IMP
Process View
The network for 'oxidative stress induced premature senescence' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
oxidative stress induced premature senescence
A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| WWOX | WW domain containing oxidoreductase | 0.989 | |
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.982 | |
| KRT5 | keratin 5 | 0.979 | |
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.971 | |
| CLOCK | clock homolog (mouse) | 0.969 | |
| S1PR5 | sphingosine-1-phosphate receptor 5 | 0.857 | |
| CBLC | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | 0.815 | |
| YAP1 | Yes-associated protein 1 | 0.711 | |
| FGF18 | fibroblast growth factor 18 | 0.645 | |
| SATB2 | SATB homeobox 2 | 0.645 | |
| KRT6C | keratin 6C | 0.499 | |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.416 | |
| SNX9 | sorting nexin 9 | 0.402 | |
| WNT1 | wingless-type MMTV integration site family, member 1 | 0.381 | |
| CACNA1G | calcium channel, voltage-dependent, T type, alpha 1G subunit | 0.379 | |
| TP73 | tumor protein p73 | 0.295 | |
| AHR | aryl hydrocarbon receptor | 0.245 | |
| DTX1 | deltex homolog 1 (Drosophila) | 0.225 | |
| AMOTL1 | angiomotin like 1 | 0.199 | |
| WIF1 | WNT inhibitory factor 1 | 0.198 | |
| CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 0.188 | |
| PKP1 | plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) | 0.187 | |
| LBX1 | ladybird homeobox 1 | 0.177 | |
| SFRP1 | secreted frizzled-related protein 1 | 0.164 | |
| WNT10A | wingless-type MMTV integration site family, member 10A | 0.149 | |
| FGF3 | fibroblast growth factor 3 | 0.142 | |
| SOX1 | SRY (sex determining region Y)-box 1 | 0.132 | |
| FGF4 | fibroblast growth factor 4 | 0.120 | |
| MMP11 | matrix metallopeptidase 11 (stromelysin 3) | 0.119 | |
| FOXC2 | forkhead box C2 (MFH-1, mesenchyme forkhead 1) | 0.114 | |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.111 | |
| CRLF1 | cytokine receptor-like factor 1 | 0.095 | |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.094 | |
| KRT14 | keratin 14 | 0.093 | |
| DLX4 | distal-less homeobox 4 | 0.093 | |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.092 | |
| HES2 | hairy and enhancer of split 2 (Drosophila) | 0.084 | |
| WNT3 | wingless-type MMTV integration site family, member 3 | 0.082 | |
| IHH | Indian hedgehog | 0.079 | |
| FGF8 | fibroblast growth factor 8 (androgen-induced) | 0.079 | |
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.075 | |
| NPAS2 | neuronal PAS domain protein 2 | 0.072 | |
| HS3ST6 | heparan sulfate (glucosamine) 3-O-sulfotransferase 6 | 0.061 | |
| ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 0.057 | |
| FOXF2 | forkhead box F2 | 0.056 | |
| SLC6A2 | solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 | 0.055 | |
| WNT4 | wingless-type MMTV integration site family, member 4 | 0.055 | |
| WNT7A | wingless-type MMTV integration site family, member 7A | 0.054 | |
| AQP5 | aquaporin 5 | 0.054 | |
| FOXL1 | forkhead box L1 | 0.054 | |
| NPAS1 | neuronal PAS domain protein 1 | 0.053 | |
| HMX1 | H6 family homeobox 1 | 0.052 | |
| BHLHE23 | basic helix-loop-helix family, member e23 | 0.052 | |
| FOXD3 | forkhead box D3 | 0.050 | |
| FOXE1 | forkhead box E1 (thyroid transcription factor 2) | 0.049 | |
| LMX1A | LIM homeobox transcription factor 1, alpha | 0.049 | |
| WNT10B | wingless-type MMTV integration site family, member 10B | 0.049 | |
| NKD2 | naked cuticle homolog 2 (Drosophila) | 0.048 | |
| SPG20 | spastic paraplegia 20 (Troyer syndrome) | 0.048 | |
| SNX18 | sorting nexin 18 | 0.047 | |
| IRX4 | iroquois homeobox 4 | 0.045 | |
| SOX21 | SRY (sex determining region Y)-box 21 | 0.045 | |
| GGN | gametogenetin | 0.045 | |
| TLX3 | T-cell leukemia homeobox 3 | 0.045 | |
| ALOX12 | arachidonate 12-lipoxygenase | 0.044 | |
| SLC18A3 | solute carrier family 18 (vesicular acetylcholine), member 3 | 0.043 | |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.043 | |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.042 | |
| SIX2 | SIX homeobox 2 | 0.042 | |
| BNC1 | basonuclin 1 | 0.042 | |
| H2AFX | H2A histone family, member X | 0.041 | |
| NKX2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.041 | |
| DUOX1 | dual oxidase 1 | 0.041 | |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.039 | |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 0.039 | |
| SHH | sonic hedgehog | 0.039 | |
| POU3F1 | POU class 3 homeobox 1 | 0.039 | |
| HOXC12 | homeobox C12 | 0.038 | |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | 0.037 | |
| BMP1 | bone morphogenetic protein 1 | 0.037 | |
| HOXD13 | homeobox D13 | 0.037 | |
| RAX | retina and anterior neural fold homeobox | 0.036 | |
| HOXC8 | homeobox C8 | 0.036 | |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | 0.036 | |
| FOXB1 | forkhead box B1 | 0.035 | |
| KCNJ5 | potassium inwardly-rectifying channel, subfamily J, member 5 | 0.035 | |
| OCA2 | oculocutaneous albinism II | 0.035 | |
| C1QL1 | complement component 1, q subcomponent-like 1 | 0.035 | |
| IGSF21 | immunoglobin superfamily, member 21 | 0.035 | |
| SCARF2 | scavenger receptor class F, member 2 | 0.034 | |
| ABI2 | abl-interactor 2 | 0.034 | |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.034 | |
| KCNK9 | potassium channel, subfamily K, member 9 | 0.033 | |
| EPAS1 | endothelial PAS domain protein 1 | 0.032 | |
| FZD10 | frizzled homolog 10 (Drosophila) | 0.032 | |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4 | 0.032 | |
| FIBCD1 | fibrinogen C domain containing 1 | 0.032 | |
| CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | 0.031 | |
| WNT5B | wingless-type MMTV integration site family, member 5B | 0.031 | |
| SFRP5 | secreted frizzled-related protein 5 | 0.031 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Pten | phosphatase and tensin homolog | 0.142 | |
| Cry1 | cryptochrome 1 (photolyase-like) | 0.118 | |
| Clock | circadian locomotor output cycles kaput | 0.096 | |
| Per2 | period homolog 2 (Drosophila) | 0.066 | |
| Cry2 | cryptochrome 2 (photolyase-like) | 0.042 | |
| Npas2 | neuronal PAS domain protein 2 | 0.012 | |
| Trp63 | transformation related protein 63 | 0.011 | |
| Ahr | aryl-hydrocarbon receptor | 0.011 |