IMP

Process View

Rattus norvegicus

1 genes annotated in rat

regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of natural killer cell mediated cytotoxicity directed against tumor cell target"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" (in gray)

Name	Description	Probability	Func Analog Organism
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.741
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.639	Rat
Ccr2	chemokine (C-C motif) receptor 2	0.628
Klrc2	killer cell lectin-like receptor subfamily C, member 2	0.447	Rat
Tlr7	toll-like receptor 7	0.310
Nkg7	natural killer cell group 7 sequence	0.270
Rgs1	regulator of G-protein signaling 1	0.269
Gzmk	granzyme K	0.254
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.209
Ccl2	chemokine (C-C motif) ligand 2	0.192
Il7r	interleukin 7 receptor	0.177
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.165
Tnfrsf12a	tumor necrosis factor receptor superfamily, member 12a	0.150
Cd2	Cd2 molecule	0.147
Serpine1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.145
Mcpt8	mast cell protease 8	0.142
Timp1	TIMP metallopeptidase inhibitor 1	0.126
Mmp12	matrix metallopeptidase 12	0.125
Pcsk1	proprotein convertase subtilisin/kexin type 1	0.120
Cd8a	CD8a molecule	0.117
Gzmm	granzyme M (lymphocyte met-ase 1)	0.109
Xcl1	chemokine (C motif) ligand 1	0.100
Clec12a	C-type lectin domain family 12, member A	0.094
Ccr5	chemokine (C-C motif) receptor 5	0.085
Zap70	zeta-chain (TCR) associated protein kinase	0.083
Myc	myelocytomatosis oncogene	0.082
Igsf6	immunoglobulin superfamily, member 6	0.079
Il1b	interleukin 1 beta	0.076
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.073
Il1rl1	interleukin 1 receptor-like 1	0.072
Cxcl10	chemokine (C-X-C motif) ligand 10	0.065
Il6	interleukin 6	0.062
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.060	Rat
Slc13a1	solute carrier family 13 (sodium/sulfate symporters), member 1	0.057
Klrb1a	killer cell lectin-like receptor subfamily B, member 1A	0.055
Sell	selectin L	0.051
Cyp2c13	cytochrome P450, family 2, subfamily c, polypeptide 13	0.049
Sit1	signaling threshold regulating transmembrane adaptor 1	0.049
Itgb2	integrin, beta 2	0.048
Prf1	perforin 1 (pore forming protein)	0.045
LOC300024	similar to Ly6-B antigen gene	0.044
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.043
Cyp2c12	cytochrome P450, family 2, subfamily c, polypeptide 12	0.043
Mcpt3	mast cell peptidase 3	0.043
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.041
Slc9a4	solute carrier family 9 (sodium/hydrogen exchanger), member 4	0.040
Mos	Moloney sarcoma oncogene	0.040
Oas1b	2-5 oligoadenylate synthetase 1B	0.037
Samsn1	SAM domain, SH3 domain and nuclear localization signals, 1	0.037
Cd72	Cd72 molecule	0.036
Vom1r102	vomeronasal 1 receptor 102	0.035
Atf3	activating transcription factor 3	0.035
Cnr2	cannabinoid receptor 2 (macrophage)	0.035
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.034
Fam65b	family with sequence similarity 65, member B	0.033
Gzmb	granzyme B	0.033
Unc5cl	unc-5 homolog C (C. elegans)-like	0.032
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.031
Hbegf	heparin-binding EGF-like growth factor	0.031
Ccl4	chemokine (C-C motif) ligand 4	0.030
Ubd	ubiquitin D	0.030
Ifng	interferon gamma	0.030
Ccl19	chemokine (C-C motif) ligand 19	0.029
Ambn	ameloblastin	0.029
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.029
Oasl	2'-5'-oligoadenylate synthetase-like	0.028
Plaur	plasminogen activator, urokinase receptor	0.028
Tnni3k	TNNI3 interacting kinase	0.028
Skap1	src kinase associated phosphoprotein 1	0.028
Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.027
Gpr114	G protein-coupled receptor 114	0.027
Epsti1	epithelial stromal interaction 1 (breast)	0.027
Klra22	killer cell lectin-like receptor subfamily A, member 22	0.026	Rat
Ctsj	cathepsin J	0.026
Il1rn	interleukin 1 receptor antagonist	0.026
Ccl9	chemokine (C-C motif) ligand 9	0.026
Vom1r93	vomeronasal 1 receptor 93	0.025
Il18r1	interleukin 18 receptor 1	0.025
Spn	sialophorin	0.025
Serpinb3a	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A	0.025
Ccl5	chemokine (C-C motif) ligand 5	0.025
Slfn3	schlafen 3	0.024
LOC100361053	mCG1039741-like	0.024
Grin2a	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.024
Spic	Spi-C transcription factor (Spi-1/PU.1 related)	0.022
Il10ra	interleukin 10 receptor, alpha	0.022
RT1-A3	RT1 class I, locus A3	0.021
Rt1.aa	MHC class I RT1.Aa alpha-chain	0.021
MGC105649	hypothetical LOC302884	0.021
Cd3g	CD3 molecule, gamma	0.021
Zcwpw1	zinc finger, CW-type with PWWP domain 1	0.020
Mcpt4	mast cell protease 4	0.020
Ccl20	chemokine (C-C motif) ligand 20	0.019
Clec7a	C-type lectin domain family 7, member a	0.019	Rat
Prl2a1	Prolactin family 2, subfamily a, member 1	0.019
Pou1f1	POU class 1 homeobox 1	0.019
RGD1566368	similar to Solute carrier family 6 (neurotransmitter transporter), member 20	0.019
Reg3g	regenerating islet-derived 3 gamma	0.018
Ccl7	chemokine (C-C motif) ligand 7	0.018
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.018
Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	0.018
Prl2b1	Prolactin family 2, subfamily b, member 1	0.018
Lrrc8c	leucine rich repeat containing 8 family, member C	0.018
LOC679551	similar to MIC2 like 1	0.018
Ch25h	cholesterol 25-hydroxylase	0.017
Gpr64	G protein-coupled receptor 64	0.017
Kcnv1	potassium channel, subfamily V, member 1	0.017
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.017	Rat
Fcer1a	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	0.017
Prdm1	PR domain containing 1, with ZNF domain	0.017
Itpkc	inositol 1,4,5-trisphosphate 3-kinase C	0.017
Clec4f	C-type lectin domain family 4, member f	0.017
Cd247	Cd247 molecule	0.017
Cd86	CD86 molecule	0.017
Gfra3	GDNF family receptor alpha 3	0.016
Ldb3	LIM domain binding 3	0.016
LOC100362325	rCG28200-like	0.016
Serpinb7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	0.015
Cd244	Cd244 molecule, natural killer cell receptor 2B4	0.015
Cxcr3	chemokine (C-X-C motif) receptor 3	0.015
Stx11	syntaxin 11	0.015
Myo1f	myosin IF	0.015
Olr1226	olfactory receptor 1226	0.015
Scin	scinderin	0.015
Sh2d2a	SH2 domain protein 2A	0.015
Cxcl11	chemokine (C-X-C motif) ligand 11	0.014
Gem	GTP binding protein (gene overexpressed in skeletal muscle)	0.014
RGD1311993	hypothetical LOC315072	0.014
S100vp	S100 calcium-binding protein, ventral prostate	0.014
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.014
Prm2	protamine 2	0.014
Dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)	0.014
Rasgrp4	RAS guanyl releasing protein 4	0.014
LOC100361765	homeobox B2	0.013
Cd22	CD22 molecule	0.013
Pla1a	phospholipase A1 member A	0.013
Pik3cd	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.013
Gen1	Gen homolog 1, endonuclease (Drosophila)	0.013
Slc22a25	solute carrier family 22, member 25	0.013
Fcrla	Fc receptor-like A	0.013
C6	complement component 6	0.013
Rhoh	ras homolog gene family, member H	0.013
Litaf	lipopolysaccharide-induced TNF factor	0.013
Serpinb2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.013
P2ry14	purinergic receptor P2Y, G-protein coupled, 14	0.012
Ccr6	chemokine (C-C motif) receptor 6	0.012
Myct1	myc target 1	0.012
Serpinb3	serine protease inhibitor B3	0.012
Rem2	RAS (RAD and GEM) like GTP binding 2	0.012
Igfl3	IGF-like family member 3	0.012
Rhoj	ras homolog gene family, member J	0.012
Runx1	runt-related transcription factor 1	0.012
Rnd1	Rho family GTPase 1	0.012
Cyp2c7	cytochrome P450, family 2, subfamily c, polypeptide 7	0.012
Il2	interleukin 2	0.012
Phex	phosphate regulating endopeptidase homolog, X-linked	0.012
Has2	hyaluronan synthase 2	0.012
Gpx2	glutathione peroxidase 2	0.012
Stab2	stabilin 2	0.012
Dppa3	developmental pluripotency-associated 3	0.012
Maml2	mastermind like 2 (Drosophila)	0.012
RGD1562844	similar to serine (or cysteine) proteinase inhibitor, clade B, member 9	0.012
Sgms2	sphingomyelin synthase 2	0.012
Fas	Fas (TNF receptor superfamily, member 6)	0.012
Tcrb	T-cell receptor beta chain	0.012
Sele	selectin E	0.012
Gimap6	GTPase, IMAP family member 6	0.011
Si	sucrase-isomaltase (alpha-glucosidase)	0.011
Reg3b	regenerating islet-derived 3 beta	0.011
Cela1	chymotrypsin-like elastase family, member 1	0.011
Bin2	bridging integrator 2	0.011
Parvg	parvin, gamma	0.011
Smek1	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	0.011
Egr2	early growth response 2	0.011
LOC690020	similar to killer cell lectin-like receptor, subfamily A, member 17	0.011	Rat
Cd200r2	Cd200 receptor 2	0.010
Gzma	granzyme A	0.010
LOC687399	hypothetical protein LOC687399	0.010
RGD1311300	similar to T cell receptor V delta 6	0.010
Lcn2	lipocalin 2	0.010
Map4k2	mitogen activated protein kinase kinase kinase kinase 2	0.010
Dhrs7	dehydrogenase/reductase (SDR family) member 7	0.010
Nfkbid	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta	0.010
LOC494538	ABP beta	0.010
Csn3	casein kappa	0.010
Stap1	signal transducing adaptor family member 1	0.010
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.010