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Homo sapiens

2 genes annotated in human

protein kinase c activating g protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein kinase c activating g protein coupled receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein kinase c activating g protein coupled receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
DRD2	dopamine receptor D2	1.000
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.999
CAV1	caveolin 1, caveolae protein, 22kDa	0.995
PRLHR	prolactin releasing hormone receptor	0.936
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.886
CAV2	caveolin 2	0.859
PRKCG	protein kinase C, gamma	0.827
NECAB2	N-terminal EF-hand calcium binding protein 2	0.720
ACCN2	amiloride-sensitive cation channel 2, neuronal	0.533
ATXN7L3	ataxin 7-like 3	0.517
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.474
ADORA1	adenosine A1 receptor	0.382
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.315
CCKBR	cholecystokinin B receptor	0.223
PCDHB5	protocadherin beta 5	0.163
CYTH2	cytohesin 2	0.146
EDN1	endothelin 1	0.097	Mouse
CNR1	cannabinoid receptor 1 (brain)	0.077
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.071
EPOR	erythropoietin receptor	0.070
PTPRF	protein tyrosine phosphatase, receptor type, F	0.069
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.068
CYR61	cysteine-rich, angiogenic inducer, 61	0.059
ERP27	endoplasmic reticulum protein 27	0.056
SCG5	secretogranin V (7B2 protein)	0.054
EDNRA	endothelin receptor type A	0.051	Rat
GJA1	gap junction protein, alpha 1, 43kDa	0.049
CTGF	connective tissue growth factor	0.046
BDKRB2	bradykinin receptor B2	0.044
CALCRL	calcitonin receptor-like	0.041
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.040
PCDH8	protocadherin 8	0.040
SDPR	serum deprivation response	0.040
PTEN	phosphatase and tensin homolog	0.038
CIC	capicua homolog (Drosophila)	0.037
TRAF5	TNF receptor-associated factor 5	0.036
BFSP2	beaded filament structural protein 2, phakinin	0.036
SPRR2A	small proline-rich protein 2A	0.035
FKBP2	FK506 binding protein 2, 13kDa	0.034
EDNRB	endothelin receptor type B	0.033
NID2	nidogen 2 (osteonidogen)	0.032
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.031
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.030
NOXA1	NADPH oxidase activator 1	0.029
DLC1	deleted in liver cancer 1	0.029
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.028
TXNRD1	thioredoxin reductase 1	0.027
PRKCDBP	protein kinase C, delta binding protein	0.026
AP1G2	adaptor-related protein complex 1, gamma 2 subunit	0.024
COL4A2	collagen, type IV, alpha 2	0.024
POSTN	periostin, osteoblast specific factor	0.024
STX1A	syntaxin 1A (brain)	0.023
ASPN	asporin	0.023
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.022
COL4A1	collagen, type IV, alpha 1	0.022
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.022
CPA3	carboxypeptidase A3 (mast cell)	0.022
COL8A1	collagen, type VIII, alpha 1	0.022
COL3A1	collagen, type III, alpha 1	0.021
ELTD1	EGF, latrophilin and seven transmembrane domain containing 1	0.021
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.021
IGSF21	immunoglobin superfamily, member 21	0.020
NPHP1	nephronophthisis 1 (juvenile)	0.020
ENPEP	glutamyl aminopeptidase (aminopeptidase A)	0.020
CNN3	calponin 3, acidic	0.020
KRT31	keratin 31	0.019
SOX17	SRY (sex determining region Y)-box 17	0.019
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.019
EGF	epidermal growth factor	0.019
TM4SF1	transmembrane 4 L six family member 1	0.019
SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	0.019
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.019
ARL4C	ADP-ribosylation factor-like 4C	0.019
PCDH17	protocadherin 17	0.018
GCM1	glial cells missing homolog 1 (Drosophila)	0.018
SULF1	sulfatase 1	0.018
LHB	luteinizing hormone beta polypeptide	0.018
GRIA4	glutamate receptor, ionotrophic, AMPA 4	0.018
SNAI2	snail homolog 2 (Drosophila)	0.018
KRT14	keratin 14	0.018
GPR6	G protein-coupled receptor 6	0.018
SPP1	secreted phosphoprotein 1	0.018
PRRX1	paired related homeobox 1	0.018
CALD1	caldesmon 1	0.017
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.017
GUCA1A	guanylate cyclase activator 1A (retina)	0.017
GFI1	growth factor independent 1 transcription repressor	0.017
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.017
TRPC6	transient receptor potential cation channel, subfamily C, member 6	0.017
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.017
MUC1	mucin 1, cell surface associated	0.016
F2RL2	coagulation factor II (thrombin) receptor-like 2	0.016
NTM	neurotrimin	0.016
GNG11	guanine nucleotide binding protein (G protein), gamma 11	0.016
PIP4K2B	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	0.016
DDR2	discoidin domain receptor tyrosine kinase 2	0.016
BMP2	bone morphogenetic protein 2	0.015
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.015
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.015
ITPRIPL1	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	0.015
RGS5	regulator of G-protein signaling 5	0.015
SPAG8	sperm associated antigen 8	0.015
DDB2	damage-specific DNA binding protein 2, 48kDa	0.015
NID1	nidogen 1	0.015
CDSN	corneodesmosin	0.015
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.015
SCG2	secretogranin II	0.015
BNC1	basonuclin 1	0.015
SRCIN1	SRC kinase signaling inhibitor 1	0.015
ACCN1	amiloride-sensitive cation channel 1, neuronal	0.014
PTHLH	parathyroid hormone-like hormone	0.014
GPX7	glutathione peroxidase 7	0.014
BFSP1	beaded filament structural protein 1, filensin	0.014
TGM5	transglutaminase 5	0.014
PCSK1	proprotein convertase subtilisin/kexin type 1	0.014
CD93	CD93 molecule	0.014
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.014
LOX	lysyl oxidase	0.014
ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0.014
DOK6	docking protein 6	0.014
KLHL26	kelch-like 26 (Drosophila)	0.014
KRT13	keratin 13	0.014
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D	0.014
CDH5	cadherin 5, type 2 (vascular endothelium)	0.014
PSG7	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)	0.014
NOL4	nucleolar protein 4	0.014
CCL7	chemokine (C-C motif) ligand 7	0.014
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	0.014
EXTL1	exostoses (multiple)-like 1	0.014
BMX	BMX non-receptor tyrosine kinase	0.013
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.013
RIN2	Ras and Rab interactor 2	0.013
COL12A1	collagen, type XII, alpha 1	0.013
TNP2	transition protein 2 (during histone to protamine replacement)	0.013
SELE	selectin E	0.013
FAP	fibroblast activation protein, alpha	0.013
PI15	peptidase inhibitor 15	0.013
SCN2A	sodium channel, voltage-gated, type II, alpha subunit	0.013
GJD2	gap junction protein, delta 2, 36kDa	0.013
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.013
ZNF132	zinc finger protein 132	0.013
GRIK1	glutamate receptor, ionotropic, kainate 1	0.013
TRIB2	tribbles homolog 2 (Drosophila)	0.013
GRM7	glutamate receptor, metabotropic 7	0.013
GRIP1	glutamate receptor interacting protein 1	0.013
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.013
ZNF205	zinc finger protein 205	0.013
GRIA3	glutamate receptor, ionotrophic, AMPA 3	0.013
NOTCH2NL	notch 2 N-terminal like	0.013
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.012
TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	0.012
ADRB2	adrenergic, beta-2-, receptor, surface	0.012
SOCS2	suppressor of cytokine signaling 2	0.012
BLK	B lymphoid tyrosine kinase	0.012
VIP	vasoactive intestinal peptide	0.012
GRM6	glutamate receptor, metabotropic 6	0.012
CCDC14	coiled-coil domain containing 14	0.012
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.012
SCRG1	stimulator of chondrogenesis 1	0.012
CNGA3	cyclic nucleotide gated channel alpha 3	0.012
KRT75	keratin 75	0.012
IGFBP3	insulin-like growth factor binding protein 3	0.012
AICDA	activation-induced cytidine deaminase	0.012
SFRP4	secreted frizzled-related protein 4	0.012
WISP1	WNT1 inducible signaling pathway protein 1	0.012
ANKRD13D	ankyrin repeat domain 13 family, member D	0.012
IL33	interleukin 33	0.012
GAST	gastrin	0.012
GFI1B	growth factor independent 1B transcription repressor	0.012
COL5A2	collagen, type V, alpha 2	0.012
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.012
PLA2G5	phospholipase A2, group V	0.012
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.012
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.012
ADA	adenosine deaminase	0.012
PARVA	parvin, alpha	0.012
ZNF643	zinc finger protein 643	0.011
AMIGO2	adhesion molecule with Ig-like domain 2	0.011
CRH	corticotropin releasing hormone	0.011
CEND1	cell cycle exit and neuronal differentiation 1	0.011
CORIN	corin, serine peptidase	0.011
RUNDC3A	RUN domain containing 3A	0.011
CX3CL1	chemokine (C-X3-C motif) ligand 1	0.011
ANXA3	annexin A3	0.011
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.011
PLUNC	palate, lung and nasal epithelium associated	0.011
SLC22A14	solute carrier family 22, member 14	0.011
LAMB3	laminin, beta 3	0.011
C21orf7	chromosome 21 open reading frame 7	0.011
SMCR7	Smith-Magenis syndrome chromosome region, candidate 7	0.011
ZMAT3	zinc finger, matrin-type 3	0.011
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.011
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.011
TEF	thyrotrophic embryonic factor	0.011
IMPG1	interphotoreceptor matrix proteoglycan 1	0.011
IGFBP1	insulin-like growth factor binding protein 1	0.011
COL11A1	collagen, type XI, alpha 1	0.011
CDKL1	cyclin-dependent kinase-like 1 (CDC2-related kinase)	0.011
AFF2	AF4/FMR2 family, member 2	0.011
ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	0.011
DOK4	docking protein 4	0.011
UBQLN4	ubiquilin 4	0.011
FILIP1L	filamin A interacting protein 1-like	0.011
BCL2L10	BCL2-like 10 (apoptosis facilitator)	0.011
IRS4	insulin receptor substrate 4	0.011
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.011
TPPP	tubulin polymerization promoting protein	0.011
SCG3	secretogranin III	0.011
SLC22A4	solute carrier family 22 (organic cation/ergothioneine transporter), member 4	0.011
EPHA2	EPH receptor A2	0.011
EBF1	early B-cell factor 1	0.011
SPARCL1	SPARC-like 1 (hevin)	0.011
CAMK1G	calcium/calmodulin-dependent protein kinase IG	0.011
AVPR1B	arginine vasopressin receptor 1B	0.010
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.010
HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	0.010
RGS4	regulator of G-protein signaling 4	0.010
CCDC136	coiled-coil domain containing 136	0.010
TNFRSF8	tumor necrosis factor receptor superfamily, member 8	0.010
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.010
OPRK1	opioid receptor, kappa 1	0.010
HIST1H1A	histone cluster 1, H1a	0.010
TGFBR1	transforming growth factor, beta receptor 1	0.010
C3orf52	chromosome 3 open reading frame 52	0.010
KIF1A	kinesin family member 1A	0.010
DCN	decorin	0.010