The network for 'regulation of angiogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of angiogenesis

Any process that modulates the frequency, rate or extent of angiogenesis.

Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl2 chemokine (C-C motif) ligand 2 0.580
Csf1 colony stimulating factor 1 (macrophage) 0.476
Il1rl1 interleukin 1 receptor-like 1 0.367
Hpx hemopexin 0.364
Fosl1 fos-like antigen 1 0.331
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.309
Mmp3 matrix metallopeptidase 3 0.284
Mdfic MyoD family inhibitor domain containing 0.207
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.204
Cga glycoprotein hormones, alpha polypeptide 0.197
Il6 interleukin 6 0.183
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.178
LOC60591 calcium-activated potassium channel beta subunit 0.176
Reg3g regenerating islet-derived 3 gamma 0.170
Crisp1 cysteine-rich secretory protein 1 0.167
Adora2a adenosine A2a receptor 0.161
Il1b interleukin 1 beta 0.158
Id3 inhibitor of DNA binding 3 0.154
Gzmk granzyme K 0.153
Hspa1a heat shock 70kD protein 1A 0.149
Fgfr2 fibroblast growth factor receptor 2 0.145
Fgf2 fibroblast growth factor 2 0.145
Alb albumin 0.144
Ccl3 chemokine (C-C motif) ligand 3 0.144
Ahsg alpha-2-HS-glycoprotein 0.143
Cpb2 carboxypeptidase B2 (plasma) 0.142
Il8rb interleukin 8 receptor, beta 0.135
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.135
Edn1 endothelin 1 0.134
Iapp islet amyloid polypeptide 0.130
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.120
Akr1c18 aldo-keto reductase family 1, member C18 0.118
Tacr1 tachykinin receptor 1 0.115
Selp selectin P 0.113
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.107
RGD1564327 similar to integrin alpha 8 0.105
Met met proto-oncogene 0.102
Cd4 Cd4 molecule 0.101
Cxcl2 chemokine (C-X-C motif) ligand 2 0.098
Pgf placental growth factor 0.097
Igh-6 immunoglobulin heavy chain 6 0.097
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.095
Mmp10 matrix metallopeptidase 10 0.095
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.093
Mmp9 matrix metallopeptidase 9 0.092
Col12a1 collagen, type XII, alpha 1 0.092
Ccr5 chemokine (C-C motif) receptor 5 0.090
Tpsab1 tryptase alpha/beta 1 0.089
Sell selectin L 0.089
Il4 interleukin 4 0.089
Myo1d myosin ID 0.087
Il2ra interleukin 2 receptor, alpha 0.084
Pld2 phospholipase D2 0.083
Cd200r1 CD200 receptor 1 0.083
Adam2 ADAM metallopeptidase domain 2 0.081
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.081
Gal galanin prepropeptide 0.080
Il7 interleukin 7 0.080
Cdh5 cadherin 5 0.079
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.078
Cmklr1 chemokine-like receptor 1 0.078
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.075
Cst8 cystatin 8 (cystatin-related epididymal specific) 0.073
Il9r interleukin 9 receptor 0.073
Sox7 SRY (sex determining region Y)-box 7 0.072
Prok2 prokineticin 2 0.071
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.071
Mmp13 matrix metallopeptidase 13 0.070
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.069
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.068
Calcb calcitonin-related polypeptide, beta 0.068
Cxcr5 chemokine (C-X-C motif) receptor 5 0.068
Prrx1 paired related homeobox 1 0.067
Gna15 guanine nucleotide binding protein, alpha 15 0.067
Nos3 nitric oxide synthase 3, endothelial cell 0.066
Cd80 Cd80 molecule 0.065
Gpr116 G protein-coupled receptor 116 0.065
Trim47 tripartite motif-containing 47 0.064
Klf4 Kruppel-like factor 4 (gut) 0.064
Rup2 urinary protein 2 0.063
Prkch protein kinase C, eta 0.063
Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M 0.063
LOC299282 Serine protease inhibitor 0.062
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.062
Bst1 bone marrow stromal cell antigen 1 0.061
Stip1 stress-induced phosphoprotein 1 0.061
Lamp2 lysosomal-associated membrane protein 2 0.060
Arl5c ADP-ribosylation factor-like 5C 0.059
Ptpre protein tyrosine phosphatase, receptor type, E 0.059
Calcrl calcitonin receptor-like 0.059
Itih3 inter-alpha trypsin inhibitor, heavy chain 3 0.059
Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 0.058
Has2 hyaluronan synthase 2 0.058
Orm1 orosomucoid 1 0.057
Il1rn interleukin 1 receptor antagonist 0.056
Pemt phosphatidylethanolamine N-methyltransferase 0.055
Cfp complement factor properdin 0.055
Smgb neonatal submandibular gland protein B 0.054
Rgs1 regulator of G-protein signaling 1 0.053
A1i3 alpha-1-inhibitor III 0.052
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
plcg1 phospholipase C, gamma 1 0.641
kdrl kinase insert domain receptor like 0.602
notch3 notch homolog 3 0.546
fbn2b fibrillin 2b 0.428
dll4 delta-like 4 (Drosophila) 0.337
efnb2a ephrin B2a 0.263
cdh5 cadherin 5 0.257
nrarpa notch-regulated ankyrin repeat protein a 0.239
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.178
fn1 fibronectin 1 0.176
nrp1a neuropilin 1a 0.153
foxn4 forkhead box N4 0.136
ephb4a eph receptor B4a 0.121
cxcr4a chemokine (C-X-C motif) receptor 4a 0.121
ccm2 cerebral cavernous malformation 2 0.118
vegfc vascular endothelial growth factor c 0.117
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.097
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.095
sulf1 sulfatase 1 0.092
tie2 endothelium-specific receptor tyrosine kinase 2 0.089
agtr2 angiotensin II receptor, type 2 0.086
dlc deltaC 0.084
etv2 ets variant gene 2 0.082
dla deltaA 0.082
plxnd1 plexin D1 0.078
ilk integrin linked kinase 0.077
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.069
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.067
krit1 KRIT1, ankyrin repeat containing 0.067
jag2 jagged 2 0.063
ptgs1 prostaglandin-endoperoxide synthase 1 0.062
col5a2l collagen, type V, alpha 2-like 0.062
hs6st2 heparan sulfate 6-O-sulfotransferase 2 0.061
lama5 laminin, alpha 5 0.058
dnd dead end 0.056
epas1b endothelial PAS domain protein 1b 0.053
hoxb5b homeo box B5b 0.052
dlb deltaB 0.050
calcrla calcitonin receptor-like a 0.048
antxr1 anthrax toxin receptor 1 0.047
irx3a iroquois homeobox protein 3a 0.047
tal1 T-cell acute lymphocytic leukemia 1 0.047
mcamb melanoma cell adhesion molecule b 0.047
wnt11r wingless-type MMTV integration site family, member 11, related 0.045
vegfaa vascular endothelial growth factor Aa 0.045
si:ch73-60e21.1 si:ch73-60e21.1 0.045
sox9a SRY-box containing gene 9a 0.045
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.044
tcf12 transcription factor 12 0.044
nf1a neurofibromin 1a 0.044
fsta follistatin a 0.043
sulf2 sulfatase 2 0.043
selp selectin P 0.041
bmp2b bone morphogenetic protein 2b 0.041
pdgfrb2 platelet derived growth factor receptor beta 2 0.040
neurod4 neurogenic differentiation 4 0.040
edn1 endothelin 1 0.040
nphs2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.039
col2a1a collagen type II, alpha-1a 0.038
traf4a tnf receptor-associated factor 4a 0.038
gli2a GLI-Kruppel family member GLI2a 0.038
hspa12b heat shock protein 12B 0.037
olig2 oligodendrocyte lineage transcription factor 2 0.036
nrp1b neuropilin 1b 0.036
ankrd6 ankyrin repeat domain 6 0.035
prdm16 PR domain containing 16 0.035
pitx3 paired-like homeodomain transcription factor 3 0.035
ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.035
sb:cb560 sb:cb560 0.035
thbs1 thrombospondin 1 0.034
pcdh18b protocadherin 18b 0.034
tbx20 T-box 20 0.033
fras1 Fraser syndrome 1 0.033
si:ch211-212m21.5 si:ch211-212m21.5 0.033
dlg2 discs, large (Drosophila) homolog 2 0.032
nrp2a neuropilin 2a 0.032
hlxb9la homeo box HB9 like a 0.032
dld deltaD 0.032
atoh8 atonal homolog 8 0.031
flt4 fms-related tyrosine kinase 4 0.031
olig4 oligodendrocyte transcription factor 4 0.031
hhex hematopoietically expressed homeobox 0.031
arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.031
acvrl1 activin A receptor type II-like 1 0.031
pax8 paired box gene 8 0.030
LOC796298 isotocin receptor-like 1 0.030
LOC100003514 protein kinase C alpha type-like 0.030
twist1a twist1a 0.029
tie1 endothelium-specific receptor tyrosine kinase 1 0.029
cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 0.028
gja3 gap junction protein, alpha 3 0.028
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.028
wt1b wilms tumor 1b 0.028
igf1ra insulin-like growth factor 1a receptor 0.028
ntn2 netrin 2 0.028
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.028
wt1a wilms tumor 1a 0.027
bty bloodthirsty 0.027
eng1a engrailed 1a 0.027
hoxb4a homeo box B4a 0.027
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.999
FAS Fas (TNF receptor superfamily, member 6) 0.986
FGFR2 fibroblast growth factor receptor 2 0.957
TEK TEK tyrosine kinase, endothelial 0.956
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.940
CCR5 chemokine (C-C motif) receptor 5 0.936
VEGFA vascular endothelial growth factor A 0.932
CAV1 caveolin 1, caveolae protein, 22kDa 0.925
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.914
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.911
FGFR1 fibroblast growth factor receptor 1 0.856
IL8 interleukin 8 0.835
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.830
LAT linker for activation of T cells 0.829
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.820
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.797
TAL1 T-cell acute lymphocytic leukemia 1 0.793
PLAUR plasminogen activator, urokinase receptor 0.765
PLCG1 phospholipase C, gamma 1 0.756
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.753
CXCL2 chemokine (C-X-C motif) ligand 2 0.722
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.704
JAG1 jagged 1 0.699
PECAM1 platelet/endothelial cell adhesion molecule 0.686
HOXB5 homeobox B5 0.674
FGF1 fibroblast growth factor 1 (acidic) 0.654
MET met proto-oncogene (hepatocyte growth factor receptor) 0.652
PLAU plasminogen activator, urokinase 0.646
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.636
CDH5 cadherin 5, type 2 (vascular endothelium) 0.619
TIMP3 TIMP metallopeptidase inhibitor 3 0.600
THBS1 thrombospondin 1 0.580
NOTCH1 notch 1 0.578
SKIL SKI-like oncogene 0.553
RUNX1 runt-related transcription factor 1 0.534
CYR61 cysteine-rich, angiogenic inducer, 61 0.527
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.517
DUSP1 dual specificity phosphatase 1 0.508
IL2RB interleukin 2 receptor, beta 0.507
KLF4 Kruppel-like factor 4 (gut) 0.503
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.496
JUN jun proto-oncogene 0.495
EGFR epidermal growth factor receptor 0.493
PRKCA protein kinase C, alpha 0.490
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.474
CAV2 caveolin 2 0.473
COL4A1 collagen, type IV, alpha 1 0.458
COL4A2 collagen, type IV, alpha 2 0.457
YAP1 Yes-associated protein 1 0.448
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.442
DAXX death-domain associated protein 0.418
STAT1 signal transducer and activator of transcription 1, 91kDa 0.400
CCL5 chemokine (C-C motif) ligand 5 0.397
TGFB1 transforming growth factor, beta 1 0.395
MEF2C myocyte enhancer factor 2C 0.389
FGA fibrinogen alpha chain 0.383
IL6 interleukin 6 (interferon, beta 2) 0.381
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.368
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.366
COL5A1 collagen, type V, alpha 1 0.363
IL4R interleukin 4 receptor 0.361
CREBBP CREB binding protein 0.361
ANGPT2 angiopoietin 2 0.350
ANXA5 annexin A5 0.347
EFNA1 ephrin-A1 0.337
BCL6 B-cell CLL/lymphoma 6 0.325
EP300 E1A binding protein p300 0.323
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.320
CXCL5 chemokine (C-X-C motif) ligand 5 0.315
CCL20 chemokine (C-C motif) ligand 20 0.306
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.298
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.295
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.286
SLA Src-like-adaptor 0.273
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.273
STAB1 stabilin 1 0.272
COL6A1 collagen, type VI, alpha 1 0.264
TJP1 tight junction protein 1 (zona occludens 1) 0.264
PBX1 pre-B-cell leukemia homeobox 1 0.262
CD34 CD34 molecule 0.260
CCL2 chemokine (C-C motif) ligand 2 0.260
LMO2 LIM domain only 2 (rhombotin-like 1) 0.258
IFNG interferon, gamma 0.257
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.255
FOS FBJ murine osteosarcoma viral oncogene homolog 0.250
CXCL3 chemokine (C-X-C motif) ligand 3 0.249
NOTCH3 notch 3 0.247
PDGFA platelet-derived growth factor alpha polypeptide 0.246
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.240
ENG endoglin 0.239
NRP1 neuropilin 1 0.239
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.234
FGF10 fibroblast growth factor 10 0.233
PPL periplakin 0.232
MEF2A myocyte enhancer factor 2A 0.219
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.216
HDAC7 histone deacetylase 7 0.215
GRB10 growth factor receptor-bound protein 10 0.215
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.214
RGS2 regulator of G-protein signaling 2, 24kDa 0.212
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Mus musculus
Name Description Probability Func Analog Organism
Pax2 paired box gene 2 0.991
Rarg retinoic acid receptor, gamma 0.978
Ccr2 chemokine (C-C motif) receptor 2 0.978
Col1a1 collagen, type I, alpha 1 0.967
Kdr kinase insert domain protein receptor 0.958
Csf1 colony stimulating factor 1 (macrophage) 0.949
Bmp4 bone morphogenetic protein 4 0.949
Lhx1 LIM homeobox protein 1 0.942
Vegfa vascular endothelial growth factor A 0.933
Wt1 Wilms tumor 1 homolog 0.910
Ccl2 chemokine (C-C motif) ligand 2 0.900
Tcf21 transcription factor 21 0.866
Foxc1 forkhead box C1 0.846
Fgfr2 fibroblast growth factor receptor 2 0.845
Gli3 GLI-Kruppel family member GLI3 0.834
Nos3 nitric oxide synthase 3, endothelial cell 0.826
Adm adrenomedullin 0.815
Nos2 nitric oxide synthase 2, inducible 0.802
Smad3 MAD homolog 3 (Drosophila) 0.795
Gata4 GATA binding protein 4 0.768
Selp selectin, platelet 0.757
Sox7 SRY-box containing gene 7 0.755
Twist2 twist homolog 2 (Drosophila) 0.754
Lepr leptin receptor 0.735
Pbx1 pre B-cell leukemia transcription factor 1 0.729
Apoe apolipoprotein E 0.724
Bmp5 bone morphogenetic protein 5 0.714
Trp53 transformation related protein 53 0.701
Acvrl1 activin A receptor, type II-like 1 0.701
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.697
Fzd1 frizzled homolog 1 (Drosophila) 0.694
Lyz2 lysozyme 2 0.691
Epha4 Eph receptor A4 0.688
Plat plasminogen activator, tissue 0.678
Adra2b adrenergic receptor, alpha 2b 0.675
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.671
Tgfbr2 transforming growth factor, beta receptor II 0.647
Flt1 FMS-like tyrosine kinase 1 0.643
Pten phosphatase and tensin homolog 0.642
Shh sonic hedgehog 0.637
Lox lysyl oxidase 0.624
Cxcl13 chemokine (C-X-C motif) ligand 13 0.613
Clock circadian locomotor output cycles kaput 0.609
Efnb2 ephrin B2 0.598
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.597
Foxf1a forkhead box F1a 0.583
Apc adenomatosis polyposis coli 0.582
Emx2 empty spiracles homolog 2 (Drosophila) 0.569
Nog noggin 0.562
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.557
Tgfbr3 transforming growth factor, beta receptor III 0.554
Hoxd13 homeobox D13 0.537
Epas1 endothelial PAS domain protein 1 0.533
Snai1 snail homolog 1 (Drosophila) 0.528
Pax3 paired box gene 3 0.513
Ccr1 chemokine (C-C motif) receptor 1 0.510
Ifng interferon gamma 0.507
Gata6 GATA binding protein 6 0.504
Npr3 natriuretic peptide receptor 3 0.501
Id3 inhibitor of DNA binding 3 0.492
C3 complement component 3 0.492
Myod1 myogenic differentiation 1 0.485
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.480
Ddr2 discoidin domain receptor family, member 2 0.464
Tgfb1 transforming growth factor, beta 1 0.450
Ephb2 Eph receptor B2 0.448
Cd7 CD7 antigen 0.448
Sox9 SRY-box containing gene 9 0.446
Fgf10 fibroblast growth factor 10 0.439
Prf1 perforin 1 (pore forming protein) 0.438
Htra3 HtrA serine peptidase 3 0.438
Eln elastin 0.436
Ccl3 chemokine (C-C motif) ligand 3 0.433
Smad6 MAD homolog 6 (Drosophila) 0.432
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.431
Upk3b uroplakin 3B 0.421
Stat3 signal transducer and activator of transcription 3 0.421
Gpc3 glypican 3 0.419
Cdh5 cadherin 5 0.415
Vhl von Hippel-Lindau tumor suppressor 0.414
Cyr61 cysteine rich protein 61 0.409
Sox17 SRY-box containing gene 17 0.407
Col4a3 collagen, type IV, alpha 3 0.406
Islr immunoglobulin superfamily containing leucine-rich repeat 0.405
Ptprb protein tyrosine phosphatase, receptor type, B 0.404
Fzd4 frizzled homolog 4 (Drosophila) 0.403
Pthlh parathyroid hormone-like peptide 0.401
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.396
Nrp1 neuropilin 1 0.394
Cav1 caveolin 1, caveolae protein 0.392
Epha3 Eph receptor A3 0.388
Adcy4 adenylate cyclase 4 0.388
Flt4 FMS-like tyrosine kinase 4 0.386
Ctnnb1 catenin (cadherin associated protein), beta 1 0.382
Folr2 folate receptor 2 (fetal) 0.378
Id1 inhibitor of DNA binding 1 0.372
Bnc1 basonuclin 1 0.370
C3ar1 complement component 3a receptor 1 0.369
Tlr2 toll-like receptor 2 0.368
Pax6 paired box gene 6 0.366
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism