Rattus norvegicus

0 known processes

Ch25h

cholesterol 25-hydroxylase

Ch25h biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to peptide hormone GO:0043434 278 0.107
regulation of cell proliferation GO:0042127 359 0.098
anatomical structure morphogenesis GO:0009653 298 0.096
positive regulation of developmental process GO:0051094 283 0.096
positive regulation of fever generation GO:0031622 5 0.095
regulation of nervous system development GO:0051960 264 0.085
response to peptide GO:1901652 292 0.083
positive regulation of neurogenesis GO:0050769 165 0.080
regulation of cell development GO:0060284 263 0.074
cellular response to lipid GO:0071396 201 0.074
t cell chemotaxis GO:0010818 2 0.069
inflammatory response GO:0006954 150 0.064
eosinophil chemotaxis GO:0048245 3 0.064
regulation of neurogenesis GO:0050767 247 0.064
aging GO:0007568 241 0.063
regulation of cytokine production GO:0001817 56 0.061
cellular response to oxygen containing compound GO:1901701 386 0.061
response to tumor necrosis factor GO:0034612 56 0.060
positive regulation of nervous system development GO:0051962 178 0.060
regulation of molecular function GO:0065009 398 0.055
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.055
regulation of phosphorus metabolic process GO:0051174 349 0.053
positive regulation of biosynthetic process GO:0009891 319 0.053
cellular amine metabolic process GO:0044106 38 0.053
regulation of cell differentiation GO:0045595 320 0.052
cellular amino acid metabolic process GO:0006520 107 0.052
amine metabolic process GO:0009308 38 0.051
positive regulation of cellular biosynthetic process GO:0031328 295 0.050
response to growth factor GO:0070848 189 0.049
regulation of multicellular organismal development GO:2000026 376 0.047
response to molecule of bacterial origin GO:0002237 194 0.046
immune system process GO:0002376 204 0.045
immune response GO:0006955 104 0.045
positive regulation of cell development GO:0010720 176 0.045
intracellular signal transduction GO:0035556 314 0.045
positive regulation of cell differentiation GO:0045597 217 0.045
regulation of mast cell chemotaxis GO:0060753 1 0.045
positive regulation of cell proliferation GO:0008284 249 0.044
cellular response to molecule of bacterial origin GO:0071219 56 0.044
cellular component movement GO:0006928 248 0.044
regulation of neuron differentiation GO:0045664 208 0.043
cell projection organization GO:0030030 302 0.042
apoptotic process GO:0006915 381 0.041
response to high density lipoprotein particle GO:0055099 2 0.040
cell motility GO:0048870 202 0.040
cellular response to alkyl hydroperoxide GO:0071448 1 0.040
defense response GO:0006952 194 0.039
response to acid chemical GO:0001101 222 0.039
homeostatic process GO:0042592 331 0.039
response to alkaloid GO:0043279 132 0.039
behavior GO:0007610 205 0.039
multicellular organismal reproductive process GO:0048609 233 0.039
response to cytokine GO:0034097 215 0.039
response to ketone GO:1901654 182 0.038
regulation of protein metabolic process GO:0051246 289 0.038
regulation of neuron projection development GO:0010975 161 0.037
response to bacterium GO:0009617 200 0.037
cytokine production GO:0001816 61 0.037
negative regulation of cellular metabolic process GO:0031324 281 0.037
response to estrogen GO:0043627 232 0.037
positive regulation of response to stimulus GO:0048584 285 0.036
chemotaxis GO:0006935 66 0.036
oxoacid metabolic process GO:0043436 290 0.036
negative regulation of macromolecule metabolic process GO:0010605 260 0.036
response to nutrient levels GO:0031667 370 0.036
regulation of cellular amino acid metabolic process GO:0006521 2 0.036
regulation of rna metabolic process GO:0051252 391 0.036
eosinophil migration GO:0072677 3 0.036
regulation of intracellular signal transduction GO:1902531 218 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.035
single organism reproductive process GO:0044702 297 0.035
response to nutrient GO:0007584 248 0.035
chemical homeostasis GO:0048878 292 0.034
regulation of cytokine biosynthetic process GO:0042035 3 0.034
cellular chemical homeostasis GO:0055082 247 0.033
regulation of cellular component movement GO:0051270 150 0.033
multicellular organism reproduction GO:0032504 233 0.033
regulation of cellular amine metabolic process GO:0033238 8 0.033
cellular response to organic cyclic compound GO:0071407 202 0.032
cellular response to interleukin 1 GO:0071347 37 0.032
cellular response to tumor necrosis factor GO:0071356 46 0.032
cellular ion homeostasis GO:0006873 184 0.032
regulation of signal transduction GO:0009966 318 0.032
nucleic acid templated transcription GO:0097659 379 0.032
leukocyte migration GO:0050900 38 0.031
cellular component assembly GO:0022607 360 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.031
response to glucocorticoid GO:0051384 223 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
pseudopodium assembly GO:0031269 3 0.031
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.030
organic acid metabolic process GO:0006082 292 0.030
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.030
cytokine biosynthetic process GO:0042089 3 0.030
programmed cell death GO:0012501 392 0.030
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.030
negative regulation of cell death GO:0060548 229 0.030
response to toxic substance GO:0009636 133 0.030
cellular response to endogenous stimulus GO:0071495 377 0.029
regulation of phosphorylation GO:0042325 248 0.029
response to hypoxia GO:0001666 231 0.029
cellular metal ion homeostasis GO:0006875 172 0.029
regulation of interleukin 1 alpha biosynthetic process GO:0050721 1 0.029
cellular cation homeostasis GO:0030003 180 0.029
macromolecular complex subunit organization GO:0043933 339 0.029
reactive nitrogen species metabolic process GO:2001057 1 0.029
regulation of catalytic activity GO:0050790 304 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
regulation of cellular component organization GO:0051128 368 0.029
positive regulation of signaling GO:0023056 270 0.029
divalent inorganic cation homeostasis GO:0072507 165 0.028
response to oxidative stress GO:0006979 186 0.028
cytoskeleton organization GO:0007010 111 0.028
response to radiation GO:0009314 137 0.028
response to inorganic substance GO:0010035 377 0.028
metal ion homeostasis GO:0055065 186 0.028
angiogenesis GO:0001525 53 0.028
protein phosphorylation GO:0006468 345 0.028
carbohydrate derivative metabolic process GO:1901135 346 0.028
cardiovascular system development GO:0072358 134 0.028
anion transport GO:0006820 178 0.027
response to wounding GO:0009611 254 0.027
response to interleukin 13 GO:0035962 3 0.027
neuron development GO:0048666 286 0.027
response to reactive oxygen species GO:0000302 120 0.027
positive regulation of cell communication GO:0010647 271 0.027
cellular response to lipopolysaccharide GO:0071222 55 0.027
neuron differentiation GO:0030182 368 0.027
positive regulation of protein metabolic process GO:0051247 178 0.026
cellular divalent inorganic cation homeostasis GO:0072503 162 0.026
response to extracellular stimulus GO:0009991 380 0.026
t helper 1 cell extravasation GO:0035687 1 0.026
cellular response to external stimulus GO:0071496 118 0.026
regulation of cellular localization GO:0060341 263 0.026
calcium ion homeostasis GO:0055074 162 0.026
negative regulation of protein metabolic process GO:0051248 114 0.026
regulation of lymphocyte chemotaxis GO:1901623 1 0.026
negative regulation of gene expression GO:0010629 199 0.025
cellular response to oxidative stress GO:0034599 76 0.025
positive regulation of protein phosphorylation GO:0001934 135 0.025
positive regulation of gene expression GO:0010628 244 0.025
organelle organization GO:0006996 266 0.025
single organism organelle organization GO:1902589 180 0.025
b cell mediated immunity GO:0019724 4 0.025
response to temperature stimulus GO:0009266 94 0.025
positive regulation of intracellular signal transduction GO:1902533 138 0.024
regulation of ion transport GO:0043269 245 0.024
secretion by cell GO:0032940 248 0.024
cation transport GO:0006812 382 0.024
positive regulation of programmed cell death GO:0043068 157 0.024
positive regulation of cellular component organization GO:0051130 200 0.024
negative regulation of developmental process GO:0051093 125 0.024
cellular catabolic process GO:0044248 295 0.024
cellular ketone metabolic process GO:0042180 51 0.024
regulation of t cell chemotaxis GO:0010819 1 0.024
central nervous system development GO:0007417 311 0.024
regulation of behavior GO:0050795 61 0.024
cellular response to peptide GO:1901653 133 0.023
positive regulation of rna biosynthetic process GO:1902680 197 0.023
metal ion transport GO:0030001 289 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
cellular homeostasis GO:0019725 252 0.023
positive regulation of molecular function GO:0044093 230 0.023
cellular component biogenesis GO:0044085 368 0.023
response to transforming growth factor beta GO:0071559 46 0.023
response to biotic stimulus GO:0009607 226 0.023
lymphocyte migration GO:0072676 3 0.022
organic acid transport GO:0015849 116 0.022
positive regulation of transcription factor import into nucleus GO:0042993 4 0.022
cytosolic calcium ion homeostasis GO:0051480 140 0.022
regulation of anatomical structure morphogenesis GO:0022603 141 0.022
response to corticosteroid GO:0031960 235 0.022
regulation of rna biosynthetic process GO:2001141 381 0.022
cytokine mediated signaling pathway GO:0019221 43 0.022
regulation of synaptic transmission GO:0050804 141 0.021
negative regulation of cell communication GO:0010648 158 0.021
regulation of apoptotic process GO:0042981 335 0.021
immunoglobulin mediated immune response GO:0016064 4 0.021
carboxylic acid transport GO:0046942 115 0.021
cellular response to cytokine stimulus GO:0071345 127 0.021
cd8 positive alpha beta t cell extravasation GO:0035697 0 0.021
negative regulation of immune response to tumor cell GO:0002838 2 0.021
positive regulation of neuron differentiation GO:0045666 126 0.020
regulation of locomotion GO:0040012 148 0.020
positive regulation of nucleic acid templated transcription GO:1903508 197 0.020
response to ethanol GO:0045471 162 0.020
cellular response to high density lipoprotein particle stimulus GO:0071403 2 0.020
neurological system process GO:0050877 219 0.020
ion homeostasis GO:0050801 212 0.020
anatomical structure formation involved in morphogenesis GO:0048646 83 0.020
positive regulation of interleukin 1 alpha biosynthetic process GO:0050726 1 0.020
negative regulation of metabolic process GO:0009892 331 0.020
regulation of defense response GO:0031347 68 0.020
response to alkyl hydroperoxide GO:0033195 1 0.020
cellular response to lipoteichoic acid GO:0071223 1 0.020
mast cell chemotaxis GO:0002551 4 0.020
negative regulation of signaling GO:0023057 157 0.020
cellular calcium ion homeostasis GO:0006874 160 0.020
organic anion transport GO:0015711 132 0.019
positive regulation of behavior GO:0048520 38 0.019
blood vessel morphogenesis GO:0048514 58 0.019
positive regulation of immune system process GO:0002684 90 0.019
regulation of response to external stimulus GO:0032101 106 0.019
positive regulation of apoptotic process GO:0043065 154 0.019
regulation of transcription dna templated GO:0006355 374 0.019
macromolecule catabolic process GO:0009057 58 0.019
response to carbohydrate GO:0009743 183 0.019
regulation of programmed cell death GO:0043067 341 0.019
negative regulation of molecular function GO:0044092 133 0.019
reactive oxygen species metabolic process GO:0072593 37 0.019
response to other organism GO:0051707 220 0.019
response to decreased oxygen levels GO:0036293 237 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
single organismal cell cell adhesion GO:0016337 42 0.018
small gtpase mediated signal transduction GO:0007264 36 0.018
interleukin 1 biosynthetic process GO:0042222 1 0.018
positive regulation of transport GO:0051050 245 0.018
tumor necrosis factor mediated signaling pathway GO:0033209 4 0.018
negative regulation of phosphorus metabolic process GO:0010563 80 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
ras protein signal transduction GO:0007265 29 0.018
cell adhesion GO:0007155 110 0.018
single organism intracellular transport GO:1902582 166 0.018
response to mechanical stimulus GO:0009612 134 0.018
muscle system process GO:0003012 115 0.018
organophosphate metabolic process GO:0019637 370 0.017
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002858 1 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
nucleoside metabolic process GO:0009116 179 0.017
interleukin 1 alpha production GO:0032610 1 0.017
reproduction GO:0000003 245 0.017
wound healing GO:0042060 122 0.017
lymphocyte chemotaxis GO:0048247 3 0.017
positive regulation of rna metabolic process GO:0051254 203 0.017
negative regulation of cellular biosynthetic process GO:0031327 161 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
temperature homeostasis GO:0001659 17 0.017
regulation of cell projection organization GO:0031344 175 0.017
cellular response to organonitrogen compound GO:0071417 197 0.016
nucleobase containing small molecule metabolic process GO:0055086 316 0.016
response to axon injury GO:0048678 59 0.016
carbohydrate derivative biosynthetic process GO:1901137 124 0.016
positive regulation of t cell chemotaxis GO:0010820 1 0.016
negative regulation of response to stimulus GO:0048585 155 0.016
natural killer cell mediated immune response to tumor cell GO:0002423 1 0.016
carboxylic acid metabolic process GO:0019752 289 0.016
lipid metabolic process GO:0006629 283 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
regulation of immunoglobulin production GO:0002637 4 0.016
positive regulation of t cell migration GO:2000406 1 0.016
pseudopodium organization GO:0031268 3 0.016
protein complex assembly GO:0006461 263 0.016
response to amino acid GO:0043200 75 0.016
rna biosynthetic process GO:0032774 380 0.016
cellular response to biotic stimulus GO:0071216 59 0.016
positive regulation of signal transduction GO:0009967 175 0.016
multi multicellular organism process GO:0044706 138 0.016
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 13 0.016
vesicle mediated transport GO:0016192 181 0.015
positive regulation of cell death GO:0010942 184 0.015
transcription dna templated GO:0006351 377 0.015
calcium ion transport GO:0006816 131 0.015
regulation of response to wounding GO:1903034 69 0.015
positive regulation of tumor necrosis factor production GO:0032760 8 0.015
response to estradiol GO:0032355 164 0.015
neuron projection development GO:0031175 273 0.015
positive regulation of interleukin 1 alpha production GO:0032730 1 0.015
negative regulation of signal transduction GO:0009968 83 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
multicellular organismal homeostasis GO:0048871 49 0.015
regulation of proteolysis GO:0030162 66 0.015
alcohol metabolic process GO:0006066 77 0.015
response to insulin GO:0032868 133 0.015
sexual reproduction GO:0019953 148 0.015
reproductive process GO:0022414 372 0.015
ion transmembrane transport GO:0034220 365 0.015
proteolysis GO:0006508 175 0.015
response to lipopolysaccharide GO:0032496 191 0.015
regulation of nucleic acid templated transcription GO:1903506 380 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
regulation of t cell migration GO:2000404 1 0.015
regulation of response to stress GO:0080134 126 0.015
positive regulation of cytokine biosynthetic process GO:0042108 1 0.015
positive regulation of chemotaxis GO:0050921 23 0.015
growth GO:0040007 165 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
positive regulation of lymphocyte migration GO:2000403 1 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
mast cell migration GO:0097531 4 0.014
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 8 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
neutrophil chemotaxis GO:0030593 11 0.014
innate immune response GO:0045087 35 0.014
organic substance catabolic process GO:1901575 316 0.014
regulation of protein localization GO:0032880 81 0.014
peptidyl amino acid modification GO:0018193 126 0.014
mapk cascade GO:0000165 140 0.014
interleukin 1 alpha biosynthetic process GO:0050719 1 0.014
taxis GO:0042330 67 0.014
regulation of inflammatory response GO:0050727 48 0.014
negative regulation of biosynthetic process GO:0009890 168 0.014
reactive oxygen species biosynthetic process GO:1903409 8 0.014
divalent inorganic cation transport GO:0072511 134 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
response to isoquinoline alkaloid GO:0014072 28 0.013
regulation of nucleocytoplasmic transport GO:0046822 28 0.013
positive regulation of cytokine production GO:0001819 42 0.013
single organism behavior GO:0044708 130 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
cognition GO:0050890 92 0.013
regulation of protein modification process GO:0031399 194 0.013
protein complex subunit organization GO:0071822 302 0.013
positive regulation of leukocyte chemotaxis GO:0002690 10 0.013
positive regulation of defense response GO:0031349 37 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
helper t cell diapedesis GO:0035685 1 0.013
regulation of protein transport GO:0051223 68 0.013
regulation of lymphocyte migration GO:2000401 1 0.013
brain development GO:0007420 247 0.013
response to glucose GO:0009749 136 0.013
negative regulation of innate immune response GO:0045824 4 0.013
regulation of establishment of protein localization GO:0070201 69 0.013
regulation of immune response to tumor cell GO:0002837 3 0.013
regulation of catabolic process GO:0009894 113 0.013
cation homeostasis GO:0055080 195 0.013
fever generation GO:0001660 9 0.013
response to interleukin 1 GO:0070555 55 0.013
learning or memory GO:0007611 90 0.013
tumor necrosis factor superfamily cytokine production GO:0071706 13 0.013
regulation of metal ion transport GO:0010959 118 0.013
single organism biosynthetic process GO:0044711 342 0.013
response to ammonium ion GO:0060359 71 0.013
response to metal ion GO:0010038 253 0.013
protein catabolic process GO:0030163 30 0.013
regulation of peptide transport GO:0090087 87 0.013
positive regulation of locomotion GO:0040017 102 0.013
rhythmic process GO:0048511 156 0.013
cell activation GO:0001775 97 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.012
multi organism reproductive process GO:0044703 262 0.012
regulation of protein maturation GO:1903317 50 0.012
regeneration GO:0031099 163 0.012
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
amino acid transport GO:0006865 70 0.012
oxidation reduction process GO:0055114 304 0.012
positive regulation of synaptic transmission GO:0050806 62 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
sequestering of metal ion GO:0051238 9 0.012
cellular response to vitamin k GO:0071307 1 0.012
catabolic process GO:0009056 351 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
cellular response to stress GO:0033554 269 0.012
muscle contraction GO:0006936 88 0.012
t cell migration GO:0072678 2 0.012
cellular response to acid chemical GO:0071229 75 0.012
regulation of secretion by cell GO:1903530 208 0.012
regulation of system process GO:0044057 208 0.012
protein import GO:0017038 37 0.012
regulation of dna metabolic process GO:0051052 60 0.012
purine containing compound metabolic process GO:0072521 253 0.012
glycosaminoglycan biosynthetic process GO:0006024 4 0.012
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.012
actin filament based process GO:0030029 86 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
dna metabolic process GO:0006259 96 0.012
protein processing GO:0016485 68 0.012
head development GO:0060322 247 0.012
locomotion GO:0040011 237 0.012
single organism cellular localization GO:1902580 102 0.012
multicellular organismal signaling GO:0035637 44 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.011
blood vessel development GO:0001568 69 0.011
nucleotide metabolic process GO:0009117 279 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
positive regulation of response to external stimulus GO:0032103 51 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
response to fatty acid GO:0070542 65 0.011
positive regulation of phosphate metabolic process GO:0045937 262 0.011
transmembrane transport GO:0055085 412 0.011
response to morphine GO:0043278 27 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 35 0.011
response to hexose GO:0009746 144 0.011
response to organophosphorus GO:0046683 102 0.011
regulation of organelle organization GO:0033043 80 0.011
chemosensory behavior GO:0007635 2 0.011
regulation of immune response GO:0050776 55 0.011
divalent metal ion transport GO:0070838 132 0.011
cellular lipid metabolic process GO:0044255 208 0.011
response to oxygen levels GO:0070482 265 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
nuclear import GO:0051170 35 0.011
establishment of protein localization GO:0045184 141 0.011
positive regulation of cell motility GO:2000147 97 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
macromolecule localization GO:0033036 252 0.011
regulation of chemotaxis GO:0050920 29 0.011
negative regulation of response to tumor cell GO:0002835 2 0.011
negative regulation of nervous system development GO:0051961 79 0.010
response to external biotic stimulus GO:0043207 221 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.010
response to heat GO:0009408 60 0.010
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.010
single organism nuclear import GO:1902593 35 0.010
regulation of immune system process GO:0002682 123 0.010
response to vitamin GO:0033273 131 0.010
nucleoside triphosphate metabolic process GO:0009141 144 0.010
positive regulation of cell migration GO:0030335 96 0.010
macromolecular complex assembly GO:0065003 273 0.010
developmental growth GO:0048589 100 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
protein transport GO:0015031 132 0.010
dendrite development GO:0016358 72 0.010
regulation of calcium ion transport GO:0051924 77 0.010
aminoglycan biosynthetic process GO:0006023 4 0.010
negative regulation of transport GO:0051051 136 0.010
regulation of cellular catabolic process GO:0031329 101 0.010
purine ribonucleotide metabolic process GO:0009150 227 0.010
regulation of cell cycle GO:0051726 73 0.010
secretion GO:0046903 307 0.010
regulation of anion transport GO:0044070 43 0.010
lipid storage GO:0019915 1 0.010

Ch25h disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.014
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013
organ system cancer DOID:0050686 0 0.011
central nervous system disease DOID:331 0 0.010