IMP
Process View
The network for 'negative regulation of cd4 positive alpha beta t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of cd4 positive alpha beta t cell activation
Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CCR5 | chemokine (C-C motif) receptor 5 | 0.999 | |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | 0.995 | |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.946 | |
| IL8 | interleukin 8 | 0.896 | |
| IL2RG | interleukin 2 receptor, gamma | 0.881 | |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.730 | |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.725 | |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.588 | |
| DPP4 | dipeptidyl-peptidase 4 | 0.498 | |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 0.460 | |
| IL1B | interleukin 1, beta | 0.388 | |
| IDE | insulin-degrading enzyme | 0.382 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.382 | |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.340 | |
| CCL22 | chemokine (C-C motif) ligand 22 | 0.227 | |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.227 | |
| IL7R | interleukin 7 receptor | 0.206 | |
| CCR1 | chemokine (C-C motif) receptor 1 | 0.192 | |
| IL6 | interleukin 6 (interferon, beta 2) | 0.186 | |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.163 | |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.160 | |
| CCR4 | chemokine (C-C motif) receptor 4 | 0.148 | |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.134 | |
| CCL11 | chemokine (C-C motif) ligand 11 | 0.129 | |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.124 | |
| CCL3 | chemokine (C-C motif) ligand 3 | 0.121 | |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.117 | |
| CCL7 | chemokine (C-C motif) ligand 7 | 0.107 | |
| SOCS3 | suppressor of cytokine signaling 3 | 0.094 | |
| VCAM1 | vascular cell adhesion molecule 1 | 0.089 | |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.082 | |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.080 | |
| PCDH9 | protocadherin 9 | 0.078 | |
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 0.076 | |
| SELE | selectin E | 0.073 | |
| TNF | tumor necrosis factor | 0.065 | |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.061 | |
| CD83 | CD83 molecule | 0.060 | |
| RGS1 | regulator of G-protein signaling 1 | 0.060 | |
| ICAM1 | intercellular adhesion molecule 1 | 0.059 | |
| NCOR2 | nuclear receptor corepressor 2 | 0.058 | |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.056 | |
| FPR3 | formyl peptide receptor 3 | 0.055 | |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 0.053 | |
| CXCL6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.052 | |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.052 | |
| IL10 | interleukin 10 | 0.049 | |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.047 | |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.046 | |
| CH25H | cholesterol 25-hydroxylase | 0.045 | |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.044 | |
| IFNG | interferon, gamma | 0.042 | |
| DARC | Duffy blood group, chemokine receptor | 0.041 | |
| EBI3 | Epstein-Barr virus induced 3 | 0.041 | |
| ARRB1 | arrestin, beta 1 | 0.041 | |
| IL1RN | interleukin 1 receptor antagonist | 0.040 | |
| MMP12 | matrix metallopeptidase 12 (macrophage elastase) | 0.039 | |
| HDAC9 | histone deacetylase 9 | 0.039 | |
| IL13 | interleukin 13 | 0.038 | |
| IRF4 | interferon regulatory factor 4 | 0.038 | |
| EPOR | erythropoietin receptor | 0.037 | |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.037 | |
| IL18RAP | interleukin 18 receptor accessory protein | 0.036 | |
| CCR3 | chemokine (C-C motif) receptor 3 | 0.033 | |
| IL2RB | interleukin 2 receptor, beta | 0.032 | |
| HDAC5 | histone deacetylase 5 | 0.032 | |
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.031 | |
| CCL21 | chemokine (C-C motif) ligand 21 | 0.030 | |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 0.030 | |
| INHBA | inhibin, beta A | 0.029 | |
| IL3 | interleukin 3 (colony-stimulating factor, multiple) | 0.029 | |
| MSC | musculin | 0.028 | |
| CCL3L3 | chemokine (C-C motif) ligand 3-like 3 | 0.027 | |
| PLA2G7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | 0.027 | |
| CCL17 | chemokine (C-C motif) ligand 17 | 0.026 | |
| ZFP36 | zinc finger protein 36, C3H type, homolog (mouse) | 0.026 | |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.026 | |
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.025 | |
| MMP9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 0.024 | |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.024 | |
| XCL2 | chemokine (C motif) ligand 2 | 0.024 | |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.023 | |
| XCL1 | chemokine (C motif) ligand 1 | 0.023 | |
| CD69 | CD69 molecule | 0.023 | |
| KDM2A | lysine (K)-specific demethylase 2A | 0.023 | |
| STAT4 | signal transducer and activator of transcription 4 | 0.022 | |
| IL1R2 | interleukin 1 receptor, type II | 0.022 | |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.021 | |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.021 | |
| UBD | ubiquitin D | 0.020 | |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.020 | |
| BATF | basic leucine zipper transcription factor, ATF-like | 0.020 | |
| CCL1 | chemokine (C-C motif) ligand 1 | 0.020 | |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.019 | |
| NNMT | nicotinamide N-methyltransferase | 0.018 | |
| BCL2A1 | BCL2-related protein A1 | 0.018 | |
| RGS16 | regulator of G-protein signaling 16 | 0.018 | |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 | 0.017 | |
| SLAMF8 | SLAM family member 8 | 0.017 | |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.017 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Csf2rb2 | colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) | 0.938 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.815 | |
| Rc3h1 | RING CCCH (C3H) domains 1 | 0.799 | |
| Lepr | leptin receptor | 0.623 | |
| Csf2rb | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.615 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.505 | |
| Jak2 | Janus kinase 2 | 0.448 | |
| Stat5a | signal transducer and activator of transcription 5A | 0.328 | |
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.298 | |
| Stat6 | signal transducer and activator of transcription 6 | 0.206 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.192 | |
| Socs3 | suppressor of cytokine signaling 3 | 0.162 | |
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.122 | |
| Bcl3 | B-cell leukemia/lymphoma 3 | 0.117 | |
| Cish | cytokine inducible SH2-containing protein | 0.095 | |
| Il6st | interleukin 6 signal transducer | 0.092 | |
| Ifng | interferon gamma | 0.091 | |
| Foxp3 | forkhead box P3 | 0.051 | |
| Cul5 | cullin 5 | 0.046 | |
| Il4ra | interleukin 4 receptor, alpha | 0.045 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.041 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.040 | |
| Socs2 | suppressor of cytokine signaling 2 | 0.034 | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.034 | |
| Tnf | tumor necrosis factor | 0.034 | |
| Batf | basic leucine zipper transcription factor, ATF-like | 0.033 | |
| Rc3h2 | ring finger and CCCH-type zinc finger domains 2 | 0.030 | |
| Sh2b1 | SH2B adaptor protein 1 | 0.029 | |
| Creb1 | cAMP responsive element binding protein 1 | 0.024 | |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.024 | |
| Arap3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | 0.023 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.023 | |
| Pim1 | proviral integration site 1 | 0.022 | |
| Tnip1 | TNFAIP3 interacting protein 1 | 0.019 | |
| Il3ra | interleukin 3 receptor, alpha chain | 0.019 | |
| Hhex | hematopoietically expressed homeobox | 0.018 | |
| Il6 | interleukin 6 | 0.018 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.018 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.018 | |
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.017 | |
| Mipol1 | mirror-image polydactyly gene 1 homolog (human) | 0.017 | |
| Cd80 | CD80 antigen | 0.017 | |
| Rag1 | recombination activating gene 1 | 0.017 | |
| 2310014H01Rik | RIKEN cDNA 2310014H01 gene | 0.015 | |
| Csf1r | colony stimulating factor 1 receptor | 0.015 | |
| Socs5 | suppressor of cytokine signaling 5 | 0.015 | |
| Cd40lg | CD40 ligand | 0.014 | |
| Plcg1 | phospholipase C, gamma 1 | 0.014 | |
| Ebf3 | early B-cell factor 3 | 0.013 | |
| Zfp61 | zinc finger protein 61 | 0.012 | |
| B4galt1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.011 | |
| Ifngr2 | interferon gamma receptor 2 | 0.011 | |
| Dppa5a | developmental pluripotency associated 5A | 0.011 | |
| Il2 | interleukin 2 | 0.011 | |
| Wdr26 | WD repeat domain 26 | 0.011 | |
| Zbtb37 | zinc finger and BTB domain containing 37 | 0.010 | |
| Robo3 | roundabout homolog 3 (Drosophila) | 0.010 | |
| Cd40 | CD40 antigen | 0.010 | |
| 4933426M11Rik | RIKEN cDNA 4933426M11 gene | 0.010 | |
| Il4 | interleukin 4 | 0.010 |