The network for 'cartilage development involved in endochondral bone morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cartilage development involved in endochondral bone morphogenesis

The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.

Rattus norvegicus
Name Description Probability Func Analog Organism
Col3a1 collagen, type III, alpha 1 0.994
Col1a1 collagen, type I, alpha 1 0.992
Col1a2 collagen, type I, alpha 2 0.963
Col5a1 collagen, type V, alpha 1 0.925
Fstl1 follistatin-like 1 0.668
Col12a1 collagen, type XII, alpha 1 0.565
Col5a2 collagen, type V, alpha 2 0.497
Postn periostin, osteoblast specific factor 0.350
Eln elastin 0.305
Fbn1 fibrillin 1 0.289
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.189
Col6a2 collagen, type VI, alpha 2 0.169
Loxl1 lysyl oxidase-like 1 0.128
Col14a1 collagen, type XIV, alpha 1 0.095
Col15a1 collagen, type XV, alpha 1 0.090
Bgn biglycan 0.066
Ccdc80 coiled-coil domain containing 80 0.063
Lum lumican 0.058
Col4a5 collagen, type IV, alpha 5 0.055
Pcolce procollagen C-endopeptidase enhancer 0.052
Col4a1 collagen, type IV, alpha 1 0.051
Rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.043
Lox lysyl oxidase 0.040
Mia melanoma inhibitory activity 0.032
Srpx sushi-repeat-containing protein, X-linked 0.032
Dab2 disabled homolog 2 (Drosophila) 0.031
Fndc1 fibronectin type III domain containing 1 0.030
Leprel2 leprecan-like 2 0.029
Ggcx gamma-glutamyl carboxylase 0.028
Prl8a2 prolactin family 8, subfamily a, member 2 0.027
Fn1 fibronectin 1 0.027
Capn6 calpain 6 0.022
Msx1 msh homeobox 1 0.020
Col9a2 collagen, type IX, alpha 2 0.020
Lamc1 laminin, gamma 1 0.020
Cpz carboxypeptidase Z 0.020
Mmp23 matrix metallopeptidase 23 0.019
Nid2 nidogen 2 0.019
Tgfb3 transforming growth factor, beta 3 0.018
Mfap4 microfibrillar-associated protein 4 0.018
Scarf2 scavenger receptor class F, member 2 0.017
Myl9 myosin, light chain 9, regulatory 0.017
Col9a1 collagen, type IX, alpha 1 0.017
Col11a2 collagen, type XI, alpha 2 0.017
Fkbp10 FK506 binding protein 10 0.016
Agtr1a angiotensin II receptor, type 1a 0.016
Adk adenosine kinase 0.015
Col2a1 collagen, type II, alpha 1 0.015
Cercam cerebral endothelial cell adhesion molecule 0.015
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.015
Ibsp integrin-binding sialoprotein 0.015
Fbln5 fibulin 5 0.015
Ctsk cathepsin K 0.014
Rxra retinoid X receptor alpha 0.014
Slc12a3 solute carrier family 12 (sodium/chloride transporters), member 3 0.014
Syngr2 synaptogyrin 2 0.014
Suv420h2 suppressor of variegation 4-20 homolog 2 (Drosophila) 0.014
Fmod fibromodulin 0.014
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.013
Lect1 leukocyte cell derived chemotaxin 1 0.013
Tnc tenascin C 0.013
Bmp1 bone morphogenetic protein 1 0.013
Dnm3 dynamin 3 0.013
Chia chitinase, acidic 0.012
Rhoj ras homolog gene family, member J 0.012
Megf6 multiple EGF-like-domains 6 0.012
Aspn asporin 0.012
P4ha1 prolyl 4-hydroxylase, alpha polypeptide I 0.012
Chad chondroadherin 0.012
Arhgap28 Rho GTPase activating protein 28 0.012
Maged2 melanoma antigen, family D, 2 0.012
Acan aggrecan 0.012
Ng23 Ng23 protein 0.012
Znf692 zinc finger protein 692 0.012
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.012
Sox10 SRY (sex determining region Y)-box 10 0.011
Adrb1 adrenergic, beta-1-, receptor 0.011
Pthlh parathyroid hormone-like hormone 0.011
Pxdn peroxidasin homolog (Drosophila) 0.011
Fzd2 frizzled homolog 2 (Drosophila) 0.011
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.011
Stx3 syntaxin 3 0.010
Clcn2 chloride channel 2 0.010
Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6 0.010
Cish cytokine inducible SH2-containing protein 0.010
C1qtnf5 C1q and tumor necrosis factor related protein 5 0.010
Col11a1 collagen, type XI, alpha 1 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
notch1a notch homolog 1a 0.952
sox9a SRY-box containing gene 9a 0.831
foxi1 forkhead box I1 0.826
gli2a GLI-Kruppel family member GLI2a 0.755
jag1b jagged 1b 0.740
col5a1 procollagen, type V, alpha 1 0.682
twist2 twist2 0.485
wu:fv91b12 wu:fv91b12 0.449
sox10 SRY-box containing gene 10 0.438
dlb deltaB 0.367
prdm1a PR domain containing 1a, with ZNF domain 0.342
eya1 eyes absent homolog 1 0.322
ghra growth hormone receptor a 0.274
runx3 runt-related transcription factor 3 0.270
LOC100000500 sclerostin-like 0.241
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.234
foxi3a forkhead box I3a 0.232
tp63 tumor protein p63 0.227
col2a1a collagen type II, alpha-1a 0.211
cmn calymmin 0.194
tfe3b transcription factor binding to IGHM enhancer 3b 0.179
myf5 myogenic factor 5 0.160
col9a3 collagen, type IX, alpha 3 0.145
rbp4 retinol binding protein 4, plasma 0.144
foxa1 forkhead box A1 0.121
hoxa2b homeo box A2b 0.120
col1a2 collagen, type I, alpha 2 0.117
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.117
foxd3 forkhead box D3 0.116
dld deltaD 0.097
jag2 jagged 2 0.097
shha sonic hedgehog a 0.093
efnb2a ephrin B2a 0.087
gdf6a growth differentiation factor 6a 0.084
vwf von Willebrand factor 0.083
six4b sine oculis homeobox homolog 4b 0.082
foxc1a forkhead box C1a 0.082
ihhb Indian hedgehog homolog b 0.079
cdx4 caudal type homeo box transcription factor 4 0.069
hoxd10a homeo box D10a 0.068
ctgf connective tissue growth factor 0.067
hapln1a hyaluronan and proteoglycan link protein 1a 0.065
tbx24 T-box 24 0.064
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.063
col12a1 collagen, type XII, alpha 1 0.058
nkx3.2 NK3 homeobox 2 0.056
raraa retinoic acid receptor, alpha a 0.056
satb2 SATB homeobox 2 0.055
gbx1 gastrulation brain homeobox 1 0.054
hoxa10b homeo box A10b 0.053
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.049
snai2 snail homolog 2 (Drosophila) 0.048
twist1b twist1b 0.048
hoxd12a homeo box D12a 0.045
edn1 endothelin 1 0.045
pitx3 paired-like homeodomain transcription factor 3 0.044
col1a1a collagen, type I, alpha 1a 0.043
wnt11 wingless-type MMTV integration site family, member 11 0.042
col5a2l collagen, type V, alpha 2-like 0.041
barx1 BarH-like homeobox 1 0.040
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.038
mab21l2 mab-21-like 2 0.037
lhx1b LIM homeobox 1b 0.037
atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.037
foxi3b forkhead box I3b 0.037
il17rd interleukin 17 receptor D 0.036
pax8 paired box gene 8 0.035
notch3 notch homolog 3 0.035
dlc deltaC 0.034
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.033
ascl1a achaete-scute complex-like 1a (Drosophila) 0.033
myod1 myogenic differentiation 1 0.032
gbx2 gastrulation brain homeo box 2 0.032
hoxb2a homeo box B2a 0.031
col11a1a collagen, type XI, alpha 1a 0.030
matn4 matrilin 4 0.030
hoxb5a homeo box B5a 0.030
col10a1 collagen, type X, alpha 1 0.026
hoxd13a homeo box D13a 0.025
postn periostin, osteoblast specific factor 0.024
alx4b aristaless-like homeobox 4b 0.023
pdgfaa platelet-derived growth factor alpha a 0.023
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.023
barx2 BarH-like homeobox 2 0.023
plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.022
tead3a TEA domain family member 3 a 0.022
notch2 notch homolog 2 0.021
fgfrl1a fibroblast growth factor receptor-like 1a 0.021
ghrb growth hormone receptor b 0.021
hoxb3a homeo box B3a 0.020
dlx3b distal-less homeobox gene 3b 0.020
hoxa4a homeo box A4a 0.020
hoxa9b homeo box A9b 0.020
prl prolactin 0.019
dla deltaA 0.019
rxrga retinoid x receptor, gamma a 0.019
disp1 dispatched homolog 1 (Drosophila) 0.018
fgf3 fibroblast growth factor 3 0.018
angptl2 angiopoietin-like 2 0.018
bmp7b bone morphogenetic protein 7b 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RXRA retinoid X receptor, alpha 0.999
POU5F1 POU class 5 homeobox 1 0.974
NOTCH1 notch 1 0.933
PAX3 paired box 3 0.836
TGFB1 transforming growth factor, beta 1 0.817
NOTCH3 notch 3 0.776
MED25 mediator complex subunit 25 0.670
TGFB3 transforming growth factor, beta 3 0.543
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.518
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.497
ENG endoglin 0.462
VEGFA vascular endothelial growth factor A 0.424
PTPRB protein tyrosine phosphatase, receptor type, B 0.424
NRP1 neuropilin 1 0.395
FN1 fibronectin 1 0.367
SMAD7 SMAD family member 7 0.346
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.295
JAG1 jagged 1 0.280
CREBBP CREB binding protein 0.280
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.247
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.236
FSTL1 follistatin-like 1 0.219
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.215
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.174
NCOA1 nuclear receptor coactivator 1 0.166
IGFBP3 insulin-like growth factor binding protein 3 0.162
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.144
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.143
COL1A2 collagen, type I, alpha 2 0.141
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.129
NOTCH2 notch 2 0.128
MEOX2 mesenchyme homeobox 2 0.124
COL4A1 collagen, type IV, alpha 1 0.115
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.109
SOX2 SRY (sex determining region Y)-box 2 0.102
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.098
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.097
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.097
FOXD3 forkhead box D3 0.093
HMGA1 high mobility group AT-hook 1 0.092
DLL1 delta-like 1 (Drosophila) 0.088
SPOP speckle-type POZ protein 0.086
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.084
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.081
NOTCH2NL notch 2 N-terminal like 0.080
PIAS1 protein inhibitor of activated STAT, 1 0.080
COL6A1 collagen, type VI, alpha 1 0.077
FOXG1 forkhead box G1 0.075
HOXA10 homeobox A10 0.074
RXRB retinoid X receptor, beta 0.071
GRN granulin 0.070
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.067
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.067
BMP1 bone morphogenetic protein 1 0.067
PDGFA platelet-derived growth factor alpha polypeptide 0.064
TGFBR1 transforming growth factor, beta receptor 1 0.064
ADAM11 ADAM metallopeptidase domain 11 0.063
LOX lysyl oxidase 0.062
CDH5 cadherin 5, type 2 (vascular endothelium) 0.061
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.059
COL3A1 collagen, type III, alpha 1 0.057
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.054
QKI quaking homolog, KH domain RNA binding (mouse) 0.051
COL5A1 collagen, type V, alpha 1 0.050
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.049
COL7A1 collagen, type VII, alpha 1 0.049
EFNB2 ephrin-B2 0.046
MARCKSL1 MARCKS-like 1 0.046
SOCS2 suppressor of cytokine signaling 2 0.046
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.044
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.043
RXRG retinoid X receptor, gamma 0.042
FGFR1 fibroblast growth factor receptor 1 0.041
NID2 nidogen 2 (osteonidogen) 0.041
STC1 stanniocalcin 1 0.041
AXIN1 axin 1 0.040
FBLN2 fibulin 2 0.039
HOXD13 homeobox D13 0.039
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.039
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.038
MAML1 mastermind-like 1 (Drosophila) 0.036
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.036
DUSP7 dual specificity phosphatase 7 0.036
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.034
PGRMC1 progesterone receptor membrane component 1 0.033
KANK2 KN motif and ankyrin repeat domains 2 0.033
KHSRP KH-type splicing regulatory protein 0.033
MSX1 msh homeobox 1 0.032
IGFBP5 insulin-like growth factor binding protein 5 0.032
INSR insulin receptor 0.031
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.031
TWIST1 twist homolog 1 (Drosophila) 0.031
POU3F2 POU class 3 homeobox 2 0.031
COL11A1 collagen, type XI, alpha 1 0.029
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.028
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.028
INHBB inhibin, beta B 0.028
PTHLH parathyroid hormone-like hormone 0.027
SMAD4 SMAD family member 4 0.026
ARID1A AT rich interactive domain 1A (SWI-like) 0.026
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Mus musculus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 1.000
Tgfbr2 transforming growth factor, beta receptor II 0.999
Fgfr2 fibroblast growth factor receptor 2 0.999
Tgfb2 transforming growth factor, beta 2 0.998
Gli2 GLI-Kruppel family member GLI2 0.997
Fgfr1 fibroblast growth factor receptor 1 0.996
Foxc1 forkhead box C1 0.996
Bmp4 bone morphogenetic protein 4 0.995
Nos3 nitric oxide synthase 3, endothelial cell 0.992
Shh sonic hedgehog 0.992
Gli3 GLI-Kruppel family member GLI3 0.988
Fbn1 fibrillin 1 0.984
Prrx1 paired related homeobox 1 0.982
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.977
Fgfr3 fibroblast growth factor receptor 3 0.975
Sox9 SRY-box containing gene 9 0.971
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.967
Fgf8 fibroblast growth factor 8 0.944
Rarg retinoic acid receptor, gamma 0.935
Pax3 paired box gene 3 0.930
Col11a1 collagen, type XI, alpha 1 0.927
Twist2 twist homolog 2 (Drosophila) 0.926
Esr1 estrogen receptor 1 (alpha) 0.926
Pkd1 polycystic kidney disease 1 homolog 0.922
Chrd chordin 0.890
Runx2 runt related transcription factor 2 0.876
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.871
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.870
Prrx2 paired related homeobox 2 0.857
Acvr1 activin A receptor, type 1 0.821
Col2a1 collagen, type II, alpha 1 0.817
Hoxd11 homeobox D11 0.811
Rxra retinoid X receptor alpha 0.798
Smo smoothened homolog (Drosophila) 0.796
Pthlh parathyroid hormone-like peptide 0.791
Lox lysyl oxidase 0.776
Meox2 mesenchyme homeobox 2 0.775
Col1a2 collagen, type I, alpha 2 0.752
Foxc2 forkhead box C2 0.725
Hoxa11 homeobox A11 0.718
Dlx5 distal-less homeobox 5 0.711
Col3a1 collagen, type III, alpha 1 0.705
Col5a2 collagen, type V, alpha 2 0.705
Eln elastin 0.693
Vegfa vascular endothelial growth factor A 0.669
Hand2 heart and neural crest derivatives expressed transcript 2 0.651
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.637
Tbx1 T-box 1 0.633
Rara retinoic acid receptor, alpha 0.596
Smad3 MAD homolog 3 (Drosophila) 0.595
Col16a1 collagen, type XVI, alpha 1 0.577
Msx1 homeobox, msh-like 1 0.571
Col6a2 collagen, type VI, alpha 2 0.568
Npr2 natriuretic peptide receptor 2 0.553
Tcfap2a transcription factor AP-2, alpha 0.539
Gata4 GATA binding protein 4 0.528
Ctnnb1 catenin (cadherin associated protein), beta 1 0.515
Eya1 eyes absent 1 homolog (Drosophila) 0.507
Ctsk cathepsin K 0.497
Apc adenomatosis polyposis coli 0.445
Bmpr1a bone morphogenetic protein receptor, type 1A 0.439
Irs2 insulin receptor substrate 2 0.431
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.420
Pitx2 paired-like homeodomain transcription factor 2 0.414
Nodal nodal 0.411
Pax2 paired box gene 2 0.399
Egfr epidermal growth factor receptor 0.394
Col5a1 collagen, type V, alpha 1 0.373
Bmp7 bone morphogenetic protein 7 0.372
Pten phosphatase and tensin homolog 0.371
Smad7 MAD homolog 7 (Drosophila) 0.340
Hoxa3 homeobox A3 0.331
Ltbp2 latent transforming growth factor beta binding protein 2 0.327
Tgfbr1 transforming growth factor, beta receptor I 0.318
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.302
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.290
Grem1 gremlin 1 0.283
Mmp2 matrix metallopeptidase 2 0.262
Kiss1 KiSS-1 metastasis-suppressor 0.262
Tbx15 T-box 15 0.262
Thbs2 thrombospondin 2 0.254
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.243
Hoxa1 homeobox A1 0.224
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.219
Wisp1 WNT1 inducible signaling pathway protein 1 0.210
Smad4 MAD homolog 4 (Drosophila) 0.205
Col6a1 collagen, type VI, alpha 1 0.202
Hoxb3 homeobox B3 0.199
Fgfrl1 fibroblast growth factor receptor-like 1 0.186
Ednra endothelin receptor type A 0.183
Jag1 jagged 1 0.183
Msx2 homeobox, msh-like 2 0.178
Notch1 Notch gene homolog 1 (Drosophila) 0.177
Fbn2 fibrillin 2 0.177
Twist1 twist homolog 1 (Drosophila) 0.174
Dlx2 distal-less homeobox 2 0.173
Bmp5 bone morphogenetic protein 5 0.166
Fstl1 follistatin-like 1 0.165
Fgf9 fibroblast growth factor 9 0.164
En1 engrailed 1 0.163
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism