IMP

Process View

Rattus norvegicus

4 genes annotated in rat

somatostatin signaling pathway

The series of molecular signals generated as a consequence of the peptide somatostatin (SST) binding to a somatostatin receptor (SSTR). The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "somatostatin signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "somatostatin signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Hes2	hairy and enhancer of split 2 (Drosophila)	0.250
Omp	olfactory marker protein	0.193
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.161
Grm8	glutamate receptor, metabotropic 8	0.150
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.133
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.125
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.110
Chrna3	cholinergic receptor, nicotinic, alpha 3	0.102
Olr1867	olfactory receptor 1867	0.100
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.095
Grm6	glutamate receptor, metabotropic 6	0.093
Grin2b	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.088
Trhr2	thyrotropin releasing hormone receptor 2	0.086
Gjb5	gap junction protein, beta 5	0.085
Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.082
Avpr1b	arginine vasopressin receptor 1B	0.081
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.078
Calcr	calcitonin receptor	0.075
RGD1308544	LOC361192	0.074
Chrna4	cholinergic receptor, nicotinic, alpha 4	0.069
Pmfbp1	polyamine modulated factor 1 binding protein 1	0.069
Calca	calcitonin-related polypeptide alpha	0.068
Nmbr	neuromedin B receptor	0.066
Grpr	gastrin releasing peptide receptor	0.065
Unc5a	unc-5 homolog A (C. elegans)	0.061
Cacna1i	calcium channel, voltage-dependent, T type, alpha 1I subunit	0.060
Nrl	neural retina leucine zipper	0.060
RGD1564664	similar to LOC387763 protein	0.057
Tas2r107	taste receptor, type 2, member 107	0.056
Htr3a	5-hydroxytryptamine (serotonin) receptor 3a	0.056
Egr4	early growth response 4	0.056
Scnn1g	sodium channel, nonvoltage-gated 1, gamma	0.055
Cckbr	cholecystokinin B receptor	0.053
Olr1078	olfactory receptor 1078	0.052
Dusp4	dual specificity phosphatase 4	0.051
Gpr83	G protein-coupled receptor 83	0.051
Sct	secretin	0.048
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.048
Grm5	glutamate receptor, metabotropic 5	0.047
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.047
Snap91	synaptosomal-associated protein 91	0.045
Dclk2	doublecortin-like kinase 2	0.045
Fev	FEV (ETS oncogene family)	0.044
Neurog3	neurogenin 3	0.043
Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.042
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.042
Grm1	glutamate receptor, metabotropic 1	0.041
Clstn3	calsyntenin 3	0.040
LOC100361571	keratin associated protein 1-3-like	0.040
Atp12a	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	0.040
Cnga3	cyclic nucleotide gated channel alpha 3	0.039
Il8rb	interleukin 8 receptor, beta	0.039
Drd1a	dopamine receptor D1A	0.039
Slc7a12	solute carrier family 7 (cationic amino acid transporter, y+ system), member 12	0.038
Hrh3	histamine receptor H3	0.038
Olr416	olfactory receptor 416	0.037
Slc6a7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.037
Il1rn	interleukin 1 receptor antagonist	0.037
Prp15	proline-rich protein 15	0.036
Faslg	Fas ligand (TNF superfamily, member 6)	0.035
Il4	interleukin 4	0.035
Glp1r	glucagon-like peptide 1 receptor	0.035
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.035
Hpca	hippocalcin	0.035
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.034
Rgs9	regulator of G-protein signaling 9	0.034
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.034
Ddn	dendrin	0.033
Cela2a	chymotrypsin-like elastase family, member 2A	0.033
Th	tyrosine hydroxylase	0.033
Itpka	inositol 1,4,5-trisphosphate 3-kinase A	0.033
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.033
Glra1	glycine receptor, alpha 1	0.033
Cpb1	carboxypeptidase B1 (tissue)	0.033
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.032
Gpr26	G protein-coupled receptor 26	0.032
Slc22a13	solute carrier family 22 (organic anion transporter), member 13	0.032
Fgf2	fibroblast growth factor 2	0.032
Syt5	synaptotagmin V	0.031
Fgf4	fibroblast growth factor 4	0.031
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.031
Grm7	glutamate receptor, metabotropic 7	0.030
Ifna1	interferon-alpha 1	0.030
Calcb	calcitonin-related polypeptide, beta	0.029
Cxcl6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.029
Slc7a3	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	0.028
Chrm5	cholinergic receptor, muscarinic 5	0.028
Kif6	kinesin family member 6	0.028
Ccr3	chemokine (C-C motif) receptor 3	0.028
Zg16	zymogen granule protein 16	0.028
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.028
Smr3a	submaxillary gland androgen regulated protein 3A	0.028
Il9r	interleukin 9 receptor	0.028
Drd3	dopamine receptor D3	0.028
LOC689154	hypothetical protein LOC689154	0.028
Chrm1	cholinergic receptor, muscarinic 1	0.026
Kcnq2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.026
Grid1	glutamate receptor, ionotropic, delta 1	0.026
Aqp2	aquaporin 2 (collecting duct)	0.026
Ghrhr	growth hormone releasing hormone receptor	0.026
Oprl1	opiate receptor-like 1	0.025	Rat
Gck	glucokinase	0.025
Ido1	indoleamine 2,3-dioxygenase 1	0.025
Pcyt1b	phosphate cytidylyltransferase 1, choline, beta	0.025
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	0.025
LOC680122	similar to sin3 associated polypeptide	0.025
Iapp	islet amyloid polypeptide	0.025
Crhr1	corticotropin releasing hormone receptor 1	0.025
Tagln3	transgelin 3	0.025
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.025
Epor	erythropoietin receptor	0.025
Phox2a	paired-like homeobox 2a	0.025
Hapln2	hyaluronan and proteoglycan link protein 2	0.025
Inha	inhibin alpha	0.025
Sstr5	somatostatin receptor 5	0.024
Sstr1	somatostatin receptor 1	0.024
Crhbp	corticotropin releasing hormone binding protein	0.024
Serp2	stress-associated endoplasmic reticulum protein family member 2	0.024
Ptprh	protein tyrosine phosphatase, receptor type, H	0.024
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.023
Adam3a	ADAM metallopeptidase domain 3A (cyritestin 1)	0.023
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	0.023
Prph2	peripherin 2	0.023
Cst8	cystatin 8 (cystatin-related epididymal specific)	0.023
Grp	gastrin releasing peptide	0.023
Prl	prolactin	0.023
Kctd16	potassium channel tetramerisation domain containing 16	0.023
Ppbp	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.023
Adarb2	adenosine deaminase, RNA-specific, B2	0.022
Cyp11b1	cytochrome P450, family 11, subfamily b, polypeptide 1	0.022
Cartpt	CART prepropeptide	0.022
Sec1	secretory blood group 1	0.022
LOC246267	resection-induced TPI (rs11)	0.022
Ecel1	endothelin converting enzyme-like 1	0.022
RGD1560871	similar to plexin 1	0.022
Syt13	synaptotagmin XIII	0.022
Npffr2	neuropeptide FF receptor 2	0.022
Slc6a18	solute carrier family 6, member 18	0.022
Uts2	urotensin 2	0.021
Syp	synaptophysin	0.021
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.021
Duox2	dual oxidase 2	0.021
Lif	leukemia inhibitory factor	0.020
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.020
Prss3	protease, serine, 3	0.020
Hoxc4	homeo box C4	0.020
Ptch1	patched homolog 1 (Drosophila)	0.020
Necab1	N-terminal EF-hand calcium binding protein 1	0.020
Ndufb6	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6	0.020
Cdkn2b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.020
Cntn6	contactin 6	0.020
Reg1a	regenerating islet-derived 1 alpha	0.020
Gabrd	gamma-aminobutyric acid (GABA) A receptor, delta	0.020
Cmtm2a	CKLF-like MARVEL transmembrane domain containing 2A	0.020
Olr1641	olfactory receptor 1641	0.020
Mdga1	MAM domain containing glycosylphosphatidylinositol anchor 1	0.019
Msx2	msh homeobox 2	0.019
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.019
Nrg1	neuregulin 1	0.019
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.019
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	0.018
Barhl2	BarH-like homeobox 2	0.018
Vom1r97	vomeronasal 1 receptor 97	0.018
Gjb4	gap junction protein, beta 4	0.018
Gzmk	granzyme K	0.018
Amn	amnionless homolog (mouse)	0.018
Gpr1	G protein-coupled receptor 1	0.018
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.018
Oprm1	opioid receptor, mu 1	0.018	Rat
Galr3	galanin receptor 3	0.018
Drp2	dystrophin related protein 2	0.018
Mchr1	melanin-concentrating hormone receptor 1	0.018
Cxcr5	chemokine (C-X-C motif) receptor 5	0.018
Il1rl2	interleukin 1 receptor-like 2	0.018
Ucn2	urocortin 2	0.018
Chrna2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	0.018
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.018
Alpi	alkaline phosphatase, intestinal	0.017
Amph	amphiphysin	0.017
Psg29	pregnancy-specific glycoprotein 29	0.017
Olr1361	olfactory receptor 1361	0.017
Ctsj	cathepsin J	0.017
Prokr1	prokineticin receptor 1	0.017
Slc8a3	solute carrier family 8 (sodium/calcium exchanger), member 3	0.017
Gabbr1	gamma-aminobutyric acid (GABA) B receptor 1	0.017
Cdx2	caudal type homeo box 2	0.017
Rgs8	regulator of G-protein signaling 8	0.017
Kcnk1	potassium channel, subfamily K, member 1	0.017
F2rl1	coagulation factor II (thrombin) receptor-like 1	0.017
Syt2	synaptotagmin II	0.017
RGD1310262	hypothetical LOC304650	0.017
Vom2r53	vomeronasal 2 receptor, 53	0.017
Rasgrp4	RAS guanyl releasing protein 4	0.017
Ltb4r	leukotriene B4 receptor	0.017
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.017
Avpr2	arginine vasopressin receptor 2	0.017
Grik3	glutamate receptor, ionotropic, kainate 3	0.016
RT1-M4	RT1 class Ib, locus M4	0.016
Prl3b1	Prolactin family 3, subfamily b, member 1	0.016
Grm2	glutamate receptor, metabotropic 2	0.016
Prl4a1	prolactin family 4, subfamily a, member 1	0.016
Prlhr	prolactin releasing hormone receptor	0.016
Smcp	sperm mitochondria-associated cysteine-rich protein	0.016
Crybg3	beta-gamma crystallin domain containing 3	0.016
Il2ra	interleukin 2 receptor, alpha	0.016
Tshb	thyroid stimulating hormone, beta	0.016
Krt31	keratin 31	0.016
Slc17a7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.016
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.016
Syt7	synaptotagmin VII	0.016
Gdf9	growth differentiation factor 9	0.015
Clcn1	chloride channel 1	0.015
Shox2	short stature homeobox 2	0.015
Bcl2	B-cell CLL/lymphoma 2	0.015
Chrnb3	cholinergic receptor, nicotinic, beta 3	0.015
Cops5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.015
Prap1	proline-rich acidic protein 1	0.015
Gucy2e	guanylate cyclase 2E	0.015
Sstr2	somatostatin receptor 2	0.015
Mmp10	matrix metallopeptidase 10	0.015
Cyp2g1	cytochrome P450, family 2, subfamily g, polypeptide 1	0.015
Fgf14	fibroblast growth factor 14	0.015
Cnga4	cyclic nucleotide gated channel alpha 4	0.015
Uhmk1	U2AF homology motif (UHM) kinase 1	0.015
Cxcl3	chemokine (C-X-C motif) ligand 3	0.015
Naaladl1	N-acetylated alpha-linked acidic dipeptidase-like 1	0.015
Spam1	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	0.015
Scn4a	sodium channel, voltage-gated, type IV, alpha subunit	0.014
Galr1	galanin receptor 1	0.014	Rat
Cpne9	copine family member IX	0.014
Tub	tubby homolog (mouse)	0.014
Kcnt1	potassium channel, subfamily T, member 1	0.014
Cuta	cutA divalent cation tolerance homolog (E. coli)	0.014
Smad9	SMAD family member 9	0.014
Ccl22	chemokine (C-C motif) ligand 22	0.014
Mc5r	melanocortin 5 receptor	0.014
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.014
Insrr	insulin receptor-related receptor	0.014
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.014
Svs1	seminal vesicle secretory protein 1	0.014
Rup2	urinary protein 2	0.014
Tas2r126	taste receptor, type 2, member 126	0.014
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.014
RGD1563533	similar to novel protein	0.014
Tas1r3	taste receptor, type 1, member 3	0.014
Gpr6	G protein-coupled receptor 6	0.014
Fosl1	fos-like antigen 1	0.013
Xylt1	xylosyltransferase 1	0.013
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.013
Sst	somatostatin	0.013
Pde1b	phosphodiesterase 1B, calmodulin-dependent	0.013
Tas2r119	taste receptor, type 2, member 119	0.013
Ugt2b7	UDP glucuronosyltransferase 2 family, polypeptide B7	0.013
RGD1559748	similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)	0.013
Krt4	keratin 4	0.013
Mr1	major histocompatibility complex, class I-related	0.013
Taar1	trace-amine-associated receptor 1	0.013
Mog	myelin oligodendrocyte glycoprotein	0.013
Kl	Klotho	0.013
Bcan	brevican	0.013
Taf10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.013
Rorb	RAR-related orphan receptor B	0.013
Pspn	persephin	0.013
Kcnv1	potassium channel, subfamily V, member 1	0.013
Gnrhr	gonadotropin releasing hormone receptor	0.013
Fgf17	fibroblast growth factor 17	0.013
Rln1	relaxin 1	0.013
Il10	interleukin 10	0.013
Il24	interleukin 24	0.013
Cacng7	calcium channel, voltage-dependent, gamma subunit 7	0.013
Drd5	dopamine receptor D5	0.013
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.013
Prok1	prokineticin 1	0.013
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.013
Nrcam	neuronal cell adhesion molecule	0.012
Gcnt3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.012
Gja6	gap junction protein, alpha 6	0.012
Fam83f	family with sequence similarity 83, member F	0.012
Cyp11b3	cytochrome P450, family 11, subfamily b, polypeptide 3	0.012
Grk1	G protein-coupled receptor kinase 1	0.012
Il8ra	interleukin 8 receptor, alpha	0.012
Aqp6	aquaporin 6, kidney specific	0.012
Adam6	a disintegrin and metallopeptidase domain 6	0.012
Ngb	neuroglobin	0.012
Shc3	SHC (Src homology 2 domain containing) transforming protein 3	0.012
Tff1	trefoil factor 1	0.012
Prss27	protease, serine 27	0.012
Csf3	colony stimulating factor 3 (granulocyte)	0.012
Rims3	regulating synaptic membrane exocytosis 3	0.012
Gpr173	G-protein coupled receptor 173	0.012
Pnoc	prepronociceptin	0.012
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.012
Sorcs3	sortilin-related VPS10 domain containing receptor 3	0.012
Slc28a3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	0.012
Pou3f2	POU class 3 homeobox 2	0.012
Tbx3	T-box 3	0.012
Tulp1	tubby like protein 1	0.012
Hand1	heart and neural crest derivatives expressed 1	0.012
Socs7	suppressor of cytokine signaling 7	0.012
Hpcal4	hippocalcin-like 4	0.012
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.012
Uts2r	urotensin 2 receptor	0.012
Gng7	guanine nucleotide binding protein (G protein), gamma 7	0.012
Tubb3	tubulin, beta 3	0.011
Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11	0.011
Dpf1	D4, zinc and double PHD fingers family 1	0.011
Sp3	Sp3 transcription factor	0.011
Fcer2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.011
Sdcbp2	syndecan binding protein (syntenin) 2	0.011
Ncr1	natural cytotoxicity triggering receptor 1	0.011
Npy5r	neuropeptide Y receptor Y5	0.011
Hspe1	heat shock protein 1 (chaperonin 10)	0.011
Tas2r13	taste receptor, type 2, member 13	0.011
Ptprq	protein tyrosine phosphatase, receptor type, Q	0.011
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.011
Cyp2b3	cytochrome P450, family 2, subfamily b, polypeptide 3	0.011
Olr442	olfactory receptor 442	0.011
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.011
Tacr1	tachykinin receptor 1	0.011
Gucy2f	guanylate cyclase 2F	0.011
Grip2	glutamate receptor interacting protein 2	0.011
Lgals4	lectin, galactoside-binding, soluble, 4	0.011
Galr2	galanin receptor 2	0.011	Rat
Svop	SV2 related protein	0.011
Cckar	cholecystokinin A receptor	0.011
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.011
Fam148b	family with sequence similarity 148, member B	0.011
RGD1565057	similar to hypothetical protein FLJ32871	0.011
Fgf11	fibroblast growth factor 11	0.011
Tg	thyroglobulin	0.011
Chst3	carbohydrate (chondroitin 6) sulfotransferase 3	0.011
Syt10	synaptotagmin X	0.011
Arc	activity-regulated cytoskeleton-associated protein	0.011
Nmur2	neuromedin U receptor 2	0.011
Cort	cortistatin	0.011
Slc12a5	solute carrier family 12 (potassium-chloride transporter), member 5	0.011
Nfasc	neurofascin	0.011
Kcnk15	potassium channel, subfamily K, member 15	0.011
Tbx2	T-box 2	0.011
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.010
Odf1	outer dense fiber of sperm tails 1	0.010
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.010
Apcs	amyloid P component, serum	0.010
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.010
Syn1	synapsin I	0.010
Kctd13	potassium channel tetramerisation domain containing 13	0.010
Cacng8	calcium channel, voltage-dependent, gamma subunit 8	0.010
Hcn1	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	0.010
Il5ra	interleukin 5 receptor, alpha	0.010
Dbc1	deleted in bladder cancer 1 (human)	0.010
Retnla	resistin like alpha	0.010