The network for 'calcium ion dependent exocytosis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

calcium ion dependent exocytosis

The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, requiring the presence of calcium ions.

Mus musculus
Name Description Probability Func Analog Organism
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 0.961
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 0.928
Stx1a syntaxin 1A (brain) 0.822
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.785
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.729
Snap25 synaptosomal-associated protein 25 0.694
Syt2 synaptotagmin II 0.519
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.518
Grid1 glutamate receptor, ionotropic, delta 1 0.516
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.419
Bsn bassoon 0.415
Thrb thyroid hormone receptor beta 0.380
Syt6 synaptotagmin VI 0.370
Pax3 paired box gene 3 0.365
Drd2 dopamine receptor D2 0.364
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.350
Raver2 ribonucleoprotein, PTB-binding 2 0.340
Syp synaptophysin 0.300
Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 0.293
Gad2 glutamic acid decarboxylase 2 0.272
Kifc2 kinesin family member C2 0.247
Scn8a sodium channel, voltage-gated, type VIII, alpha 0.234
Slc12a5 solute carrier family 12, member 5 0.226
Grm1 glutamate receptor, metabotropic 1 0.216
Rab3a RAB3A, member RAS oncogene family 0.212
Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 0.209
Htt huntingtin 0.196
Sh3gl2 SH3-domain GRB2-like 2 0.195
Cdh23 cadherin 23 (otocadherin) 0.193
Ush1g Usher syndrome 1G homolog (human) 0.189
Pcsk2 proprotein convertase subtilisin/kexin type 2 0.181
Gabra5 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 0.180
Cnr1 cannabinoid receptor 1 (brain) 0.177
Cacnb2 calcium channel, voltage-dependent, beta 2 subunit 0.170
Rho rhodopsin 0.161
Psen2 presenilin 2 0.157
Syn2 synapsin II 0.154
Stx7 syntaxin 7 0.146
Kif1a kinesin family member 1A 0.142
Crhr1 corticotropin releasing hormone receptor 1 0.135
Prkcc protein kinase C, gamma 0.135
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.135
Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 0.134
Fgf13 fibroblast growth factor 13 0.133
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.130
Syt10 synaptotagmin X 0.130
Zfpm2 zinc finger protein, multitype 2 0.129
Dll1 delta-like 1 (Drosophila) 0.126
Syt1 synaptotagmin I 0.125
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.124
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.122
Cux2 cut-like homeobox 2 0.121
Gpr3 G-protein coupled receptor 3 0.117
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.116
Egfl7 EGF-like domain 7 0.115
Syt7 synaptotagmin VII 0.108
Sult4a1 sulfotransferase family 4A, member 1 0.107
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.105
Src Rous sarcoma oncogene 0.105
Grm8 glutamate receptor, metabotropic 8 0.102
Fgf12 fibroblast growth factor 12 0.102
Sdcbp syndecan binding protein 0.101
Neurod1 neurogenic differentiation 1 0.099
Rims2 regulating synaptic membrane exocytosis 2 0.098
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.098
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.097
Cbln1 cerebellin 1 precursor protein 0.097
Vamp4 vesicle-associated membrane protein 4 0.095
Npas1 neuronal PAS domain protein 1 0.093
AI118078 expressed sequence AI118078 0.093
Pgr progesterone receptor 0.092
Insm1 insulinoma-associated 1 0.090
Cacna2d3 calcium channel, voltage-dependent, alpha2/delta subunit 3 0.089
B3galt1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.089
Hrh1 histamine receptor H1 0.088
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 0.084
Homer1 homer homolog 1 (Drosophila) 0.084
L1cam L1 cell adhesion molecule 0.083
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.082
Elavl2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) 0.082
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.081
Stx1b syntaxin 1B 0.080
Nrg3 neuregulin 3 0.080
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.079
Dynlt1b dynein light chain Tctex-type 1D 0.079
Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) 0.079
Map3k5 mitogen-activated protein kinase kinase kinase 5 0.079
Rab27a RAB27A, member RAS oncogene family 0.078
Dll4 delta-like 4 (Drosophila) 0.076
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.076
Atoh1 atonal homolog 1 (Drosophila) 0.076
Elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.075
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.074
Gria4 glutamate receptor, ionotropic, AMPA4 (alpha 4) 0.074
Gjd2 gap junction protein, delta 2 0.073
Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 0.073
Otx2 orthodenticle homolog 2 (Drosophila) 0.073
Mtmr6 myotubularin related protein 6 0.072
Dmrtc2 doublesex and mab-3 related transcription factor like family C2 0.072
Gpr98 G protein-coupled receptor 98 0.069
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nr2f6a nuclear receptor subfamily 2, group F, member 6a 0.285
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.153
wu:fi38e01 wu:fi38e01 0.129
LOC100535118 l-rhamnose-binding lectin CSL3-like 0.113
zgc:171779 zgc:171779 0.110
zp3b zona pellucida glycoprotein 3b 0.109
zpcx zona pellucida protein C 0.108
LOC100333772 zona pellucida sperm-binding protein 4-like 0.092
zgc:111868 zgc:111868 0.088
zgc:171818 zgc:171818 0.088
or107-1 odorant receptor, family D, subfamily 107, member 1 0.085
or102-1 odorant receptor, family C, subfamily 102, member 1 0.084
esyt3 extended synaptotagmin-like protein 3 0.083
trpc1 transient receptor potential cation channel, subfamily C, member 1 0.080
zp3a.2 zona pellucida glycoprotein 3a.2 0.078
wu:fi42e03 wu:fi42e03 0.078
zp3a.1 zona pellucida glycoprotein 3a.1 0.074
zp2.2 zona pellucida glycoprotein 2.2 0.072
LOC100332822 hypothetical protein LOC100332822 0.071
zgc:165518 zgc:165518 0.070
crb2a crumbs homolog 2a 0.067
retsatl retinol saturase (all-trans-retinol 13,14-reductase) like 0.066
acsbg2 acyl-CoA synthetase bubblegum family member 2 0.064
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.063
si:ch211-14a17.7 si:ch211-14a17.7 0.061
LOC795984 hypothetical LOC795984 0.061
si:dkeyp-98a7.10 si:dkeyp-98a7.10 0.059
zgc:91835 zgc:91835 0.057
stat3 signal transduction and activation of transcription 3 0.056
mib mind bomb 0.055
slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.051
asph aspartate beta-hydroxylase 0.050
islr2 immunoglobulin superfamily containing leucine-rich repeat 2 0.050
zp3.1 zona pellucida glycoprotein 3.1 0.050
zgc:122991 zgc:122991 0.048
npm2 nucleoplasmin 2 0.048
lamb2 laminin, beta 2 (laminin S) 0.047
hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.046
wu:fi34b01 wu:fi34b01 0.045
sept2 septin 2 0.044
ache acetylcholinesterase 0.043
pob partial optokinetic response b 0.042
atp1a3a ATPase, Na+/K+ transporting, alpha 3a polypeptide 0.042
ilk integrin linked kinase 0.042
arpc5a actin related protein 2/3 complex, subunit 5A 0.042
wu:fk73a07 wu:fk73a07 0.041
eno2 enolase 2 0.041
si:dkey-229d11.5 si:dkey-229d11.5 0.040
si:dkey-46g23.5 si:dkey-46g23.5 0.039
rab2a RAB2A, member RAS oncogene family 0.039
LOC100008344 hypothetical protein LOC100008344 0.039
avpl arginine vasopressin-like 0.038
sox4a SRY-box containing gene 4a 0.038
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.038
chat choline acetyltransferase 0.038
wu:fc18f06 wu:fc18f06 0.037
zgc:171474 zgc:171474 0.037
nudt9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 0.036
yrk Yes-related kinase 0.036
LOC567452 G protein-coupled receptor kinase 5-like 0.036
dzip1 DAZ interacting protein 1 0.035
wu:fb50h02 wu:fb50h02 0.035
gh1 growth hormone 1 0.034
ripk2 receptor-interacting serine-threonine kinase 2 0.033
LOC100332505 hypothetical protein LOC100332505 0.033
valopa vertebrate ancient long opsin a 0.032
notch3 notch homolog 3 0.032
calm1b calmodulin 1b 0.031
zgc:64040 zgc:64040 0.031
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.031
wu:fi34e01 wu:fi34e01 0.031
si:dkey-90l23.1 si:dkey-90l23.1 0.031
elf2b E74-like factor 2b (ets domain transcription factor) 0.031
gtf3ab general transcription factor IIIA, b 0.030
sept6 septin 6 0.030
clock clock 0.030
ptpra protein tyrosine phosphatase, receptor type, A 0.029
zgc:171446 zgc:171446 0.029
ewsr1a Ewing sarcoma breakpoint region 1a 0.029
ttc39c tetratricopeptide repeat domain 39C 0.028
LOC100534739 hypothetical protein LOC100534739 0.027
rab11bb RAB11B, member RAS oncogene family, b 0.027
gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a 0.026
wnt8-2 wnt8-like protein 2 0.026
syne1a spectrin repeat containing, nuclear envelope 1a 0.026
vwf von Willebrand factor 0.026
psen1 presenilin 1 0.025
klf7l Kruppel-like factor 7 (ubiquitous), like 0.025
zgc:165539 zgc:165539 0.025
si:ch73-90k17.1 si:ch73-90k17.1 0.025
prkcz protein kinase C, zeta 0.025
tgfb1a transforming growth factor, beta 1a 0.024
grk5 G protein-coupled receptor kinase 5 0.024
rad21 RAD21 homolog (S. pombe) 0.024
stx1b syntaxin 1B 0.024
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.024
rtcd1 RNA terminal phosphate cyclase domain 1 0.024
ptpn11b protein tyrosine phosphatase, non-receptor type 11, b 0.024
ntrk2b neurotrophic tyrosine kinase, receptor, type 2b 0.024
her12 hairy-related 12 0.024
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SNAP25 synaptosomal-associated protein, 25kDa 0.589
OCRL oculocerebrorenal syndrome of Lowe 0.368
SNAP23 synaptosomal-associated protein, 23kDa 0.165
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.059
FOXD3 forkhead box D3 0.050
JAG1 jagged 1 0.027
SOX2 SRY (sex determining region Y)-box 2 0.025
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.023
NOTCH3 notch 3 0.021
STX4 syntaxin 4 0.018
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.017
IRF2 interferon regulatory factor 2 0.016
HMGA1 high mobility group AT-hook 1 0.016
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 0.015
ANXA7 annexin A7 0.014
PICALM phosphatidylinositol binding clathrin assembly protein 0.011
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.011
LPHN1 latrophilin 1 0.011
BSN bassoon (presynaptic cytomatrix protein) 0.011
SYT1 synaptotagmin I 0.010
SRRM4 serine/arginine repetitive matrix 4 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.168
Snap25 synaptosomal-associated protein 25 0.088
Gnao1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.072
Unc5a unc-5 homolog A (C. elegans) 0.064
Stx1a syntaxin 1A (brain) 0.058
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.049
Rab3a RAB3A, member RAS oncogene family 0.046
Dlg4 discs, large homolog 4 (Drosophila) 0.044
Apba1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.040
Itgb1 integrin, beta 1 0.032
Grm2 glutamate receptor, metabotropic 2 0.032
Neurod2 neurogenic differentiation 2 0.031
Pdx1 pancreatic and duodenal homeobox 1 0.029
Sstr3 somatostatin receptor 3 0.029
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.029
Hpcal4 hippocalcin-like 4 0.028
Cplx1 complexin 1 0.027
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.025
Rims1 regulating synaptic membrane exocytosis 1 0.024
Kcnc3 potassium voltage gated channel, Shaw-related subfamily, member 3 0.023
Tnks2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.023
Camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.022
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.021
Gnaz guanine nucleotide binding protein (G protein), alpha z polypeptide 0.020
Tnr tenascin R 0.020
Cspg5 chondroitin sulfate proteoglycan 5 0.020
Oprl1 opiate receptor-like 1 0.019
Pnck pregnancy upregulated non-ubiquitously expressed CaM kinase 0.019
Ccbp2 chemokine binding protein 2 0.018
Lrrc7 leucine rich repeat containing 7 0.018
Nell1 NEL-like 1 (chicken) 0.017
Syn1 synapsin I 0.017
Gucy2f guanylate cyclase 2F 0.017
Freq frequenin homolog (Drosophila) 0.015
Syt11 synaptotagmin XI 0.015
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.015
Cartpt CART prepropeptide 0.014
Gck glucokinase 0.014
Prps1 phosphoribosyl pyrophosphate synthetase 1 0.014
Adra2c adrenergic, alpha-2C-, receptor 0.014
Sez6l2 seizure related 6 homolog (mouse)-like 2 0.014
Ube2d2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.014
Faim2 Fas apoptotic inhibitory molecule 2 0.013
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.013
Pcsk2 proprotein convertase subtilisin/kexin type 2 0.013
Sst somatostatin 0.013
Grid2 glutamate receptor, ionotropic, delta 2 0.013
Cntfr ciliary neurotrophic factor receptor 0.013
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.012
Tspyl1 TSPY-like 1 0.012
Nlgn3 neuroligin 3 0.012
Rbm3 RNA binding motif (RNP1, RRM) protein 3 0.012
Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.012
Mcf2l MCF.2 cell line derived transforming sequence-like 0.012
Crhbp corticotropin releasing hormone binding protein 0.012
St18 suppression of tumorigenicity 18 0.012
Adap1 ArfGAP with dual PH domains 1 0.012
Odf4 outer dense fiber of sperm tails 4 0.012
Ptch1 patched homolog 1 (Drosophila) 0.011
Slc16a8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.011
Syt7 synaptotagmin VII 0.011
Accn2 amiloride-sensitive cation channel 2, neuronal 0.011
Grm1 glutamate receptor, metabotropic 1 0.011
Sstr2 somatostatin receptor 2 0.011
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.011
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.011
RGD1562618 similar to RIKEN cDNA 6030419C18 gene 0.010
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.010
Elk3 ELK3, ETS-domain protein 0.010
Cryba2 crystallin, beta A2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism