The network for 'establishment of tissue polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of tissue polarity

Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.

Drosophila melanogaster
Name Description Probability Func Analog Organism
fz frizzled 1.000
ttk tramtrack 0.998
Rho1 CG8416 gene product from transcript CG8416-RB 0.994
rok Rho-kinase 0.991
ed echinoid 0.991
Vang Van Gogh 0.990
dsh dishevelled 0.988
pk prickle 0.974
stan starry night 0.972
in inturned 0.957
cindr CIN85 and CD2AP orthologue 0.952
N Notch 0.943
G-oalpha47A G protein oalpha 47A 0.937
wdb widerborst 0.925
sano serrano 0.915
Pkn Protein kinase related to protein kinase N 0.907
Rac1 CG2248 gene product from transcript CG2248-RA 0.903
neur neuralized 0.892
CG32556 CG32556 gene product from transcript CG32556-RB 0.877
rst roughest 0.876
hbs hibris 0.873
msn misshapen 0.869
fj four-jointed 0.846
mirr mirror 0.846
CG42251 CG42251 gene product from transcript CG42251-RC 0.811
aop anterior open 0.797
Egfr Epidermal growth factor receptor 0.788
arm armadillo 0.783
crb crumbs 0.777
ptc patched 0.773
argos CG4531 gene product from transcript CG4531-RA 0.768
Hop Hsp70/Hsp90 organizing protein homolog 0.752
gish gilgamesh 0.741
frtz fritz 0.731
frc fringe connection 0.724
Mtl Mig-2-like 0.704
scrib scribbled 0.703
Wnt4 Wnt oncogene analog 4 0.675
aPKC atypical protein kinase C 0.673
Nrx-IV Neurexin IV 0.657
ru roughoid 0.639
fw furrowed 0.621
eyg eyegone 0.614
hep hemipterous 0.597
Tom Twin of m4 0.545
mwh multiple wing hairs 0.544
rin rasputin 0.532
ovo CG6824 gene product from transcript CG6824-RE 0.527
zip zipper 0.518
csw corkscrew 0.517
Cdc42 CG12530 gene product from transcript CG12530-RA 0.503
sty sprouty 0.500
trc tricornered 0.497
par-1 CG8201 gene product from transcript CG8201-RA 0.470
Ras85D Ras oncogene at 85D 0.460
Traf4 TNF-receptor-associated factor 4 0.451
puc puckered 0.447
cno canoe 0.442
CG31687 CG31687 gene product from transcript CG31687-RA 0.430
Jra Jun-related antigen 0.407
shg shotgun 0.398
CG15730 CG15730 gene product from transcript CG15730-RA 0.395
dgo diego 0.393
ft fat 0.384
tinc tincar 0.371
fz2 frizzled 2 0.369
Fas1 Fasciclin 1 0.366
fy fuzzy 0.364
fng fringe 0.340
ds dachsous 0.335
sca scabrous 0.327
wg wingless 0.323
CG14905 CG14905 gene product from transcript CG14905-RA 0.323
phl pole hole 0.318
Akt1 CG4006 gene product from transcript CG4006-RA 0.318
ro rough 0.317
pyd polychaetoid 0.310
fry furry 0.282
pnt pointed 0.278
sev sevenless 0.269
lin lines 0.267
nej nejire 0.255
Moe Moesin 0.248
Pka-C1 cAMP-dependent protein kinase 1 0.241
Syx1A Syntaxin 1A 0.235
Peb Protein ejaculatory bulb 0.233
nmo nemo 0.229
caup caupolican 0.225
Parp Poly-(ADP-ribose) polymerase 0.217
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.217
svp seven up 0.217
ena enabled 0.210
ric8a CG15797 gene product from transcript CG15797-RA 0.208
kermit CG11546 gene product from transcript CG11546-RB 0.205
alph alphabet 0.204
ssh slingshot 0.197
raps rapsynoid 0.176
insc inscuteable 0.174
sdk sidekick 0.163
dos daughter of sevenless 0.161
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RHOA ras homolog gene family, member A 0.996
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.987
ARHGAP1 Rho GTPase activating protein 1 0.960
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.931
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.860
GDA guanine deaminase 0.810
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.787
LRRK2 leucine-rich repeat kinase 2 0.751
TPBG trophoblast glycoprotein 0.733
BCAR1 breast cancer anti-estrogen resistance 1 0.589
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.554
AFF4 AF4/FMR2 family, member 4 0.474
AFF1 AF4/FMR2 family, member 1 0.440
APC adenomatous polyposis coli 0.392
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.375
CSNK1E casein kinase 1, epsilon 0.347
CABLES1 Cdk5 and Abl enzyme substrate 1 0.286
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.276
KRT5 keratin 5 0.265
AXIN1 axin 1 0.237
SEC23A Sec23 homolog A (S. cerevisiae) 0.218
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.217
JAM3 junctional adhesion molecule 3 0.185
RIN1 Ras and Rab interactor 1 0.181
SGSM2 small G protein signaling modulator 2 0.175
MCC mutated in colorectal cancers 0.174
SMAD2 SMAD family member 2 0.172
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.166
CEP164 centrosomal protein 164kDa 0.164
TTC30B tetratricopeptide repeat domain 30B 0.158
LRP6 low density lipoprotein receptor-related protein 6 0.157
PROX1 prospero homeobox 1 0.151
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.142
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.137
SH3RF3 SH3 domain containing ring finger 3 0.135
WNT3A wingless-type MMTV integration site family, member 3A 0.134
SATB2 SATB homeobox 2 0.129
EGFR epidermal growth factor receptor 0.127
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.127
EZR ezrin 0.113
FZD1 frizzled homolog 1 (Drosophila) 0.112
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.109
F11R F11 receptor 0.109
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.106
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.105
MYO6 myosin VI 0.101
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.099
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.098
CFL1 cofilin 1 (non-muscle) 0.097
RHOC ras homolog gene family, member C 0.097
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.097
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.095
NCKAP1 NCK-associated protein 1 0.092
SREBF2 sterol regulatory element binding transcription factor 2 0.091
PTN pleiotrophin 0.091
BCL6 B-cell CLL/lymphoma 6 0.086
MED24 mediator complex subunit 24 0.085
SERINC1 serine incorporator 1 0.085
INVS inversin 0.084
WT1 Wilms tumor 1 0.084
SOX4 SRY (sex determining region Y)-box 4 0.084
TSG101 tumor susceptibility gene 101 0.083
CHN2 chimerin (chimaerin) 2 0.082
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.081
ESRRG estrogen-related receptor gamma 0.081
CDK9 cyclin-dependent kinase 9 0.079
KRT6C keratin 6C 0.078
CCNT1 cyclin T1 0.078
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.074
ATXN1 ataxin 1 0.073
ELL2 elongation factor, RNA polymerase II, 2 0.072
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.072
WNT5A wingless-type MMTV integration site family, member 5A 0.072
LAMP2 lysosomal-associated membrane protein 2 0.070
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.069
TJP2 tight junction protein 2 (zona occludens 2) 0.068
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.066
TYRP1 tyrosinase-related protein 1 0.066
SORBS3 sorbin and SH3 domain containing 3 0.066
JUB jub, ajuba homolog (Xenopus laevis) 0.065
CDH5 cadherin 5, type 2 (vascular endothelium) 0.064
KAT2A K(lysine) acetyltransferase 2A 0.063
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.063
CAV1 caveolin 1, caveolae protein, 22kDa 0.063
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.062
RTKN rhotekin 0.062
GRB7 growth factor receptor-bound protein 7 0.061
CDK19 cyclin-dependent kinase 19 0.060
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.059
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.058
CSNK1D casein kinase 1, delta 0.057
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.056
SPRR2A small proline-rich protein 2A 0.056
LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) 0.055
ACTG1 actin, gamma 1 0.055
PXN paxillin 0.054
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.054
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.051
BAK1 BCL2-antagonist/killer 1 0.051
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.050
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Mus musculus
Name Description Probability Func Analog Organism
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Dvl2 dishevelled 2, dsh homolog (Drosophila) 1.000
Ptk7 PTK7 protein tyrosine kinase 7 0.995
Wnt5a wingless-related MMTV integration site 5A 0.995
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.995
Gli3 GLI-Kruppel family member GLI3 0.988
Dlg4 discs, large homolog 4 (Drosophila) 0.983
Wnt3a wingless-related MMTV integration site 3A 0.981
Axin1 axin 1 0.956
Fzd1 frizzled homolog 1 (Drosophila) 0.936
Fgfr2 fibroblast growth factor receptor 2 0.936
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.933
Ctnnb1 catenin (cadherin associated protein), beta 1 0.919
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.893
Dlg1 discs, large homolog 1 (Drosophila) 0.884
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.790
Tbx3 T-box 3 0.761
Arpc4 actin related protein 2/3 complex, subunit 4 0.737
Vangl1 vang-like 1 (van gogh, Drosophila) 0.683
Rac1 RAS-related C3 botulinum substrate 1 0.675
Lrp6 low density lipoprotein receptor-related protein 6 0.522
Fjx1 four jointed box 1 (Drosophila) 0.493
Wnt4 wingless-related MMTV integration site 4 0.471
Psen1 presenilin 1 0.455
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.448
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.430
Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) 0.386
Sall4 sal-like 4 (Drosophila) 0.376
Trp63 transformation related protein 63 0.354
Efna4 ephrin A4 0.350
Rnd3 Rho family GTPase 3 0.343
Fzd7 frizzled homolog 7 (Drosophila) 0.336
Pax2 paired box gene 2 0.334
Gopc golgi associated PDZ and coiled-coil motif containing 0.329
Foxc1 forkhead box C1 0.329
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.325
Wdr1 WD repeat domain 1 0.307
Tcfcp2l1 transcription factor CP2-like 1 0.297
Dact3 dapper homolog 3, antagonist of beta-catenin (xenopus) 0.288
Gpc3 glypican 3 0.276
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.273
Msn moesin 0.269
Dlg2 discs, large homolog 2 (Drosophila) 0.263
Fgfr1 fibroblast growth factor receptor 1 0.243
Sox11 SRY-box containing gene 11 0.230
Tgfa transforming growth factor alpha 0.228
Egfr epidermal growth factor receptor 0.218
Arhgap1 Rho GTPase activating protein 1 0.211
Fgfr4 fibroblast growth factor receptor 4 0.209
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.209
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.206
Fgfr3 fibroblast growth factor receptor 3 0.205
Ric8 resistance to inhibitors of cholinesterase 8 homolog (C. elegans) 0.203
Fzd4 frizzled homolog 4 (Drosophila) 0.197
Dll1 delta-like 1 (Drosophila) 0.193
Hoxa13 homeobox A13 0.189
Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.188
Sall1 sal-like 1 (Drosophila) 0.186
Litaf LPS-induced TN factor 0.186
Fzd2 frizzled homolog 2 (Drosophila) 0.186
Pou3f3 POU domain, class 3, transcription factor 3 0.185
Lrp2 low density lipoprotein receptor-related protein 2 0.183
Shh sonic hedgehog 0.182
Epha1 Eph receptor A1 0.181
Sfrp1 secreted frizzled-related protein 1 0.180
Tead2 TEA domain family member 2 0.175
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.173
Cachd1 cache domain containing 1 0.172
Fzd8 frizzled homolog 8 (Drosophila) 0.169
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.168
Trp73 transformation related protein 73 0.163
Sema4c sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 0.160
Scube1 signal peptide, CUB domain, EGF-like 1 0.159
Apaf1 apoptotic peptidase activating factor 1 0.157
Sdcbp syndecan binding protein 0.150
Bmp7 bone morphogenetic protein 7 0.149
Rarb retinoic acid receptor, beta 0.149
Ntf3 neurotrophin 3 0.147
Myo6 myosin VI 0.142
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.141
Tcf7l2 transcription factor 7-like 2, T-cell specific, HMG-box 0.140
Lef1 lymphoid enhancer binding factor 1 0.135
Lhx1 LIM homeobox protein 1 0.135
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.131
Porcn porcupine homolog (Drosophila) 0.127
Pofut1 protein O-fucosyltransferase 1 0.127
T brachyury 0.125
Gli2 GLI-Kruppel family member GLI2 0.123
Fzd10 frizzled homolog 10 (Drosophila) 0.121
Mdk midkine 0.120
Twist2 twist homolog 2 (Drosophila) 0.118
Hoxd9 homeobox D9 0.118
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.115
Ptk2 PTK2 protein tyrosine kinase 2 0.113
Wnt5b wingless-related MMTV integration site 5B 0.112
Bmp5 bone morphogenetic protein 5 0.112
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.112
Bdnf brain derived neurotrophic factor 0.111
Amhr2 anti-Mullerian hormone type 2 receptor 0.105
Irx2 Iroquois related homeobox 2 (Drosophila) 0.105
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd82 Cd82 molecule 0.175
Marcks myristoylated alanine rich protein kinase C substrate 0.166
Myl9 myosin, light chain 9, regulatory 0.151
Ednrb endothelin receptor type B 0.115
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.108
Nfia nuclear factor I/A 0.102
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.097
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.090
Spon1 spondin 1, extracellular matrix protein 0.088
Plagl1 pleiomorphic adenoma gene-like 1 0.088
Baiap2 BAI1-associated protein 2 0.086
Fgfr4 fibroblast growth factor receptor 4 0.079
Prx periaxin 0.074
Fzd1 frizzled homolog 1 (Drosophila) 0.071
Ece1 endothelin converting enzyme 1 0.066
Add3 adducin 3 (gamma) 0.065
Perp PERP, TP53 apoptosis effector 0.065
RGD1559896 similar to RIKEN cDNA 2310022B05 0.062
Kcnd2 potassium voltage-gated channel, Shal-related subfamily, member 2 0.060
Tead3 TEA domain family member 3 0.059
Tagln transgelin 0.059
Ggn gametogenetin 0.058
Ppp4r1 protein phosphatase 4, regulatory subunit 1 0.055
Ntf3 neurotrophin 3 0.054
Slit3 slit homolog 3 (Drosophila) 0.054
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.053
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.051
Sh2b1 SH2B adaptor protein 1 0.051
Krt5 keratin 5 0.051
Fgfr1 Fibroblast growth factor receptor 1 0.050
Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region 0.050
Zfp278 zinc finger protein 278 0.050
Arvcf armadillo repeat gene deleted in velo-cardio-facial syndrome 0.049
Bmp4 bone morphogenetic protein 4 0.048
Bnc1 basonuclin 1 0.048
Pvrl2 poliovirus receptor-related 2 0.047
Aebp1 AE binding protein 1 0.046
Axin1 axin 1 0.046
Rimbp2 RIMS binding protein 2 0.045
Igfbp5 insulin-like growth factor binding protein 5 0.045
Rgs19 regulator of G-protein signaling 19 0.045
Paqr5 progestin and adipoQ receptor family member V 0.041
Lrfn2 leucine rich repeat and fibronectin type III domain containing 2 0.041
Aph1a anterior pharynx defective 1 homolog A (C. elegans) 0.041
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.040
Sppl2b signal peptide peptidase-like 2B 0.039
Cdc2l5 cell division cycle 2-like 5 (cholinesterase-related cell division controller) 0.038
Rassf2 Ras association (RalGDS/AF-6) domain family member 2 0.038
Gpc3 glypican 3 0.037
Efemp1 EGF-containing fibulin-like extracellular matrix protein 1 0.037
Solh small optic lobes homolog (Drosophila) 0.037
Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 0.036
Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 0.036
Rab17 RAB17, member RAS oncogene family 0.036
Cald1 caldesmon 1 0.035
Il9 interleukin 9 0.035
Rxra retinoid X receptor alpha 0.035
Nfib nuclear factor I/B 0.035
Lgals7 lectin, galactoside-binding, soluble, 7 0.035
Foxo1 forkhead box O1 0.035
Hspb7 heat shock protein family, member 7 (cardiovascular) 0.034
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.033
Speg SPEG complex locus 0.033
Ube2m ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 0.033
Cdh20 cadherin 20 0.032
Usf2 upstream transcription factor 2, c-fos interacting 0.032
Krt15 keratin 15 0.031
Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 0.031
Zfp469 zinc finger protein 469 0.031
S100a16 S100 calcium binding protein A16 0.031
Stard8 StAR-related lipid transfer (START) domain containing 8 0.031
Tekt1 tektin 1 0.031
Spry1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.031
Hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 0.031
Cbx2 chromobox homolog 2 (Pc class homolog, Drosophila) 0.031
LOC688455 hypothetical protein LOC688455 0.030
Igfbpl1 insulin-like growth factor binding protein-like 1 0.030
Upk2 uroplakin 2 0.030
Lrp3 low density lipoprotein receptor-related protein 3 0.030
Tcfe2a transcription factor E2a 0.030
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.030
Map3k7ip1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 0.029
Sp1 Sp1 transcription factor 0.029
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.029
Thrb thyroid hormone receptor beta 0.029
Sostdc1 sclerostin domain containing 1 0.029
Galnt2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2) 0.029
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.029
Smpx small muscle protein, X-linked 0.028
Timp4 tissue inhibitor of metalloproteinase 4 0.028
Nov nephroblastoma overexpressed gene 0.028
Itih1 inter-alpha trypsin inhibitor, heavy chain 1 0.028
Ptk7 PTK7 protein tyrosine kinase 7 0.028
Vom2r52 vomeronasal 2 receptor, 52 0.028
Fance Fanconi anemia, complementation group E 0.027
Krt7 keratin 7 0.027
Purb purine rich element binding protein B 0.027
Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 0.027
Reln reelin 0.027
Pzp pregnancy-zone protein 0.027
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism