The network for 'positive regulation of icosanoid secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of icosanoid secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell.

Homo sapiens
Name Description Probability Func Analog Organism
MAP2K4 mitogen-activated protein kinase kinase 4 0.994
IL1R1 interleukin 1 receptor, type I 0.766
MAPK14 mitogen-activated protein kinase 14 0.458
KIAA1712 KIAA1712 0.314
IL1RAP interleukin 1 receptor accessory protein 0.237
XPO7 exportin 7 0.213
IL1RN interleukin 1 receptor antagonist 0.203
LRRK2 leucine-rich repeat kinase 2 0.198
KIAA1377 KIAA1377 0.180
C1orf93 chromosome 1 open reading frame 93 0.179
BBS10 Bardet-Biedl syndrome 10 0.111
IL8 interleukin 8 0.105
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 0.089
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.063
CXCL3 chemokine (C-X-C motif) ligand 3 0.056
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.056
ZBTB25 zinc finger and BTB domain containing 25 0.052
CCL20 chemokine (C-C motif) ligand 20 0.051
MAPK1 mitogen-activated protein kinase 1 0.041
TRAF5 TNF receptor-associated factor 5 0.040
CXCL2 chemokine (C-X-C motif) ligand 2 0.040
MAP2K3 mitogen-activated protein kinase kinase 3 0.040
ZFP36L1 zinc finger protein 36, C3H type-like 1 0.037
LMO4 LIM domain only 4 0.034
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.034
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.028
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.027
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.027
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 0.026
ATF2 activating transcription factor 2 0.026
ZC3HC1 zinc finger, C3HC-type containing 1 0.025
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.025
RGS2 regulator of G-protein signaling 2, 24kDa 0.025
HPD 4-hydroxyphenylpyruvate dioxygenase 0.024
C6 complement component 6 0.023
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.023
SBF1 SET binding factor 1 0.022
C7orf36 chromosome 7 open reading frame 36 0.021
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.021
IL6 interleukin 6 (interferon, beta 2) 0.020
AQP7 aquaporin 7 0.020
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.020
AQP9 aquaporin 9 0.020
IL1R2 interleukin 1 receptor, type II 0.020
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.020
LGALS4 lectin, galactoside-binding, soluble, 4 0.019
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.018
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.018
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.018
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.018
CCL4 chemokine (C-C motif) ligand 4 0.018
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 0.018
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.017
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) 0.017
RDH16 retinol dehydrogenase 16 (all-trans) 0.016
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.016
TRMT2A TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae) 0.016
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.016
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.016
GLYAT glycine-N-acyltransferase 0.016
ABP1 amiloride binding protein 1 (amine oxidase (copper-containing)) 0.015
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 0.015
ADH6 alcohol dehydrogenase 6 (class V) 0.015
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.015
FRZB frizzled-related protein 0.015
C8A complement component 8, alpha polypeptide 0.015
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.015
STAB2 stabilin 2 0.015
CCL2 chemokine (C-C motif) ligand 2 0.014
IRAK2 interleukin-1 receptor-associated kinase 2 0.014
GH1 growth hormone 1 0.014
NLRP3 NLR family, pyrin domain containing 3 0.014
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.014
AGXT alanine-glyoxylate aminotransferase 0.014
C8B complement component 8, beta polypeptide 0.014
G6PC glucose-6-phosphatase, catalytic subunit 0.014
TRAF1 TNF receptor-associated factor 1 0.014
GP2 glycoprotein 2 (zymogen granule membrane) 0.014
SOD2 superoxide dismutase 2, mitochondrial 0.014
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.013
FABP1 fatty acid binding protein 1, liver 0.013
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.013
PLG plasminogen 0.013
GPR84 G protein-coupled receptor 84 0.013
PLAUR plasminogen activator, urokinase receptor 0.013
MAT1A methionine adenosyltransferase I, alpha 0.013
CXCL5 chemokine (C-X-C motif) ligand 5 0.013
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.013
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.013
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.013
HAL histidine ammonia-lyase 0.013
FOXN1 forkhead box N1 0.013
GPX2 glutathione peroxidase 2 (gastrointestinal) 0.013
GPR109B G protein-coupled receptor 109B 0.013
BCL2A1 BCL2-related protein A1 0.013
IL7R interleukin 7 receptor 0.013
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 0.013
TLR2 toll-like receptor 2 0.012
GADD45G growth arrest and DNA-damage-inducible, gamma 0.012
KNG1 kininogen 1 0.012
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Lta lymphotoxin A 0.994
Tnf tumor necrosis factor 0.981
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.930
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.708
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.516
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.399
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.335
Ltb lymphotoxin B 0.213
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.186
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.167
Il7 interleukin 7 0.162
Ifng interferon gamma 0.158
Cxcl13 chemokine (C-X-C motif) ligand 13 0.152
Ctsk cathepsin K 0.123
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.099
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.091
Cxcr5 chemokine (C-X-C motif) receptor 5 0.091
Cd40 CD40 antigen 0.072
Il1r1 interleukin 1 receptor, type I 0.060
Cd19 CD19 antigen 0.057
Il10 interleukin 10 0.051
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.049
Tox thymocyte selection-associated high mobility group box 0.046
Lyz2 lysozyme 2 0.046
Il6 interleukin 6 0.043
Ccl2 chemokine (C-C motif) ligand 2 0.041
Nos2 nitric oxide synthase 2, inducible 0.031
Traf6 TNF receptor-associated factor 6 0.026
Ikbkg inhibitor of kappaB kinase gamma 0.024
Btk Bruton agammaglobulinemia tyrosine kinase 0.023
Traf2 TNF receptor-associated factor 2 0.022
Pou2af1 POU domain, class 2, associating factor 1 0.021
Nlrp3 NLR family, pyrin domain containing 3 0.019
S1pr2 sphingosine-1-phosphate receptor 2 0.018
Ikzf1 IKAROS family zinc finger 1 0.017
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.017
Irak4 interleukin-1 receptor-associated kinase 4 0.015
Tcf3 transcription factor 3 0.014
Irg1 immunoresponsive gene 1 0.013
Il4 interleukin 4 0.012
Pdcd1 programmed cell death 1 0.011
Cd80 CD80 antigen 0.011
Il1rn interleukin 1 receptor antagonist 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.033
Vegfa vascular endothelial growth factor A 0.028
Syt4 synaptotagmin IV 0.027
Csnk1g1 casein kinase 1, gamma 1 0.026
Arl5a ADP-ribosylation factor-like 5A 0.020
Rnf123 ring finger protein 123 0.019
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.018
Mll4 myeloid/lymphoid or mixed-lineage leukemia 4 0.017
Nsf N-ethylmaleimide-sensitive factor 0.016
Tmem171 transmembrane protein 171 0.016
Kcnk1 potassium channel, subfamily K, member 1 0.015
Amph amphiphysin 0.014
Map2k4 mitogen activated protein kinase kinase 4 0.014
Jun Jun oncogene 0.014
Stk40 serine/threonine kinase 40 0.014
Ctbp1 C-terminal binding protein 1 0.014
Tgm1 transglutaminase 1, K polypeptide 0.013
Lancl2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.013
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.013
Snrk SNF related kinase 0.011
Mapk8 mitogen-activated protein kinase 8 0.011
Tagln3 transgelin 3 0.011
Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 0.011
Kcnt1 potassium channel, subfamily T, member 1 0.011
Socs3 suppressor of cytokine signaling 3 0.010
RGD621098 similar to RIKEN cDNA D230025D16Rik 0.010
Nenf neuron derived neurotrophic factor 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism