The network for 'macromolecule localization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

macromolecule localization

Any process in which a macromolecule is transported to, or maintained in, a specific location.

Danio rerio
Name Description Probability Func Analog Organism
pkd2 polycystic kidney disease 2 0.788
sox3 SRY-box containing gene 3 0.595
nanos3 nanos homolog 3 0.337
raraa retinoic acid receptor, alpha a 0.327
alcamb activated leukocyte cell adhesion molecule b 0.311
tpm4 tropomyosin 4 0.289
gpia glucose phosphate isomerase a 0.255
cnn2 calponin 2 0.247
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.227
flot2a flotillin 2a 0.220
rpl13a ribosomal protein L13a 0.208
wnt4a wingless-type MMTV integration site family, member 4a 0.192
cx39.9 connexin 39.9 0.184
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.178
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.175
anxa1a annexin A1a 0.175
rab1a RAB1A, member RAS oncogene family 0.175
shha sonic hedgehog a 0.173
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.162
lef1 lymphocyte enhancer binding factor 1 0.152
trim3a tripartite motif-containing 3a 0.147
cdh1 cadherin 1, epithelial 0.146
arpc5a actin related protein 2/3 complex, subunit 5A 0.142
col8a1a collagen, type VIII, alpha 1a 0.140
egr1 early growth response 1 0.138
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.138
dlg1 discs, large (Drosophila) homolog 1 0.138
strap serine/threonine kinase receptor associated protein 0.134
fezf2 FEZ family zinc finger 2 0.134
mib mind bomb 0.133
fgfr1a fibroblast growth factor receptor 1a 0.130
ccnb1 cyclin B1 0.124
oprm1 opioid receptor, mu 1 0.123
ccm2 cerebral cavernous malformation 2 0.121
prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.120
efnb2a ephrin B2a 0.119
psen1 presenilin 1 0.119
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.118
s1pr2 sphingosine-1-phosphate receptor 2 0.118
wnt11r wingless-type MMTV integration site family, member 11, related 0.118
has2 hyaluronan synthase 2 0.118
wls wntless homolog (Drosophila) 0.117
per2 period homolog 2 (Drosophila) 0.115
si:dkey-8l13.4 si:dkey-8l13.4 0.115
ef1a elongation factor 1-alpha 0.114
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.112
sec23a Sec23 homolog A (S. cerevisiae) 0.110
dag1 dystroglycan 1 0.108
si:dkey-228g21.4 si:dkey-228g21.4 0.107
fhla four and a half LIM domains a 0.105
nkx2.2a NK2 transcription factor related 2a 0.104
tfec transcription factor EC 0.102
sept2 septin 2 0.101
stm starmaker 0.101
plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.101
atp1b3b ATPase, Na+/K+ transporting, beta 3b polypeptide 0.101
ssrp1a structure specific recognition protein 1a 0.100
wnt11 wingless-type MMTV integration site family, member 11 0.099
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.099
grhl2b grainyhead-like 2b (Drosophila) 0.098
eif3ha eukaryotic translation initiation factor 3, subunit H, a 0.098
pob partial optokinetic response b 0.097
mef2a myocyte enhancer factor 2a 0.096
pparg peroxisome proliferator activated receptor gamma 0.095
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.094
copa coatomer protein complex, subunit alpha 0.094
acvr1b activin A receptor, type IB 0.093
fgf3 fibroblast growth factor 3 0.092
ube2na ubiquitin-conjugating enzyme E2Na 0.091
rarab retinoic acid receptor, alpha b 0.090
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.090
fzd7b frizzled homolog 7b 0.089
ywhag1 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1 0.089
atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 0.088
chd7 chromodomain helicase DNA binding protein 7 0.087
prrc1 proline-rich coiled-coil 1 0.086
pax7a paired box gene 7a 0.086
cct7 chaperonin containing TCP1, subunit 7 (eta) 0.086
traf4a tnf receptor-associated factor 4a 0.085
pabpc1a poly A binding protein, cytoplasmic 1 a 0.085
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.085
esr2b estrogen receptor 2b 0.084
rag1 recombination activating gene 1 0.084
yap1 Yes-associated protein 1 0.083
igf1 insulin-like growth factor 1 0.082
elk4 ELK4, ETS-domain protein 0.082
axin1 axin 1 0.081
nup50 nucleoporin 50 0.080
satb2 SATB homeobox 2 0.080
ptbp1a polypyrimidine tract binding protein 1a 0.080
pbx4 pre-B-cell leukemia transcription factor 4 0.080
adcyap1a adenylate cyclase activating polypeptide 1a 0.078
ptmaa prothymosin, alpha a 0.078
krt4 keratin 4 0.077
slit3 slit (Drosophila) homolog 3 0.077
ncor1 nuclear receptor co-repressor 1 0.076
st3gal2l ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like 0.076
wnt10a wingless-type MMTV integration site family, member 10a 0.076
atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.076
notch2 notch homolog 2 0.076
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
goa-1 Protein GOA-1 0.369
mig-5 Protein MIG-5 0.360
atn-1 Protein ATN-1 0.341
vab-3 Protein VAB-3 0.333
egl-18 Protein EGL-18 0.315
chc-1 Protein CHC-1 0.312
unc-83 Protein UNC-83 0.308
nhr-45 Protein NHR-45 0.307
D1081.8 Protein D1081.8 0.296
ubq-1 Protein UBQ-1 0.285
rpl-4 Protein RPL-4 0.284
unc-112 Protein UNC-112 0.282
unc-104 Protein UNC-104 0.279
rskn-2 Protein RSKN-2 0.261
acy-1 Protein ACY-1 0.259
abt-4 Protein ABT-4 0.258
nphp-4 Protein NPHP-4 0.256
unc-52 Protein UNC-52 0.256
egl-8 Protein EGL-8 0.256
vha-8 Protein VHA-8 0.253
egl-44 Protein EGL-44 0.249
sma-6 Protein SMA-6 0.247
viln-1 Protein VILN-1 0.233
prg-1 Protein PRG-1 0.233
mut-16 Protein MUT-16 0.230
sar-1 Protein SAR-1 0.230
pat-3 Protein PAT-3 0.229
xpo-2 Protein XPO-2 0.227
plc-3 Protein PLC-3 0.226
bli-4 Protein BLI-4 0.226
sad-1 Protein SAD-1 0.226
egl-46 Protein EGL-46 0.226
npp-7 Protein NPP-7 0.224
glt-1 Protein GLT-1 0.224
ptr-14 Protein PTR-14 0.223
F08B12.1 Protein F08B12.1 0.222
T27A3.1 Protein T27A3.1 0.221
col-157 Protein COL-157 0.221
gld-1 Protein GLD-1 0.220
C05D11.7 Protein C05D11.7 0.218
sqt-1 Protein SQT-1 0.218
unc-6 Protein UNC-6 0.217
nstp-2 Protein NSTP-2 0.217
R166.2 Protein R166.2 0.216
dnc-2 Protein DNC-2 0.216
epg-4 Protein EPG-4 0.215
ima-2 Protein IMA-2 0.214
his-64 Protein HIS-64 0.212
sams-1 Protein SAMS-1 0.212
mua-6 Protein MUA-6 0.212
pes-7 Protein PES-7 0.210
pas-2 Protein PAS-2 0.210
hpo-28 Protein HPO-28 0.209
C46C11.3 Protein C46C11.3 0.207
sma-9 Protein SMA-9 0.206
ZC449.5 Protein ZC449.5 0.206
scd-1 Protein SCD-1 0.205
lin-36 Protein LIN-36 0.205
osm-5 Protein OSM-5 0.204
egl-21 Protein EGL-21 0.204
plc-1 Protein PLC-1 0.204
F19B6.1 Protein F19B6.1 0.201
unc-9 Protein UNC-9 0.201
pkg-1 Protein PKG-1 0.201
sem-4 Protein SEM-4 0.201
elt-6 Protein ELT-6 0.200
lag-1 Protein LAG-1 0.198
che-2 Protein CHE-2 0.198
mtm-3 Protein MTM-3 0.197
sas-4 Protein SAS-4 0.197
C10E2.6 Protein C10E2.6 0.197
glo-4 Protein GLO-4 0.197
lbp-2 Protein LBP-2 0.197
zyg-8 Protein ZYG-8 0.197
skr-2 Protein SKR-2 0.197
F57B10.4 Protein F57B10.4 0.196
abl-1 Protein ABL-1 0.196
set-1 Protein SET-1 0.196
unc-10 Protein UNC-10 0.196
C16D9.4 Protein C16D9.4 0.195
cyk-4 Protein CYK-4 0.195
mig-2 Protein MIG-2 0.195
egal-1 Protein EGAL-1 0.194
npp-1 Protein NPP-1 0.193
tol-1 Protein TOL-1 0.193
mcm-5 Protein MCM-5 0.193
col-117 Protein COL-117 0.193
pmk-3 Protein PMK-3 0.193
B0495.8 Protein B0495.8 0.193
Y54E5A.7 Protein Y54E5A.7 0.193
npp-19 Protein NPP-19 0.192
hlh-1 Protein HLH-1 0.192
col-180 Protein COL-180 0.192
camt-1 Protein CAMT-1 0.192
mat-3 Protein MAT-3 0.191
R90.1 Protein R90.1 0.191
let-268 Protein LET-268 0.191
cul-2 Protein CUL-2 0.191
egg-6 Protein EGG-6 0.190
chd-7 Protein CHD-7 0.190
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Pfn1 profilin 1 0.906
Dnm1l dynamin 1-like 0.796
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.709
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.662
Gria2 glutamate receptor, ionotropic, AMPA 2 0.657
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.651
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.638
Stip1 stress-induced phosphoprotein 1 0.634
Dynll1 dynein light chain LC8-type 1 0.634
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.623
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.581
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.561
Hsph1 heat shock 105/110 protein 1 0.560
Snap25 synaptosomal-associated protein 25 0.542
Cd44 Cd44 molecule 0.516
Stx1a syntaxin 1A (brain) 0.497
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.495
Ppp2r2c protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform 0.494
Rab6a RAB6A, member RAS oncogene family 0.492
Actb actin, beta 0.475
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.475
Rraga Ras-related GTP binding A 0.470
Syt4 synaptotagmin IV 0.467
Arpc1b actin related protein 2/3 complex, subunit 1B 0.455
Syngr2 synaptogyrin 2 0.454
Stx12 syntaxin 12 0.451
Dlg1 discs, large homolog 1 (Drosophila) 0.443
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.434
Pkia protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.430
Cd36 CD36 molecule (thrombospondin receptor) 0.429
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.427
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.425
Arf1 ADP-ribosylation factor 1 0.424
Wisp1 WNT1 inducible signaling pathway protein 1 0.409
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 0.408
Rhob ras homolog gene family, member B 0.403
Lmna lamin A 0.399
Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform 0.398
Nrxn1 neurexin 1 0.395
Stat6 signal transducer and activator of transcription 6 0.392
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.378
Nfia nuclear factor I/A 0.377
Mtpn myotrophin 0.377
Timp3 TIMP metallopeptidase inhibitor 3 0.373
Ptprc protein tyrosine phosphatase, receptor type, C 0.371
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.369
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.365
Cbs cystathionine beta synthase 0.364
Myl6l myosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like 0.358
Rhoa ras homolog gene family, member A 0.357
Kif1b kinesin family member 1B 0.356
Serpinb6a serine (or cysteine) peptidase inhibitor, clade B, member 6a 0.356
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.346
Prrx1 paired related homeobox 1 0.343
Jak1 Janus kinase 1 0.342
Myadm myeloid-associated differentiation marker 0.340
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.335
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.334
Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 0.329
Syn1 synapsin I 0.327
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.325
Ccl4 chemokine (C-C motif) ligand 4 0.318
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.317
S1pr2 sphingosine-1-phosphate receptor 2 0.316
Wdr1 WD repeat domain 1 0.315
Accn2 amiloride-sensitive cation channel 2, neuronal 0.314
Tpm3 tropomyosin 3, gamma 0.312
Wasl Wiskott-Aldrich syndrome-like 0.306
Ptafr platelet-activating factor receptor 0.299
Anxa2 annexin A2 0.298
Bglap bone gamma-carboxyglutamate (gla) protein 0.294
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.291
Ide insulin degrading enzyme 0.289
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.286
Ncan neurocan 0.285
Myo1c myosin IC 0.283
Mpeg1 macrophage expressed 1 0.283
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.282
Vps35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.279
Cast calpastatin 0.278
Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.277
Hnrnpf heterogeneous nuclear ribonucleoprotein F 0.277
Nlrp6 NLR family, pyrin domain containing 6 0.276
Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 0.270
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.270
Rap1b RAP1B, member of RAS oncogene family 0.268
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.268
Rab7a RAB7A, member RAS oncogene family 0.267
Picalm phosphatidylinositol binding clathrin assembly protein 0.265
RGD1560925 similar to 2610034M16Rik protein 0.265
Casp12 caspase 12 0.265
Eif4h eukaryotic translation initiation factor 4H 0.263
Mapk1 mitogen activated protein kinase 1 0.259
Ccr5 chemokine (C-C motif) receptor 5 0.257
Hp haptoglobin 0.256
Nras neuroblastoma ras oncogene 0.252
Ccl2 chemokine (C-C motif) ligand 2 0.252
Grip1 glutamate receptor interacting protein 1 0.251
Il1a interleukin 1 alpha 0.250
Wdfy1 WD repeat and FYVE domain containing 1 0.250
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism