The network for 'myelination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

myelination

The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.

Rattus norvegicus
Name Description Probability Func Analog Organism
Plp1 proteolipid protein 1 0.788
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.694
S100b S100 calcium binding protein B 0.579
Mag myelin-associated glycoprotein 0.466
Timp3 TIMP metallopeptidase inhibitor 3 0.448
Dbp D site of albumin promoter (albumin D-box) binding protein 0.439
Cd9 CD9 molecule 0.369
Mpz myelin protein zero 0.328
Mbp myelin basic protein 0.295
Ddr1 discoidin domain receptor tyrosine kinase 1 0.225
S100a6 S100 calcium binding protein A6 0.212
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.185
Pllp plasma membrane proteolipid (plasmolipin) 0.171
Serinc5 serine incorporator 5 0.168
Usf2 upstream transcription factor 2, c-fos interacting 0.166
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.148
Sel1l sel-1 suppressor of lin-12-like (C. elegans) 0.146
Plcl1 phospholipase C-like 1 0.140
Rabep1 rabaptin, RAB GTPase binding effector protein 1 0.133
Anxa5 annexin A5 0.129
Hspb2 heat shock protein beta 2 0.127
Egr1 early growth response 1 0.124
Gata6 GATA binding protein 6 0.123
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.106
Bcl2 B-cell CLL/lymphoma 2 0.104
Ptch1 patched homolog 1 (Drosophila) 0.102
Acbd5 acyl-Coenzyme A binding domain containing 5 0.088
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.087
RT1-DOa RT1 class II, locus DOa 0.087
Fasn fatty acid synthase 0.086
Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.085
Ugt8 UDP glycosyltransferase 8 0.081
Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.077
Apod apolipoprotein D 0.077
Pcyox1 prenylcysteine oxidase 1 0.069
Rara retinoic acid receptor, alpha 0.069
Ids iduronate 2-sulfatase 0.069
Tmod2 tropomodulin 2 0.068
Fgfr1 Fibroblast growth factor receptor 1 0.068
Epn1 Epsin 1 0.067
P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 0.067
Tagln2 transgelin 2 0.066
Neurod2 neurogenic differentiation 2 0.063
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.063
Asmt acetylserotonin O-methyltransferase 0.063
Pmp22 peripheral myelin protein 22 0.063
Myh4 myosin, heavy chain 4, skeletal muscle 0.061
Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 0.061
Srebf1 sterol regulatory element binding transcription factor 1 0.060
Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) 0.057
Tspan2 tetraspanin 2 0.057
Cav1 caveolin 1, caveolae protein 0.057
Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase 0.056
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.056
Ppp1r3b protein phosphatase 1, regulatory (inhibitor) subunit 3B 0.055
Zmym4 zinc finger, MYM-type 4 0.055
Slc22a2 solute carrier family 22 (organic cation transporter), member 2 0.054
Syt3 synaptotagmin III 0.053
Serinc3 serine incorporator 3 0.053
Scn7a sodium channel, voltage-gated, type VII, alpha 0.053
Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 0.052
Dgkb diacylglycerol kinase, beta 0.051
Ntf3 neurotrophin 3 0.050
Gpr37 G protein-coupled receptor 37 0.049
Tm4sf1 transmembrane 4 L six family member 1 0.049
Unc5b unc-5 homolog B (C. elegans) 0.049
Dchs1 dachsous 1 (Drosophila) 0.049
Triobp TRIO and F-actin binding protein 0.048
Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.048
Afap1l2 actin filament associated protein 1-like 2 0.048
Ifna1 interferon-alpha 1 0.047
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.046
Bmp6 bone morphogenetic protein 6 0.046
Prkcd protein kinase C, delta 0.046
Tmie transmembrane inner ear 0.045
Slc48a1 solute carrier family 48 (heme transporter), member 1 0.045
Csda cold shock domain protein A 0.045
Rhob ras homolog gene family, member B 0.044
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.044
Myo6 myosin VI 0.044
Fam69b family with sequence similarity 69, member B 0.044
Lpar1 lysophosphatidic acid receptor 1 0.044
Fgfr2 fibroblast growth factor receptor 2 0.044
Cplx2 complexin 2 0.043
Mthfr methylenetetrahydrofolate reductase (NAD(P)H) 0.043
Nr3c2 nuclear receptor subfamily 3, group C, member 2 0.043
Pgm3 phosphoglucomutase 3 0.042
Klf4 Kruppel-like factor 4 (gut) 0.041
Lect1 leukocyte cell derived chemotaxin 1 0.041
Fry furry homolog (Drosophila) 0.040
Olfml2b olfactomedin-like 2B 0.040
Pdpn podoplanin 0.040
Mmp2 matrix metallopeptidase 2 0.039
Fkbp4 FK506 binding protein 4 0.039
Tff1 trefoil factor 1 0.038
Ccnd3 cyclin D3 0.038
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.038
Dnase1l3 deoxyribonuclease 1-like 3 0.038
Ctf1 cardiotrophin 1 0.037
Clcn1 chloride channel 1 0.037
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.939
sox10 SRY-box containing gene 10 0.744
eya1 eyes absent homolog 1 0.573
nf1a neurofibromin 1a 0.546
gpm6aa glycoprotein M6Aa 0.540
notch3 notch homolog 3 0.512
six3b sine oculis homeobox homolog 3b 0.455
cdh2 cadherin 2, neuronal 0.454
tp63 tumor protein p63 0.381
dmd dystrophin 0.381
col2a1a collagen type II, alpha-1a 0.318
bnc2 basonuclin 2 0.303
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.287
egr1 early growth response 1 0.285
plp1a proteolipid protein 1a 0.281
nrg1 neuregulin 1 0.265
foxi3a forkhead box I3a 0.258
dlc deltaC 0.211
six3a sine oculis homeobox homolog 3a 0.209
her9 hairy-related 9 0.209
foxa2 forkhead box A2 0.198
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.196
neurod neurogenic differentiation 0.190
egr2b early growth response 2b 0.162
fabp7a fatty acid binding protein 7, brain, a 0.149
zgc:114181 zgc:114181 0.149
sox19a SRY-box containing gene 19a 0.148
dld deltaD 0.147
rxrga retinoid x receptor, gamma a 0.141
dpysl5a dihydropyrimidinase-like 5a 0.129
kbp kif1-binding protein 0.119
gpm6ba glycoprotein M6Ba 0.117
gpm6ab glycoprotein M6Ab 0.113
dnmt8 DNA (cytosine-5-)-methyltransferase 8 0.108
robo2 roundabout homolog 2 0.098
tfe3b transcription factor binding to IGHM enhancer 3b 0.097
nort notch-regulated transcript 0.097
foxj1a forkhead box J1a 0.093
cadm3 cell adhesion molecule 3 0.091
her12 hairy-related 12 0.091
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.090
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.086
lrp2 low density lipoprotein-related protein 2 0.085
gng13b guanine nucleotide binding protein (G protein), gamma 13b 0.084
notch1a notch homolog 1a 0.083
ascl1a achaete-scute complex-like 1a (Drosophila) 0.083
cdx4 caudal type homeo box transcription factor 4 0.081
mdka midkine-related growth factor 0.078
prom1b prominin 1 b 0.078
pax6b paired box gene 6b 0.076
nrarpa notch-regulated ankyrin repeat protein a 0.073
spna2 spectrin alpha 2 0.068
six2a sine oculis-related homeobox 2a 0.067
lrrc4.1 leucine rich repeat containing 4.1 0.064
hnf1bb HNF1 homeobox Bb 0.060
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.059
nhsl1a NHS-like 1a 0.058
hgfa hepatocyte growth factor a 0.058
eya2 eyes absent homolog 2 (Drosophila) 0.058
otx2 orthodenticle homolog 2 0.057
jag1b jagged 1b 0.056
pax6a paired box gene 6a 0.056
emx1 empty spiracles homeobox 1 0.056
stmn1b stathmin 1b 0.054
dpysl3 dihydropyrimidinase-like 3 0.053
dla deltaA 0.052
foxj1b forkhead box J1b 0.052
prnprs3 prion protein, related sequence 3 0.051
lypd6 LY6/PLAUR domain containing 6 0.051
hsp90a.1 heat shock protein 90-alpha 1 0.050
met met proto-oncogene (hepatocyte growth factor receptor) 0.048
rarga retinoic acid receptor gamma a 0.048
mmp2 matrix metalloproteinase 2 0.048
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.046
sox21b SRY-box containing gene 21 b 0.046
unc5b unc-5 homolog B (C. elegans) 0.044
pou3f1 POU class 3 homeobox 1 0.043
pou3f3b POU class 3 homeobox 3b 0.043
olfm1b olfactomedin 1b 0.041
nrp2b neuropilin 2b 0.040
rorcb RAR-related orphan receptor C b 0.040
vcana versican a 0.039
nrp1a neuropilin 1a 0.039
dcn decorin 0.039
foxd3 forkhead box D3 0.039
ocrl oculocerebrorenal syndrome of Lowe 0.038
tuba8l3 tubulin, alpha 8 like 3 0.037
card14 caspase recruitment domain family, member 14 0.037
myo10l1 myosin X-like 1 0.036
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.036
cldn5a claudin 5a 0.036
efna3b ephrin A3b 0.036
zic6 zic family member 6 0.035
zbtb4 zinc finger and BTB domain containing 4 0.035
phox2a paired-like homeobox 2a 0.035
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.035
kif17 kinesin family member 17 0.033
furinb furin (paired basic amino acid cleaving enzyme) b 0.033
mllt11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.033
emp2 epithelial membrane protein 2 0.033
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RARA retinoic acid receptor, alpha 0.890
TSC2 tuberous sclerosis 2 0.458
TRAF2 TNF receptor-associated factor 2 0.348
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.299
TRAF5 TNF receptor-associated factor 5 0.237
MED25 mediator complex subunit 25 0.219
SOX10 SRY (sex determining region Y)-box 10 0.161
NCOA1 nuclear receptor coactivator 1 0.156
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.145
INADL InaD-like (Drosophila) 0.100
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.091
BTRC beta-transducin repeat containing 0.088
APP amyloid beta (A4) precursor protein 0.079
FGF1 fibroblast growth factor 1 (acidic) 0.078
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.067
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.065
PAX3 paired box 3 0.061
DMD dystrophin 0.055
TRADD TNFRSF1A-associated via death domain 0.055
JAM2 junctional adhesion molecule 2 0.050
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.037
TRAF1 TNF receptor-associated factor 1 0.036
ZMYND11 zinc finger, MYND-type containing 11 0.036
DIS3 DIS3 mitotic control homolog (S. cerevisiae) 0.032
TRAF3 TNF receptor-associated factor 3 0.032
YAP1 Yes-associated protein 1 0.031
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.027
UTRN utrophin 0.025
PSEN1 presenilin 1 0.023
RXRB retinoid X receptor, beta 0.023
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.022
MET met proto-oncogene (hepatocyte growth factor receptor) 0.020
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.020
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.019
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.019
TGFBR1 transforming growth factor, beta receptor 1 0.018
RXRA retinoid X receptor, alpha 0.017
ENG endoglin 0.016
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.016
DTNA dystrobrevin, alpha 0.015
SPOP speckle-type POZ protein 0.015
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.015
ADAM17 ADAM metallopeptidase domain 17 0.014
CD81 CD81 molecule 0.014
PRKCZ protein kinase C, zeta 0.014
GLIS2 GLIS family zinc finger 2 0.014
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 0.013
CD63 CD63 molecule 0.013
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.013
CDH5 cadherin 5, type 2 (vascular endothelium) 0.012
JAM3 junctional adhesion molecule 3 0.012
EGFR epidermal growth factor receptor 0.012
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.012
BIRC3 baculoviral IAP repeat containing 3 0.012
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.012
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.012
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.011
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.011
CD40 CD40 molecule, TNF receptor superfamily member 5 0.011
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.011
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.986
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.980
Isl1 ISL1 transcription factor, LIM/homeodomain 0.974
Egr2 early growth response 2 0.957
Klk1b5 kallikrein 1-related peptidase b5 0.955
Tgfb2 transforming growth factor, beta 2 0.949
Apc adenomatosis polyposis coli 0.947
Otx2 orthodenticle homolog 2 (Drosophila) 0.917
Ntf3 neurotrophin 3 0.917
Emx1 empty spiracles homolog 1 (Drosophila) 0.917
Ctnnb1 catenin (cadherin associated protein), beta 1 0.915
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.915
Fgfr1 fibroblast growth factor receptor 1 0.885
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.882
Shh sonic hedgehog 0.856
Lef1 lymphoid enhancer binding factor 1 0.850
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.831
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.826
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.823
Sox2 SRY-box containing gene 2 0.817
Bdnf brain derived neurotrophic factor 0.788
Rarg retinoic acid receptor, gamma 0.781
Ret ret proto-oncogene 0.777
Klk1b21 kallikrein 1-related peptidase b21 0.771
Plp1 proteolipid protein (myelin) 1 0.748
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.723
Rxra retinoid X receptor alpha 0.723
Cd44 CD44 antigen 0.695
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.683
Fgf8 fibroblast growth factor 8 0.670
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.632
Sox9 SRY-box containing gene 9 0.629
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.624
Id3 inhibitor of DNA binding 3 0.584
Hand2 heart and neural crest derivatives expressed transcript 2 0.578
Pax6 paired box gene 6 0.569
Mobp myelin-associated oligodendrocytic basic protein 0.560
Id1 inhibitor of DNA binding 1 0.546
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.534
Nf1 neurofibromatosis 1 0.534
Jag1 jagged 1 0.533
Ugt8a UDP galactosyltransferase 8A 0.512
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.506
Tcf4 transcription factor 4 0.499
Ptgs2 prostaglandin-endoperoxide synthase 2 0.496
Pax2 paired box gene 2 0.486
Vegfa vascular endothelial growth factor A 0.486
Klk1b11 kallikrein 1-related peptidase b11 0.484
Pitx2 paired-like homeodomain transcription factor 2 0.481
Hes1 hairy and enhancer of split 1 (Drosophila) 0.476
Chd7 chromodomain helicase DNA binding protein 7 0.476
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.469
Ctrb1 chymotrypsinogen B1 0.460
Insm1 insulinoma-associated 1 0.459
Olig2 oligodendrocyte transcription factor 2 0.457
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.443
Lhx3 LIM homeobox protein 3 0.436
Pou3f3 POU domain, class 3, transcription factor 3 0.415
Sox10 SRY-box containing gene 10 0.413
Klk6 kallikrein related-peptidase 6 0.410
Stac2 SH3 and cysteine rich domain 2 0.405
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.403
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.402
Tjp1 tight junction protein 1 0.397
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.385
Nab2 Ngfi-A binding protein 2 0.381
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.371
Tff2 trefoil factor 2 (spasmolytic protein 1) 0.367
Hr hairless 0.366
Unc5c unc-5 homolog C (C. elegans) 0.366
Gad2 glutamic acid decarboxylase 2 0.364
Gata4 GATA binding protein 4 0.361
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.360
Grm1 glutamate receptor, metabotropic 1 0.359
Dcc deleted in colorectal carcinoma 0.358
Dlg4 discs, large homolog 4 (Drosophila) 0.358
Apoe apolipoprotein E 0.357
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.354
Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) 0.345
Mog myelin oligodendrocyte glycoprotein 0.342
Spp1 secreted phosphoprotein 1 0.331
Hif1a hypoxia inducible factor 1, alpha subunit 0.331
Scn5a sodium channel, voltage-gated, type V, alpha 0.329
Pou3f2 POU domain, class 3, transcription factor 2 0.327
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.324
2210010C04Rik RIKEN cDNA 2210010C04 gene 0.322
Lta lymphotoxin A 0.320
Pax8 paired box gene 8 0.318
Klk1b26 kallikrein 1-related petidase b26 0.316
Gli3 GLI-Kruppel family member GLI3 0.316
Nrg1 neuregulin 1 0.313
Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) 0.312
Hexa hexosaminidase A 0.312
Npas3 neuronal PAS domain protein 3 0.310
Lhx1 LIM homeobox protein 1 0.308
Tlr4 toll-like receptor 4 0.305
Pax3 paired box gene 3 0.305
Prnp prion protein 0.302
Klk1 kallikrein 1 0.295
Gpr37l1 G protein-coupled receptor 37-like 1 0.293
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism