IMP

Process View

Rattus norvegicus

28 genes annotated in rat

response to isoquinoline alkaloid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to isoquinoline alkaloid"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to isoquinoline alkaloid" (in gray)

Name	Description	Probability	Func Analog Organism
RT1-Ba	RT1 class II, locus Ba	0.391
Junb	jun B proto-oncogene	0.282
Egr1	early growth response 1	0.266
Fos	FBJ osteosarcoma oncogene	0.236	Rat
Neurl3	neuralized homolog 3 (Drosophila)	0.198
Egr2	early growth response 2	0.195	Rat
Cxcl2	chemokine (C-X-C motif) ligand 2	0.158
RT1-Da	RT1 class II, locus Da	0.092
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.092
Btg2	BTG family, member 2	0.087
Ccl4	chemokine (C-C motif) ligand 4	0.074	Rat
Nr4a3	nuclear receptor subfamily 4, group A, member 3	0.048
Dusp1	dual specificity phosphatase 1	0.046
Ier2	immediate early response 2	0.040
Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.039
RT1-Bb	RT1 class II, locus Bb	0.035
Ccl3	chemokine (C-C motif) ligand 3	0.034	Rat
Cd247	Cd247 molecule	0.034
Atf3	activating transcription factor 3	0.033	Rat
Cd74	Cd74 molecule, major histocompatibility complex, class II invariant chain	0.033
Drd1a	dopamine receptor D1A	0.033
Il1a	interleukin 1 alpha	0.029
Grm1	glutamate receptor, metabotropic 1	0.028
Sst	somatostatin	0.028
Glra1	glycine receptor, alpha 1	0.028
Jun	Jun oncogene	0.027
Mog	myelin oligodendrocyte glycoprotein	0.027
Ccnl1	cyclin L1	0.027
Sstr2	somatostatin receptor 2	0.027	Rat
Opcml	opioid binding protein/cell adhesion molecule-like	0.026
Zfp36	zinc finger protein 36	0.026
Adora2a	adenosine A2a receptor	0.025
Vat1	vesicle amine transport protein 1 homolog (T californica)	0.025
Vip	vasoactive intestinal peptide	0.024
Tgfb1	transforming growth factor, beta 1	0.023
Socs3	suppressor of cytokine signaling 3	0.023
Phox2a	paired-like homeobox 2a	0.023
Kcnv1	potassium channel, subfamily V, member 1	0.022
RGD1564664	similar to LOC387763 protein	0.022
Hpca	hippocalcin	0.022
RT1-Db1	RT1 class II, locus Db1	0.022	Rat
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.021
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.021
Serpinb2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.020
Crhbp	corticotropin releasing hormone binding protein	0.020
Grp	gastrin releasing peptide	0.020
F2rl1	coagulation factor II (thrombin) receptor-like 1	0.019
Dusp6	dual specificity phosphatase 6	0.019
Il18	interleukin 18	0.019
Arc	activity-regulated cytoskeleton-associated protein	0.019
Gad1	glutamate decarboxylase 1	0.019
Ppp1r15a	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.019
Aldh6a1	aldehyde dehydrogenase 6 family, member A1	0.019
Ctxn1	cortexin 1	0.019
Csrp1	cysteine and glycine-rich protein 1	0.019
Acmsd	aminocarboxymuconate semialdehyde decarboxylase	0.019
Gpr88	G-protein coupled receptor 88	0.018
Kl	Klotho	0.018
Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.018
Cgm4	carcinoembryonic antigen gene family 4	0.018
Kcnj16	potassium inwardly-rectifying channel, subfamily J, member 16	0.018
Coro1b	coronin, actin-binding protein, 1B	0.018
Nr4a2	nuclear receptor subfamily 4, group A, member 2	0.018
Hrh4	histamine receptor H4	0.018
Rgs1	regulator of G-protein signaling 1	0.018
Shank2	SH3 and multiple ankyrin repeat domains 2	0.017
Nmur2	neuromedin U receptor 2	0.017
Dusp4	dual specificity phosphatase 4	0.017
Ccl20	chemokine (C-C motif) ligand 20	0.017	Rat
Neu2	sialidase 2 (cytosolic sialidase)	0.017
Il17re	interleukin 17 receptor E	0.017
Tagln3	transgelin 3	0.017
Klf4	Kruppel-like factor 4 (gut)	0.016
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.016
Dlgap3	discs, large (Drosophila) homolog-associated protein 3	0.016
Rasal1	RAS protein activator like 1 (GAP1 like)	0.016
Cartpt	CART prepropeptide	0.016
Il9r	interleukin 9 receptor	0.016
Tacr1	tachykinin receptor 1	0.016
Psp	parotid secretory protein	0.016
Fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.016
Txnrd1	thioredoxin reductase 1	0.015
Cldn19	claudin 19	0.015
LOC100363783	rCG53773-like	0.015
Slc7a12	solute carrier family 7 (cationic amino acid transporter, y+ system), member 12	0.015
Marcksl1	MARCKS-like 1	0.015
Grin2b	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.015
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.015
Il10	interleukin 10	0.015
Sirpa	signal-regulatory protein alpha	0.015
Mepe	matrix extracellular phosphoglycoprotein	0.015
Cort	cortistatin	0.014
S1pr2	sphingosine-1-phosphate receptor 2	0.014
Ccl2	chemokine (C-C motif) ligand 2	0.014
Fosl1	fos-like antigen 1	0.014	Rat
Il10ra	interleukin 10 receptor, alpha	0.014
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.014
Cd37	CD37 molecule	0.014
Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	0.014
Krt4	keratin 4	0.014
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.014
Cx3cl1	chemokine (C-X3-C motif) ligand 1	0.014
Chrm1	cholinergic receptor, muscarinic 1	0.014
Mmp10	matrix metallopeptidase 10	0.014
Gabra4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.014
Adrb1	adrenergic, beta-1-, receptor	0.014
Syt4	synaptotagmin IV	0.014
Sstr1	somatostatin receptor 1	0.014
Ch25h	cholesterol 25-hydroxylase	0.013
Nmbr	neuromedin B receptor	0.013
Cnp	2',3'-cyclic nucleotide 3' phosphodiesterase	0.013
Bcan	brevican	0.013
Calb1	calbindin 1	0.013
Il1r2	interleukin 1 receptor, type II	0.013
Cckar	cholecystokinin A receptor	0.013
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	0.013
Pax6	paired box 6	0.013
Ptgs2	prostaglandin-endoperoxide synthase 2	0.013
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.013
Cyr61	cysteine-rich, angiogenic inducer, 61	0.013
Acr	acrosin	0.013
Kif6	kinesin family member 6	0.013
Syt13	synaptotagmin XIII	0.013
Glp1r	glucagon-like peptide 1 receptor	0.013
Gng7	guanine nucleotide binding protein (G protein), gamma 7	0.013
Zyx	zyxin	0.013
Grm6	glutamate receptor, metabotropic 6	0.012
Crh	corticotropin releasing hormone	0.012
Gper	G protein-coupled estrogen receptor 1	0.012
Gpr116	G protein-coupled receptor 116	0.012
Il8rb	interleukin 8 receptor, beta	0.012
Gfra2	GDNF family receptor alpha 2	0.012
Sval2	seminal vesicle antigen-like 2	0.012
Omp	olfactory marker protein	0.012
Plek	pleckstrin	0.012
Ppt1	palmitoyl-protein thioesterase 1	0.012
Il6	interleukin 6	0.012
Prol1	proline rich, lacrimal 1	0.012
Mas1	MAS1 oncogene	0.012
Ces1c	carboxylesterase 1C	0.012
Tbx2	T-box 2	0.012
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.012
Dpep1	dipeptidase 1 (renal)	0.012
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.012
Ckmt1	creatine kinase, mitochondrial 1	0.012
Ttll3	tubulin tyrosine ligase-like family, member 3	0.012
Tac1	tachykinin 1	0.012
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.012
Il1rn	interleukin 1 receptor antagonist	0.012
Smad3	SMAD family member 3	0.012
Arpp21	cAMP-regulated phosphoprotein 21	0.011
Plp1	proteolipid protein 1	0.011
Taok2	TAO kinase 2	0.011
Vcsa2	variable coding sequence A2	0.011
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.011
Pou3f1	POU class 3 homeobox 1	0.011
Gabrp	gamma-aminobutyric acid (GABA-A) receptor, pi	0.011
Pllp	plasma membrane proteolipid (plasmolipin)	0.011
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.011
Klf6	Kruppel-like factor 6	0.011
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.011
Clic3	chloride intracellular channel 3	0.011
Fgf10	fibroblast growth factor 10	0.011
Svs3a	seminal vesicle secretory protein 3A	0.011
Ttc22	tetratricopeptide repeat domain 22	0.011
Ache	acetylcholinesterase	0.011
Cntn1	contactin 1	0.011
Rgs4	regulator of G-protein signaling 4	0.011
Fcgr3a	Fc fragment of IgG, low affinity IIIa, receptor	0.011
Syn1	synapsin I	0.011
Syn2	synapsin II	0.011
Hes2	hairy and enhancer of split 2 (Drosophila)	0.011
Vom2r53	vomeronasal 2 receptor, 53	0.011
Camkv	CaM kinase-like vesicle-associated	0.011
Foxe1	forkhead box E1 (thyroid transcription factor 2)	0.011
Psg19	pregnancy specific glycoprotein 19	0.011
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.011
Plau	plasminogen activator, urokinase	0.011
Chrna4	cholinergic receptor, nicotinic, alpha 4	0.011
Taf6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.011
Slc8a3	solute carrier family 8 (sodium/calcium exchanger), member 3	0.011
Smr3a	submaxillary gland androgen regulated protein 3A	0.011
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1	0.011
Mgat5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	0.010
Lrfn2	leucine rich repeat and fibronectin type III domain containing 2	0.010
Atxn1	ataxin 1	0.010
Ncan	neurocan	0.010
Reg3b	regenerating islet-derived 3 beta	0.010
Extl3	exostoses (multiple)-like 3	0.010
Prl	prolactin	0.010
Il1r1	interleukin 1 receptor, type I	0.010
Slc17a7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.010
Gnb2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.010
Pmfbp1	polyamine modulated factor 1 binding protein 1	0.010
Dlk1	delta-like 1 homolog (Drosophila)	0.010
Mobkl2a	MOB1, Mps One Binder kinase activator-like 2A (yeast)	0.010
Acox3	acyl-Coenzyme A oxidase 3, pristanoyl	0.010
Hrh2	histamine receptor H 2	0.010
Ptafr	platelet-activating factor receptor	0.010
PVR	poliovirus receptor	0.010
Hpgds	hematopoietic prostaglandin D synthase	0.010
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.010
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.010
Folr2	folate receptor 2 (fetal)	0.010
Chga	chromogranin A	0.010
Atp12a	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	0.010