IMP
Process View
nuclear transcribed mrna catabolic process nonsense mediated decay
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "nuclear transcribed mrna catabolic process nonsense mediated decay"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Hnrnph1 | heterogeneous nuclear ribonucleoprotein H1 | 0.578 | ||
| Srsf1 | serine/arginine-rich splicing factor 1 | 0.293 | ||
| Snrnp40 | small nuclear ribonucleoprotein 40 (U5) | 0.216 | ||
| Ddx17 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | 0.181 | Yeast | |
| Anp32b | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.175 | ||
| Hmgn1 | high mobility group nucleosomal binding domain 1 | 0.164 | ||
| Hnrnpm | heterogeneous nuclear ribonucleoprotein M | 0.143 | ||
| Ddx5 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 0.132 | Yeast | |
| Tial1 | Tia1 cytotoxic granule-associated RNA binding protein-like 1 | 0.112 | Yeast | |
| Hnrnph3 | heterogeneous nuclear ribonucleoprotein H3 | 0.101 | ||
| Ogt | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | 0.082 | ||
| Srrt | serrate RNA effector molecule homolog (Arabidopsis) | 0.081 | ||
| Crebzf | CREB/ATF bZIP transcription factor | 0.078 | ||
| Nxf1 | nuclear RNA export factor 1 homolog (S. cerevisiae) | 0.069 | ||
| Hnrnpa2b1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.056 | ||
| Npm1 | nucleophosmin 1 | 0.051 | ||
| D4Wsu53e | DNA segment, Chr 4, Wayne State University 53, expressed | 0.048 | ||
| Prpf4b | PRP4 pre-mRNA processing factor 4 homolog B (yeast) | 0.044 | ||
| Clk1 | CDC-like kinase 1 | 0.042 | ||
| Srsf7 | serine/arginine-rich splicing factor 7 | 0.041 | ||
| Zfp329 | zinc finger protein 329 | 0.037 | ||
| Cetn3 | centrin 3 | 0.037 | ||
| 2500003M10Rik | RIKEN cDNA 2500003M10 gene | 0.036 | ||
| Ddx39b | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.035 | ||
| Prpf38b | PRP38 pre-mRNA processing factor 38 (yeast) domain containing B | 0.035 | ||
| Gcfc1 | GC-rich sequence DNA-binding factor 1 | 0.034 | ||
| Psmd10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.033 | ||
| Tia1 | cytotoxic granule-associated RNA binding protein 1 | 0.033 | Yeast | |
| Luc7l3 | LUC7-like 3 (S. cerevisiae) | 0.032 | ||
| Znrd1 | zinc ribbon domain containing, 1 | 0.032 | ||
| Sfrs18 | serine/arginine-rich splicing factor 18 | 0.031 | ||
| Snrpe | small nuclear ribonucleoprotein E | 0.028 | ||
| Thoc4 | THO complex 4 | 0.027 | ||
| Plrg1 | pleiotropic regulator 1, PRL1 homolog (Arabidopsis) | 0.026 | ||
| Cct3 | chaperonin containing Tcp1, subunit 3 (gamma) | 0.026 | ||
| Srsf9 | serine/arginine-rich splicing factor 9 | 0.025 | ||
| Pnn | pinin | 0.022 | ||
| Tardbp | TAR DNA binding protein | 0.021 | ||
| Cct4 | chaperonin containing Tcp1, subunit 4 (delta) | 0.021 | ||
| Ewsr1 | Ewing sarcoma breakpoint region 1 | 0.021 | ||
| Acin1 | apoptotic chromatin condensation inducer 1 | 0.021 | ||
| Khdrbs1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.020 | ||
| Snrpb2 | U2 small nuclear ribonucleoprotein B | 0.020 | ||
| Eif3g | eukaryotic translation initiation factor 3, subunit G | 0.020 | ||
| Sfpq | splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) | 0.019 | ||
| Polr2d | polymerase (RNA) II (DNA directed) polypeptide D | 0.019 | ||
| Sf3a3 | splicing factor 3a, subunit 3 | 0.019 | ||
| Rbmxrt | RNA binding motif protein, X chromosome retrogene | 0.019 | ||
| Kat2a | K(lysine) acetyltransferase 2A | 0.019 | ||
| Uimc1 | ubiquitin interaction motif containing 1 | 0.018 | ||
| Sesn1 | sestrin 1 | 0.018 | ||
| Pfdn2 | prefoldin 2 | 0.018 | ||
| Ik | IK cytokine | 0.018 | ||
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.017 | ||
| Ythdc1 | YTH domain containing 1 | 0.017 | ||
| Smu1 | smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) | 0.017 | ||
| Rpl7l1 | ribosomal protein L7-like 1 | 0.016 | ||
| Ccnl2 | cyclin L2 | 0.016 | ||
| Clk2 | CDC-like kinase 2 | 0.016 | ||
| Rbm14 | RNA binding motif protein 14 | 0.016 | ||
| 2310036O22Rik | RIKEN cDNA 2310036O22 gene | 0.016 | ||
| Ubp1 | upstream binding protein 1 | 0.016 | ||
| Cherp | calcium homeostasis endoplasmic reticulum protein | 0.016 | ||
| Fam13b | family with sequence similarity 13, member B | 0.016 | ||
| Naa38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.015 | ||
| U2af1 | U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 | 0.015 | ||
| Safb | scaffold attachment factor B | 0.015 | ||
| Ngdn | neuroguidin, EIF4E binding protein | 0.015 | ||
| Wsb1 | WD repeat and SOCS box-containing 1 | 0.015 | ||
| Ppm1g | protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform | 0.015 | ||
| Clk4 | CDC like kinase 4 | 0.014 | ||
| Prmt1 | protein arginine N-methyltransferase 1 | 0.014 | ||
| Cetn2 | centrin 2 | 0.014 | ||
| Rpl4 | ribosomal protein L4 | 0.014 | ||
| Sf1 | splicing factor 1 | 0.014 | ||
| Cnot2 | CCR4-NOT transcription complex, subunit 2 | 0.014 | ||
| Commd2 | COMM domain containing 2 | 0.014 | ||
| Ywhaq | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 0.014 | ||
| Gtf2f1 | general transcription factor IIF, polypeptide 1 | 0.014 | ||
| Kpnb1 | karyopherin (importin) beta 1 | 0.014 | ||
| Taf11 | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor | 0.013 | ||
| Pabpn1 | poly(A) binding protein, nuclear 1 | 0.013 | ||
| Ncoa5 | nuclear receptor coactivator 5 | 0.013 | ||
| Zfc3h1 | zinc finger, C3H1-type containing | 0.013 | ||
| Phf5a | PHD finger protein 5A | 0.013 | ||
| Ylpm1 | YLP motif containing 1 | 0.013 | ||
| Fbl | fibrillarin | 0.012 | ||
| Brd8 | bromodomain containing 8 | 0.012 | ||
| Mat2a | methionine adenosyltransferase II, alpha | 0.012 | ||
| Prpf8 | pre-mRNA processing factor 8 | 0.012 | ||
| Sf3b1 | splicing factor 3b, subunit 1 | 0.012 | ||
| Nup188 | nucleoporin 188 | 0.012 | ||
| Cct7 | chaperonin containing Tcp1, subunit 7 (eta) | 0.012 | ||
| Tmem123 | transmembrane protein 123 | 0.012 | ||
| Stx16 | syntaxin 16 | 0.012 | ||
| Bag6 | BCL2-associated athanogene 6 | 0.012 | ||
| Eif2a | eukaryotic translation initiation factor 2A | 0.012 | ||
| Rbm10 | RNA binding motif protein 10 | 0.012 | ||
| 2810046L04Rik | RIKEN cDNA 2810046L04 gene | 0.011 | ||
| 4933424B01Rik | RIKEN cDNA 4933424B01 gene | 0.011 | ||
| Magohb | mago-nashi homolog B (Drosophila) | 0.011 | ||
| Cenpc1 | centromere protein C1 | 0.011 | ||
| Ddx41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.011 | ||
| Mybbp1a | MYB binding protein (P160) 1a | 0.011 | ||
| Fam48a | family with sequence similarity 48, member A | 0.011 | ||
| Eif2c2 | eukaryotic translation initiation factor 2C, 2 | 0.011 | ||
| Shfm1 | split hand/foot malformation (ectrodactyly) type 1 | 0.011 | ||
| Srsf3 | serine/arginine-rich splicing factor 3 | 0.010 | ||
| Med10 | mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae) | 0.010 | ||
| Ubap2 | ubiquitin-associated protein 2 | 0.010 | ||
| Drosha | drosha, ribonuclease type III | 0.010 | ||
| Kars | lysyl-tRNA synthetase | 0.010 | ||
| Hnrnpf | heterogeneous nuclear ribonucleoprotein F | 0.010 |