IMP

Process View

Homo sapiens

26 genes annotated in human

congenital disorder of glycosylation

DOID:5212

A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "congenital disorder of glycosylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "congenital disorder of glycosylation" (in gray)

Name	Description	Probability
COG4	component of oligomeric golgi complex 4	1.000
COG7	component of oligomeric golgi complex 7	0.995
COG3	component of oligomeric golgi complex 3	0.974
DPAGT1	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	0.868
COG8	component of oligomeric golgi complex 8	0.840
G6PC3	glucose 6 phosphatase, catalytic, 3	0.602
COG1	component of oligomeric golgi complex 1	0.589
SCFD1	sec1 family domain containing 1	0.471
ALG8	asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)	0.412
CYB561D2	cytochrome b-561 domain containing 2	0.411
SRPRB	signal recognition particle receptor, B subunit	0.399
TM9SF1	transmembrane 9 superfamily member 1	0.359
EI24	etoposide induced 2.4 mRNA	0.337
COG2	component of oligomeric golgi complex 2	0.322
TMX2	thioredoxin-related transmembrane protein 2	0.279
ALG3	asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae)	0.259
PMVK	phosphomevalonate kinase	0.239
SIGMAR1	sigma non-opioid intracellular receptor 1	0.232
ATP13A1	ATPase type 13A1	0.227
SUB1	SUB1 homolog (S. cerevisiae)	0.207
IFRD2	interferon-related developmental regulator 2	0.200
TSTA3	tissue specific transplantation antigen P35B	0.189
TMEM214	transmembrane protein 214	0.161
MYCBP	c-myc binding protein	0.156
METTL13	methyltransferase like 13	0.152
NUDT15	nudix (nucleoside diphosphate linked moiety X)-type motif 15	0.143
ORMDL2	ORM1-like 2 (S. cerevisiae)	0.138
SNRPB2	small nuclear ribonucleoprotein polypeptide B	0.130
SLC5A6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	0.121
TCTN3	tectonic family member 3	0.115
COASY	CoA synthase	0.112
TXNDC9	thioredoxin domain containing 9	0.112
DPM2	dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit	0.110
UBXN8	UBX domain protein 8	0.098
DOLK	dolichol kinase	0.095
COG6	component of oligomeric golgi complex 6	0.092
YIF1A	Yip1 interacting factor homolog A (S. cerevisiae)	0.090
SLC1A5	solute carrier family 1 (neutral amino acid transporter), member 5	0.077
ALG5	asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae)	0.073
ALG6	asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)	0.067
MFSD3	major facilitator superfamily domain containing 3	0.062
BET1	blocked early in transport 1 homolog (S. cerevisiae)	0.062
NIP7	nuclear import 7 homolog (S. cerevisiae)	0.060
GPR172A	G protein-coupled receptor 172A	0.059
MLEC	malectin	0.059
SCAMP3	secretory carrier membrane protein 3	0.058
C17orf90	chromosome 17 open reading frame 90	0.057
C14orf169	chromosome 14 open reading frame 169	0.054
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.053
SRP19	signal recognition particle 19kDa	0.051
CUTA	cutA divalent cation tolerance homolog (E. coli)	0.050
C11orf24	chromosome 11 open reading frame 24	0.047
HSPB11	heat shock protein family B (small), member 11	0.046
UNC50	unc-50 homolog (C. elegans)	0.046
SCAMP2	secretory carrier membrane protein 2	0.046
SEP15	15 kDa selenoprotein	0.045
CCDC86	coiled-coil domain containing 86	0.045
STX5	syntaxin 5	0.045
DUS1L	dihydrouridine synthase 1-like (S. cerevisiae)	0.043
TMEM138	transmembrane protein 138	0.042
ZDHHC16	zinc finger, DHHC-type containing 16	0.040
GMPPA	GDP-mannose pyrophosphorylase A	0.040
TMX1	thioredoxin-related transmembrane protein 1	0.037
GTF2A2	general transcription factor IIA, 2, 12kDa	0.037
INTS5	integrator complex subunit 5	0.036
PIGU	phosphatidylinositol glycan anchor biosynthesis, class U	0.036
SLMO2	slowmo homolog 2 (Drosophila)	0.033
GPR89A	G protein-coupled receptor 89A	0.032
METTL1	methyltransferase like 1	0.032
AUP1	ancient ubiquitous protein 1	0.032
ICMT	isoprenylcysteine carboxyl methyltransferase	0.032
NDUFA3	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa	0.030
MTX1	metaxin 1	0.030
ALDH18A1	aldehyde dehydrogenase 18 family, member A1	0.029
NARS2	asparaginyl-tRNA synthetase 2, mitochondrial (putative)	0.029
PTDSS1	phosphatidylserine synthase 1	0.029
UBIAD1	UbiA prenyltransferase domain containing 1	0.028
USP16	ubiquitin specific peptidase 16	0.028
PRPS2	phosphoribosyl pyrophosphate synthetase 2	0.028
FTSJ1	FtsJ homolog 1 (E. coli)	0.028
ZMPSTE24	zinc metallopeptidase (STE24 homolog, S. cerevisiae)	0.027
TMEM14B	transmembrane protein 14B	0.027
C12orf52	chromosome 12 open reading frame 52	0.027
FDXACB1	ferredoxin-fold anticodon binding domain containing 1	0.027
PIGM	phosphatidylinositol glycan anchor biosynthesis, class M	0.026
NOL6	nucleolar protein family 6 (RNA-associated)	0.026
ABCD3	ATP-binding cassette, sub-family D (ALD), member 3	0.026
SRPR	signal recognition particle receptor (docking protein)	0.026
PHKB	phosphorylase kinase, beta	0.026
FAM86B1	family with sequence similarity 86, member B1	0.025
C7orf49	chromosome 7 open reading frame 49	0.025
CNPY2	canopy 2 homolog (zebrafish)	0.025
MFSD5	major facilitator superfamily domain containing 5	0.025
SERP1	stress-associated endoplasmic reticulum protein 1	0.023
CLPTM1L	CLPTM1-like	0.023
C7orf28B	chromosome 7 open reading frame 28B	0.022
CNIH	cornichon homolog (Drosophila)	0.021
GALNT7	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	0.021
SEC23B	Sec23 homolog B (S. cerevisiae)	0.021
RPN2	ribophorin II	0.021
CCDC59	coiled-coil domain containing 59	0.020
SPCS3	signal peptidase complex subunit 3 homolog (S. cerevisiae)	0.020
FBXL15	F-box and leucine-rich repeat protein 15	0.020
SCAND1	SCAN domain containing 1	0.020
TEX264	testis expressed 264	0.019
TMEM161A	transmembrane protein 161A	0.019
ARFIP2	ADP-ribosylation factor interacting protein 2	0.019
ACN9	ACN9 homolog (S. cerevisiae)	0.019
TMEM187	transmembrane protein 187	0.019
DUSP11	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	0.019
TMCO1	transmembrane and coiled-coil domains 1	0.019
DPH2	DPH2 homolog (S. cerevisiae)	0.018
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.018
GLT25D1	glycosyltransferase 25 domain containing 1	0.018
EIF3M	eukaryotic translation initiation factor 3, subunit M	0.018
NME3	non-metastatic cells 3, protein expressed in	0.018
TXNDC12	thioredoxin domain containing 12 (endoplasmic reticulum)	0.018
NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2	0.018
MOGS	mannosyl-oligosaccharide glucosidase	0.017
SLC35C2	solute carrier family 35, member C2	0.017
PEMT	phosphatidylethanolamine N-methyltransferase	0.017
LCLAT1	lysocardiolipin acyltransferase 1	0.017
GTF3C2	general transcription factor IIIC, polypeptide 2, beta 110kDa	0.017
GOLT1B	golgi transport 1B	0.017
QRICH2	glutamine rich 2	0.017
C1D	C1D nuclear receptor corepressor	0.017
RABGGTB	Rab geranylgeranyltransferase, beta subunit	0.017
B3GAT3	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	0.016
HMGN3	high mobility group nucleosomal binding domain 3	0.016
SSR1	signal sequence receptor, alpha	0.016
TMEM179B	transmembrane protein 179B	0.016
PTPLB	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b	0.016
B4GALT7	xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)	0.016
POP5	processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)	0.016
GGCX	gamma-glutamyl carboxylase	0.016
C20orf4	chromosome 20 open reading frame 4	0.016
MIS12	MIS12, MIND kinetochore complex component, homolog (S. pombe)	0.015
TRIM27	tripartite motif containing 27	0.015
PIGO	phosphatidylinositol glycan anchor biosynthesis, class O	0.015
COG5	component of oligomeric golgi complex 5	0.015
PGRMC1	progesterone receptor membrane component 1	0.015
BOLA1	bolA homolog 1 (E. coli)	0.015
HS2ST1	heparan sulfate 2-O-sulfotransferase 1	0.015
PNPO	pyridoxamine 5'-phosphate oxidase	0.015
KIAA0100	KIAA0100	0.015
HDHD3	haloacid dehalogenase-like hydrolase domain containing 3	0.014
ZDHHC6	zinc finger, DHHC-type containing 6	0.014
TTC35	tetratricopeptide repeat domain 35	0.014
KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.014
CLN3	ceroid-lipofuscinosis, neuronal 3	0.014
PSMG1	proteasome (prosome, macropain) assembly chaperone 1	0.014
ADAT1	adenosine deaminase, tRNA-specific 1	0.014
PFDN4	prefoldin subunit 4	0.014
PREB	prolactin regulatory element binding	0.014
SNX2	sorting nexin 2	0.013
TYW1	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	0.013
MEN1	multiple endocrine neoplasia I	0.013
GMPPB	GDP-mannose pyrophosphorylase B	0.013
ABHD3	abhydrolase domain containing 3	0.013
HDHD1	haloacid dehalogenase-like hydrolase domain containing 1	0.013
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.013
EIF4E	eukaryotic translation initiation factor 4E	0.013
SEPT2	septin 2	0.013
ISOC1	isochorismatase domain containing 1	0.013
ERLIN1	ER lipid raft associated 1	0.013
SLC35B1	solute carrier family 35, member B1	0.013
TMEM168	transmembrane protein 168	0.013
BCAS2	breast carcinoma amplified sequence 2	0.013
MTFR1	mitochondrial fission regulator 1	0.012
STT3A	STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)	0.012
BCAP31	B-cell receptor-associated protein 31	0.012
DPY19L4	dpy-19-like 4 (C. elegans)	0.012
SLC35A2	solute carrier family 35 (UDP-galactose transporter), member A2	0.012
NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	0.012
POLD3	polymerase (DNA-directed), delta 3, accessory subunit	0.012
PPIP5K2	diphosphoinositol pentakisphosphate kinase 2	0.012
DPP3	dipeptidyl-peptidase 3	0.012
ALG12	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	0.012
C8orf55	chromosome 8 open reading frame 55	0.012
CSTF1	cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa	0.012
UBA3	ubiquitin-like modifier activating enzyme 3	0.012
PRKRIR	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	0.012
EIF2B1	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	0.012
ABCC10	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	0.012
MINPP1	multiple inositol-polyphosphate phosphatase 1	0.012
SMN2	survival of motor neuron 2, centromeric	0.012
UBE4A	ubiquitination factor E4A (UFD2 homolog, yeast)	0.012
CCDC77	coiled-coil domain containing 77	0.011
SLC33A1	solute carrier family 33 (acetyl-CoA transporter), member 1	0.011
IPO4	importin 4	0.011
STRAP	serine/threonine kinase receptor associated protein	0.011
C2orf43	chromosome 2 open reading frame 43	0.011
PIGK	phosphatidylinositol glycan anchor biosynthesis, class K	0.011
KIAA0776	KIAA0776	0.011
SPRYD4	SPRY domain containing 4	0.011
SRP54	signal recognition particle 54kDa	0.011
HYOU1	hypoxia up-regulated 1	0.011
PARN	poly(A)-specific ribonuclease (deadenylation nuclease)	0.011
WDR46	WD repeat domain 46	0.011
RNFT1	ring finger protein, transmembrane 1	0.011
ANAPC5	anaphase promoting complex subunit 5	0.011
PEX3	peroxisomal biogenesis factor 3	0.011
TMEM208	transmembrane protein 208	0.011
EXTL2	exostoses (multiple)-like 2	0.011
GORASP2	golgi reassembly stacking protein 2, 55kDa	0.011
JAGN1	jagunal homolog 1 (Drosophila)	0.010
CHPF2	chondroitin polymerizing factor 2	0.010
GMDS	GDP-mannose 4,6-dehydratase	0.010
PPRC1	peroxisome proliferator-activated receptor gamma, coactivator-related 1	0.010
SLC31A1	solute carrier family 31 (copper transporters), member 1	0.010
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.010
RPP25	ribonuclease P/MRP 25kDa subunit	0.010
MPG	N-methylpurine-DNA glycosylase	0.010
NUDT5	nudix (nucleoside diphosphate linked moiety X)-type motif 5	0.010
C2orf29	chromosome 2 open reading frame 29	0.010
CENPE	centromere protein E, 312kDa	0.010
C6orf120	chromosome 6 open reading frame 120	0.010
SLC50A1	solute carrier family 50 (sugar transporter), member 1	0.010
SGSM3	small G protein signaling modulator 3	0.010
ALG1	asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)	0.010
SLC35C1	solute carrier family 35, member C1	0.010
SRD5A3	steroid 5 alpha-reductase 3	0.007
PMM2	phosphomannomutase 2	0.007
MPI	mannose phosphate isomerase	0.005
ALG9	asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae)	0.004
MPDU1	mannose-P-dolichol utilization defect 1	0.004
B4GALT1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.003
RFT1	RFT1 homolog (S. cerevisiae)	0.003
DPM3	dolichyl-phosphate mannosyltransferase polypeptide 3	0.002
MGAT2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	0.001
SLC35A1	solute carrier family 35 (CMP-sialic acid transporter), member A1	0.001
ALG11	asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)	0.001
DPM1	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit	0.000