IMP

Process View

Danio rerio

3 genes annotated in zebrafish

cerebellar granular layer development

The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cerebellar granular layer development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cerebellar granular layer development" (in gray)

Name	Description	Probability	Func Analog Organism
hgfa	hepatocyte growth factor a	0.961
foxa3	forkhead box A3	0.675
neurod	neurogenic differentiation	0.552
hgfb	hepatocyte growth factor b	0.531
kal1b	Kallmann syndrome 1b sequence	0.277
pcdh19	protocadherin 19	0.277
nkx6.1	NK6 transcription factor related, locus 1 (Drosophila)	0.209
dcc	deleted in colorectal carcinoma	0.194
hoxa4a	homeo box A4a	0.190
wnt3a	wingless-type MMTV integration site family, member 3A	0.173
gata6	GATA-binding protein 6	0.131
mdkb	midkine-related growth factor b	0.127	Mouse
mnx1	motor neuron and pancreas homeobox 1	0.120
c9	complement component 9	0.119
foxa2	forkhead box A2	0.113
phox2a	paired-like homeobox 2a	0.096
fgfr2	fibroblast growth factor receptor 2	0.092
brd2a	bromodomain-containing 2a	0.078
prdm16	PR domain containing 16	0.076
myca	myelocytomatosis oncogene a	0.069
olig4	oligodendrocyte transcription factor 4	0.067
nkx6.2	NK6 transcription factor related, locus 2	0.067
rpl23a	ribosomal protein L23a	0.066
pax6a	paired box gene 6a	0.063
sfrp1a	secreted frizzled-related protein 1a	0.056
spon1b	spondin 1b	0.054
fabp2	fatty acid binding protein 2, intestinal	0.054
hhex	hematopoietically expressed homeobox	0.049
dnmt8	DNA (cytosine-5-)-methyltransferase 8	0.048
wif1	wnt inhibitory factor 1	0.048
meis1	myeloid ecotropic viral integration 1	0.048
pdgfrl	platelet-derived growth factor receptor-like	0.047
fgfr3	fibroblast growth factor receptor 3	0.047
met	met proto-oncogene (hepatocyte growth factor receptor)	0.041
igfbp2a	insulin-like growth factor binding protein 2a	0.040
lrrtm1	leucine rich repeat transmembrane neuronal 1	0.040
col4a5	collagen, type IV, alpha 5 (Alport syndrome)	0.038
hoxb8a	homeo box B8a	0.037
lamb2l	laminin, beta 2-like	0.036
egr2b	early growth response 2b	0.036
nkd1	naked cuticle homolog 1 (Drosophila)	0.036
kal1a	Kallmann syndrome 1a sequence	0.035
prom1a	prominin 1a	0.035
sox11a	SRY-box containing gene 11a	0.035
id2a	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a	0.035
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.033
aldob	aldolase b, fructose-bisphosphate	0.032
bty	bloodthirsty	0.032
ptgds	prostaglandin D2 synthase	0.032
plxnb2b	plexin b2b	0.031
alcama	activated leukocyte cell adhesion molecule a	0.031
lmx1b.2	LIM homeobox transcription factor 1, beta 2	0.031
sox2	SRY-box containing gene 2	0.030
tfeb	transcription factor EB	0.029
foxa1	forkhead box A1	0.029
bmp16	bone morphogenetic protein 16	0.028
col5a3b	collagen type V alpha-3b	0.028
dusp6	dual specificity phosphatase 6	0.027
oprd1b	opioid receptor, delta 1b	0.026
limk2	LIM domain kinase 2	0.026
zbtb16a	zinc finger and BTB domain containing 16a	0.025
sulf2l	sulfatase 2, like	0.025
cp	ceruloplasmin	0.024
cdh6	cadherin 6	0.023
cadm1a	cell adhesion molecule 1a	0.023
vim	vimentin	0.023
st8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.023
mpz	myelin protein zero	0.022
pabpc1b	poly A binding protein, cytoplasmic 1 b	0.022
fbp1b	fructose-1,6-bisphosphatase 1b	0.022
ass1	argininosuccinate synthetase 1	0.021
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.020
anxa5b	annexin A5b	0.020
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.020
apoc2	apolipoprotein C-II	0.020
jam3b	junctional adhesion molecule 3b	0.019
otpb	orthopedia homolog b	0.019
tm4sf4	transmembrane 4 L six family member 4	0.019
zgc:195154	zgc:195154	0.019
myod1	myogenic differentiation 1	0.019
bhmt	betaine-homocysteine methyltransferase	0.019
serpinc1	serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1	0.018
hmx2	H6 family homeobox 2	0.018
dbx1a	developing brain homeobox 1a	0.018
bhlhe41	basic helix-loop-helix family, member e41	0.018
sst1.1	somatostatin 1, tandem duplicate 1	0.017
apom	apolipoprotein M	0.017
lepr	leptin receptor	0.017
chrna6	cholinergic receptor, nicotinic, alpha 6	0.017
eng2a	engrailed 2a	0.017
rbp4	retinol binding protein 4, plasma	0.017
foxf1	forkhead box F1	0.017
pnrc2	proline-rich nuclear receptor coactivator 2	0.016
rgs4	regulator of G-protein signalling 4	0.016
vtnb	vitronectin b	0.016
pea3	ETS-domain transcription factor pea3	0.016
mbnl2	muscleblind-like 2 (Drosophila)	0.016
ghrl	ghrelin/obestatin preprohormone	0.015
slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.015
bhlhe40	basic helix-loop-helix family, member e40	0.015
spry1	sprouty homolog 1 (Drosophila)	0.015
prok2	prokineticin 2	0.014
agt	angiotensinogen	0.014
sema3aa	semaphorin 3aa	0.014
pcdh18a	protocadherin 18a	0.014
cdh4	cadherin 4, retinal	0.013
fgfrl1a	fibroblast growth factor receptor-like 1a	0.013
cadm4	cell adhesion molecule 4	0.013
col4a6	collagen, type IV, alpha 6	0.013
grn1	granulin 1	0.013
mmp9	matrix metalloproteinase 9	0.013
ccl25b	chemokine (C-C motif) ligand 25b	0.013
pcdh10b	protocadherin 10b	0.013
ppdpfb	pancreatic progenitor cell differentiation and proliferation factor b	0.013
zgc:162630	zgc:162630	0.012
cadm2b	cell adhesion molecule 2b	0.012
cx43	connexin 43	0.012
mgp	matrix Gla protein	0.012
LOC572344	hypothetical protein LOC572344	0.012
elna	elastin a	0.012
hoxc8a	homeo box C8a	0.012
gsc	goosecoid	0.012
gbx2	gastrulation brain homeo box 2	0.012
fgg	fibrinogen, gamma polypeptide	0.011
zgc:85838	zgc:85838	0.011
ier2	immediate early response 2	0.011
zgc:193613	zgc:193613	0.011
zgc:161979	zgc:161979	0.011
itih2	inter-alpha (globulin) inhibitor H2	0.011
gria1a	glutamate receptor, ionotropic, AMPA 1a	0.011
meis2.2	myeloid ecotropic viral integration site 2.2	0.011
rbp2a	retinol binding protein 2a, cellular	0.011
dusp2	dual specificity phosphatase 2	0.011
zgc:63990	zgc:63990	0.010
si:dkey-22o12.2	si:dkey-22o12.2	0.010
rhoub	ras homolog gene family, member Ub	0.010
mst1	macrophage stimulating 1 (hepatocyte growth factor-like)	0.010	Zebrafish
ucp1	uncoupling protein 1	0.010
irx5a	iroquois homeobox protein 5a	0.010
fga	fibrinogen alpha chain	0.010
sb:cb1058	sb:cb1058	0.010
her9	hairy-related 9	0.010
gria4a	glutamate receptor, ionotropic, AMPA 4a	0.010