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Process View

Danio rerio

12 genes annotated in zebrafish

establishment or maintenance of apical basal cell polarity

Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment or maintenance of apical basal cell polarity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "establishment or maintenance of apical basal cell polarity" (in gray)

Name	Description	Probability	Func Analog Organism
crb2a	crumbs homolog 2a	0.981
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.978
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.450
celsr3	cadherin, EGF LAG seven-pass G-type receptor 3	0.445
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.398	Fly
mpp5a	membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)	0.280
ythdf1	YTH domain family, member 1	0.238
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.218
ilk	integrin linked kinase	0.204	Mouse
guca1c	guanylate cyclase activator 1C	0.198
crb2b	crumbs homolog 2b	0.191
prkci	protein kinase C, iota	0.176
ift88	intraflagellar transport 88 homolog	0.163
crb3b	crumbs homolog 3b	0.130
pacsin3	protein kinase C and casein kinase substrate in neurons 3	0.126
cdh2	cadherin 2, neuronal	0.125
lamb1a	laminin, beta 1a	0.120
crb1	crumbs homolog 1 (Drosophila)	0.116
pitpnb	phosphotidylinositol transfer protein, beta	0.115
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.112
dag1	dystroglycan 1	0.093
crb3a	crumbs homolog 3a	0.092
kif7	kinesin family member 7	0.084
kif17	kinesin family member 17	0.083
mstna	myostatin a	0.081
tbx2b	T-box 2b	0.075
tfec	transcription factor EC	0.068
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.067
prickle1a	prickle-like 1 (Drosophila) a	0.067
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.062
krt8	keratin 8	0.058
spry2	sprouty homolog 2	0.057
shdb	Src homology 2 domain containing transforming protein D, b	0.056
lama1	laminin, alpha 1	0.056
celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.055
pfn2	profilin 2	0.055
mib	mind bomb	0.053
ehd1	EH-domain containing 1	0.053
cplx4a	complexin 4a	0.053
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.052
stil	TAL1 (SCL) interrupting locus	0.052
erbb3a	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a	0.049	Fly
crx	cone-rod homeobox	0.048
synj1	synaptojanin 1	0.048
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.047
zfpl1	zinc finger protein-like 1	0.047
zgc:114199	zgc:114199	0.047
gro2	groucho 2	0.046
tpm1	tropomyosin 1 (alpha)	0.044
ephb4b	eph receptor B4b	0.043
lrp2	low density lipoprotein-related protein 2	0.043
nrg1	neuregulin 1	0.042
acvr1b	activin A receptor, type IB	0.041
flr	fleer	0.041
pvrl1a	poliovirus receptor-related 1a	0.039
prnprs3	prion protein, related sequence 3	0.038
rnd3a	Rho family GTPase 3a	0.037
osr2	odd-skipped related 2 (Drosophila)	0.036
laptm4a	lysosomal-associated protein transmembrane 4 alpha	0.036
casz1	castor zinc finger 1	0.035
si:ch211-134j6.3	si:ch211-134j6.3	0.033
dynlt3	dynein, light chain, Tctex-type 3	0.033
card14	caspase recruitment domain family, member 14	0.033
rhpn2	rhophilin, Rho GTPase binding protein 2	0.032
atp1a3b	ATPase, Na+/K+ transporting, alpha 3b polypeptide	0.032
prkcz	protein kinase C, zeta	0.031	Zebrafish
cntn1b	contactin 1b	0.031
rel	v-rel reticuloendotheliosis viral oncogene homolog	0.031
lsr	lipolysis stimulated lipoprotein receptor	0.031
cxadr	coxsackie virus and adenovirus receptor	0.031
inhbaa	inhibin, beta Aa	0.030
egr2b	early growth response 2b	0.030
nras	neuroblastoma RAS viral (v-ras) oncogene homolog	0.030	Zebrafish Fly
sp2	sp2 transcription factor	0.028
mxi1	max interacting protein	0.028
cdc73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.028
has2	hyaluronan synthase 2	0.027
ripply2	ripply2	0.027
tob1a	transducer of ERBB2, 1a	0.027
si:dkey-8l13.4	si:dkey-8l13.4	0.026
dnm2l	dynamin2-like	0.026
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.026
si:ch211-272f3.4	si:ch211-272f3.4	0.025
grk7a	G-protein-coupled receptor kinase 7a	0.025
olfm1b	olfactomedin 1b	0.025
eya1	eyes absent homolog 1	0.025	Mouse
tfa	transferrin-a	0.025
ripply1	ripply1	0.025
csad	cysteine sulfinic acid decarboxylase	0.024
gamt	guanidinoacetate N-methyltransferase	0.024
abca5	ATP-binding cassette, sub-family A (ABC1), member 5	0.023
dlg1	discs, large (Drosophila) homolog 1	0.023
vcl	vinculin	0.023
gyltl1b	glycosyltransferase-like 1b	0.023
opn4x1	opsin 4x1	0.023
skia	nuclear oncoprotein skia	0.022
cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.022
nrp2b	neuropilin 2b	0.021
cldn12	claudin 12	0.021
LOC100003514	protein kinase C alpha type-like	0.021
dctn1a	dynactin 1a	0.020
fgf3	fibroblast growth factor 3	0.020
tmprss4a	transmembrane protease, serine 4a	0.020
si:ch1073-204j4.2	si:ch1073-204j4.2	0.020
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.020
si:ch211-241e15.2	si:ch211-241e15.2	0.019
spag1	sperm associated antigen 1	0.019
acsl4a	acyl-CoA synthetase long-chain family member 4a	0.019
hprt1	hypoxanthine phosphoribosyltransferase 1	0.018
rtn4a	reticulon 4a	0.018
enpp6	ectonucleotide pyrophosphatase/phosphodiesterase 6	0.018
zgc:110298	zgc:110298	0.018
insrb	insulin receptor b	0.017
arhgef7b	Rho guanine nucleotide exchange factor (GEF) 7b	0.017
calm1b	calmodulin 1b	0.017
notch1a	notch homolog 1a	0.017
etnk1	ethanolamine kinase 1	0.017
bmp2k	BMP2 inducible kinase	0.016
src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.016
dhdhl	dihydrodiol dehydrogenase (dimeric), like	0.016
ywhabl	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like	0.016
pkp2	plakophilin 2	0.016
vsx1	visual system homeobox 1 homolog, chx10-like	0.016
thop1	thimet oligopeptidase 1	0.015
inhbb	inhibin, beta B	0.015
sox9a	SRY-box containing gene 9a	0.015
egfra	epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	0.015	Fly
vps39	vacuolar protein sorting 39 homolog (S. cerevisiae)	0.015
plcg1	phospholipase C, gamma 1	0.015
fzd7a	frizzled homolog 7a	0.014
slc4a4a	solute carrier family 4, member 4a	0.014
prkca	protein kinase C, alpha	0.014	Zebrafish
igf2b	insulin-like growth factor 2b	0.014
spry4	sprouty (Drosophila) homolog 4	0.014
zgc:195154	zgc:195154	0.014
LOC100331502	melanopsin-B-like	0.014
rab11fip4a	RAB11 family interacting protein 4 (class II) a	0.014
psen1	presenilin 1	0.014
ccdc151	coiled-coil domain containing 151	0.014
npepps	aminopeptidase puromycin sensitive	0.014
vim	vimentin	0.014
axin1	axin 1	0.013
cacnb2b	calcium channel, voltage-dependent, beta 2b	0.013
igf2a	insulin-like growth factor 2a	0.013
opn4a	opsin 4a (melanopsin)	0.013
smad1	MAD homolog 1 (Drosophila)	0.013
mobkl3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.013
lims1	LIM and senescent cell antigen-like domains 1	0.013
dusp4	dual specificity phosphatase 4	0.013
cyt1	type I cytokeratin, enveloping layer	0.013
fam43b	family with sequence similarity 43, member B	0.013
atp6v1d	ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D	0.013
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.012
cast	calpastatin	0.012
entpd3	ectonucleoside triphosphate diphosphohydrolase 3	0.012
zgc:77395	zgc:77395	0.012
tmem50a	transmembrane protein 50A	0.012
zgc:66100	zgc:66100	0.012
chm	choroideremia	0.012
rp2	retinitis pigmentosa 2 (X-linked recessive)	0.012
ntrk3b	neurotrophic tyrosine kinase, receptor, type 3b	0.012
kitb	kit receptor b	0.012
zgc:55813	zgc:55813	0.012
scrib	scribbled homolog (Drosophila)	0.012	Human Worm
cdh6	cadherin 6	0.012
si:ch211-207m11.1	si:ch211-207m11.1	0.012
LOC561662	Golgi phosphoprotein 3-like	0.012
ppargc1al	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like	0.012
six2a	sine oculis-related homeobox 2a	0.012
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.012	Fly
sdcbp	syndecan binding protein (syntenin)	0.012
zgc:114045	zgc:114045	0.012
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.012
slc13a1	solute carrier family 13 (sodium/sulphate symporters), member 1	0.011
cx52.9	connexin 52.9	0.011
atp1a3a	ATPase, Na+/K+ transporting, alpha 3a polypeptide	0.011
si:ch73-178d14.1	si:ch73-178d14.1	0.011
actr3	ARP3 actin-related protein 3 homolog (yeast)	0.011
pxn	paxillin	0.011
actr1	ARP1 actin-related protein 1, centractin (yeast)	0.011
arf6	ADP-ribosylation factor 6	0.011
gmds	GDP-mannose 4,6-dehydratase	0.011
zgc:100829	zgc:100829	0.011
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.011
hoxc10a	homeo box C10a and homeobox protein Hox-C10a-like	0.011
cdh1	cadherin 1, epithelial	0.011	Zebrafish
zgc:56429	zgc:56429	0.011
zgc:91860	zgc:91860	0.011
sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.011
prkcbb	protein kinase C, beta b	0.011	Zebrafish
ap1s2	adaptor-related protein complex 1, sigma 2 subunit	0.011
tsc22d1	TSC22 domain family, member 1	0.011
vangl2	vang-like 2 (van gogh, Drosophila)	0.011
hnf1bb	HNF1 homeobox Bb	0.011
epor	erythropoietin receptor	0.010
wt1b	wilms tumor 1b	0.010