IMP

Process View

Homo sapiens

1 genes annotated in human

cardioblast cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardioblast cell fate specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cardioblast cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
JAG1	jagged 1	1.000
NOTCH1	notch 1	0.992	Fly
CSNK1E	casein kinase 1, epsilon	0.985
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.949	Fly
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.810	Fly
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.667	Fly
AXIN1	axin 1	0.583
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.430
DAXX	death-domain associated protein	0.426
NOTCH3	notch 3	0.390	Fly
CTNNBIP1	catenin, beta interacting protein 1	0.290
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.256
LRRK2	leucine-rich repeat kinase 2	0.233
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.232
DLL1	delta-like 1 (Drosophila)	0.231
MAML1	mastermind-like 1 (Drosophila)	0.144
CEP164	centrosomal protein 164kDa	0.129
NOTCH2NL	notch 2 N-terminal like	0.127
NCOA2	nuclear receptor coactivator 2	0.124
JAG2	jagged 2	0.120
FZD1	frizzled homolog 1 (Drosophila)	0.114
LRP6	low density lipoprotein receptor-related protein 6	0.101
CPE	carboxypeptidase E	0.096
NOTCH2	notch 2	0.077	Fly
PRPF3	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	0.076
REPS2	RALBP1 associated Eps domain containing 2	0.075
APC	adenomatous polyposis coli	0.073
TCF4	transcription factor 4	0.067
AR	androgen receptor	0.067
PML	promyelocytic leukemia	0.054
WT1	Wilms tumor 1	0.047
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.046
TWIST2	twist homolog 2 (Drosophila)	0.045
CTNND1	catenin (cadherin-associated protein), delta 1	0.044
EGFL7	EGF-like-domain, multiple 7	0.043
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.039
RFWD2	ring finger and WD repeat domain 2	0.038
JUN	jun proto-oncogene	0.037
SORBS3	sorbin and SH3 domain containing 3	0.037
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.035
PKP4	plakophilin 4	0.035
SMAD1	SMAD family member 1	0.031
XIAP	X-linked inhibitor of apoptosis	0.029
GLIS2	GLIS family zinc finger 2	0.028
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.028
FZD8	frizzled homolog 8 (Drosophila)	0.027
MYST2	MYST histone acetyltransferase 2	0.025
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.024
HES1	hairy and enhancer of split 1, (Drosophila)	0.023
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.023
DSP	desmoplakin	0.023
RUNX1	runt-related transcription factor 1	0.022
FOXD3	forkhead box D3	0.021
TIFA	TRAF-interacting protein with forkhead-associated domain	0.020
BAHD1	bromo adjacent homology domain containing 1	0.020
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.019
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.018
MCC	mutated in colorectal cancers	0.018
PTK7	PTK7 protein tyrosine kinase 7	0.018
SP100	SP100 nuclear antigen	0.017
PITX1	paired-like homeodomain 1	0.017
CRMP1	collapsin response mediator protein 1	0.017
CSNK1D	casein kinase 1, delta	0.016
TAL1	T-cell acute lymphocytic leukemia 1	0.016
SNIP1	Smad nuclear interacting protein 1	0.016
GSK3B	glycogen synthase kinase 3 beta	0.015
IER2	immediate early response 2	0.014
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.014
NKD2	naked cuticle homolog 2 (Drosophila)	0.014
JUP	junction plakoglobin	0.013	Fly
PTPRB	protein tyrosine phosphatase, receptor type, B	0.013
DPPA2	developmental pluripotency associated 2	0.013
FAM110A	family with sequence similarity 110, member A	0.013
ZFYVE9	zinc finger, FYVE domain containing 9	0.013
FERMT2	fermitin family member 2	0.012
HSD17B14	hydroxysteroid (17-beta) dehydrogenase 14	0.012
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.012	Fly
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.012
CDK10	cyclin-dependent kinase 10	0.011
ZNF512B	zinc finger protein 512B	0.011
FAM110C	family with sequence similarity 110, member C	0.011
HOXC8	homeobox C8	0.011
JUND	jun D proto-oncogene	0.011
C9orf100	chromosome 9 open reading frame 100	0.011
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.011
HIC1	hypermethylated in cancer 1	0.011
FOXO1	forkhead box O1	0.011
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.010
KLHL12	kelch-like 12 (Drosophila)	0.010
FOXO3	forkhead box O3	0.010
PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	0.010
OCLN	occludin	0.010
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.010
DSG2	desmoglein 2	0.010