The network for 'cardiac conduction system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac conduction system development

The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.

Homo sapiens
Name Description Probability Func Analog Organism
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.998
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.998
TBX5 T-box 5 0.997
JAG1 jagged 1 0.881
MAML1 mastermind-like 1 (Drosophila) 0.878
NOTCH1 notch 1 0.868
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.416
NOTCH3 notch 3 0.385
PAX8 paired box 8 0.384
SPEN spen homolog, transcriptional regulator (Drosophila) 0.223
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.182
GATA4 GATA binding protein 4 0.148
NOTCH2 notch 2 0.054
XIAP X-linked inhibitor of apoptosis 0.052
ATXN1L ataxin 1-like 0.048
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.035
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.029
TAL1 T-cell acute lymphocytic leukemia 1 0.027
DLL1 delta-like 1 (Drosophila) 0.026
EP300 E1A binding protein p300 0.025
SNW1 SNW domain containing 1 0.024
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.018
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.016
TNS4 tensin 4 0.016
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.014
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.012
ARL3 ADP-ribosylation factor-like 3 0.012
TBX1 T-box 1 0.011
IQGAP2 IQ motif containing GTPase activating protein 2 0.011
TCF12 transcription factor 12 0.010
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
tbx5a T-box 5a 0.981
tbx20 T-box 20 0.977
tbx2b T-box 2b 0.729
mespa mesoderm posterior a 0.690
bmp4 bone morphogenetic protein 4 0.650
her7 hairy and enhancer of split related-7 0.650
her1 hairy-related 1 0.634
has2 hyaluronan synthase 2 0.595
vcana versican a 0.586
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.580
nkx2.5 NK2 transcription factor related 5 0.527
hand2 heart and neural crest derivatives expressed transcript 2 0.510
kdrl kinase insert domain receptor like 0.466
tbx2a T-box gene 2a 0.455
mespb mesoderm posterior b 0.372
pcdh8 protocadherin 8 0.369
myl7 myosin, light polypeptide 7, regulatory 0.347
oep one-eyed pinhead 0.294
fbn2b fibrillin 2b 0.289
tbx24 T-box 24 0.264
etv2 ets variant gene 2 0.262
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.262
hnf1ba HNF1 homeobox Ba 0.257
hspb12 heat shock protein, alpha-crystallin-related, b12 0.246
hoxa13b homeo box A13b 0.240
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.218
spaw southpaw 0.213
cdh5 cadherin 5 0.193
hoxa9a homeo box A9a 0.191
tbx16 T-box gene 16 0.186
tnnc1a troponin C type 1a (slow) 0.178
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.177
fn1 fibronectin 1 0.174
tbx5b T-box 5b 0.172
nppa natriuretic peptide precursor A 0.163
tgfb3 transforming growth factor, beta 3 0.162
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.159
dlc deltaC 0.157
slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.151
myf5 myogenic factor 5 0.149
cdh2 cadherin 2, neuronal 0.147
rxrga retinoid x receptor, gamma a 0.140
smyd1b SET and MYND domain containing 1b 0.139
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.138
tbx6 T-box gene 6 0.134
foxn4 forkhead box N4 0.128
alcama activated leukocyte cell adhesion molecule a 0.125
ripply1 ripply1 0.125
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.109
mib mind bomb 0.109
sesn1 sestrin 1 0.095
ripply2 ripply2 0.094
gata5 GATA-binding protein 5 0.088
twist1a twist1a 0.085
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.083
tpm4 tropomyosin 4 0.081
hoxa11a homeo box A11a 0.081
wnt11r wingless-type MMTV integration site family, member 11, related 0.078
notch1a notch homolog 1a 0.076
mef2cb myocyte enhancer factor 2cb 0.074
hoxa9b homeo box A9b 0.074
hoxd11a homeo box D11a 0.072
notch1b notch homolog 1b 0.071
dld deltaD 0.063
prdm1a PR domain containing 1a, with ZNF domain 0.062
gdf6b growth differentiation factor 6b 0.061
tmem88a transmembrane protein 88 a 0.061
lft1 lefty1 0.060
osr2 odd-skipped related 2 (Drosophila) 0.060
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.060
rbm24a RNA binding motif protein 24a 0.058
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.056
tbx1 T-box 1 0.055
si:ch211-235f6.2 si:ch211-235f6.2 0.055
vmhc ventricular myosin heavy chain 0.055
rbpms2 RNA binding protein with multiple splicing 2 0.055
tbx18 T-box 18 0.055
gata4 GATA-binding protein 4 0.054
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.054
igf2b insulin-like growth factor 2b 0.050
klf2a Kruppel-like factor 2a 0.049
fhla four and a half LIM domains a 0.049
rhoua ras homolog gene family, member Ua 0.048
synpo2lb synaptopodin 2-like b 0.048
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.048
lft2 lefty2 0.048
scube2 signal peptide, CUB domain, EGF-like 2 0.046
plekha7 pleckstrin homology domain containing, family A member 7 0.045
runx1 runt-related transcription factor 1 0.045
zgc:195154 zgc:195154 0.044
gli1 GLI-Kruppel family member 1 0.044
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.044
hoxd13a homeo box D13a 0.043
aplnrb apelin receptor b 0.041
tie1 endothelium-specific receptor tyrosine kinase 1 0.041
hoxd10a homeo box D10a 0.041
foxh1 forkhead box H1 0.040
crb2a crumbs homolog 2a 0.040
zgc:63523 zgc:63523 0.040
cx43 connexin 43 0.040
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Pitx2 paired-like homeodomain transcription factor 2 0.999
Tbx3 T-box 3 0.994
Notch1 Notch gene homolog 1 (Drosophila) 0.983
Hand2 heart and neural crest derivatives expressed transcript 2 0.981
Shh sonic hedgehog 0.971
Jag1 jagged 1 0.971
Fgf8 fibroblast growth factor 8 0.970
Fgfr2 fibroblast growth factor receptor 2 0.933
Gata4 GATA binding protein 4 0.849
Hoxa1 homeobox A1 0.845
Rxra retinoid X receptor alpha 0.844
Pax3 paired box gene 3 0.826
Pitx1 paired-like homeodomain transcription factor 1 0.815
Foxc1 forkhead box C1 0.771
Isl1 ISL1 transcription factor, LIM/homeodomain 0.748
Id1 inhibitor of DNA binding 1 0.732
Efnb2 ephrin B2 0.709
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.702
Id3 inhibitor of DNA binding 3 0.699
Foxc2 forkhead box C2 0.690
Bmp4 bone morphogenetic protein 4 0.615
Mesp1 mesoderm posterior 1 0.547
Tbx5 T-box 5 0.542
Ntf3 neurotrophin 3 0.539
Psen1 presenilin 1 0.538
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.514
Scn5a sodium channel, voltage-gated, type V, alpha 0.513
Hoxa13 homeobox A13 0.483
Ctnnb1 catenin (cadherin associated protein), beta 1 0.465
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.435
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.434
Chd7 chromodomain helicase DNA binding protein 7 0.389
Notch2 Notch gene homolog 2 (Drosophila) 0.365
Vegfa vascular endothelial growth factor A 0.351
Zfpm2 zinc finger protein, multitype 2 0.338
Foxg1 forkhead box G1 0.326
Fgf10 fibroblast growth factor 10 0.313
Hand1 heart and neural crest derivatives expressed transcript 1 0.312
Tcfap2a transcription factor AP-2, alpha 0.309
Gata6 GATA binding protein 6 0.304
Tbx1 T-box 1 0.284
Pax2 paired box gene 2 0.281
Gata3 GATA binding protein 3 0.267
Bmpr1a bone morphogenetic protein receptor, type 1A 0.258
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.250
Tgfb2 transforming growth factor, beta 2 0.240
Ryr2 ryanodine receptor 2, cardiac 0.232
Foxh1 forkhead box H1 0.198
Col13a1 collagen, type XIII, alpha 1 0.188
Egfr epidermal growth factor receptor 0.184
Sox9 SRY-box containing gene 9 0.183
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.176
Hmx1 H6 homeobox 1 0.144
Pax6 paired box gene 6 0.129
Vangl2 vang-like 2 (van gogh, Drosophila) 0.126
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.122
Atoh7 atonal homolog 7 (Drosophila) 0.119
Nkx3-2 NK3 homeobox 2 0.114
Dll1 delta-like 1 (Drosophila) 0.113
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.111
Dll4 delta-like 4 (Drosophila) 0.104
Smad6 MAD homolog 6 (Drosophila) 0.101
Noto notochord homolog (Xenopus laevis) 0.101
Ighmbp2 immunoglobulin mu binding protein 2 0.096
Sox2 SRY-box containing gene 2 0.094
Hes1 hairy and enhancer of split 1 (Drosophila) 0.092
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.090
Sall4 sal-like 4 (Drosophila) 0.087
Bdnf brain derived neurotrophic factor 0.086
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.085
Gbx2 gastrulation brain homeobox 2 0.085
Nos3 nitric oxide synthase 3, endothelial cell 0.072
Nodal nodal 0.072
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.067
Lmx1b LIM homeobox transcription factor 1 beta 0.065
Wt1 Wilms tumor 1 homolog 0.064
Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) 0.063
Tlx3 T-cell leukemia, homeobox 3 0.063
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.061
Gjb6 gap junction protein, beta 6 0.060
Foxf1a forkhead box F1a 0.059
Acvr1 activin A receptor, type 1 0.058
Foxe3 forkhead box E3 0.058
Cdx2 caudal type homeobox 2 0.052
Pcdh12 protocadherin 12 0.051
Gja5 gap junction protein, alpha 5 0.050
Hmx3 H6 homeobox 3 0.049
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.047
Pou5f1 POU domain, class 5, transcription factor 1 0.046
Smo smoothened homolog (Drosophila) 0.046
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.045
Nkx6-1 NK6 homeobox 1 0.045
Sox11 SRY-box containing gene 11 0.044
Gsc goosecoid homeobox 0.044
Wnt7a wingless-related MMTV integration site 7A 0.042
Bcl2 B-cell leukemia/lymphoma 2 0.042
Foxd3 forkhead box D3 0.041
Fgf3 fibroblast growth factor 3 0.041
Gpc3 glypican 3 0.041
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism