The network for 'enteroendocrine cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

enteroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.

Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.920
hh hedgehog 0.917
hth homothorax 0.912
eya eyes absent 0.858
Dad Daughters against dpp 0.793
dco discs overgrown 0.764
dpp decapentaplegic 0.680
ci cubitus interruptus 0.667
wg wingless 0.317
shn schnurri 0.299
Med Medea 0.289
gbb glass bottom boat 0.282
en engrailed 0.281
sog short gastrulation 0.234
Egfr Epidermal growth factor receptor 0.213
Atg1 Autophagy-specific gene 1 0.211
Dfd Deformed 0.205
crb crumbs 0.201
tsh teashirt 0.185
ush u-shaped 0.167
osa CG7467 gene product from transcript CG7467-RD 0.166
vri vrille 0.154
ab abrupt 0.135
dally division abnormally delayed 0.127
kn knot 0.125
SoxN SoxNeuro 0.116
tld tolloid 0.112
ptc patched 0.104
Hcf Host cell factor 0.098
dm diminutive 0.092
dap dacapo 0.086
so sine oculis 0.083
ed echinoid 0.079
tara taranis 0.071
NFAT NFAT homolog 0.066
Doc2 Dorsocross2 0.062
vg vestigial 0.062
Peb Protein ejaculatory bulb 0.061
smo smoothened 0.060
CG8929 CG8929 gene product from transcript CG8929-RA 0.058
bowl brother of odd with entrails limited 0.055
pasha partner of drosha 0.055
ds dachsous 0.053
stnB stoned B 0.052
Akt1 CG4006 gene product from transcript CG4006-RA 0.051
por porcupine 0.050
dve defective proventriculus 0.050
Coq2 Coenzyme Q biosynthesis protein 2 0.049
D Dichaete 0.048
drl derailed 0.048
unk unkempt 0.046
heph hephaestus 0.045
zfh2 Zn finger homeodomain 2 0.044
grh grainy head 0.043
bun bunched 0.041
CycD Cyclin D 0.040
dac dachshund 0.039
Hrb87F Heterogeneous nuclear ribonucleoprotein at 87F 0.038
Ssdp Sequence-specific single-stranded DNA-binding protein 0.037
Ser Serrate 0.035
sxc super sex combs 0.034
fj four-jointed 0.034
Clk Clock 0.034
rho rhomboid 0.032
Ork1 Open rectifier K[+] channel 1 0.032
CycJ Cyclin J 0.031
osp outspread 0.031
ash2 absent, small, or homeotic discs 2 0.031
Hr46 Hormone receptor-like in 46 0.031
cry cryptochrome 0.030
Plc21C Phospholipase C at 21C 0.030
Actbeta Activin-beta 0.029
Sce Sex combs extra 0.028
EDTP Egg-derived tyrosine phosphatase 0.027
Sam-S S-adenosylmethionine Synthetase 0.027
vvl ventral veins lacking 0.026
wun wunen 0.026
ap apterous 0.026
emc extra macrochaetae 0.025
Awh Arrowhead 0.024
CG32810 CG32810 gene product from transcript CG32810-RB 0.024
hpo hippo 0.024
al aristaless 0.024
cbt cabut 0.023
sgl sugarless 0.023
put punt 0.023
Ubx Ultrabithorax 0.023
ara araucan 0.023
fng fringe 0.022
lab labial 0.022
Tl Toll 0.022
CG13625 CG13625 gene product from transcript CG13625-RA 0.022
frc fringe connection 0.022
pnr pannier 0.022
tll tailless 0.022
repo reversed polarity 0.021
prod proliferation disrupter 0.021
E23 Early gene at 23 0.021
e(y)3 enhancer of yellow 3 0.020
kni knirps 0.019
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
olig2 oligodendrocyte lineage transcription factor 2 0.925
isl1 islet1 0.869
lhx1a LIM homeobox 1a 0.861
nkx2.2a NK2 transcription factor related 2a 0.777
hlxb9la homeo box HB9 like a 0.709
pdx1 pancreatic and duodenal homeobox 1 0.609
ins preproinsulin 0.570
dla deltaA 0.527
sst1.1 somatostatin 1, tandem duplicate 1 0.465
gcga glucagon a and glucagon a-like 0.364
ascl1a achaete-scute complex-like 1a (Drosophila) 0.352
evx1 even-skipped homeobox 1 0.333
otpb orthopedia homolog b 0.315
mnx1 motor neuron and pancreas homeobox 1 0.309
neurog1 neurogenin 1 0.288
pax6b paired box gene 6b 0.255
lef1 lymphocyte enhancer binding factor 1 0.240
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.221
dlb deltaB 0.201
olfm2 olfactomedin 2 0.185
gdf6a growth differentiation factor 6a 0.183
shha sonic hedgehog a 0.167
lhx5 LIM homeobox 5 0.148
dbx1a developing brain homeobox 1a 0.124
pax8 paired box gene 8 0.122
mib mind bomb 0.117
foxa1 forkhead box A1 0.107
prox1 prospero-related homeobox gene 1 0.104
ascl1b achaete-scute complex-like 1b (Drosophila) 0.100
vsx2 visual system homeobox 2 0.093
vsx1 visual system homeobox 1 homolog, chx10-like 0.084
hoxb1a homeo box B1a 0.083
otx2 orthodenticle homolog 2 0.083
dlx6a distal-less homeobox gene 6a 0.082
pax6a paired box gene 6a 0.078
foxa2 forkhead box A2 0.075
bmp2b bone morphogenetic protein 2b 0.074
hhex hematopoietically expressed homeobox 0.074
hlxb9lb homeo box HB9 like b 0.072
olig4 oligodendrocyte transcription factor 4 0.070
osr2 odd-skipped related 2 (Drosophila) 0.069
coe2 coe2 0.069
met met proto-oncogene (hepatocyte growth factor receptor) 0.066
pax4 paired box 4 0.063
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.060
tal2 T-cell acute lymphocytic leukemia 2 0.060
adcyap1r1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 0.058
tll1 tolloid-like 1 0.055
pax9 paired box gene 9 0.055
foxa3 forkhead box A3 0.055
nkx2.3 NK2 transcription factor related 3 0.052
tpbgl trophoblast glycoprotein-like 0.049
dlx2b distal-less homeobox gene 2b 0.049
irx3a iroquois homeobox protein 3a 0.048
dld deltaD 0.046
nkx6.2 NK6 transcription factor related, locus 2 0.044
neurod neurogenic differentiation 0.042
six3a sine oculis homeobox homolog 3a 0.041
dlx1a distal-less homeobox gene 1a 0.041
eomesa eomesodermin homolog a 0.039
inab internexin neuronal intermediate filament protein, alpha b 0.038
barhl2 BarH-like 2 0.037
th tyrosine hydroxylase 0.036
atoh7 atonal homolog 7 0.035
dlx2a distal-less homeobox gene 2a 0.035
her5 hairy-related 5 0.034
foxp2 forkhead box P2 0.033
ndr2 nodal-related 2 0.031
rx3 retinal homeobox gene 3 0.030
pou3f3b POU class 3 homeobox 3b 0.030
lhx3 LIM homeobox 3 0.028
cry2b cryptochrome 2b 0.028
fgf20a fibroblast growth factor 20a 0.027
jag1b jagged 1b 0.026
phox2a paired-like homeobox 2a 0.025
pou3f2 POU class 3 homeobox 2 0.025
meis2.2 myeloid ecotropic viral integration site 2.2 0.024
bmp4 bone morphogenetic protein 4 0.024
flot1 flotillin 1 0.024
eng2b engrailed 2b 0.023
arntl1b aryl hydrocarbon receptor nuclear translocator-like 1b 0.023
camkvb CaM kinase-like vesicle-associated b 0.022
insm1a insulinoma-associated 1a 0.022
hnf4a hepatocyte nuclear factor 4, alpha 0.022
zgc:112180 zgc:112180 0.021
fzd5 frizzled homolog 5 0.021
plxnb2a plexin b2a 0.021
nkx2.1b NK2 homeobox 1b 0.021
dcc deleted in colorectal carcinoma 0.021
sox9b SRY-box containing gene 9b 0.020
osr1 odd-skipped related 1 (Drosophila) 0.019
sst2 somatostatin 2 0.019
nfasca neurofascin homolog (chicken) a 0.019
nxph1 neurexophilin 1 0.019
sult3st1 sulfotransferase family 3, cytosolic sulfotransferase 1 0.019
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.018
ebf3 early B-cell factor 3 0.018
ihha Indian hedgehog homolog a 0.018
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.017
ek1 eph-like kinase 1 0.017
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Homo sapiens
Name Description Probability Func Analog Organism
CDK6 cyclin-dependent kinase 6 0.999
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.998
CCND1 cyclin D1 0.998
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.988
BMPR1A bone morphogenetic protein receptor, type IA 0.971
CCND3 cyclin D3 0.947
TSC2 tuberous sclerosis 2 0.829
CDK4 cyclin-dependent kinase 4 0.709
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.583
BMPR1B bone morphogenetic protein receptor, type IB 0.543
CLOCK clock homolog (mouse) 0.382
NOG noggin 0.374
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.357
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.281
NEUROD1 neurogenic differentiation 1 0.260
FSTL1 follistatin-like 1 0.220
HNF1A HNF1 homeobox A 0.212
RB1 retinoblastoma 1 0.140
CDK2 cyclin-dependent kinase 2 0.130
HNF4A hepatocyte nuclear factor 4, alpha 0.105
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.097
SBF1 SET binding factor 1 0.091
CCND2 cyclin D2 0.070
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.062
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.053
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.053
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.051
ZFYVE9 zinc finger, FYVE domain containing 9 0.045
CARD11 caspase recruitment domain family, member 11 0.037
PDX1 pancreatic and duodenal homeobox 1 0.037
CCNE1 cyclin E1 0.037
CDK5 cyclin-dependent kinase 5 0.036
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.030
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.030
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.030
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.029
BBS10 Bardet-Biedl syndrome 10 0.027
CDK11B cyclin-dependent kinase 11B 0.026
NKX2-2 NK2 homeobox 2 0.026
RUNX1 runt-related transcription factor 1 0.025
FOXA2 forkhead box A2 0.022
MCM10 minichromosome maintenance complex component 10 0.017
AHR aryl hydrocarbon receptor 0.013
ZNF331 zinc finger protein 331 0.013
CDK14 cyclin-dependent kinase 14 0.011
NKX6-1 NK6 homeobox 1 0.011
DTNBP1 dystrobrevin binding protein 1 0.011
ZFYVE26 zinc finger, FYVE domain containing 26 0.011
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.011
C1orf93 chromosome 1 open reading frame 93 0.010
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.010
POU3F4 POU class 3 homeobox 4 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.996
Emx1 empty spiracles homolog 1 (Drosophila) 0.986
Neurod1 neurogenic differentiation 1 0.951
Fgf8 fibroblast growth factor 8 0.949
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.927
Pax2 paired box gene 2 0.923
Foxc1 forkhead box C1 0.907
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.876
Hand1 heart and neural crest derivatives expressed transcript 1 0.866
Gli3 GLI-Kruppel family member GLI3 0.860
Bmp4 bone morphogenetic protein 4 0.850
Lhx3 LIM homeobox protein 3 0.842
Sox9 SRY-box containing gene 9 0.840
Isl1 ISL1 transcription factor, LIM/homeodomain 0.826
Hand2 heart and neural crest derivatives expressed transcript 2 0.773
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.770
Lhx1 LIM homeobox protein 1 0.741
Pax8 paired box gene 8 0.662
Pitx2 paired-like homeodomain transcription factor 2 0.659
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.627
Gata4 GATA binding protein 4 0.593
Fgfr2 fibroblast growth factor receptor 2 0.592
Wnt3a wingless-related MMTV integration site 3A 0.555
Lhx5 LIM homeobox protein 5 0.539
Pax3 paired box gene 3 0.534
Gli2 GLI-Kruppel family member GLI2 0.525
Emx2 empty spiracles homolog 2 (Drosophila) 0.513
Clock circadian locomotor output cycles kaput 0.503
Insm1 insulinoma-associated 1 0.483
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.483
Tbx1 T-box 1 0.473
Nog noggin 0.472
Foxa2 forkhead box A2 0.454
Gata6 GATA binding protein 6 0.446
Pax6 paired box gene 6 0.422
Sox2 SRY-box containing gene 2 0.398
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.389
Kiss1 KiSS-1 metastasis-suppressor 0.359
Per2 period homolog 2 (Drosophila) 0.351
Foxc2 forkhead box C2 0.348
Tal1 T-cell acute lymphocytic leukemia 1 0.342
Rarg retinoic acid receptor, gamma 0.340
Hes1 hairy and enhancer of split 1 (Drosophila) 0.337
Nkx6-1 NK6 homeobox 1 0.328
En1 engrailed 1 0.326
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.314
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.309
Bmp7 bone morphogenetic protein 7 0.299
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.295
Cry1 cryptochrome 1 (photolyase-like) 0.282
Neurog1 neurogenin 1 0.281
Onecut1 one cut domain, family member 1 0.267
T brachyury 0.262
Hoxd13 homeobox D13 0.252
Neurog2 neurogenin 2 0.251
Sox4 SRY-box containing gene 4 0.242
Rxra retinoid X receptor alpha 0.222
Fgf15 fibroblast growth factor 15 0.222
Pou3f3 POU domain, class 3, transcription factor 3 0.218
Vax1 ventral anterior homeobox containing gene 1 0.207
Pitx1 paired-like homeodomain transcription factor 1 0.206
Ret ret proto-oncogene 0.206
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.205
Ptf1a pancreas specific transcription factor, 1a 0.204
Hoxa13 homeobox A13 0.199
Msx1 homeobox, msh-like 1 0.196
Foxf1a forkhead box F1a 0.192
Tbx3 T-box 3 0.190
Pten phosphatase and tensin homolog 0.188
Tlx3 T-cell leukemia, homeobox 3 0.188
Rara retinoic acid receptor, alpha 0.174
Mesp1 mesoderm posterior 1 0.171
Neurog3 neurogenin 3 0.167
Gdnf glial cell line derived neurotrophic factor 0.158
Fgf10 fibroblast growth factor 10 0.153
Sox11 SRY-box containing gene 11 0.146
Arx aristaless related homeobox 0.142
Sim1 single-minded homolog 1 (Drosophila) 0.140
Pdx1 pancreatic and duodenal homeobox 1 0.140
Mecom MDS1 and EVI1 complex locus 0.137
Alx3 aristaless-like homeobox 3 0.136
Sox1 SRY-box containing gene 1 0.133
Wnt4 wingless-related MMTV integration site 4 0.129
Pou3f2 POU domain, class 3, transcription factor 2 0.127
Hes5 hairy and enhancer of split 5 (Drosophila) 0.123
Gata1 GATA binding protein 1 0.122
Uncx UNC homeobox 0.119
Foxe1 forkhead box E1 0.109
Zfpm2 zinc finger protein, multitype 2 0.108
Ntf3 neurotrophin 3 0.107
Smad6 MAD homolog 6 (Drosophila) 0.106
Pcdh12 protocadherin 12 0.102
Tgfb2 transforming growth factor, beta 2 0.097
Foxd2 forkhead box D2 0.090
Dlx1 distal-less homeobox 1 0.089
Dlx2 distal-less homeobox 2 0.089
Gsc goosecoid homeobox 0.086
Adra2b adrenergic receptor, alpha 2b 0.084
Ptch1 patched homolog 1 0.083
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism