADAM metallopeptidase domain 9 0.027
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.027
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.027
EGFL7 EGF-like-domain, multiple 7 0.026
HOXB13 homeobox B13 0.026
NKX6-1 NK6 homeobox 1 0.026
LHX1 LIM homeobox 1 0.026
OCLN occludin 0.026
GATA5 GATA binding protein 5 0.026
CALCA calcitonin-related polypeptide alpha 0.025
RAX retina and anterior neural fold homeobox 0.025
LRP6 low density lipoprotein receptor-related protein 6 0.025
FHL1 four and a half LIM domains 1 0.024
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Mus musculus
Name Description Probability Func Analog Organism
Vangl2 vang-like 2 (van gogh, Drosophila) 0.998
Fgfr2 fibroblast growth factor receptor 2 0.997
Shh sonic hedgehog 0.995
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.941
Gli3 GLI-Kruppel family member GLI3 0.938
Bmp7 bone morphogenetic protein 7 0.888
Foxc1 forkhead box C1 0.873
Otx2 orthodenticle homolog 2 (Drosophila) 0.835
Tbx1 T-box 1 0.828
Pitx2 paired-like homeodomain transcription factor 2 0.804
Emx1 empty spiracles homolog 1 (Drosophila) 0.803
Eya1 eyes absent 1 homolog (Drosophila) 0.787
Bmp4 bone morphogenetic protein 4 0.719
Gdf5 growth differentiation factor 5 0.649
Fgf8 fibroblast growth factor 8 0.633
Sox2 SRY-box containing gene 2 0.620
Wnt3a wingless-related MMTV integration site 3A 0.585
Hand1 heart and neural crest derivatives expressed transcript 1 0.578
Rarg retinoic acid receptor, gamma 0.528
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.501
Fgfr1 fibroblast growth factor receptor 1 0.472
Pax3 paired box gene 3 0.459
Jag1 jagged 1 0.450
Foxc2 forkhead box C2 0.442
Yap1 yes-associated protein 1 0.418
Sfrp2 secreted frizzled-related protein 2 0.416
Msx1 homeobox, msh-like 1 0.387
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.348
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.345
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.298
Hes1 hairy and enhancer of split 1 (Drosophila) 0.293
Tcfap2a transcription factor AP-2, alpha 0.287
Hoxd13 homeobox D13 0.271
Alx4 aristaless-like homeobox 4 0.270
Vangl1 vang-like 1 (van gogh, Drosophila) 0.240
Wwtr1 WW domain containing transcription regulator 1 0.226
Notch2 Notch gene homolog 2 (Drosophila) 0.213
Emx2 empty spiracles homolog 2 (Drosophila) 0.207
Nog noggin 0.205
Lef1 lymphoid enhancer binding factor 1 0.201
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.197
Foxg1 forkhead box G1 0.195
Notch1 Notch gene homolog 1 (Drosophila) 0.192
Pax8 paired box gene 8 0.190
Psen1 presenilin 1 0.187
Fgfr3 fibroblast growth factor receptor 3 0.184
Vegfa vascular endothelial growth factor A 0.174
Pbx1 pre B-cell leukemia transcription factor 1 0.170
Gas1 growth arrest specific 1 0.167
Foxf1a forkhead box F1a 0.164
Msx2 homeobox, msh-like 2 0.161
Alx3 aristaless-like homeobox 3 0.160
Hes3 hairy and enhancer of split 3 (Drosophila) 0.157
Jun Jun oncogene 0.154
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.143
Fos FBJ osteosarcoma oncogene 0.138
Ern2 endoplasmic reticulum (ER) to nucleus signalling 2 0.136
Gpc3 glypican 3 0.135
Dlx5 distal-less homeobox 5 0.127
Dusp1 dual specificity phosphatase 1 0.125
Chd7 chromodomain helicase DNA binding protein 7 0.123
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.121
Gsc goosecoid homeobox 0.119
Tbx15 T-box 15 0.118
Dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.114
Hoxa2 homeobox A2 0.109
Pax6 paired box gene 6 0.108
Hnf1b HNF1 homeobox B 0.106
Lhx3 LIM homeobox protein 3 0.103
Tgfbr2 transforming growth factor, beta receptor II 0.100
Dll1 delta-like 1 (Drosophila) 0.098
Tbx3 T-box 3 0.097
Klf6 Kruppel-like factor 6 0.097
Dll4 delta-like 4 (Drosophila) 0.095
Smo smoothened homolog (Drosophila) 0.093
Hand2 heart and neural crest derivatives expressed transcript 2 0.092
Gli2 GLI-Kruppel family member GLI2 0.088
Efnb1 ephrin B1 0.088
Ephb3 Eph receptor B3 0.087
Gata4 GATA binding protein 4 0.086
Prrx1 paired related homeobox 1 0.085
Barx2 BarH-like homeobox 2 0.084
Ece1 endothelin converting enzyme 1 0.084
Gata6 GATA binding protein 6 0.083
Otx1 orthodenticle homolog 1 (Drosophila) 0.082
Junb Jun-B oncogene 0.081
Pax2 paired box gene 2 0.080
Btg2 B-cell translocation gene 2, anti-proliferative 0.079
Tcf21 transcription factor 21 0.076
Foxe1 forkhead box E1 0.074
Lrp6 low density lipoprotein receptor-related protein 6 0.074
Crb3 crumbs homolog 3 (Drosophila) 0.073
Lhx1 LIM homeobox protein 1 0.072
Tead1 TEA domain family member 1 0.072
Wnt5a wingless-related MMTV integration site 5A 0.067
Hoxa1 homeobox A1 0.063
Tead3 TEA domain family member 3 0.063
Htt huntingtin 0.062
Fgf3 fibroblast growth factor 3 0.062
Alx1 ALX homeobox 1 0.060
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism