The network for 'insulin secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

insulin secretion

The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin.

Rattus norvegicus
Name Description Probability Func Analog Organism
Glp1r glucagon-like peptide 1 receptor 0.262
Unc5a unc-5 homolog A (C. elegans) 0.204
Rgs9 regulator of G-protein signaling 9 0.156
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.122
Phkg1 phosphorylase kinase, gamma 1 0.122
Neurod2 neurogenic differentiation 2 0.117
Sebox SEBOX homeobox 0.100
Apoa4 apolipoprotein A-IV 0.097
Kcnk3 potassium channel, subfamily K, member 3 0.086
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.086
St18 suppression of tumorigenicity 18 0.085
Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.084
Gh1 growth hormone 1 0.083
Hipk3 homeodomain interacting protein kinase 3 0.080
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.080
Th tyrosine hydroxylase 0.077
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.076
Chrnb2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.073
Mapk10 mitogen activated protein kinase 10 0.072
Nfasc neurofascin 0.072
Sst somatostatin 0.072
Nr1i2 nuclear receptor subfamily 1, group I, member 2 0.072
Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 0.071
Pde3a phosphodiesterase 3A, cGMP inhibited 0.070
Rims1 regulating synaptic membrane exocytosis 1 0.069
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.067
Acsl4 acyl-CoA synthetase long-chain family member 4 0.065
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.061
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.060
Pnliprp2 pancreatic lipase-related protein 2 0.060
Dbp D site of albumin promoter (albumin D-box) binding protein 0.060
Pitx3 paired-like homeodomain 3 0.059
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.058
Unc13c unc-13 homolog C (C. elegans) 0.057
Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.056
Mertk c-mer proto-oncogene tyrosine kinase 0.056
Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.055
G6pc glucose-6-phosphatase, catalytic subunit 0.055
Slc22a6 solute carrier family 22 (organic anion transporter), member 6 0.055
Tmod2 tropomodulin 2 0.054
Iapp islet amyloid polypeptide 0.054
Gast gastrin 0.054
Aqp2 aquaporin 2 (collecting duct) 0.054
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.053
Gcgr glucagon receptor 0.052
Epm2aip1 EPM2A (laforin) interacting protein 1 0.052
Acot12 acyl-CoA thioesterase 12 0.052
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.052
Socs7 suppressor of cytokine signaling 7 0.051
Grm5 glutamate receptor, metabotropic 5 0.051
Bsn bassoon 0.051
Arrb1 arrestin, beta 1 0.051
Grm7 glutamate receptor, metabotropic 7 0.051
Hes3 hairy and enhancer of split 3 (Drosophila) 0.051
Crhbp corticotropin releasing hormone binding protein 0.050
Rnf208 ring finger protein 208 0.049
Avp arginine vasopressin 0.049
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.049
Ptprh protein tyrosine phosphatase, receptor type, H 0.049
Mef2d myocyte enhancer factor 2D 0.049
Camk2g calcium/calmodulin-dependent protein kinase II gamma 0.047
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.047
Lifr leukemia inhibitory factor receptor alpha 0.047
Synj1 synaptojanin 1 0.046
Ins2 insulin 2 0.046
Gck glucokinase 0.046
Trpm8 transient receptor potential cation channel, subfamily M, member 8 0.046
Kcnn3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 0.046
Accn2 amiloride-sensitive cation channel 2, neuronal 0.045
Notch4 Notch homolog 4 (Drosophila) 0.045
LOC100362331 rCG59612-like 0.045
RT1-Ba RT1 class II, locus Ba 0.045
Vegp2 von Ebners gland protein 2 0.045
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.044
Rab3b RAB3B, member RAS oncogene family 0.044
Nos2 nitric oxide synthase 2, inducible 0.043
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.043
Hivep2 human immunodeficiency virus type I enhancer binding protein 2 0.043
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.043
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.042
RGD1565859 RGD1565859 0.042
Olr1654 olfactory receptor 1654 0.042
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.042
Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.042
Dnase1 deoxyribonuclease I 0.041
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.041
Mospd4 motile sperm domain containing 4 0.041
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.041
Sox17 SRY (sex determining region Y)-box 17 0.041
Mpp3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.041
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.041
Gad2 glutamate decarboxylase 2 0.040
Flt1 FMS-related tyrosine kinase 1 0.040
Spock1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.040
Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.040
Crhr2 corticotropin releasing hormone receptor 2 0.040
Sstr2 somatostatin receptor 2 0.040
Myl7 myosin, light chain 7, regulatory 0.040
Thrb thyroid hormone receptor beta 0.039
Ucn urocortin 0.039
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
elt-6 Protein ELT-6 0.024
egl-18 Protein EGL-18 0.021
T27A3.1 Protein T27A3.1 0.016
unc-43 Protein UNC-43 0.016
kin-29 Protein KIN-29 0.016
K04F10.1 Protein K04F10.1 0.015
flt-1 Protein FLT-1 0.015
unc-9 Protein UNC-9 0.015
eat-4 Protein EAT-4 0.015
C06G3.5 Protein C06G3.5 0.015
unc-32 Protein UNC-32 0.015
got-2.2 Protein GOT-2.2 0.015
rsd-3 Protein RSD-3 0.014
F53F10.2 Protein F53F10.2 0.014
unc-104 Protein UNC-104 0.014
eat-6 Protein EAT-6 0.014
egl-8 Protein EGL-8 0.013
nrx-1 Protein NRX-1 0.013
lit-1 Protein LIT-1 0.013
tkt-1 Protein TKT-1 0.013
fox-1 Protein FOX-1 0.013
flh-2 Protein FLH-2 0.013
F54G2.1 Protein F54G2.1 0.013
lst-2 Protein LST-2 0.013
ant-1.1 Protein ANT-1.1 0.013
CELE_F10G7.5 Protein F10G7.5 0.012
ztf-27 Protein ZTF-27 0.012
C33A11.1 Protein C33A11.1 0.012
alh-4 Protein ALH-4 0.012
eya-1 Protein EYA-1 0.012
lin-48 Protein LIN-48 0.012
mth-2 Protein MTH-2 0.012
ref-1 Protein REF-1 0.012
nhr-14 Protein NHR-14 0.012
mel-11 Protein MEL-11 0.011
ten-1 Protein TEN-1 0.011
crt-1 Protein CRT-1 0.011
F55H12.3 Protein F55H12.3 0.011
osm-6 Protein OSM-6 0.011
svh-2 Protein SVH-2 0.011
nlp-16 Protein NLP-16 0.011
glr-4 Protein GLR-4 0.011
F28E10.1 Protein F28E10.1 0.011
gly-5 Protein GLY-5 0.011
aldo-2 Protein ALDO-2 0.011
magi-1 Protein MAGI-1 0.011
tag-250 Protein TAG-250 0.011
CELE_Y64G10A.6 Protein Y64G10A.6 0.011
daf-12 Protein DAF-12 0.011
F01G4.6 Protein F01G4.6 0.010
unc-94 Protein UNC-94 0.010
trp-1 Protein TRP-1 0.010
CELE_Y41E3.3 Protein Y41E3.3 0.010
ist-1 Protein IST-1 0.010
tbb-4 Protein TBB-4 0.010
cnt-2 Protein CNT-2 0.010
C34F6.10 Protein C34F6.10 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
wit wishful thinking 0.037
shn schnurri 0.026
Actbeta Activin-beta 0.019
CaMKII Calcium/calmodulin-dependent protein kinase II 0.016
trio CG18214 gene product from transcript CG18214-RA 0.015
Plc21C Phospholipase C at 21C 0.014
tim timeless 0.013
bsk basket 0.011
Dat Dopamine N acetyltransferase 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.863
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.772
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.707
PDX1 pancreatic and duodenal homeobox 1 0.562
CREBBP CREB binding protein 0.445
SREBF2 sterol regulatory element binding transcription factor 2 0.408
SNAP23 synaptosomal-associated protein, 23kDa 0.369
CCR5 chemokine (C-C motif) receptor 5 0.352
GRB2 growth factor receptor-bound protein 2 0.349
CCL4 chemokine (C-C motif) ligand 4 0.331
IL1R1 interleukin 1 receptor, type I 0.315
CCNY cyclin Y 0.310
KCNE1 potassium voltage-gated channel, Isk-related family, member 1 0.309
HNF4A hepatocyte nuclear factor 4, alpha 0.303
LIN7B lin-7 homolog B (C. elegans) 0.295
HCK hemopoietic cell kinase 0.231
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.230
INSR insulin receptor 0.211
GRB10 growth factor receptor-bound protein 10 0.210
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.209
CAPNS1 calpain, small subunit 1 0.173
MT1A metallothionein 1A 0.163
ADORA2A adenosine A2a receptor 0.160
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.143
CRHR1 corticotropin releasing hormone receptor 1 0.143
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.126
IGF1R insulin-like growth factor 1 receptor 0.124
KAT2B K(lysine) acetyltransferase 2B 0.123
NOSTRIN nitric oxide synthase trafficker 0.120
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.113
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.112
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.107
MPDZ multiple PDZ domain protein 0.102
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.097
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.096
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.096
ONECUT1 one cut homeobox 1 0.094
SNAP25 synaptosomal-associated protein, 25kDa 0.092
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.091
SH2B1 SH2B adaptor protein 1 0.091
CXCL9 chemokine (C-X-C motif) ligand 9 0.091
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.086
CXCL11 chemokine (C-X-C motif) ligand 11 0.085
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.081
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.080
HOXD12 homeobox D12 0.078
SOCS1 suppressor of cytokine signaling 1 0.076
CCL8 chemokine (C-C motif) ligand 8 0.071
CLASP1 cytoplasmic linker associated protein 1 0.071
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.068
UBQLN1 ubiquilin 1 0.067
HLA-DMA major histocompatibility complex, class II, DM alpha 0.064
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.063
KIF5B kinesin family member 5B 0.063
BLNK B-cell linker 0.063
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.063
GJD2 gap junction protein, delta 2, 36kDa 0.063
FYN FYN oncogene related to SRC, FGR, YES 0.062
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.062
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.061
SMAD3 SMAD family member 3 0.060
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.060
EP300 E1A binding protein p300 0.059
YY1 YY1 transcription factor 0.059
EGFR epidermal growth factor receptor 0.059
INCENP inner centromere protein antigens 135/155kDa 0.059
ESRRG estrogen-related receptor gamma 0.058
STX5 syntaxin 5 0.055
PSEN2 presenilin 2 (Alzheimer disease 4) 0.055
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.055
MTNR1A melatonin receptor 1A 0.054
IRF2 interferon regulatory factor 2 0.051
IL1R2 interleukin 1 receptor, type II 0.047
CCL13 chemokine (C-C motif) ligand 13 0.047
VAC14 Vac14 homolog (S. cerevisiae) 0.046
CCL2 chemokine (C-C motif) ligand 2 0.046
SMAD2 SMAD family member 2 0.045
CCL5 chemokine (C-C motif) ligand 5 0.045
HNF1B HNF1 homeobox B 0.044
POU4F2 POU class 4 homeobox 2 0.043
CDX2 caudal type homeobox 2 0.043
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.043
ARIH2 ariadne homolog 2 (Drosophila) 0.043
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.043
TGFBR1 transforming growth factor, beta receptor 1 0.042
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.042
GAB1 GRB2-associated binding protein 1 0.042
IDE insulin-degrading enzyme 0.042
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.041
PROX1 prospero homeobox 1 0.041
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.040
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.040
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.040
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.039
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.039
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.038
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.038
ARRB1 arrestin, beta 1 0.037
ATN1 atrophin 1 0.036
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.036
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Mus musculus
Name Description Probability Func Analog Organism
Clock circadian locomotor output cycles kaput 0.952
Gata4 GATA binding protein 4 0.950
Rarg retinoic acid receptor, gamma 0.947
Nf1 neurofibromatosis 1 0.934
Fgf8 fibroblast growth factor 8 0.932
Bglap bone gamma carboxyglutamate protein 0.929
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.922
Ctnnb1 catenin (cadherin associated protein), beta 1 0.899
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.893
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.878
Pax8 paired box gene 8 0.877
Fshr follicle stimulating hormone receptor 0.875
Bmp4 bone morphogenetic protein 4 0.873
Efnb2 ephrin B2 0.864
Axin1 axin 1 0.805
Cry2 cryptochrome 2 (photolyase-like) 0.789
Nos3 nitric oxide synthase 3, endothelial cell 0.785
Foxa2 forkhead box A2 0.778
Shh sonic hedgehog 0.777
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.759
Sox4 SRY-box containing gene 4 0.758
Pax3 paired box gene 3 0.752
Lhx3 LIM homeobox protein 3 0.740
Hes1 hairy and enhancer of split 1 (Drosophila) 0.725
Eya1 eyes absent 1 homolog (Drosophila) 0.713
Lepr leptin receptor 0.693
Fgfr2 fibroblast growth factor receptor 2 0.692
Insm1 insulinoma-associated 1 0.690
Gli3 GLI-Kruppel family member GLI3 0.681
Epha4 Eph receptor A4 0.668
Sox9 SRY-box containing gene 9 0.662
Fgfr1 fibroblast growth factor receptor 1 0.655
Lep leptin 0.650
Acvr2a activin receptor IIA 0.649
Foxc1 forkhead box C1 0.634
Jag1 jagged 1 0.632
Tgfb2 transforming growth factor, beta 2 0.627
Nodal nodal 0.622
Pitx2 paired-like homeodomain transcription factor 2 0.618
Meox2 mesenchyme homeobox 2 0.608
Esr1 estrogen receptor 1 (alpha) 0.592
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.591
Amhr2 anti-Mullerian hormone type 2 receptor 0.570
Ret ret proto-oncogene 0.547
Kiss1 KiSS-1 metastasis-suppressor 0.516
Smad6 MAD homolog 6 (Drosophila) 0.509
Sim1 single-minded homolog 1 (Drosophila) 0.509
Acvr1 activin A receptor, type 1 0.509
Smad3 MAD homolog 3 (Drosophila) 0.498
Cbln1 cerebellin 1 precursor protein 0.498
Pomc pro-opiomelanocortin-alpha 0.495
Nrxn1 neurexin I 0.484
Thrb thyroid hormone receptor beta 0.482
Gata5 GATA binding protein 5 0.481
Pdx1 pancreatic and duodenal homeobox 1 0.475
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.475
Isl1 ISL1 transcription factor, LIM/homeodomain 0.446
Fgf3 fibroblast growth factor 3 0.442
Pou3f3 POU domain, class 3, transcription factor 3 0.437
Apc adenomatosis polyposis coli 0.430
Eda ectodysplasin-A 0.426
Kl klotho 0.413
Per2 period homolog 2 (Drosophila) 0.411
Prox1 prospero-related homeobox 1 0.402
Prop1 paired like homeodomain factor 1 0.401
Lef1 lymphoid enhancer binding factor 1 0.396
Aldoa aldolase A, fructose-bisphosphate 0.396
Insr insulin receptor 0.386
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.383
Drd2 dopamine receptor D2 0.374
Bmpr1a bone morphogenetic protein receptor, type 1A 0.372
Vegfa vascular endothelial growth factor A 0.370
Pbx1 pre B-cell leukemia transcription factor 1 0.369
Chd7 chromodomain helicase DNA binding protein 7 0.364
Smo smoothened homolog (Drosophila) 0.363
Prlr prolactin receptor 0.361
Cry1 cryptochrome 1 (photolyase-like) 0.361
Ghr growth hormone receptor 0.361
Tgfa transforming growth factor alpha 0.361
Ephb2 Eph receptor B2 0.357
Otx2 orthodenticle homolog 2 (Drosophila) 0.353
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.353
Eng endoglin 0.335
Neurod1 neurogenic differentiation 1 0.332
Cckbr cholecystokinin B receptor 0.331
Wnt4 wingless-related MMTV integration site 4 0.331
Tgfbr2 transforming growth factor, beta receptor II 0.318
Pim3 proviral integration site 3 0.317
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.316
Ece1 endothelin converting enzyme 1 0.315
Pkm2 pyruvate kinase, muscle 0.313
Htt huntingtin 0.311
Gata6 GATA binding protein 6 0.308
Ahr aryl-hydrocarbon receptor 0.304
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.293
Tbx3 T-box 3 0.290
Fst follistatin 0.281
Nkx6-1 NK6 homeobox 1 0.279
LOC100048884 novel member of the major urinary protein (Mup) gene family 0.278
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.276
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism