The network for 'positive regulation of rab gtpase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of rab gtpase activity

Any process that activates or increases the activity of a GTPase of the Rab family.

Homo sapiens
Name Description Probability Func Analog Organism
GABARAPL1 GABA(A) receptor-associated protein like 1 0.998
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.988
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 0.978
CHD3 chromodomain helicase DNA binding protein 3 0.974
BIN1 bridging integrator 1 0.968
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.903
C19orf50 chromosome 19 open reading frame 50 0.847
MYCBP2 MYC binding protein 2 0.792
RAB4A RAB4A, member RAS oncogene family 0.626
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.587
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.557
PRKCZ protein kinase C, zeta 0.441
RAB5A RAB5A, member RAS oncogene family 0.416
PDPK1 3-phosphoinositide dependent protein kinase-1 0.399
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.391
EEA1 early endosome antigen 1 0.357
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.343
PNPLA6 patatin-like phospholipase domain containing 6 0.316
CRTC2 CREB regulated transcription coactivator 2 0.315
TSC2 tuberous sclerosis 2 0.303
RAB3IP RAB3A interacting protein (rabin3) 0.295
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.272
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.263
NCKAP1 NCK-associated protein 1 0.261
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.261
EZR ezrin 0.239
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.233
RGS2 regulator of G-protein signaling 2, 24kDa 0.223
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 0.223
FAM82A2 family with sequence similarity 82, member A2 0.216
KIAA0930 KIAA0930 0.208
FRYL FRY-like 0.205
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.199
LZTR1 leucine-zipper-like transcription regulator 1 0.195
MINK1 misshapen-like kinase 1 0.190
PLCG1 phospholipase C, gamma 1 0.179
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.158
MPRIP myosin phosphatase Rho interacting protein 0.155
WBP2 WW domain binding protein 2 0.154
KLC1 kinesin light chain 1 0.150
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.147
AKT1S1 AKT1 substrate 1 (proline-rich) 0.141
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.127
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.126
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.120
LMF2 lipase maturation factor 2 0.115
PHF3 PHD finger protein 3 0.115
CABIN1 calcineurin binding protein 1 0.108
CARD11 caspase recruitment domain family, member 11 0.106
TRAPPC2 trafficking protein particle complex 2 0.102
NBR1 neighbor of BRCA1 gene 1 0.101
ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae) 0.100
GDI1 GDP dissociation inhibitor 1 0.100
FRMD6 FERM domain containing 6 0.098
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.098
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.097
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.097
OSBPL3 oxysterol binding protein-like 3 0.093
STRN4 striatin, calmodulin binding protein 4 0.093
TSC1 tuberous sclerosis 1 0.083
CIC capicua homolog (Drosophila) 0.082
FXR2 fragile X mental retardation, autosomal homolog 2 0.082
MICALL1 MICAL-like 1 0.081
ATG14 ATG14 autophagy related 14 homolog (S. cerevisiae) 0.079
MYO9B myosin IXB 0.079
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 0.076
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.073
STBD1 starch binding domain 1 0.072
DGKZ diacylglycerol kinase, zeta 0.071
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.070
TRAPPC10 trafficking protein particle complex 10 0.067
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.066
LARP1 La ribonucleoprotein domain family, member 1 0.064
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.062
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.061
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.060
GAK cyclin G associated kinase 0.058
DCAF10 DDB1 and CUL4 associated factor 10 0.058
CDK17 cyclin-dependent kinase 17 0.058
RAB24 RAB24, member RAS oncogene family 0.058
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.057
MYO18A myosin XVIIIA 0.056
NISCH nischarin 0.056
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.056
IPO13 importin 13 0.054
EML3 echinoderm microtubule associated protein like 3 0.053
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.052
FAM65A family with sequence similarity 65, member A 0.052
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.052
CAMTA2 calmodulin binding transcription activator 2 0.051
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.050
SIN3B SIN3 homolog B, transcription regulator (yeast) 0.050
CYTH4 cytohesin 4 0.049
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.048
RALGDS ral guanine nucleotide dissociation stimulator 0.048
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.048
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.047
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 0.046
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.046
CEP350 centrosomal protein 350kDa 0.046
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
rme-4 Protein RME-4 0.014
K10B4.3 Protein K10B4.3 0.011
rpm-1 Protein RPM-1 0.010
unc-71 Protein UNC-71 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG8155 CG8155 gene product from transcript CG8155-RA 0.524
CG4552 CG4552 gene product from transcript CG4552-RA 0.170
synj synaptojanin 0.137
Rala Ras-related protein 0.105
CG6509 CG6509 gene product from transcript CG6509-RB 0.099
SCAR CG4636 gene product from transcript CG4636-RA 0.064
Hph HIF prolyl hydroxylase 0.063
HLH106 Helix loop helix protein 106 0.058
sec15 CG7034 gene product from transcript CG7034-RA 0.053
sima similar 0.051
l(2)k05819 lethal (2) k05819 0.049
Vps35 Vacuolar protein sorting 35 0.043
Smox Smad on X 0.041
jar jaguar 0.041
CG15118 CG15118 gene product from transcript CG15118-RC 0.038
ken ken and barbie 0.036
stai stathmin 0.035
CalpB Calpain-B 0.034
CG5798 CG5798 gene product from transcript CG5798-RA 0.031
Kap3 Kinesin associated protein 3 0.029
CG1233 CG1233 gene product from transcript CG1233-RB 0.029
CG6194 CG6194 gene product from transcript CG6194-RA 0.028
TSG101 tumor suppressor protein 101 0.027
cdm cadmus 0.027
lt light 0.026
EDTP Egg-derived tyrosine phosphatase 0.021
CG10631 CG10631 gene product from transcript CG10631-RA 0.020
CG7158 CG7158 gene product from transcript CG7158-RA 0.019
lgs legless 0.018
par-6 CG5884 gene product from transcript CG5884-RA 0.018
Rip11 Rab11 interacting protein 0.017
Eip75B Ecdysone-induced protein 75B 0.017
CG10254 CG10254 gene product from transcript CG10254-RB 0.017
Sra-1 specifically Rac1-associated protein 1 0.017
baz bazooka 0.017
Sbf SET domain binding factor 0.017
Klp68D Kinesin-like protein at 68D 0.017
cn cinnabar 0.016
CG3356 CG3356 gene product from transcript CG3356-RA 0.016
pkaap CG4132 gene product from transcript CG4132-RA 0.015
CG2938 CG2938 gene product from transcript CG2938-RB 0.015
CG5087 CG5087 gene product from transcript CG5087-RA 0.015
Vti1 CG3279 gene product from transcript CG3279-RA 0.014
Dlic Dynein light intermediate chain 0.013
CG33090 CG33090 gene product from transcript CG33090-RB 0.013
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.013
CG6454 CG6454 gene product from transcript CG6454-RC 0.013
pgant3 polypeptide GalNAc transferase 3 0.013
CG5270 CG5270 gene product from transcript CG5270-RB 0.012
mask multiple ankyrin repeats single KH domain 0.012
rab3-GAP CG7061 gene product from transcript CG7061-RA 0.012
CG11178 CG11178 gene product from transcript CG11178-RA 0.012
CG11055 CG11055 gene product from transcript CG11055-RB 0.011
CG11033 CG11033 gene product from transcript CG11033-RB 0.011
Eps-15 Epidermal growth factor receptor pathway substrate clone 15 0.011
schlank CG3576 gene product from transcript CG3576-RB 0.011
CG11247 CG11247 gene product from transcript CG11247-RC 0.011
wts warts 0.011
G9a CG2995 gene product from transcript CG2995-RA 0.011
Syx7 Syntaxin 7 0.011
CG10918 CG10918 gene product from transcript CG10918-RA 0.010
CG11526 CG11526 gene product from transcript CG11526-RB 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.181
Zdhhc17 zinc finger, DHHC domain containing 17 0.174
D15Ertd621e DNA segment, Chr 15, ERATO Doi 621, expressed 0.104
Mkl1 MKL (megakaryoblastic leukemia)/myocardin-like 1 0.078
Fnip1 folliculin interacting protein 1 0.046
Pcnxl3 pecanex-like 3 (Drosophila) 0.038
Stag2 stromal antigen 2 0.036
Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.026
Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform 0.024
Abtb1 ankyrin repeat and BTB (POZ) domain containing 1 0.024
Fndc3a fibronectin type III domain containing 3A 0.022
Arhgap21 Rho GTPase activating protein 21 0.022
Rab5a RAB5A, member RAS oncogene family 0.021
Cpne3 copine III 0.020
Eps15 epidermal growth factor receptor pathway substrate 15 0.020
Nckap1 NCK-associated protein 1 0.020
Rbm7 RNA binding motif protein 7 0.018
Glg1 golgi apparatus protein 1 0.018
Iqsec1 IQ motif and Sec7 domain 1 0.017
Copb1 coatomer protein complex, subunit beta 1 0.016
Lamp2 lysosomal-associated membrane protein 2 0.016
Rnf103 ring finger protein 103 0.016
Nek7 NIMA (never in mitosis gene a)-related expressed kinase 7 0.016
Tjp1 tight junction protein 1 0.016
Stxbp3a syntaxin binding protein 3A 0.015
Golim4 golgi integral membrane protein 4 0.014
Dnm1 dynamin 1 0.014
Pitpnm1 phosphatidylinositol transfer protein, membrane-associated 1 0.014
Cic capicua homolog (Drosophila) 0.014
Hivep1 human immunodeficiency virus type I enhancer binding protein 1 0.014
Evi5 ecotropic viral integration site 5 0.014
Cc2d1a coiled-coil and C2 domain containing 1A 0.013
Vps35 vacuolar protein sorting 35 0.013
Strn4 striatin, calmodulin binding protein 4 0.013
Megf8 multiple EGF-like-domains 8 0.013
March7 membrane-associated ring finger (C3HC4) 7 0.012
Ap1b1 adaptor protein complex AP-1, beta 1 subunit 0.012
Golga4 golgi autoantigen, golgin subfamily a, 4 0.011
Dennd4b DENN/MADD domain containing 4B 0.011
Rdx radixin 0.011
Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 0.011
Dlgap4 discs, large homolog-associated protein 4 (Drosophila) 0.011
Abcg2 ATP-binding cassette, sub-family G (WHITE), member 2 0.011
Rock1 Rho-associated coiled-coil containing protein kinase 1 0.011
Sh2d3c SH2 domain containing 3C 0.011
Golph3 golgi phosphoprotein 3 0.010
Sacm1l SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae) 0.010
Plekhg2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Smg5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.050
Pls3 plastin 3 (T-isoform) 0.022
Copb1 coatomer protein complex, subunit beta 1 0.022
Adar adenosine deaminase, RNA-specific 0.021
Eif3e eukaryotic translation initiation factor 3, subunit E 0.019
Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 0.018
Exoc5 exocyst complex component 5 0.017
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.017
Lgals8 lectin, galactoside-binding, soluble, 8 0.017
Nckap1 NCK-associated protein 1 0.017
Tmem59 transmembrane protein 59 0.014
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.013
Rab7a RAB7A, member RAS oncogene family 0.013
App amyloid beta (A4) precursor protein 0.013
Clcn7 chloride channel 7 0.013
Slc22a17 solute carrier family 22, member 17 0.013
RGD621098 similar to RIKEN cDNA D230025D16Rik 0.013
Ulk1 Unc-51 like kinase 1 (C. elegans) 0.013
Zfp260 zinc finger protein 260 0.012
Snx2 sorting nexin 2 0.012
RGD1565411 similar to 2610317D23Rik protein 0.012
Inpp4a inositol polyphosphate-4-phosphatase, type 1 0.012
Pi4k2a phosphatidylinositol 4-kinase type 2 alpha 0.012
Sptlc1 serine palmitoyltransferase, long chain base subunit 1 0.012
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.012
G3bp2 GTPase activating protein (SH3 domain) binding protein 2 0.011
Mcf2l MCF.2 cell line derived transforming sequence-like 0.011
Hp1bp3 heterochromatin protein 1, binding protein 3 0.011
Ubr4 ubiquitin protein ligase E3 component n-recognin 4 0.011
Mospd2 motile sperm domain containing 2 0.011
Hk1 hexokinase 1 0.011
Ampd2 adenosine monophosphate deaminase 2 (isoform L) 0.011
Brd2 bromodomain containing 2 0.011
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.010
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.010
Unc13b unc-13 homolog B (C. elegans) 0.010
Sash3 SAM and SH3 domain containing 3 0.010
Nptn neuroplastin 0.010
Lzts2 leucine zipper, putative tumor suppressor 2 0.010
Cmpk1 cytidine monophosphate (UMP-CMP) kinase 1 0.010
Arhgap5 Rho GTPase activating protein 5 0.010
Stx2 syntaxin 2 0.010
Madd MAP-kinase activating death domain 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism