IMP

Process View

Mus musculus

7 genes annotated in mouse

calcium ion dependent exocytosis of neurotransmitter

The release of a neurotransmitter into the synaptic cleft, where the release step is dependent on the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "calcium ion dependent exocytosis of neurotransmitter"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "calcium ion dependent exocytosis of neurotransmitter" (in gray)

Name	Description	Probability	Func Analog Organism
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.513
Syp	synaptophysin	0.257
Syt3	synaptotagmin III	0.241	Mouse
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.193
Scn8a	sodium channel, voltage-gated, type VIII, alpha	0.185
Rab3a	RAB3A, member RAS oncogene family	0.149
Sult4a1	sulfotransferase family 4A, member 1	0.140
Syt10	synaptotagmin X	0.134	Mouse
Bsn	bassoon	0.133
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.121
Rims2	regulating synaptic membrane exocytosis 2	0.117
Ryr1	ryanodine receptor 1, skeletal muscle	0.107
Syt7	synaptotagmin VII	0.104	Mouse
Rims1	regulating synaptic membrane exocytosis 1	0.101
Stx1a	syntaxin 1A (brain)	0.100
Syt9	synaptotagmin IX	0.099	Mouse
Hpca	hippocalcin	0.086
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.081
Kifc2	kinesin family member C2	0.080
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.078
Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	0.076
Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.070
Srrm3	serine/arginine repetitive matrix 3	0.070
Sstr3	somatostatin receptor 3	0.070
Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	0.064
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.063
Jph3	junctophilin 3	0.055
Kif1a	kinesin family member 1A	0.054
Ina	internexin neuronal intermediate filament protein, alpha	0.051
Syt6	synaptotagmin VI	0.047	Mouse
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.047
Tulp1	tubby like protein 1	0.046
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.043
Actl6b	actin-like 6B	0.040
Kif5a	kinesin family member 5A	0.039
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.037
Syn2	synapsin II	0.036
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.035
Crhr1	corticotropin releasing hormone receptor 1	0.033
Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	0.032
Gng4	guanine nucleotide binding protein (G protein), gamma 4	0.032
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.032
Sh3gl2	SH3-domain GRB2-like 2	0.031
Sebox	SEBOX homeobox	0.030
Tcap	titin-cap	0.029
Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3	0.029
Grm1	glutamate receptor, metabotropic 1	0.028
Elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.028
Snap25	synaptosomal-associated protein 25	0.027
Rnf112	ring finger protein 112	0.027
Ret	ret proto-oncogene	0.027
Pcsk1n	proprotein convertase subtilisin/kexin type 1 inhibitor	0.026
Necab2	N-terminal EF-hand calcium binding protein 2	0.025
Tnni2	troponin I, skeletal, fast 2	0.025
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.024
Syn1	synapsin I	0.024
Fbxl20	F-box and leucine-rich repeat protein 20	0.023
Pclo	piccolo (presynaptic cytomatrix protein)	0.023
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.022
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.022
Nos1	nitric oxide synthase 1, neuronal	0.022
Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	0.021
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.020	Mouse
Cux2	cut-like homeobox 2	0.020
Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1	0.020
Cntn4	contactin 4	0.020
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.019
Cpne6	copine VI	0.019
Sncb	synuclein, beta	0.019
AI118078	expressed sequence AI118078	0.019
Neurod1	neurogenic differentiation 1	0.019
Ryr2	ryanodine receptor 2, cardiac	0.019
Syt5	synaptotagmin V	0.019	Mouse Fly
Syt2	synaptotagmin II	0.018	Mouse Fly
Mmp17	matrix metallopeptidase 17	0.018
Cdh4	cadherin 4	0.018
Ephb2	Eph receptor B2	0.018
Hr	hairless	0.018
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.017
Slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	0.016
Grin2c	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	0.016
Mark1	MAP/microtubule affinity-regulating kinase 1	0.016
Nefh	neurofilament, heavy polypeptide	0.016
Prkcc	protein kinase C, gamma	0.016
Slc12a5	solute carrier family 12, member 5	0.015
Sez6l	seizure related 6 homolog like	0.015
Cplx1	complexin 1	0.015
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.014
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.014
Abcb9	ATP-binding cassette, sub-family B (MDR/TAP), member 9	0.014
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.014
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.014
Drd2	dopamine receptor D2	0.014
Sez6	seizure related gene 6	0.014
Mybpc3	myosin binding protein C, cardiac	0.014
Pde6g	phosphodiesterase 6G, cGMP-specific, rod, gamma	0.014
Sag	retinal S-antigen	0.014
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.013
Trim46	tripartite motif-containing 46	0.013
Camkv	CaM kinase-like vesicle-associated	0.013
Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.013
Tnnc2	troponin C2, fast	0.013
Aff2	AF4/FMR2 family, member 2	0.013
Srcin1	SRC kinase signaling inhibitor 1	0.013
Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.013
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.013
Shc3	src homology 2 domain-containing transforming protein C3	0.013
Cntfr	ciliary neurotrophic factor receptor	0.012
Nptx1	neuronal pentraxin 1	0.012
Cnih3	cornichon homolog 3 (Drosophila)	0.012
Sez6l2	seizure related 6 homolog like 2	0.012
L1cam	L1 cell adhesion molecule	0.012
Frmd5	FERM domain containing 5	0.012
Wnk2	WNK lysine deficient protein kinase 2	0.012
Myt1l	myelin transcription factor 1-like	0.011
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.011	Mouse
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.011
Epha5	Eph receptor A5	0.011
Kif5c	kinesin family member 5C	0.011
Sv2b	synaptic vesicle glycoprotein 2 b	0.010
Adam23	a disintegrin and metallopeptidase domain 23	0.010
Adam11	a disintegrin and metallopeptidase domain 11	0.010
Cntn3	contactin 3	0.010