The network for 'negative regulation of transcription regulatory region dna binding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transcription regulatory region dna binding

Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.

Rattus norvegicus
Name Description Probability Func Analog Organism
Cdh5 cadherin 5 0.446
Sox18 SRY (sex determining region Y)-box 18 0.176
Fgf1 fibroblast growth factor 1 0.147
Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 0.125
Sox7 SRY (sex determining region Y)-box 7 0.113
Gpr116 G protein-coupled receptor 116 0.107
Pou3f2 POU class 3 homeobox 2 0.105
Mef2d myocyte enhancer factor 2D 0.090
P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 0.087
Ptprh protein tyrosine phosphatase, receptor type, H 0.085
Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.080
Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 0.076
Mstn myostatin 0.067
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.066
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.057
Slc9a3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 0.055
Ppp1r3b protein phosphatase 1, regulatory (inhibitor) subunit 3B 0.053
Hes5 hairy and enhancer of split 5 (Drosophila) 0.049
Gja5 gap junction protein, alpha 5 0.049
Nos3 nitric oxide synthase 3, endothelial cell 0.049
Hnf4a hepatocyte nuclear factor 4, alpha 0.047
Acot12 acyl-CoA thioesterase 12 0.044
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.043
Fkbp3 FK506 binding protein 3 0.042
Mag myelin-associated glycoprotein 0.039
Cda cytidine deaminase 0.037
Trib1 tribbles homolog 1 (Drosophila) 0.036
Mybpc1 myosin binding protein C, slow type 0.036
Adra2b adrenergic, alpha-2B-, receptor 0.035
Thrb thyroid hormone receptor beta 0.035
Gata2 GATA binding protein 2 0.034
Gsk3a glycogen synthase kinase 3 alpha 0.034
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.034
Rdh2 retinol dehydrogenase 2 0.034
Hrg histidine-rich glycoprotein 0.033
G6pc glucose-6-phosphatase, catalytic subunit 0.032
Il1r1 interleukin 1 receptor, type I 0.031
Bok BCL2-related ovarian killer 0.030
Slc22a6 solute carrier family 22 (organic anion transporter), member 6 0.029
Acox3 acyl-Coenzyme A oxidase 3, pristanoyl 0.028
Acox2 acyl-Coenzyme A oxidase 2, branched chain 0.027
Espn espin 0.027
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.026
Capn9 calpain 9 0.026
Nlrp6 NLR family, pyrin domain containing 6 0.025
RGD1304644 similar to RIKEN cDNA 2310046K01 0.025
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.024
Muc4 mucin 4, cell surface associated 0.024
Dhdpsl dihydrodipicolinate synthase-like, mitochondrial 0.024
Ebna1bp2 EBNA1 binding protein 2 0.024
Olr837 olfactory receptor 837 0.023
Pklr pyruvate kinase, liver and RBC 0.023
Emcn endomucin 0.023
Rpl22l1 ribosomal protein L22 like 1 0.022
Tac2 tachykinin 2 0.022
Ttn titin 0.022
Nmu neuromedin U 0.022
Hipk3 homeodomain interacting protein kinase 3 0.021
Crybb1 crystallin, beta B1 0.021
Foxe3 forkhead box E3 0.021
Ppara peroxisome proliferator activated receptor alpha 0.021
Prlr prolactin receptor 0.021
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.020
Mpnd MPN domain containing 0.020
Acacb acetyl-Coenzyme A carboxylase beta 0.020
Esr1 estrogen receptor 1 0.020
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.020
Cga glycoprotein hormones, alpha polypeptide 0.020
Edn2 endothelin 2 0.020
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.020
Hr hairless 0.019
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.019
Slc22a3 solute carrier family 22 (extraneuronal monoamine transporter), member 3 0.019
Dao D-amino-acid oxidase 0.019
Tek TEK tyrosine kinase, endothelial 0.019
Hspa1l heat shock protein 1-like 0.019
Ppard peroxisome proliferator-activated receptor delta 0.018
Sox13 SRY (sex determining region Y)-box 13 0.018
Crct1 cysteine-rich C-terminal 1 0.018
Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 0.018
Mettl7b methyltransferase like 7B 0.018
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.018
Ppy pancreatic polypeptide 0.017
Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 0.017
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.017
Fmo1 flavin containing monooxygenase 1 0.017
Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.017
RGD1311634 similar to RIKEN cDNA 3200002M19 0.017
Akp3 alkaline phosphatase 3, intestine, not Mn requiring 0.017
Prkca protein kinase C, alpha 0.017
Tomm5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.017
Epas1 endothelial PAS domain protein 1 0.017
Pld1 phospholipase D1 0.017
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.017
Tpo thyroid peroxidase 0.017
Icam2 intercellular adhesion molecule 2 0.016
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.016
Pdcd5 programmed cell death 5 0.016
Mucdhl mucin and cadherin like 0.016
Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
per period 0.183
tim timeless 0.121
cry cryptochrome 0.046
osa CG7467 gene product from transcript CG7467-RD 0.026
Clk Clock 0.026
cwo clockwork orange 0.019
Adf1 Adh transcription factor 1 0.016
Ilp5 Insulin-like peptide 5 0.016
fas faint sausage 0.015
tlk Tousled-like kinase 0.014
l(2)k14505 lethal (2) k14505 0.014
Nf1 Neurofibromin 1 0.014
CG14966 CG14966 gene product from transcript CG14966-RA 0.013
Rdl Resistant to dieldrin 0.012
Fas3 Fasciclin 3 0.012
RpL19 Ribosomal protein L19 0.012
ns2 nucleostemin 2 0.012
RagA CG11968 gene product from transcript CG11968-RA 0.012
RpL24-like Ribosomal protein L24-like 0.011
CG9769 CG9769 gene product from transcript CG9769-RA 0.011
fru fruitless 0.011
Hsc70-3 Heat shock protein cognate 3 0.010
pdm2 POU domain protein 2 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
ZNF43 zinc finger protein 43 0.827
ZNF253 zinc finger protein 253 0.345
TAL1 T-cell acute lymphocytic leukemia 1 0.183
ZNF273 zinc finger protein 273 0.173
NCOR1 nuclear receptor corepressor 1 0.168
ZNF675 zinc finger protein 675 0.089
ZNF117 zinc finger protein 117 0.053
ZNF254 zinc finger protein 254 0.037
ZNF93 zinc finger protein 93 0.036
ZNF91 zinc finger protein 91 0.032
ZNF430 zinc finger protein 430 0.026
ZNF85 zinc finger protein 85 0.022
ZNF708 zinc finger protein 708 0.017
SKIL SKI-like oncogene 0.017
ANXA7 annexin A7 0.015
ZNF680 zinc finger protein 680 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Per2 period homolog 2 (Drosophila) 0.830
Cry2 cryptochrome 2 (photolyase-like) 0.813
Otx2 orthodenticle homolog 2 (Drosophila) 0.803
Pax2 paired box gene 2 0.673
Pitx2 paired-like homeodomain transcription factor 2 0.447
Pax6 paired box gene 6 0.373
Per1 period homolog 1 (Drosophila) 0.333
Gata4 GATA binding protein 4 0.250
Fgf8 fibroblast growth factor 8 0.207
Emx1 empty spiracles homolog 1 (Drosophila) 0.170
Hand1 heart and neural crest derivatives expressed transcript 1 0.163
Hand2 heart and neural crest derivatives expressed transcript 2 0.147
Emx2 empty spiracles homolog 2 (Drosophila) 0.142
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.105
Hes5 hairy and enhancer of split 5 (Drosophila) 0.084
Clock circadian locomotor output cycles kaput 0.077
Foxc2 forkhead box C2 0.076
Tcfap2a transcription factor AP-2, alpha 0.070
Cry1 cryptochrome 1 (photolyase-like) 0.068
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.065
Ntf3 neurotrophin 3 0.065
Atoh7 atonal homolog 7 (Drosophila) 0.051
Isl1 ISL1 transcription factor, LIM/homeodomain 0.047
Pou4f2 POU domain, class 4, transcription factor 2 0.038
Pax3 paired box gene 3 0.036
Gli3 GLI-Kruppel family member GLI3 0.036
Usp2 ubiquitin specific peptidase 2 0.033
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.032
Foxc1 forkhead box C1 0.031
Kiss1r KISS1 receptor 0.031
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.029
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.027
Osr1 odd-skipped related 1 (Drosophila) 0.026
Gsc goosecoid homeobox 0.026
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.025
Sox2 SRY-box containing gene 2 0.024
Eya1 eyes absent 1 homolog (Drosophila) 0.024
Tal1 T-cell acute lymphocytic leukemia 1 0.024
En1 engrailed 1 0.022
Mab21l2 mab-21-like 2 (C. elegans) 0.021
Coro1b coronin, actin binding protein 1B 0.020
Lef1 lymphoid enhancer binding factor 1 0.020
Sox10 SRY-box containing gene 10 0.019
Neurod1 neurogenic differentiation 1 0.019
Nodal nodal 0.018
Lhx1 LIM homeobox protein 1 0.018
Lhx9 LIM homeobox protein 9 0.017
Neurog2 neurogenin 2 0.016
Shh sonic hedgehog 0.016
Gbx2 gastrulation brain homeobox 2 0.016
Per3 period homolog 3 (Drosophila) 0.016
Ldb2 LIM domain binding 2 0.016
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.015
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.015
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.014
Msx2 homeobox, msh-like 2 0.014
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.013
Tbx3 T-box 3 0.012
Alx4 aristaless-like homeobox 4 0.011
Msx1 homeobox, msh-like 1 0.011
Dlx5 distal-less homeobox 5 0.011
Dlx2 distal-less homeobox 2 0.011
Lhx3 LIM homeobox protein 3 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism