IMP

Process View

Homo sapiens

1 genes annotated in human

negative regulation of wnt protein secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of wnt protein secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of wnt protein secretion" (in gray)

Name	Description	Probability	Func Analog Organism
MPDZ	multiple PDZ domain protein	1.000
SSTR2	somatostatin receptor 2	0.951	Human
SSTR3	somatostatin receptor 3	0.920	Human
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.604
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.325
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.318
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.300
KCNF1	potassium voltage-gated channel, subfamily F, member 1	0.292
SHANK1	SH3 and multiple ankyrin repeat domains 1	0.212
PNOC	prepronociceptin	0.104
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.102
GPRASP1	G protein-coupled receptor associated sorting protein 1	0.092
ZFR2	zinc finger RNA binding protein 2	0.082
CORT	cortistatin	0.080
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.077
DRD2	dopamine receptor D2	0.063
FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.054
GRM1	glutamate receptor, metabotropic 1	0.053
OPCML	opioid binding protein/cell adhesion molecule-like	0.052
GHRHR	growth hormone releasing hormone receptor	0.048
CALY	calcyon neuron-specific vesicular protein	0.047
ADRA1D	adrenergic, alpha-1D-, receptor	0.047
TH	tyrosine hydroxylase	0.046
KCNK4	potassium channel, subfamily K, member 4	0.045
EMX1	empty spiracles homeobox 1	0.043
KCNK13	potassium channel, subfamily K, member 13	0.043
KCNC3	potassium voltage-gated channel, Shaw-related subfamily, member 3	0.042
NEURL	neuralized homolog (Drosophila)	0.041
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.041
GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	0.041
GRM5	glutamate receptor, metabotropic 5	0.038
NGB	neuroglobin	0.038
ADAM11	ADAM metallopeptidase domain 11	0.037
GNAT1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	0.037
GPR6	G protein-coupled receptor 6	0.037
GHSR	growth hormone secretagogue receptor	0.036
SST	somatostatin	0.035
YAP1	Yes-associated protein 1	0.034
OPRD1	opioid receptor, delta 1	0.034	Human
GALR3	galanin receptor 3	0.033	Human
CHRNG	cholinergic receptor, nicotinic, gamma	0.032
UTS2R	urotensin 2 receptor	0.031
SYT3	synaptotagmin III	0.031
SOX1	SRY (sex determining region Y)-box 1	0.031
OXT	oxytocin, prepropeptide	0.030
MUC2	mucin 2, oligomeric mucus/gel-forming	0.030
GJA4	gap junction protein, alpha 4, 37kDa	0.030
ADM2	adrenomedullin 2	0.030
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.029
GCGR	glucagon receptor	0.029
TLX2	T-cell leukemia homeobox 2	0.029
CCKBR	cholecystokinin B receptor	0.028
POU4F3	POU class 4 homeobox 3	0.028
SHH	sonic hedgehog	0.028
VGF	VGF nerve growth factor inducible	0.027
INSL3	insulin-like 3 (Leydig cell)	0.027
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.026
CRYBB2	crystallin, beta B2	0.026
FOXD3	forkhead box D3	0.026
CCL1	chemokine (C-C motif) ligand 1	0.025
HAND1	heart and neural crest derivatives expressed 1	0.025
OR2C1	olfactory receptor, family 2, subfamily C, member 1	0.025
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.025
IL27	interleukin 27	0.024
RHBDL1	rhomboid, veinlet-like 1 (Drosophila)	0.024
SLC1A7	solute carrier family 1 (glutamate transporter), member 7	0.024
P2RX6	purinergic receptor P2X, ligand-gated ion channel, 6	0.024
PNLIPRP1	pancreatic lipase-related protein 1	0.023
HNF1A	HNF1 homeobox A	0.023
NKX2-8	NK2 homeobox 8	0.023
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.023
BARHL1	BarH-like homeobox 1	0.022
NOS1	nitric oxide synthase 1 (neuronal)	0.022
HRH3	histamine receptor H3	0.022
MATN4	matrilin 4	0.022
PRKCG	protein kinase C, gamma	0.022
KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	0.021
NTSR1	neurotensin receptor 1 (high affinity)	0.021
NTN3	netrin 3	0.021
USH1G	Usher syndrome 1G (autosomal recessive)	0.021
SYN2	synapsin II	0.021
PLEKHA2	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2	0.020
THPO	thrombopoietin	0.020
DRD3	dopamine receptor D3	0.020
AVPR1B	arginine vasopressin receptor 1B	0.020
LHB	luteinizing hormone beta polypeptide	0.020
CDK5R2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.020
GIP	gastric inhibitory polypeptide	0.020
GNMT	glycine N-methyltransferase	0.020
CRX	cone-rod homeobox	0.019
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.019
ZAN	zonadhesin	0.019
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.019
NPW	neuropeptide W	0.019
PRM2	protamine 2	0.019
ISLR2	immunoglobulin superfamily containing leucine-rich repeat 2	0.019
GUCY2D	guanylate cyclase 2D, membrane (retina-specific)	0.019
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.018
PRPH2	peripherin 2 (retinal degeneration, slow)	0.018
SYNGR4	synaptogyrin 4	0.018
FAM5C	family with sequence similarity 5, member C	0.018
ALPI	alkaline phosphatase, intestinal	0.018
TFR2	transferrin receptor 2	0.018
TEF	thyrotrophic embryonic factor	0.018
TNP2	transition protein 2 (during histone to protamine replacement)	0.018
CNGB1	cyclic nucleotide gated channel beta 1	0.018
IL17B	interleukin 17B	0.018
GLRA1	glycine receptor, alpha 1	0.018
CAMK2N2	calcium/calmodulin-dependent protein kinase II inhibitor 2	0.018
SLC22A6	solute carrier family 22 (organic anion transporter), member 6	0.018
ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.018
SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	0.018
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	0.018
C1orf68	chromosome 1 open reading frame 68	0.018
FGF8	fibroblast growth factor 8 (androgen-induced)	0.018
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.018
AGRP	agouti related protein homolog (mouse)	0.017
DKK4	dickkopf homolog 4 (Xenopus laevis)	0.017
OPRM1	opioid receptor, mu 1	0.017
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.017
MMP25	matrix metallopeptidase 25	0.017
GLP1R	glucagon-like peptide 1 receptor	0.017
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.017
KISS1	KiSS-1 metastasis-suppressor	0.017
OPN1SW	opsin 1 (cone pigments), short-wave-sensitive	0.017
ITPKA	inositol-trisphosphate 3-kinase A	0.017
CCIN	calicin	0.017
GJD2	gap junction protein, delta 2, 36kDa	0.017
CLCNKB	chloride channel Kb	0.017
GUCA2B	guanylate cyclase activator 2B (uroguanylin)	0.017
PAX2	paired box 2	0.016
PRKAG3	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	0.016
INA	internexin neuronal intermediate filament protein, alpha	0.016
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.016
FGF22	fibroblast growth factor 22	0.016
GP2	glycoprotein 2 (zymogen granule membrane)	0.016
NKPD1	NTPase, KAP family P-loop domain containing 1	0.016
NEUROD2	neurogenic differentiation 2	0.016
SLC7A4	solute carrier family 7 (cationic amino acid transporter, y+ system), member 4	0.016
GUCA1A	guanylate cyclase activator 1A (retina)	0.016
NEUROG3	neurogenin 3	0.016
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.016
KCNH1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.016
NXPH2	neurexophilin 2	0.016
KLHL35	kelch-like 35 (Drosophila)	0.016
F12	coagulation factor XII (Hageman factor)	0.016
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.016
SLC22A13	solute carrier family 22 (organic anion transporter), member 13	0.016
KRT33B	keratin 33B	0.016
KCNJ4	potassium inwardly-rectifying channel, subfamily J, member 4	0.015
VAX2	ventral anterior homeobox 2	0.015
GFAP	glial fibrillary acidic protein	0.015
SPP2	secreted phosphoprotein 2, 24kDa	0.015
CAMK1G	calcium/calmodulin-dependent protein kinase IG	0.015
CHRNB4	cholinergic receptor, nicotinic, beta 4	0.015
C16orf3	chromosome 16 open reading frame 3	0.015
CDH22	cadherin 22, type 2	0.015
GAL	galanin prepropeptide	0.015
RAB40A	RAB40A, member RAS oncogene family	0.015
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.015
TMSB4Y	thymosin beta 4, Y-linked	0.015
ARR3	arrestin 3, retinal (X-arrestin)	0.015
PAEP	progestagen-associated endometrial protein	0.015
CRHR2	corticotropin releasing hormone receptor 2	0.015
CRP	C-reactive protein, pentraxin-related	0.015
TM4SF5	transmembrane 4 L six family member 5	0.015
RHO	rhodopsin	0.015
ALK	anaplastic lymphoma receptor tyrosine kinase	0.015
OPN4	opsin 4	0.015
KIF25	kinesin family member 25	0.015
MC4R	melanocortin 4 receptor	0.015
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.015
ADRA1B	adrenergic, alpha-1B-, receptor	0.015
MAG	myelin associated glycoprotein	0.015
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.015
MTNR1A	melatonin receptor 1A	0.015
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.014
CHRM1	cholinergic receptor, muscarinic 1	0.014
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.014
C2orf55	chromosome 2 open reading frame 55	0.014
CSHL1	chorionic somatomammotropin hormone-like 1	0.014
OLIG2	oligodendrocyte lineage transcription factor 2	0.014
CRYBA4	crystallin, beta A4	0.014
GRIK3	glutamate receptor, ionotropic, kainate 3	0.014
C8G	complement component 8, gamma polypeptide	0.014
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.014
GABRR2	gamma-aminobutyric acid (GABA) receptor, rho 2	0.014
ESPNL	espin-like	0.014
TRH	thyrotropin-releasing hormone	0.014
SLC34A1	solute carrier family 34 (sodium phosphate), member 1	0.014
AQP2	aquaporin 2 (collecting duct)	0.014
KRT85	keratin 85	0.014
GJC2	gap junction protein, gamma 2, 47kDa	0.014
PTPRH	protein tyrosine phosphatase, receptor type, H	0.014
UPK3A	uroplakin 3A	0.013
FAM5B	family with sequence similarity 5, member B	0.013
PCSK1	proprotein convertase subtilisin/kexin type 1	0.013
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.013
PDHA2	pyruvate dehydrogenase (lipoamide) alpha 2	0.013
CASR	calcium-sensing receptor	0.013
PYY	peptide YY	0.013
KREMEN2	kringle containing transmembrane protein 2	0.013
GRK1	G protein-coupled receptor kinase 1	0.013
ARTN	artemin	0.013
LRIT1	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	0.013
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.013
RGS7	regulator of G-protein signaling 7	0.013
EZR	ezrin	0.013
SLC8A2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.013
EXOC3L1	exocyst complex component 3-like 1	0.013
SLC6A18	solute carrier family 6, member 18	0.013
ENPP7	ectonucleotide pyrophosphatase/phosphodiesterase 7	0.013
GJA3	gap junction protein, alpha 3, 46kDa	0.013
NOL4	nucleolar protein 4	0.013
C19orf26	chromosome 19 open reading frame 26	0.013
HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	0.013
NXPH3	neurexophilin 3	0.013
COL19A1	collagen, type XIX, alpha 1	0.013
KLHL1	kelch-like 1 (Drosophila)	0.013
HIST3H3	histone cluster 3, H3	0.013
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.013
FGF3	fibroblast growth factor 3	0.013
LBX1	ladybird homeobox 1	0.013
NPPC	natriuretic peptide C	0.013
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.013
AVPR2	arginine vasopressin receptor 2	0.013
CACNG2	calcium channel, voltage-dependent, gamma subunit 2	0.013
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.012
CHGB	chromogranin B (secretogranin 1)	0.012
IRGC	immunity-related GTPase family, cinema	0.012
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.012
GPR173	G protein-coupled receptor 173	0.012
SSTR1	somatostatin receptor 1	0.012	Human
PNMT	phenylethanolamine N-methyltransferase	0.012
CYP2W1	cytochrome P450, family 2, subfamily W, polypeptide 1	0.012
FOXN1	forkhead box N1	0.012
SOX3	SRY (sex determining region Y)-box 3	0.012
SCGB1D1	secretoglobin, family 1D, member 1	0.012
DRD4	dopamine receptor D4	0.012
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.012
PTH2	parathyroid hormone 2	0.012
PNPLA5	patatin-like phospholipase domain containing 5	0.012
TRIM46	tripartite motif containing 46	0.012
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.012
MBL2	mannose-binding lectin (protein C) 2, soluble	0.012
RCVRN	recoverin	0.012
PKDREJ	polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)	0.012
PAX8	paired box 8	0.012
PAX4	paired box 4	0.012
HBQ1	hemoglobin, theta 1	0.012
KCNE1L	KCNE1-like	0.012
GPR12	G protein-coupled receptor 12	0.012
ZP2	zona pellucida glycoprotein 2 (sperm receptor)	0.012
AMBP	alpha-1-microglobulin/bikunin precursor	0.012
CIDEA	cell death-inducing DFFA-like effector a	0.012
SPTB	spectrin, beta, erythrocytic	0.012
OMP	olfactory marker protein	0.012
IL1RL2	interleukin 1 receptor-like 2	0.012
ATP8B3	ATPase, aminophospholipid transporter, class I, type 8B, member 3	0.012
STX1A	syntaxin 1A (brain)	0.012
GUCA1B	guanylate cyclase activator 1B (retina)	0.012
GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	0.012
HTR3A	5-hydroxytryptamine (serotonin) receptor 3A	0.012
ATP4A	ATPase, H+/K+ exchanging, alpha polypeptide	0.012
CRB2	crumbs homolog 2 (Drosophila)	0.012
OPRL1	opiate receptor-like 1	0.012	Human
PRDM12	PR domain containing 12	0.012
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.012
NCR2	natural cytotoxicity triggering receptor 2	0.012
HCRT	hypocretin (orexin) neuropeptide precursor	0.012
TCF15	transcription factor 15 (basic helix-loop-helix)	0.011
CPLX2	complexin 2	0.011
GPR20	G protein-coupled receptor 20	0.011
TIGD3	tigger transposable element derived 3	0.011
KLK15	kallikrein-related peptidase 15	0.011
MYT1	myelin transcription factor 1	0.011
CHST5	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	0.011
MLNR	motilin receptor	0.011
ACTL6B	actin-like 6B	0.011
TBX1	T-box 1	0.011
RLN1	relaxin 1	0.011
GLRA2	glycine receptor, alpha 2	0.011
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	0.011
WNT7A	wingless-type MMTV integration site family, member 7A	0.011
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.011
HOXD3	homeobox D3	0.011
P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	0.011
EXTL1	exostoses (multiple)-like 1	0.011
GUCY2F	guanylate cyclase 2F, retinal	0.011
LHX1	LIM homeobox 1	0.011
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.011
LMX1B	LIM homeobox transcription factor 1, beta	0.011
KRTAP10-12	keratin associated protein 10-12	0.011
CDH8	cadherin 8, type 2	0.011
GGN	gametogenetin	0.011
TMEM130	transmembrane protein 130	0.011
GP5	glycoprotein V (platelet)	0.011
CRHR1	corticotropin releasing hormone receptor 1	0.011
SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5	0.011
CLCN1	chloride channel 1, skeletal muscle	0.011
MAPK4	mitogen-activated protein kinase 4	0.011
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.011
SCN2B	sodium channel, voltage-gated, type II, beta	0.011
PAX7	paired box 7	0.011
CST8	cystatin 8 (cystatin-related epididymal specific)	0.011
ATP2B3	ATPase, Ca++ transporting, plasma membrane 3	0.011
KCNV1	potassium channel, subfamily V, member 1	0.011
GFRA2	GDNF family receptor alpha 2	0.011
PRM3	protamine 3	0.011
SLC16A11	solute carrier family 16, member 11 (monocarboxylic acid transporter 11)	0.011
FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	0.011
JAK3	Janus kinase 3	0.011
AANAT	aralkylamine N-acetyltransferase	0.011
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.010
RBMXL2	RNA binding motif protein, X-linked-like 2	0.010
VSTM2A	V-set and transmembrane domain containing 2A	0.010
DUSP9	dual specificity phosphatase 9	0.010
CACNA1F	calcium channel, voltage-dependent, L type, alpha 1F subunit	0.010
C20orf195	chromosome 20 open reading frame 195	0.010
GCM1	glial cells missing homolog 1 (Drosophila)	0.010
NOS2	nitric oxide synthase 2, inducible	0.010
TEX13B	testis expressed 13B	0.010
ABCA4	ATP-binding cassette, sub-family A (ABC1), member 4	0.010
CELA2A	chymotrypsin-like elastase family, member 2A	0.010
OLIG3	oligodendrocyte transcription factor 3	0.010
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.010
HES2	hairy and enhancer of split 2 (Drosophila)	0.010
BMP10	bone morphogenetic protein 10	0.010
KBTBD5	kelch repeat and BTB (POZ) domain containing 5	0.010
GRIK4	glutamate receptor, ionotropic, kainate 4	0.010
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.010
GNG4	guanine nucleotide binding protein (G protein), gamma 4	0.010
TREML2	triggering receptor expressed on myeloid cells-like 2	0.010
HOXD9	homeobox D9	0.010
C9orf50	chromosome 9 open reading frame 50	0.010
FOXH1	forkhead box H1	0.010
CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit	0.010
BFSP1	beaded filament structural protein 1, filensin	0.010
KRT33A	keratin 33A	0.010
LRRTM1	leucine rich repeat transmembrane neuronal 1	0.010
POU1F1	POU class 1 homeobox 1	0.010
TBX10	T-box 10	0.010
FRMD1	FERM domain containing 1	0.010
NTSR2	neurotensin receptor 2	0.010
RIPPLY2	ripply2 homolog (zebrafish)	0.010
CRH	corticotropin releasing hormone	0.010