IMP

Process View

Rattus norvegicus

4 genes annotated in rat

tumor necrosis factor mediated signaling pathway

A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in rat Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "tumor necrosis factor mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "tumor necrosis factor mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Krt18	keratin 18	0.730
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.503
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.439	Mouse
Stat3	signal transducer and activator of transcription 3	0.282
Lrp10	low-density lipoprotein receptor-related protein 10	0.266
LOC100363783	rCG53773-like	0.187
Il2ra	interleukin 2 receptor, alpha	0.163
Il6	interleukin 6	0.154
Il1b	interleukin 1 beta	0.117
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.115
Icam1	intercellular adhesion molecule 1	0.114
Arl5c	ADP-ribosylation factor-like 5C	0.112
Cxcl10	chemokine (C-X-C motif) ligand 10	0.107
Ltbr	lymphotoxin beta receptor (TNFR superfamily, member 3)	0.096	Rat
Clec9a	C-type lectin domain family 9, member a	0.094
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.091
Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.085
Ptafr	platelet-activating factor receptor	0.082
Cxcl6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.082
Zyx	zyxin	0.081
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.076
Il4ra	interleukin 4 receptor, alpha	0.073
Arid5a	AT rich interactive domain 5A (Mrf1 like)	0.073
Adora2a	adenosine A2a receptor	0.071
LOC686323	similar to thyroid receptor-interacting protein 6	0.069
Bcl3	B-cell CLL/lymphoma 3	0.068
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.067
Ier3	immediate early response 3	0.064
Ccl3	chemokine (C-C motif) ligand 3	0.060
Hmox1	heme oxygenase (decycling) 1	0.060
Il13ra1	interleukin 13 receptor, alpha 1	0.060
Neurl3	neuralized homolog 3 (Drosophila)	0.058
Ripk3	receptor-interacting serine-threonine kinase 3	0.057
Ctdsp1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	0.056
Litaf	lipopolysaccharide-induced TNF factor	0.055
Socs3	suppressor of cytokine signaling 3	0.054
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.051
Ccl22	chemokine (C-C motif) ligand 22	0.050
Cxcl2	chemokine (C-X-C motif) ligand 2	0.049
Mvp	major vault protein	0.049
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.047
Ccl20	chemokine (C-C motif) ligand 20	0.047
Clptm1	cleft lip and palate associated transmembrane protein 1	0.046
Il1a	interleukin 1 alpha	0.046
Selp	selectin P	0.045
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.043
Ninj1	ninjurin 1	0.043
Lmna	lamin A	0.042
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.042
Gzmk	granzyme K	0.041
Il1rl1	interleukin 1 receptor-like 1	0.039
Eed	embryonic ectoderm development	0.038
Cd2	Cd2 molecule	0.038
Gpx2	glutathione peroxidase 2	0.038
Tgm1	transglutaminase 1, K polypeptide	0.038
Calcb	calcitonin-related polypeptide, beta	0.037
Birc3	baculoviral IAP repeat-containing 3	0.037
Myd88	myeloid differentiation primary response gene 88	0.037
Serpinb2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.037
Irak3	interleukin-1 receptor-associated kinase 3	0.036
Bcl7c	B-cell CLL/lymphoma 7C	0.036
Fosl1	fos-like antigen 1	0.035
Sell	selectin L	0.035
Gadd45a	growth arrest and DNA-damage-inducible, alpha	0.034
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.034
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.034
LOC100361706	lambda-chain C1-region-like	0.033
Socs5	suppressor of cytokine signaling 5	0.033
Plxnb2	plexin B2	0.033
Slc39a1	solute carrier family 39 (zinc transporter), member 1	0.033
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.032
Runx1	runt-related transcription factor 1	0.031
Lst1	leukocyte specific transcript 1	0.031
Vps37c	vacuolar protein sorting 37 homolog C (S. cerevisiae)	0.031
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.031
Ccl4	chemokine (C-C motif) ligand 4	0.031
Cd247	Cd247 molecule	0.031
Ptbp1	polypyrimidine tract binding protein 1	0.031
Rasgrp1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	0.029
Mt2A	metallothionein 2A	0.029
Nrg1	neuregulin 1	0.029
Fosl2	fos-like antigen 2	0.029
Ripk2	receptor-interacting serine-threonine kinase 2	0.028
Trim47	tripartite motif-containing 47	0.028
S100g	S100 calcium binding protein G	0.027
Npepl1	aminopeptidase-like 1	0.027
P2ry2	purinergic receptor P2Y, G-protein coupled, 2	0.026
Ubd	ubiquitin D	0.026
Sbno2	strawberry notch homolog 2 (Drosophila)	0.026
Hbegf	heparin-binding EGF-like growth factor	0.025
Vat1	vesicle amine transport protein 1 homolog (T californica)	0.025
Il6st	interleukin 6 signal transducer	0.024
RGD1559588	similar to cell surface receptor FDFACT	0.024
Vcan	versican	0.024
Tcrb	T-cell receptor beta chain	0.024
Epha2	Eph receptor A2	0.023
Il7	interleukin 7	0.023
Mmp8	matrix metallopeptidase 8	0.023
Zc3h11a	zinc finger CCCH-type containing 11A	0.023
Rrbp1	ribosome binding protein 1	0.023
Fas	Fas (TNF receptor superfamily, member 6)	0.023
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.022
Il1r1	interleukin 1 receptor, type I	0.022
Ppard	peroxisome proliferator-activated receptor delta	0.022
Bok	BCL2-related ovarian killer	0.022
Sap30l	SAP30-like	0.022
Muc13	mucin 13, cell surface associated	0.022
Myh9	myosin, heavy chain 9, non-muscle	0.021
Pctp	phosphatidylcholine transfer protein	0.021
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.021
Ppap2c	phosphatidic acid phosphatase type 2c	0.021
Fam65b	family with sequence similarity 65, member B	0.020
Cpne8	copine VIII	0.020
Krt19	keratin 19	0.020
Smad2	SMAD family member 2	0.020
Ceacam10	carcinoembryonic antigen-related cell adhesion molecule 10	0.020
Reg3b	regenerating islet-derived 3 beta	0.020
Cd44	Cd44 molecule	0.020
Zg16	zymogen granule protein 16	0.020
Scn11a	sodium channel, voltage-gated, type XI, alpha	0.019
Pglyrp1	peptidoglycan recognition protein 1	0.019
Lsr	lipolysis stimulated lipoprotein receptor	0.019
Ugt1a6	UDP glucuronosyltransferase 1 family, polypeptide A6	0.019
Nipa2	non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)	0.019
Pawr	PRKC, apoptosis, WT1, regulator	0.019
Ccl2	chemokine (C-C motif) ligand 2	0.019
Unc13d	unc-13 homolog D (C. elegans)	0.019
Csf1	colony stimulating factor 1 (macrophage)	0.019
Lbp	lipopolysaccharide binding protein	0.019
Fcnb	ficolin B	0.019
St3gal4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	0.019
Tec	tec protein tyrosine kinase	0.018
RGD1305793	similar to hypothetical protein FLJ20154	0.018
Slc44a4	solute carrier family 44, member 4	0.018
Ch25h	cholesterol 25-hydroxylase	0.018
Sele	selectin E	0.018
Ptgs2	prostaglandin-endoperoxide synthase 2	0.018
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.018
Ece1	endothelin converting enzyme 1	0.018
Tfpi2	tissue factor pathway inhibitor 2	0.018
Rassf1	Ras association (RalGDS/AF-6) domain family member 1	0.018
Map3k1	mitogen activated protein kinase kinase kinase 1	0.017
Agtr1a	angiotensin II receptor, type 1a	0.017
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.017
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.017
Prkcb	protein kinase C, beta	0.017
Ddr1	discoidin domain receptor tyrosine kinase 1	0.017
Fip1l1	FIP1 like 1 (S. cerevisiae)	0.017
Inhba	inhibin beta-A	0.017
Arfgap1	ADP-ribosylation factor GTPase activating protein 1	0.017
Clca4	chloride channel accessory 4	0.017
Rhbdf1	rhomboid 5 homolog 1 (Drosophila)	0.017
Slit3	slit homolog 3 (Drosophila)	0.017
Cx3cl1	chemokine (C-X3-C motif) ligand 1	0.016
Klhl10	kelch-like 10 (Drosophila)	0.016
Nkg7	natural killer cell group 7 sequence	0.016
Ugdh	UDP-glucose dehydrogenase	0.016
Itgad	integrin, alpha D	0.016
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.016
Pfkfb3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.016
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.016
Skap1	src kinase associated phosphoprotein 1	0.016
Fhl2	four and a half LIM domains 2	0.016
Map2k3	mitogen activated protein kinase kinase 3	0.016
Ptpre	protein tyrosine phosphatase, receptor type, E	0.016
Pik3cd	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.016
Psd4	pleckstrin and Sec7 domain containing 4	0.016
Pbsn	probasin	0.016
Hgf	hepatocyte growth factor	0.016
Gzmm	granzyme M (lymphocyte met-ase 1)	0.016
Dok2	docking protein 2	0.016
Guca2a	guanylate cyclase activator 2a (guanylin)	0.016
Ccdc102a	coiled-coil domain containing 102A	0.016
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.016
Abcc3	ATP-binding cassette, subfamily C (CFTR/MRP), member 3	0.016
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.016
Ggt1	gamma-glutamyltransferase 1	0.015
Dpep1	dipeptidase 1 (renal)	0.015
Dusp4	dual specificity phosphatase 4	0.015
Sdad1	SDA1 domain containing 1	0.015
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.015
Piga	phosphatidylinositol glycan anchor biosynthesis, class A	0.015
Znf654	zinc finger protein 654	0.015
Krt86	keratin 86	0.015
Mgat1	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	0.015
Rab11b	RAB11B, member RAS oncogene family	0.015
Rps6ka3	ribosomal protein S6 kinase polypeptide 3	0.015
Clec11a	C-type lectin domain family 11, member a	0.015
Hp1bp3	heterochromatin protein 1, binding protein 3	0.015
Casp3	caspase 3	0.015
Cdh17	cadherin 17	0.015
Phf11	PHD finger protein 11	0.015
Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	0.015
RGD1559690	similar to hypothetical protein FLJ25416	0.015
Mta2	metastasis associated 1 family, member 2	0.015
Slc30a4	solute carrier family 30 (zinc transporter), member 4	0.015
Osgin1	oxidative stress induced growth inhibitor 1	0.015
Il1r2	interleukin 1 receptor, type II	0.015
Myc	myelocytomatosis oncogene	0.015
Plekhg2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	0.015
Lad1	ladinin 1	0.015
Wt1	Wilms tumor 1	0.015
Ifitm3	interferon induced transmembrane protein 3	0.015
Cyp4f5	cytochrome P450, family 4, subfamily f, polypeptide 5	0.015
Cflar	CASP8 and FADD-like apoptosis regulator	0.014
Flnb	filamin, beta	0.014
Bin2	bridging integrator 2	0.014
Adm	adrenomedullin	0.014
Ctse	cathepsin E	0.014
Krt1-5	keratin complex 1, acidic, gene 5	0.014
LOC100362108	poly (ADP-ribose) polymerase family, member 10	0.014
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.014
Plcg2	phospholipase C, gamma 2	0.014
Slc1a3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	0.014
S100a8	S100 calcium binding protein A8	0.014
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.014
Eftud2	elongation factor Tu GTP binding domain containing 2	0.014
Tmem134	transmembrane protein 134	0.014
Adcy5	adenylate cyclase 5	0.014
Jak3	Janus kinase 3	0.014
Cd40	CD40 molecule, TNF receptor superfamily member 5	0.014	Rat
Il8rb	interleukin 8 receptor, beta	0.014
Smad1	SMAD family member 1	0.014
Tmed1	transmembrane emp24 protein transport domain containing 1	0.014
Slc3a2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.014
Capn13	calpain 13	0.014
Vrk3	vaccinia related kinase 3	0.014
Ccl5	chemokine (C-C motif) ligand 5	0.014
Nab1	Ngfi-A binding protein 1	0.014
Trmt6	tRNA methyltransferase 6 homolog (S. cerevisiae)	0.014
Helb	helicase (DNA) B	0.014
Nrp2	neuropilin 2	0.014
Nckap1	NCK-associated protein 1	0.013
Tubb6	tubulin, beta 6	0.013
LOC686781	similar to NFkB interacting protein 1	0.013
Comt	catechol-O-methyltransferase	0.013
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.013
Il16	interleukin 16	0.013
Pigt	phosphatidylinositol glycan anchor biosynthesis, class T	0.013
Mefv	Mediterranean fever	0.013
Tspan4	tetraspanin 4	0.013
Dlc1	deleted in liver cancer 1	0.013
Gfpt1	glutamine fructose-6-phosphate transaminase 1	0.013
Slc7a1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	0.013
Ptprcap	protein tyrosine phosphatase, receptor type, C-associated protein	0.013
Gak	cyclin G associated kinase	0.013
Itgb7	integrin, beta 7	0.013
Aspn	asporin	0.013
Rnd1	Rho family GTPase 1	0.013
Baz1a	bromodomain adjacent to zinc finger domain, 1A	0.013
Ltbp2	latent transforming growth factor beta binding protein 2	0.013
Phemx	pan hematopoietic expression	0.013
Smad7	SMAD family member 7	0.013
Ier5	immediate early response 5	0.013
Dem1	defects in morphology 1 homolog (S. cerevisiae)	0.013
Erp27	endoplasmic reticulum protein 27	0.012
Baiap2l1	BAI1-associated protein 2-like 1	0.012
Sycp2	synaptonemal complex protein 2	0.012
Lcn2	lipocalin 2	0.012
Wdr26	WD repeat domain 26	0.012
Lat	linker for activation of T cells	0.012
Ino80e	INO80 complex subunit E	0.012
Faslg	Fas ligand (TNF superfamily, member 6)	0.012
Anxa7	annexin A7	0.012
Prkd2	protein kinase D2	0.012
Elmo3	engulfment and cell motility 3	0.012
Cldn7	claudin 7	0.012
Plekhn1	pleckstrin homology domain containing, family N member 1	0.012
Grpr	gastrin releasing peptide receptor	0.012
Slc16a3	solute carrier family 16, member 3 (monocarboxylic acid transporter 4)	0.012
Sstr1	somatostatin receptor 1	0.012
Bin1	bridging integrator 1	0.012
Sept1	septin 1	0.012
Tifa	TRAF-interacting protein with forkhead-associated domain	0.012
Sc65	synaptonemal complex protein SC65	0.012
Stx6	syntaxin 6	0.012
Cab39	calcium binding protein 39	0.012
Gcg	glucagon	0.012
Gpr114	G protein-coupled receptor 114	0.012
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.012
Abhd4	abhydrolase domain containing 4	0.012
Clcn2	chloride channel 2	0.012
Gpr176	G protein-coupled receptor 176	0.012
Smcp	sperm mitochondria-associated cysteine-rich protein	0.012
Pld2	phospholipase D2	0.012
Mcpt2	mast cell protease 2	0.012
Kcnab1	potassium voltage-gated channel, shaker-related subfamily, beta member 1	0.012
Gfi1	growth factor independent 1 transcription repressor	0.012
Sat1	spermidine/spermine N1-acetyl transferase 1	0.012
Nop58	nucleolar protein NOP58	0.011
Cd14	CD14 molecule	0.011
Cdkn2aip	CDKN2A interacting protein	0.011
Eng	endoglin	0.011
Foxq1	forkhead box Q1	0.011
Cdcp1	CUB domain containing protein 1	0.011
Plscr1	phospholipid scramblase 1	0.011
LOC300024	similar to Ly6-B antigen gene	0.011
Krt7	keratin 7	0.011
Plaur	plasminogen activator, urokinase receptor	0.011
Ppm1j	protein phosphatase 1J	0.011
Zbp1	Z-DNA binding protein 1	0.011
Odf4	outer dense fiber of sperm tails 4	0.011
Gja5	gap junction protein, alpha 5	0.011
Prol1	proline rich, lacrimal 1	0.011
Gch1	GTP cyclohydrolase 1	0.011
Actg2	actin, gamma 2, smooth muscle, enteric	0.011
Nup188	nucleoporin 188	0.011
Dio2	deiodinase, iodothyronine, type II	0.011
LOC100361913	rCG54286-like	0.011
Cttn	cortactin	0.011
Man2c1	mannosidase, alpha, class 2C, member 1	0.011
Grin2a	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.011
Tmem171	transmembrane protein 171	0.011
Bcl2l2	Bcl2-like 2	0.011
Utp14a	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	0.011
Grm5	glutamate receptor, metabotropic 5	0.011
RT1-EC2	RT1 class Ib, locus EC2	0.011
Prss22	protease, serine, 22	0.011
Foxi2	forkhead box I2	0.011
Slc10a3	solute carrier family 10 (sodium/bile acid cotransporter family), member 3	0.011
Mospd3	motile sperm domain containing 3	0.011
Myo5b	myosin Vb	0.011
Lrrfip1	leucine rich repeat (in FLII) interacting protein 1	0.011
Tnni3	troponin I type 3 (cardiac)	0.011
RGD1563365	similar to DNA segment, Chr 10, Wayne State University 102, expressed	0.011
Tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a	0.011
Dlgap2	discs, large (Drosophila) homolog-associated protein 2	0.011
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.011
Sirt7	sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)	0.011
Arg2	arginase type II	0.011
Fadd	Fas (TNFRSF6)-associated via death domain	0.011
Zc3h12a	zinc finger CCCH type containing 12A	0.011
Snx18	sorting nexin 18	0.011
Coro1b	coronin, actin-binding protein, 1B	0.011
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.011
Tapbp	TAP binding protein	0.011
Lmo7	LIM domain 7	0.011
Btnl7	butyrophilin-like 7	0.011
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.010
Muc4	mucin 4, cell surface associated	0.010
Stk17b	serine/threonine kinase 17b	0.010
Lama5	laminin, alpha 5	0.010
Il2rb	interleukin 2 receptor, beta	0.010
Adam17	ADAM metallopeptidase domain 17	0.010
Cyp2c22	cytochrome P450, family 2, subfamily c, polypeptide 22	0.010
Apeh	N-acylaminoacyl-peptide hydrolase	0.010
Map2k1	mitogen activated protein kinase kinase 1	0.010
Unc13b	unc-13 homolog B (C. elegans)	0.010
Tpm1	tropomyosin 1, alpha	0.010
Pou2af1	POU class 2 associating factor 1	0.010
Rbbp8	retinoblastoma binding protein 8	0.010
Plcd1	phospholipase C, delta 1	0.010
Pkn3	protein kinase N3	0.010
Fibp	fibroblast growth factor (acidic) intracellular binding protein	0.010
Dusp2	dual specificity phosphatase 2	0.010
Il9r	interleukin 9 receptor	0.010
Poll	polymerase (DNA directed), lambda	0.010
Hes1	hairy and enhancer of split 1 (Drosophila)	0.010
Cyp2c12	cytochrome P450, family 2, subfamily c, polypeptide 12	0.010
Rprd1b	regulation of nuclear pre-mRNA domain containing 1B	0.010
Stard3	StAR-related lipid transfer (START) domain containing 3	0.010
Hps3	Hermansky-Pudlak syndrome 3 homolog (human)	0.010
Trim8	tripartite motif-containing 8	0.010
Hist1h1d	histone cluster 1, H1d	0.010
Uts2r	urotensin 2 receptor	0.010
Kdm3a	lysine (K)-specific demethylase 3A	0.010
Ly6b	lymphocyte antigen 6 complex, locus B	0.010