IMP
Process View
ruffle assembly
The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "ruffle assembly"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CDC42 | cell division cycle 42 (GTP binding protein, 25kDa) | 0.936 | ||
| ZYX | zyxin | 0.302 | ||
| BAIAP2 | BAI1-associated protein 2 | 0.243 | ||
| NCOA1 | nuclear receptor coactivator 1 | 0.243 | ||
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.199 | ||
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) | 0.183 | ||
| DLG5 | discs, large homolog 5 (Drosophila) | 0.097 | ||
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.094 | Mouse | |
| RALBP1 | ralA binding protein 1 | 0.093 | ||
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.088 | Human | |
| RAB6A | RAB6A, member RAS oncogene family | 0.085 | ||
| ACTB | actin, beta | 0.084 | ||
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.077 | ||
| SORBS3 | sorbin and SH3 domain containing 3 | 0.075 | ||
| SH3RF3 | SH3 domain containing ring finger 3 | 0.065 | ||
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.056 | ||
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.056 | ||
| C17orf28 | chromosome 17 open reading frame 28 | 0.051 | ||
| RAB5A | RAB5A, member RAS oncogene family | 0.051 | ||
| WASF1 | WAS protein family, member 1 | 0.049 | ||
| RIN1 | Ras and Rab interactor 1 | 0.047 | ||
| NCKAP1 | NCK-associated protein 1 | 0.041 | ||
| RHOC | ras homolog gene family, member C | 0.039 | ||
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.037 | ||
| FAT1 | FAT tumor suppressor homolog 1 (Drosophila) | 0.036 | ||
| NCKIPSD | NCK interacting protein with SH3 domain | 0.035 | ||
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.034 | ||
| WASF2 | WAS protein family, member 2 | 0.031 | ||
| EMP3 | epithelial membrane protein 3 | 0.030 | ||
| TSC22D1 | TSC22 domain family, member 1 | 0.029 | ||
| SORBS1 | sorbin and SH3 domain containing 1 | 0.026 | ||
| RASSF5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.023 | ||
| SH3RF1 | SH3 domain containing ring finger 1 | 0.023 | ||
| RHEB | Ras homolog enriched in brain | 0.021 | ||
| AP2A2 | adaptor-related protein complex 2, alpha 2 subunit | 0.021 | ||
| PNPLA6 | patatin-like phospholipase domain containing 6 | 0.020 | ||
| XIRP1 | xin actin-binding repeat containing 1 | 0.019 | ||
| PAK2 | p21 protein (Cdc42/Rac)-activated kinase 2 | 0.018 | ||
| HTT | huntingtin | 0.018 | ||
| VASP | vasodilator-stimulated phosphoprotein | 0.018 | Human | |
| S100A11 | S100 calcium binding protein A11 | 0.018 | ||
| PFN1 | profilin 1 | 0.017 | ||
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.017 | ||
| RAB14 | RAB14, member RAS oncogene family | 0.017 | ||
| CLDN4 | claudin 4 | 0.016 | ||
| RHOG | ras homolog gene family, member G (rho G) | 0.015 | Mouse | |
| DLG4 | discs, large homolog 4 (Drosophila) | 0.015 | ||
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.015 | ||
| CHN2 | chimerin (chimaerin) 2 | 0.014 | ||
| BAG1 | BCL2-associated athanogene | 0.014 | ||
| CLDN7 | claudin 7 | 0.013 | ||
| RAB1B | RAB1B, member RAS oncogene family | 0.013 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.013 | ||
| PEBP4 | phosphatidylethanolamine-binding protein 4 | 0.013 | ||
| NCK1 | NCK adaptor protein 1 | 0.012 | ||
| ABI1 | abl-interactor 1 | 0.012 | ||
| FHOD1 | formin homology 2 domain containing 1 | 0.012 | ||
| PAWR | PRKC, apoptosis, WT1, regulator | 0.012 | ||
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.012 | ||
| ENAH | enabled homolog (Drosophila) | 0.012 | Human | |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.011 | ||
| HIP1 | huntingtin interacting protein 1 | 0.011 | ||
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.011 | ||
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.011 | ||
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 0.011 | ||
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.011 | ||
| CRMP1 | collapsin response mediator protein 1 | 0.011 | ||
| CLTC | clathrin, heavy chain (Hc) | 0.010 | ||
| FXYD5 | FXYD domain containing ion transport regulator 5 | 0.010 | ||
| GOLGB1 | golgin B1 | 0.010 | ||
| TJP1 | tight junction protein 1 (zona occludens 1) | 0.010 | ||
| TTC19 | tetratricopeptide repeat domain 19 | 0.010 | ||
| SH3BGRL3 | SH3 domain binding glutamic acid-rich protein like 3 | 0.010 |